In @elife.bsky.social: Spatial confinement induces oscillatory migration of epidermal keratinocytes and forms a three-compartment epithelial structure with epithelial–mesenchymal transition dynamics doi.org/10.7554/eLif...
Spatial confinement induces oscillatory migration of epidermal keratinocytes and forms a three-compartment epithelial structure with epithelial–mesenchymal transition dynamics
Skin cells can preserve the original epithelium while forming a new one beneath 3 µm pores, with passage dependent on actin polymerization and restrained by Piezo1 and keratin 6.
doi.org
November 7, 2026 at 3:09 AM
In @elife.bsky.social: Spatial confinement induces oscillatory migration of epidermal keratinocytes and forms a three-compartment epithelial structure with epithelial–mesenchymal transition dynamics doi.org/10.7554/eLif...
“Deep vein thrombosis exacerbated by syndecan-4 shedding and piezo1-dependent endothelial-mesenchymal transition” (2026)
by Ke Chen, Zhen-Zhen Chen, Jin-Wei Tian, Jun-Zhuo Wang, Lun Xiao, Hai-Zeng Zhang, Wen-Bin Wang, Dong-Ming Zhou, Xiao-Qiang Li, Jun Xie, Wen-Dong Li
CC: PubChat
by Ke Chen, Zhen-Zhen Chen, Jin-Wei Tian, Jun-Zhuo Wang, Lun Xiao, Hai-Zeng Zhang, Wen-Bin Wang, Dong-Ming Zhou, Xiao-Qiang Li, Jun Xie, Wen-Dong Li
CC: PubChat
Deep vein thrombosis exacerbated by syndecan-4 shedding and piezo1-dependent endothelial-mesenchymal transition
by Ke Chen, Zhen-Zhen Chen, Jin-Wei Tian, Jun-Zhuo Wang, Lun Xiao, Hai-Zeng Zhang, Wen-Bin Wang, Dong-Ming Zhou, Xiao-Qiang Li, Jun Xie, Wen-Dong Li
Abstract Background and Aims Deep vein thrombosis (DVT) remains a major health burden with incompletely understood mechanisms and…
pubchat.org
November 5, 2026 at 8:26 AM
“Deep vein thrombosis exacerbated by syndecan-4 shedding and piezo1-dependent endothelial-mesenchymal transition” (2026)
by Ke Chen, Zhen-Zhen Chen, Jin-Wei Tian, Jun-Zhuo Wang, Lun Xiao, Hai-Zeng Zhang, Wen-Bin Wang, Dong-Ming Zhou, Xiao-Qiang Li, Jun Xie, Wen-Dong Li
CC: PubChat
by Ke Chen, Zhen-Zhen Chen, Jin-Wei Tian, Jun-Zhuo Wang, Lun Xiao, Hai-Zeng Zhang, Wen-Bin Wang, Dong-Ming Zhou, Xiao-Qiang Li, Jun Xie, Wen-Dong Li
CC: PubChat
This project was in part inspired by the beautiful work from @mmpathak.bsky.social and her team who have previously used a similar imaging strategy to visualise calcium flickers that depend on PIEZO1 activation.
November 6, 2026 at 12:08 AM
This project was in part inspired by the beautiful work from @mmpathak.bsky.social and her team who have previously used a similar imaging strategy to visualise calcium flickers that depend on PIEZO1 activation.
Direct axial compression of mouse bones triggers anti-aging proteins like piezo1 and PEDF. Naturally, the first thing commenters tried to do was turn lab-bench bone stress into a concrete workout routine. 1/4
November 2, 2026 at 9:00 PM
Direct axial compression of mouse bones triggers anti-aging proteins like piezo1 and PEDF. Naturally, the first thing commenters tried to do was turn lab-bench bone stress into a concrete workout routine. 1/4
뼈가 노화를 늦추고 수명을 늘리는 단백질을 분비할 가능성
생쥐 실험에서 뼈에 가해지는 기계적 자극 이 골세포의 노화 억제 물질 분비를 유도하고, 여러 장기의 노화를 늦출 수 있음이 확인됨 힘을 감지하는 단백질 PIEZO1 을 골세포에서 제거한 생쥐는 기억력과 반사 기능이 저하되고, 여러 장기의 노화와 염증이 증가했으며...
생쥐 실험에서 뼈에 가해지는 기계적 자극 이 골세포의 노화 억제 물질 분비를 유도하고, 여러 장기의 노화를 늦출 수 있음이 확인됨 힘을 감지하는 단백질 PIEZO1 을 골세포에서 제거한 생쥐는 기억력과 반사 기능이 저하되고, 여러 장기의 노화와 염증이 증가했으며...
뼈가 노화를 늦추고 수명을 늘리는 단백질을 분비할 가능성
생쥐 실험에서 뼈에 가해지는 기계적 자극 이 골세포의 노화 억제 물질 분비를 유도하고, 여러 장기의 노화를 늦출 수 있음이 확인됨 힘을 감지하는 단백질 PIEZO1 을 골세포에서 제거한 생쥐는 기억력과 반사 기능이 저하되고, 여러 장기의 노화와 염증이 증가했으며...
news.hada.io
November 2, 2026 at 2:00 PM
뼈가 노화를 늦추고 수명을 늘리는 단백질을 분비할 가능성
생쥐 실험에서 뼈에 가해지는 기계적 자극 이 골세포의 노화 억제 물질 분비를 유도하고, 여러 장기의 노화를 늦출 수 있음이 확인됨 힘을 감지하는 단백질 PIEZO1 을 골세포에서 제거한 생쥐는 기억력과 반사 기능이 저하되고, 여러 장기의 노화와 염증이 증가했으며...
생쥐 실험에서 뼈에 가해지는 기계적 자극 이 골세포의 노화 억제 물질 분비를 유도하고, 여러 장기의 노화를 늦출 수 있음이 확인됨 힘을 감지하는 단백질 PIEZO1 을 골세포에서 제거한 생쥐는 기억력과 반사 기능이 저하되고, 여러 장기의 노화와 염증이 증가했으며...
南方医科大学などの研究チームは、骨の力覚センサー（Piezo1）が全身の老化を抑制し寿命を延ばすことを解明した。骨への動的負荷（DTAL）や骨由来の抗老化因子「PEDF」の投与が、免疫の若返りや多臓器の老化防止に有効であることを示し、運動困難者向けの新たなアンチエイジング治療の可能性を提示している。
doi.org/10.1016/j.cm...
doi.org/10.1016/j.cm...
November 7, 2026 at 11:57 PM
南方医科大学などの研究チームは、骨の力覚センサー（Piezo1）が全身の老化を抑制し寿命を延ばすことを解明した。骨への動的負荷（DTAL）や骨由来の抗老化因子「PEDF」の投与が、免疫の若返りや多臓器の老化防止に有効であることを示し、運動困難者向けの新たなアンチエイジング治療の可能性を提示している。
doi.org/10.1016/j.cm...
doi.org/10.1016/j.cm...
Great study shows PIEZO1 upregulation in bladder epithelial cells post uropathogenic E. coli infection, driving chronic pain via the SLC7A11-glutamate axis. IL-6 signaling linked! PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5
No description available
www.cell.com
November 3, 2026 at 1:00 AM
Mechanosensation in macrophages is a thing. Piezo1-mediated release of nerve growth factor remodelled nociceptive sensory neurons contributing to visceral pain irrespective of intestinal inflammation. Great paper, and great summary by Claire Olingy: www.science.org/doi/... 🧪
An autonomous macrophage-nociceptor mechanosensory relay drives chronic visceral pain
Tissue-resident macrophages sense colonic stiffening via Piezo1, releasing NGF to sensitize TRPV1+ nociceptors for visceral pain.
www.science.org
October 30, 2026 at 7:28 AM
Mechanosensation in macrophages is a thing. Piezo1-mediated release of nerve growth factor remodelled nociceptive sensory neurons contributing to visceral pain irrespective of intestinal inflammation. Great paper, and great summary by Claire Olingy: www.science.org/doi/... 🧪
Epithelial mechanosensation dysregulation drives chronic bladder pain. PIEZO1 upregulation, linked to IL-6 signaling, enhances nociceptive innervation via the SLC7A11-glutamate axis. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5
No description available
www.cell.com
November 1, 2026 at 12:00 AM
Epithelial mechanosensation dysregulation drives chronic bladder pain. PIEZO1 upregulation, linked to IL-6 signaling, enhances nociceptive innervation via the SLC7A11-glutamate axis. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA 🧪
进一步研究显示，骨骼中的骨细胞能够通过PIEZO1蛋白感知机械压力，并释放多种具有保护作用的分子。这些物质进入血液后，可能帮助恢复免疫细胞的活力，并促使其他器官中的部分细胞呈现更年轻的状态。
研究团队还发现，一种名为色素上皮衍生因子（PEDF）的蛋白质具有重要作用。向老年小鼠注射这种蛋白质，也能产生部分抗衰老效果。
研究人员认为，骨骼不仅承担支撑身体的功能，还可能通过感知运动产生的机械压力，参与调节全身衰老。
这一发现为研究运动延缓衰老的机制提供了新线索，也可能帮助未来开发适合行动不便者的抗衰老治疗方法。不过，目前尚无证据证明，对人体骨骼施加类似压力也能延长寿命。
2/2
研究团队还发现，一种名为色素上皮衍生因子（PEDF）的蛋白质具有重要作用。向老年小鼠注射这种蛋白质，也能产生部分抗衰老效果。
研究人员认为，骨骼不仅承担支撑身体的功能，还可能通过感知运动产生的机械压力，参与调节全身衰老。
这一发现为研究运动延缓衰老的机制提供了新线索，也可能帮助未来开发适合行动不便者的抗衰老治疗方法。不过，目前尚无证据证明，对人体骨骼施加类似压力也能延长寿命。
2/2
November 2, 2026 at 6:25 PM
进一步研究显示，骨骼中的骨细胞能够通过PIEZO1蛋白感知机械压力，并释放多种具有保护作用的分子。这些物质进入血液后，可能帮助恢复免疫细胞的活力，并促使其他器官中的部分细胞呈现更年轻的状态。
研究团队还发现，一种名为色素上皮衍生因子（PEDF）的蛋白质具有重要作用。向老年小鼠注射这种蛋白质，也能产生部分抗衰老效果。
研究人员认为，骨骼不仅承担支撑身体的功能，还可能通过感知运动产生的机械压力，参与调节全身衰老。
这一发现为研究运动延缓衰老的机制提供了新线索，也可能帮助未来开发适合行动不便者的抗衰老治疗方法。不过，目前尚无证据证明，对人体骨骼施加类似压力也能延长寿命。
2/2
研究团队还发现，一种名为色素上皮衍生因子（PEDF）的蛋白质具有重要作用。向老年小鼠注射这种蛋白质，也能产生部分抗衰老效果。
研究人员认为，骨骼不仅承担支撑身体的功能，还可能通过感知运动产生的机械压力，参与调节全身衰老。
这一发现为研究运动延缓衰老的机制提供了新线索，也可能帮助未来开发适合行动不便者的抗衰老治疗方法。不过，目前尚无证据证明，对人体骨骼施加类似压力也能延长寿命。
2/2
Aβ42 oligomers disrupt calcium homeostasis via Piezo1 and induce neurotoxicity in differentiated SH-SY5Y cells #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11212419/latest
https://www.researchsquare.com/article/rs-11212419/latest
October 30, 2026 at 2:03 PM
Aβ42 oligomers disrupt calcium homeostasis via Piezo1 and induce neurotoxicity in differentiated SH-SY5Y cells #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11212419/latest
https://www.researchsquare.com/article/rs-11212419/latest
A new study in Science #Immunology demonstrates how mechanical sensing in gut macrophages can lead to colitis-associated visceral pain in mice. https://scim.ag/3VWgsqM
An autonomous macrophage-nociceptor mechanosensory relay drives chronic visceral pain
Tissue-resident macrophages sense colonic stiffening via Piezo1, releasing NGF to sensitize TRPV1+ nociceptors for visceral pain.
scim.ag
October 27, 2026 at 3:00 PM
A new study in Science #Immunology demonstrates how mechanical sensing in gut macrophages can lead to colitis-associated visceral pain in mice. https://scim.ag/3VWgsqM
Excessive mechanosensation via PIEZO1 in bladder epithelium drives nociceptive nerve growth and chronic pain post E. coli infection, linking IL-6 and SLC7A11 pathways. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5
No description available
www.cell.com
October 28, 2026 at 3:00 AM
Tissue-resident macrophages sense colonic stiffening via Piezo1, releasing NGF to sensitize TRPV1+ nociceptors for visceral pain @sciimmunology.bsky.social
www.science.org/doi/10.1126/... 🇨🇳
www.science.org/doi/10.1126/... 🇨🇳
October 24, 2026 at 1:03 AM
Tissue-resident macrophages sense colonic stiffening via Piezo1, releasing NGF to sensitize TRPV1+ nociceptors for visceral pain @sciimmunology.bsky.social
www.science.org/doi/10.1126/... 🇨🇳
www.science.org/doi/10.1126/... 🇨🇳
Extract: Join a multidisciplinary project in medicinal chemistry focusing on Piezo1 inhibitors for sickle cell disease. The role involves virtual screening, AI techniques, and organic synthesis.
October 25, 2026 at 11:44 AM
Extract: Join a multidisciplinary project in medicinal chemistry focusing on Piezo1 inhibitors for sickle cell disease. The role involves virtual screening, AI techniques, and organic synthesis.
RRIDs were included in this in Phytomedicine paper. RRIDs improve reproducibility in scientific research. #methodsmatter #reproducibility #ReproducibleResearch
Isoliquiritigenin attenuates doxorubicin-induced cardiomyopathy by alleviating mitochondrial dysfunction and oxidative damage through the Piezo1/Ca²⁺/Pdk4 signaling axis
Read the full paper: Isoliquiritigenin attenuates doxorubicin-induced cardiomyopathy by alleviating mitochondrial dysfunction and oxidative damage through the Piezo1/Ca²⁺/Pdk4 signaling axis
doi.org
October 25, 2026 at 7:00 AM
RRIDs were included in this in Phytomedicine paper. RRIDs improve reproducibility in scientific research. #methodsmatter #reproducibility #ReproducibleResearch
Excessive mechanosensation from PIEZO1 in bladder epithelial cells boosts nociceptive innervation and chronic pain via the SLC7A11-glutamate axis, triggered by IL-6. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5
No description available
www.cell.com
October 25, 2026 at 6:00 AM
MULTIVALENT ACE2 ENGAGEMENT ACTIVATES PIEZO1-SPHINGOMYELINASE SIGNALING IN SARS-COV-2 SPIKE-MEDIATED CELL-CELL FUSION https://www.biorxiv.org/content/10.64898/2026.10.22.761047v1
October 23, 2026 at 9:30 PM
MULTIVALENT ACE2 ENGAGEMENT ACTIVATES PIEZO1-SPHINGOMYELINASE SIGNALING IN SARS-COV-2 SPIKE-MEDIATED CELL-CELL FUSION https://www.biorxiv.org/content/10.64898/2026.10.22.761047v1
A preprint using: PIEZO1 Antibody - BS (RRID:AB_11003149) from #Novus was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
www.biorxiv.org
October 24, 2026 at 12:00 PM
A preprint using: PIEZO1 Antibody - BS (RRID:AB_11003149) from #Novus was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
MULTIVALENT ACE2 ENGAGEMENT ACTIVATES PIEZO1-SPHINGOMYELINASE SIGNALING IN SARS-COV-2 SPIKE-MEDIATED CELL-CELL FUSION https://www.biorxiv.org/content/10.64898/2026.10.22.761047v1
October 23, 2026 at 9:30 PM
MULTIVALENT ACE2 ENGAGEMENT ACTIVATES PIEZO1-SPHINGOMYELINASE SIGNALING IN SARS-COV-2 SPIKE-MEDIATED CELL-CELL FUSION https://www.biorxiv.org/content/10.64898/2026.10.22.761047v1
Excessive mechanosensation in bladder epithelium drives chronic pain via the PIEZO1-SLC7A11-glutamate axis. IL-6 boosts PIEZO1, linking infection to sensory dysfunction. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5
No description available
www.cell.com
October 20, 2026 at 10:00 AM
We've got 2 awesome speakers! Zoya Mann, Yaps Lab, U. Queensland, Australia "The way less obvious: how Piezo1 regulates apoptotic extrusion by tuning tissue tension" & Yu-Chiun Wang, Riken BDR, Japan "Cell-intrinsic compliance mechanism enables release of tensile stress to prevent tissue rupture"
October 20, 2026 at 8:38 PM
We've got 2 awesome speakers! Zoya Mann, Yaps Lab, U. Queensland, Australia "The way less obvious: how Piezo1 regulates apoptotic extrusion by tuning tissue tension" & Yu-Chiun Wang, Riken BDR, Japan "Cell-intrinsic compliance mechanism enables release of tensile stress to prevent tissue rupture"
The authors included RRIDs in their in Scientific Reports paper! We value the author's support of reproducibility. #accelerateopenscience #STMpublishing #methodsmatter
Actin derangement and increased Piezo1 activity in Ras-transformed cells promote cyclic stretch-induced cell detachment and apoptosis - Scientific Reports
Read the full paper: Actin derangement and increased Piezo1 activity in Ras-transformed cells promote cyclic stretch-induced cell detachment and apoptosis
doi.org
October 18, 2026 at 7:01 AM
The authors included RRIDs in their in Scientific Reports paper! We value the author's support of reproducibility. #accelerateopenscience #STMpublishing #methodsmatter