GranucciLab
@granuccilab.bsky.social
Cellular and Molecular Immunology Laboratory headed by Prof. Francesca Granucci @BtBsUNIMIB | University of Milano-Bicocca, Milan, Italy
Pinned
Microbial adhesion promotes Piezo1 activation to initiate innate immunity - Nature Immunology
Granucci and colleagues identify microbial adhesion to myeloid cells as a critical initiating event that precedes engagement of pattern recognition receptors.
www.nature.com
What if PRRs are not the first to sense #infection?
🚨Our new paper out in #NatureImmunology! @natimmunol.nature.com
Microbial adhesion acts an unrecognized danger signal, activating #Piezo1 → LTB4 and triggering #PRR independent early #neutrophil recruitment.
🔗 www.nature.com/articles/s41...
🚨Our new paper out in #NatureImmunology! @natimmunol.nature.com
Microbial adhesion acts an unrecognized danger signal, activating #Piezo1 → LTB4 and triggering #PRR independent early #neutrophil recruitment.
🔗 www.nature.com/articles/s41...
Reposted by GranucciLab
Il sistema immunitario “sente” fisicamente i microbi prima ancora di riconoscerli come tali
Il “contatto fisico” dei microrganismi con le cellule immunitarie potrebbe essere la chiave di volta della risposta di un organismo nelle prime fasi di un’infezione. Grazie a questo meccanismo, il sistema…
Il “contatto fisico” dei microrganismi con le cellule immunitarie potrebbe essere la chiave di volta della risposta di un organismo nelle prime fasi di un’infezione. Grazie a questo meccanismo, il sistema…
Il sistema immunitario “sente” fisicamente i microbi prima ancora di riconoscerli come tali
Il “contatto fisico” dei microrganismi con le cellule immunitarie potrebbe essere la chiave di volta della risposta di un organismo nelle prime fasi di un’infezione. Grazie a questo meccanismo, il sistema immunitario può iniziare a reagire prima ancora di avere identificato il microrganismo attraverso i suoi segnali molecolari. A rivelarlo è lo studio “Microbial adhesion promotes Piezo1 activation to initiate innate immunity…
www.saluteh24.com
September 15, 2026 at 9:44 AM
Il sistema immunitario “sente” fisicamente i microbi prima ancora di riconoscerli come tali
Il “contatto fisico” dei microrganismi con le cellule immunitarie potrebbe essere la chiave di volta della risposta di un organismo nelle prime fasi di un’infezione. Grazie a questo meccanismo, il sistema…
Il “contatto fisico” dei microrganismi con le cellule immunitarie potrebbe essere la chiave di volta della risposta di un organismo nelle prime fasi di un’infezione. Grazie a questo meccanismo, il sistema…
Missed the full story? Here’s the 2-minute version. 👀
Our @natimmunol.nature.com RESEARCH BRIEFING is out: Dendritic cells sense #microbial adhesion to launch innate #immunity before canonical PRR recognition during #infection.
www.nature.com/articles/s41...
Full pdf: rdcu.be/ANm25wd4PkRa
Our @natimmunol.nature.com RESEARCH BRIEFING is out: Dendritic cells sense #microbial adhesion to launch innate #immunity before canonical PRR recognition during #infection.
www.nature.com/articles/s41...
Full pdf: rdcu.be/ANm25wd4PkRa
Dendritic cells sense microbial adhesion to launch innate immunity - Nature Immunology
In a mouse skin infection model, microbial adhesion to CD11c+ myeloid cells activates PIEZO1 and an LTB4–IL-1α–CXCL1 cascade that recruits neutrophils before Toll-like receptor signaling becomes domin...
www.nature.com
September 12, 2026 at 4:44 PM
Missed the full story? Here’s the 2-minute version. 👀
Our @natimmunol.nature.com RESEARCH BRIEFING is out: Dendritic cells sense #microbial adhesion to launch innate #immunity before canonical PRR recognition during #infection.
www.nature.com/articles/s41...
Full pdf: rdcu.be/ANm25wd4PkRa
Our @natimmunol.nature.com RESEARCH BRIEFING is out: Dendritic cells sense #microbial adhesion to launch innate #immunity before canonical PRR recognition during #infection.
www.nature.com/articles/s41...
Full pdf: rdcu.be/ANm25wd4PkRa
Reposted by GranucciLab
In a mouse skin infection model, microbial adhesion to CD11c+ myeloid cells activates PIEZO1 and an LTB4–IL-1α–CXCL1 cascade that recruits neutrophils before Toll-like receptor signaling becomes dominant
www.nature.com/articles/s41...
www.nature.com/articles/s41... @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41... @natimmunol.nature.com
September 11, 2026 at 5:03 PM
In a mouse skin infection model, microbial adhesion to CD11c+ myeloid cells activates PIEZO1 and an LTB4–IL-1α–CXCL1 cascade that recruits neutrophils before Toll-like receptor signaling becomes dominant
www.nature.com/articles/s41...
www.nature.com/articles/s41... @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41... @natimmunol.nature.com
What if PRRs are not the first to sense #infection?
🚨Our new paper out in #NatureImmunology! @natimmunol.nature.com
Microbial adhesion acts an unrecognized danger signal, activating #Piezo1 → LTB4 and triggering #PRR independent early #neutrophil recruitment.
🔗 www.nature.com/articles/s41...
🚨Our new paper out in #NatureImmunology! @natimmunol.nature.com
Microbial adhesion acts an unrecognized danger signal, activating #Piezo1 → LTB4 and triggering #PRR independent early #neutrophil recruitment.
🔗 www.nature.com/articles/s41...
Microbial adhesion promotes Piezo1 activation to initiate innate immunity - Nature Immunology
Granucci and colleagues identify microbial adhesion to myeloid cells as a critical initiating event that precedes engagement of pattern recognition receptors.
www.nature.com
September 10, 2026 at 6:36 AM
What if PRRs are not the first to sense #infection?
🚨Our new paper out in #NatureImmunology! @natimmunol.nature.com
Microbial adhesion acts an unrecognized danger signal, activating #Piezo1 → LTB4 and triggering #PRR independent early #neutrophil recruitment.
🔗 www.nature.com/articles/s41...
🚨Our new paper out in #NatureImmunology! @natimmunol.nature.com
Microbial adhesion acts an unrecognized danger signal, activating #Piezo1 → LTB4 and triggering #PRR independent early #neutrophil recruitment.
🔗 www.nature.com/articles/s41...
The @febsletters.bsky.social Special Issue on dendritic cell biology is now online, offering a timely overview of recent progress in the field.
It was a pleasure to be involved as a guest editor with Laura Marongiu & @fandreata.bsky.social
It was a pleasure to be involved as a guest editor with Laura Marongiu & @fandreata.bsky.social
Our special issue on dendritic cell biology in health and disease is online now!
Featuring 7 free Review articles on the role of dendritic cells in metabolism, cancer, and immunity, and more.
Read the issue for free here ➡️ tinyurl.com/2zw4znee
#dendriticcells #immunology @fandreata.bsky.social
Featuring 7 free Review articles on the role of dendritic cells in metabolism, cancer, and immunity, and more.
Read the issue for free here ➡️ tinyurl.com/2zw4znee
#dendriticcells #immunology @fandreata.bsky.social
July 28, 2025 at 1:29 PM
The @febsletters.bsky.social Special Issue on dendritic cell biology is now online, offering a timely overview of recent progress in the field.
It was a pleasure to be involved as a guest editor with Laura Marongiu & @fandreata.bsky.social
It was a pleasure to be involved as a guest editor with Laura Marongiu & @fandreata.bsky.social
✨ That’s a wrap on The Power of Multiplexed Imaging!
A full week of hands-on sessions, inspiring lectures, a great seminar, and data analysis!
Huge thanks to all participants for your energy. Can’t wait for the next edition — stay tuned! 🔬🌈
#MultiplexImaging #SpatialBiology
A full week of hands-on sessions, inspiring lectures, a great seminar, and data analysis!
Huge thanks to all participants for your energy. Can’t wait for the next edition — stay tuned! 🔬🌈
#MultiplexImaging #SpatialBiology
July 5, 2025 at 10:02 AM
✨ That’s a wrap on The Power of Multiplexed Imaging!
A full week of hands-on sessions, inspiring lectures, a great seminar, and data analysis!
Huge thanks to all participants for your energy. Can’t wait for the next edition — stay tuned! 🔬🌈
#MultiplexImaging #SpatialBiology
A full week of hands-on sessions, inspiring lectures, a great seminar, and data analysis!
Huge thanks to all participants for your energy. Can’t wait for the next edition — stay tuned! 🔬🌈
#MultiplexImaging #SpatialBiology
We had a great time at #SIICA2025 in beautiful Perugia! 🌿
It was a pleasure to share our research, connect with the community, and be inspired by so much great science.
Special shoutout to our @roccagiuseppe.bsky.social for winning the Best Poster Award – well deserved! 🏆🎉
#Immunology
It was a pleasure to share our research, connect with the community, and be inspired by so much great science.
Special shoutout to our @roccagiuseppe.bsky.social for winning the Best Poster Award – well deserved! 🏆🎉
#Immunology
June 21, 2025 at 3:28 PM
We had a great time at #SIICA2025 in beautiful Perugia! 🌿
It was a pleasure to share our research, connect with the community, and be inspired by so much great science.
Special shoutout to our @roccagiuseppe.bsky.social for winning the Best Poster Award – well deserved! 🏆🎉
#Immunology
It was a pleasure to share our research, connect with the community, and be inspired by so much great science.
Special shoutout to our @roccagiuseppe.bsky.social for winning the Best Poster Award – well deserved! 🏆🎉
#Immunology
🚀 Registrations are OPEN!
Join the 2nd edition of The Power of Multiplexed Imaging — a deep dive into spatial biology.
🔬 Inspiring talks, hands-on training, cutting-edge tech!
Secure your spot 👉 academy.unimib.it/power-advanc...
#MultiplexedImaging #SpatialBiology #ImagingCourse
Join the 2nd edition of The Power of Multiplexed Imaging — a deep dive into spatial biology.
🔬 Inspiring talks, hands-on training, cutting-edge tech!
Secure your spot 👉 academy.unimib.it/power-advanc...
#MultiplexedImaging #SpatialBiology #ImagingCourse
May 6, 2025 at 2:56 PM
🚀 Registrations are OPEN!
Join the 2nd edition of The Power of Multiplexed Imaging — a deep dive into spatial biology.
🔬 Inspiring talks, hands-on training, cutting-edge tech!
Secure your spot 👉 academy.unimib.it/power-advanc...
#MultiplexedImaging #SpatialBiology #ImagingCourse
Join the 2nd edition of The Power of Multiplexed Imaging — a deep dive into spatial biology.
🔬 Inspiring talks, hands-on training, cutting-edge tech!
Secure your spot 👉 academy.unimib.it/power-advanc...
#MultiplexedImaging #SpatialBiology #ImagingCourse
✨ Reminiscing about last year’s multiplexed imaging course—such a fantastic experience! 🤩 We were thrilled to have @colinchulab.bsky.social, along with all the students & guests! Truly inspiring days of learning. Big things coming—stay tuned! 👀🚀🔬 #SpatialBiology #MultiplexImaging
March 7, 2025 at 4:28 PM
✨ Reminiscing about last year’s multiplexed imaging course—such a fantastic experience! 🤩 We were thrilled to have @colinchulab.bsky.social, along with all the students & guests! Truly inspiring days of learning. Big things coming—stay tuned! 👀🚀🔬 #SpatialBiology #MultiplexImaging