Giedroc Lab
@giedroclab.bsky.social
Chemical and physical biology of infectious disease | bioinorganic chemistry | biophysical chemistry | bioanalytical chemistry | IUB chemistry | https://giedroc.lab.indiana.edu/
A bit late, but excited to share our new PNAS paper! We uncovered a molecular switching mechanism in COG0523 proteins driven by self-activation via an arginine finger in the CTD.
Read more details here: link.growkudos.com/1e5gtwm2lmo
Read more details here: link.growkudos.com/1e5gtwm2lmo
July 1, 2026 at 5:57 PM
A bit late, but excited to share our new PNAS paper! We uncovered a molecular switching mechanism in COG0523 proteins driven by self-activation via an arginine finger in the CTD.
Read more details here: link.growkudos.com/1e5gtwm2lmo
Read more details here: link.growkudos.com/1e5gtwm2lmo
Huge congratulations to the most recent PhD in our lab, @jsrocchio.bsky.social, on his first-author paper in ACS Infectious Diseases! Joey built this beautiful toolkit for probing peptidoglycan biosynthesis and antibiotic action in A. baumannii cells. 🦠 #IUResearch tinyurl.com/46d8x9eb
Monitoring UDP-MurNAc (UM)-Stem Peptide Intermediates from the Cellular and Recombinant Acinetobacter baumannii MurCDEF Pathway
Increasing multidrug resistance in nosocomial, opportunistic bacterial pathogens motivates a need to exploit metabolic pathways of therapeutic value. Here, we describe a one-pot reconstitution of the ...
pubs.acs.org
March 18, 2026 at 3:48 PM
Huge congratulations to the most recent PhD in our lab, @jsrocchio.bsky.social, on his first-author paper in ACS Infectious Diseases! Joey built this beautiful toolkit for probing peptidoglycan biosynthesis and antibiotic action in A. baumannii cells. 🦠 #IUResearch tinyurl.com/46d8x9eb
Reposted by Giedroc Lab
Excited to co-chair the 2026 Gordon Research Seminar (GRS) on Thiol-Based Redox Regulation & Signaling with Taylor Covington, a meeting for early career researchers in redox research
📍 Castelldefels (Barcelona), Spain ☀️
📅 July 11–12, 2026
#Redox #Thiols #EarlyCareerResearchers
More details ↓
📍 Castelldefels (Barcelona), Spain ☀️
📅 July 11–12, 2026
#Redox #Thiols #EarlyCareerResearchers
More details ↓
March 16, 2026 at 12:17 PM
Excited to co-chair the 2026 Gordon Research Seminar (GRS) on Thiol-Based Redox Regulation & Signaling with Taylor Covington, a meeting for early career researchers in redox research
📍 Castelldefels (Barcelona), Spain ☀️
📅 July 11–12, 2026
#Redox #Thiols #EarlyCareerResearchers
More details ↓
📍 Castelldefels (Barcelona), Spain ☀️
📅 July 11–12, 2026
#Redox #Thiols #EarlyCareerResearchers
More details ↓
Excited to share our new preprint on self-S-sulfonation in persulfide dioxygenase CstB from S. aureus, unveiling how it detoxifies thiol persulfides via a dynamic loop shuttle to produce thiosulfate, no sulfite released! Crystal structures, MS, & mechanistic insights included.
tinyurl.com/4sr3ayz5
tinyurl.com/4sr3ayz5
doi.org
March 6, 2026 at 3:59 PM
Excited to share our new preprint on self-S-sulfonation in persulfide dioxygenase CstB from S. aureus, unveiling how it detoxifies thiol persulfides via a dynamic loop shuttle to produce thiosulfate, no sulfite released! Crystal structures, MS, & mechanistic insights included.
tinyurl.com/4sr3ayz5
tinyurl.com/4sr3ayz5
Huge congratulations to grad student @katherinelegg.bsky.social on her new Science Advances paper, “CH•••S hydrogen bonds drive molecular recognition of ergothioneine by the microbial transporter”! 🎉 A beautiful collaboration of biochemistry, structural biology, NMR, and MD. tinyurl.com/3wxchjhp
March 2, 2026 at 2:28 PM
Huge congratulations to grad student @katherinelegg.bsky.social on her new Science Advances paper, “CH•••S hydrogen bonds drive molecular recognition of ergothioneine by the microbial transporter”! 🎉 A beautiful collaboration of biochemistry, structural biology, NMR, and MD. tinyurl.com/3wxchjhp
Fantastic science this weekend at @iuqcb.bsky.social's Watanabe Symposium. Our grad student @jsrocchio.bsky.social even won the student poster competition! Thanks to @tripletstatesguy.bsky.social, @glycocode.bsky.social and all other speakers for great talks! #IUresearch
April 14, 2025 at 2:48 PM
Fantastic science this weekend at @iuqcb.bsky.social's Watanabe Symposium. Our grad student @jsrocchio.bsky.social even won the student poster competition! Thanks to @tripletstatesguy.bsky.social, @glycocode.bsky.social and all other speakers for great talks! #IUresearch
Our grad student @katherinelegg.bsky.social was a co-author on this recent publication in collaboration with the Reniere lab at UW! @gramnegativity.bsky.social was first author and has a great thread below going over the paper. Congrats Katherine, Lauren and all those involved!
The latest (and penultimate! 👀) article from the @mreniere.bsky.social lab is finally out! I’m really proud of this one in which I took a genetic approach (shocking, I know) to probe how Staph is able to grow in cystic fibrosis sputum: journals.asm.org/doi/10.1128/...
Analysis of genetic requirements and nutrient availability for Staphylococcus aureus growth in cystic fibrosis sputum | mBio
Staphylococcus aureus is a major cause of lung infections in people with cystic fibrosis (CF). This work
identifies genes required for S. aureus growth in this niche, which represent potential targets...
journals.asm.org
April 9, 2025 at 4:25 PM
Our grad student @katherinelegg.bsky.social was a co-author on this recent publication in collaboration with the Reniere lab at UW! @gramnegativity.bsky.social was first author and has a great thread below going over the paper. Congrats Katherine, Lauren and all those involved!
Our lab has two talks coming up!
1️⃣ @emmcraechem.bsky.social is on a queer in academia panel at the OASIS conference tomorrow (Apr. 5th)!
2️⃣ @jsrocchio.bsky.social is giving a talk about a COG0523 protein in Ab at QCB evening on Apr. 17th!
Both events require registration! See flyers for more details!
1️⃣ @emmcraechem.bsky.social is on a queer in academia panel at the OASIS conference tomorrow (Apr. 5th)!
2️⃣ @jsrocchio.bsky.social is giving a talk about a COG0523 protein in Ab at QCB evening on Apr. 17th!
Both events require registration! See flyers for more details!
April 4, 2025 at 2:23 PM
Our lab has two talks coming up!
1️⃣ @emmcraechem.bsky.social is on a queer in academia panel at the OASIS conference tomorrow (Apr. 5th)!
2️⃣ @jsrocchio.bsky.social is giving a talk about a COG0523 protein in Ab at QCB evening on Apr. 17th!
Both events require registration! See flyers for more details!
1️⃣ @emmcraechem.bsky.social is on a queer in academia panel at the OASIS conference tomorrow (Apr. 5th)!
2️⃣ @jsrocchio.bsky.social is giving a talk about a COG0523 protein in Ab at QCB evening on Apr. 17th!
Both events require registration! See flyers for more details!
Don't miss Dr. Giedroc's talk on Tues., Apr. 9 at 9AM EDT on the Biometals webinar! It's an opportunity to learn more about grad student @mkosterb.bsky.social's work on metalloproteome integrity (with the Weerapana lab, Skaar lab and @chazinwalter.bsky.social). Register: shorturl.at/38yWM #biometals
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cassyni.com
March 27, 2025 at 4:01 PM
Don't miss Dr. Giedroc's talk on Tues., Apr. 9 at 9AM EDT on the Biometals webinar! It's an opportunity to learn more about grad student @mkosterb.bsky.social's work on metalloproteome integrity (with the Weerapana lab, Skaar lab and @chazinwalter.bsky.social). Register: shorturl.at/38yWM #biometals
Reposted by Giedroc Lab
📅 Save the date!
1️⃣ Fri, Apr 11: 1st Annual Undergrad. Chemical Biology Symposium
Talks, poster session, facility tour, pizza, no registration!
2️⃣ Sat, Apr 12: 14th Annual Watanabe Symposium
Talks, lunch, poster session, registration required!
Questions? [email protected] or [email protected]
#IUResearch
1️⃣ Fri, Apr 11: 1st Annual Undergrad. Chemical Biology Symposium
Talks, poster session, facility tour, pizza, no registration!
2️⃣ Sat, Apr 12: 14th Annual Watanabe Symposium
Talks, lunch, poster session, registration required!
Questions? [email protected] or [email protected]
#IUResearch
March 24, 2025 at 3:27 PM
📅 Save the date!
1️⃣ Fri, Apr 11: 1st Annual Undergrad. Chemical Biology Symposium
Talks, poster session, facility tour, pizza, no registration!
2️⃣ Sat, Apr 12: 14th Annual Watanabe Symposium
Talks, lunch, poster session, registration required!
Questions? [email protected] or [email protected]
#IUResearch
1️⃣ Fri, Apr 11: 1st Annual Undergrad. Chemical Biology Symposium
Talks, poster session, facility tour, pizza, no registration!
2️⃣ Sat, Apr 12: 14th Annual Watanabe Symposium
Talks, lunch, poster session, registration required!
Questions? [email protected] or [email protected]
#IUResearch
Reposted by Giedroc Lab
Our annual QCB fellowship competition for 2025 is now open! We're offering 3-5 awards for PhD students in QCB trainer labs, including 1-2 for international students. Apply by April 13, 2025, midnight. Spread the word!🧑🔬 #QCBFellowship #IUResearch #PhDFunding iuqcb.indiana.edu/about/traine...
Trainee Fellowship Competition – QCB
iuqcb.indiana.edu
March 20, 2025 at 1:53 PM
Our annual QCB fellowship competition for 2025 is now open! We're offering 3-5 awards for PhD students in QCB trainer labs, including 1-2 for international students. Apply by April 13, 2025, midnight. Spread the word!🧑🔬 #QCBFellowship #IUResearch #PhDFunding iuqcb.indiana.edu/about/traine...
Our lab is seeking a highly motivated postdoctoral research associate to study zinc metallochaperones from the COG0523 superfamily of small GTPases. Apply here: shorturl.at/UmQYM or send application materials to Prof. Giedroc directly at [email protected]. Looking for strong biochemists; please share!
Postdoctoral Fellow (Zinc Metallochaperones)
The Department of Chemistry in the College of Arts + Sciences, consists of a well-rounded research community with cutting-edge expertise in a wide variety of modern disciplines including materials che...
indiana.peopleadmin.com
February 11, 2025 at 3:50 PM
Our lab is seeking a highly motivated postdoctoral research associate to study zinc metallochaperones from the COG0523 superfamily of small GTPases. Apply here: shorturl.at/UmQYM or send application materials to Prof. Giedroc directly at [email protected]. Looking for strong biochemists; please share!
Congratulations to our long-time collaborator Eric Skaar on receiving this prestigious Award in Molecular Biology from the National Academy of Sciences!
www.nasonline.org/award/nas-aw...
www.nasonline.org/award/nas-aw...
NAS Award in Molecular Biology – NAS
The NAS Award in Molecular Biology is supported by Pfizer Inc. and recognizes a recent notable discovery by a young scientist (no older than 50) who is a citizen of the United States. The award is pre...
www.nasonline.org
January 29, 2025 at 9:59 PM
Congratulations to our long-time collaborator Eric Skaar on receiving this prestigious Award in Molecular Biology from the National Academy of Sciences!
www.nasonline.org/award/nas-aw...
www.nasonline.org/award/nas-aw...
@betainverse.bsky.social, our former research scientist, is now the Director of the METACyt Biomolecular NMR Laboratory! She'll oversee the training and operation of our state-of-the-art 600 MHz and newly installed 800 MHz Bruker Ascend instruments. Congratulations, Katie! 🧲 #NMR #IUResearch
December 19, 2024 at 7:51 PM
@betainverse.bsky.social, our former research scientist, is now the Director of the METACyt Biomolecular NMR Laboratory! She'll oversee the training and operation of our state-of-the-art 600 MHz and newly installed 800 MHz Bruker Ascend instruments. Congratulations, Katie! 🧲 #NMR #IUResearch
Our review on bacterial metallostasis is now online in Chemical Reviews! This collaboration by the Giedroc (@betainverse.bsky.social and @jsrocchio.bsky.social) and Capdevila labs delves into bacterial metal regulation. 🦠 #Microbiology #ChemicalReviews #BacterialMetallostasis doi.org/10.1021/acs....
December 15, 2024 at 5:59 PM
Our review on bacterial metallostasis is now online in Chemical Reviews! This collaboration by the Giedroc (@betainverse.bsky.social and @jsrocchio.bsky.social) and Capdevila labs delves into bacterial metal regulation. 🦠 #Microbiology #ChemicalReviews #BacterialMetallostasis doi.org/10.1021/acs....
Drs. @betainverse.bsky.social and Diaz-Rodriguez purified EgtU, an ABC transporter that imports ergothioneine into bacterial cells, paving the way for structural and functional studies of uptake systems in S. pneumoniae and other pathogens. Kudos to the team! #BacterialTransporters shorturl.at/AUPTJ
Expression and purification of the intact bacterial ergothioneine transporter EgtU
The bacterial ATP-binding cassette (ABC) transporter EgtU is responsible for uptake of the cellular antioxidant ergothioneine in Streptococcus pneumon…
shorturl.at
December 10, 2024 at 5:52 PM
Drs. @betainverse.bsky.social and Diaz-Rodriguez purified EgtU, an ABC transporter that imports ergothioneine into bacterial cells, paving the way for structural and functional studies of uptake systems in S. pneumoniae and other pathogens. Kudos to the team! #BacterialTransporters shorturl.at/AUPTJ
Our very talented undergrad, Clare Frawley, presented her first poster today at the Indiana University Undergraduate Research Conference! 📊 🌟 Clare has been working with our grad student @jsrocchio.bsky.social on unnatural amino acid incorporation for live-cell cross linking studies! #IUResearch
December 6, 2024 at 9:07 PM
Our very talented undergrad, Clare Frawley, presented her first poster today at the Indiana University Undergraduate Research Conference! 📊 🌟 Clare has been working with our grad student @jsrocchio.bsky.social on unnatural amino acid incorporation for live-cell cross linking studies! #IUResearch
🎉 Exciting milestone! Our paper on CiaR-controlled Ccn sRNAs modulating Zn-resistance in S. pneumoniae is out! Congrats to @iuqcb.bsky.social's @mkosterb.bsky.social and Dr. Abigail Garrett. This marks Prof Giedroc's 200th peer-reviewed paper!🔬🧬 #sRNAs #MetalHomeostasis shorturl.at/lMFM3
The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance
Author summary Zn and Mn are essential micronutrients for many bacteria, including Streptococcus pneumoniae. While Zn performs vital structural or catalytic roles in certain proteins, in excess, Zn ca...
shorturl.at
December 4, 2024 at 3:38 PM
🎉 Exciting milestone! Our paper on CiaR-controlled Ccn sRNAs modulating Zn-resistance in S. pneumoniae is out! Congrats to @iuqcb.bsky.social's @mkosterb.bsky.social and Dr. Abigail Garrett. This marks Prof Giedroc's 200th peer-reviewed paper!🔬🧬 #sRNAs #MetalHomeostasis shorturl.at/lMFM3
🎉 Our grad student @katherinelegg.bsky.social is a co-author on a new preprint about the genetic requirements and nutrient needs for Staphylococcus aureus growth in cystic fibrosis sputum. Congrats to @gramnegativity.bsky.social and all involved! shorturl.at/yfZQA 🧬 #CysticFibrosis #Microbiology
Analysis of genetic requirements and nutrient availability for Staphylococcus aureus growth in cystic fibrosis sputum
Staphylococcus aureus is one of the most common pathogens isolated from the lungs of people with cystic fibrosis (CF), but little is known about its ability to colonize this niche. We performed a Tn-s...
pmc.ncbi.nlm.nih.gov
December 2, 2024 at 3:00 PM
🎉 Our grad student @katherinelegg.bsky.social is a co-author on a new preprint about the genetic requirements and nutrient needs for Staphylococcus aureus growth in cystic fibrosis sputum. Congrats to @gramnegativity.bsky.social and all involved! shorturl.at/yfZQA 🧬 #CysticFibrosis #Microbiology
Dr. Giedroc contributed to "Trace Metals and Infectious Diseases," exploring metals' roles in microbial-host interactions. Edited by Eric Skaar and Jerome Nriagu, the volume shows metallobiology's significance for infectious disease research. 📚🔬 #Metallobiology #InfectiousDiseases shorturl.at/ua8kq
Trace Metals and Infectious Diseases
Experts explore the influence of trace metals on the pathogenesis of infectious diseases.Many parts of the world in which common infectious diseases are ende...
mitpress.mit.edu
November 26, 2024 at 4:38 PM
Dr. Giedroc contributed to "Trace Metals and Infectious Diseases," exploring metals' roles in microbial-host interactions. Edited by Eric Skaar and Jerome Nriagu, the volume shows metallobiology's significance for infectious disease research. 📚🔬 #Metallobiology #InfectiousDiseases shorturl.at/ua8kq
As the lab migrates over to #ChemSky, we are debuting our new lab logo designed by our own graduate student @jsrocchio.bsky.social. Happy to be here!
November 25, 2024 at 4:54 PM
As the lab migrates over to #ChemSky, we are debuting our new lab logo designed by our own graduate student @jsrocchio.bsky.social. Happy to be here!