Anthony Hessel, PhD
@hesselanthony.bsky.social
Muscle physiologist at Uni of Muenster. Founder, Accelerated Muscle Biotechnologies. Dog foster / diva boston terrier parent. My wife tolerates me well. He/him.🥼🧪🔬💪♥️ #MyoBlue #NoKing
Reposted by Anthony Hessel, PhD
😃 In a new article published in J Biomech, Zero et al. show initial pre‑activation muscle length doesn’t significantly change the stretch–shortening cycle in permeabilized single fibres; non–cross‑bridge elements like titin were unlikely altered by starting length.
👀 buff.ly/eFwJbQe
👀 buff.ly/eFwJbQe
May 7, 2026 at 8:12 PM
😃 In a new article published in J Biomech, Zero et al. show initial pre‑activation muscle length doesn’t significantly change the stretch–shortening cycle in permeabilized single fibres; non–cross‑bridge elements like titin were unlikely altered by starting length.
👀 buff.ly/eFwJbQe
👀 buff.ly/eFwJbQe
Reposted by Anthony Hessel, PhD
Check out the new articles posted in our special issue, The Integrative Biology of Exercise, drawing on work in vertebrates and invertebrates to illustrate the plasticity or evolutionary changes necessary for exercise or sustained locomotion
journals.biologists.com/jeb/issue/22...
journals.biologists.com/jeb/issue/22...
April 9, 2026 at 8:30 AM
Check out the new articles posted in our special issue, The Integrative Biology of Exercise, drawing on work in vertebrates and invertebrates to illustrate the plasticity or evolutionary changes necessary for exercise or sustained locomotion
journals.biologists.com/jeb/issue/22...
journals.biologists.com/jeb/issue/22...
Reposted by Anthony Hessel, PhD
We are hiring a POSTDOC on an NIH award to measure inertial effects of (in)active muscle. Please share and re-post widely! Please send expressions of interest to my UML email.
January 27, 2026 at 1:40 PM
We are hiring a POSTDOC on an NIH award to measure inertial effects of (in)active muscle. Please share and re-post widely! Please send expressions of interest to my UML email.
Reposted by Anthony Hessel, PhD
In honor of #BioVault, watch the full interview with Accelerated Muscle Biotechnologies as Anthony Hessel, PhD and Khoi Nguyen, PhD share benefits to muscle research, directions in x-ray diffraction, and more!
Post: https://bit.ly/asi-amb-collab-840A-biovault
840A: https://bit.ly/840A-BioVault
Post: https://bit.ly/asi-amb-collab-840A-biovault
840A: https://bit.ly/840A-BioVault
March 18, 2026 at 2:01 PM
In honor of #BioVault, watch the full interview with Accelerated Muscle Biotechnologies as Anthony Hessel, PhD and Khoi Nguyen, PhD share benefits to muscle research, directions in x-ray diffraction, and more!
Post: https://bit.ly/asi-amb-collab-840A-biovault
840A: https://bit.ly/840A-BioVault
Post: https://bit.ly/asi-amb-collab-840A-biovault
840A: https://bit.ly/840A-BioVault
👏Thank you for your service. There is nothing more direct then meeting with those with power of the purse. We all need to stay engaged with these people, letting them know how important the science infratructure and training pipelines are to the economic superiority of the States.
First meeting is Rep Mfume’s office. #FundResearch #NIH #NSF @biophysicalsoc.bsky.social #BPS at the Capital advocating for #sciwnce #ResearchSavesLives @repkweisimfume.bsky.social
March 18, 2026 at 2:18 PM
👏Thank you for your service. There is nothing more direct then meeting with those with power of the purse. We all need to stay engaged with these people, letting them know how important the science infratructure and training pipelines are to the economic superiority of the States.
Reposted by Anthony Hessel, PhD
Aurora Scientific is proud to introduce our much-anticipated new product, built in partnership with @ambiotech.us:
840A BioVault!
aurorascientific.com/products/mus...
A portable chamber that takes your experiments from bench to beamline.
840A BioVault!
aurorascientific.com/products/mus...
A portable chamber that takes your experiments from bench to beamline.
March 11, 2026 at 2:11 PM
Aurora Scientific is proud to introduce our much-anticipated new product, built in partnership with @ambiotech.us:
840A BioVault!
aurorascientific.com/products/mus...
A portable chamber that takes your experiments from bench to beamline.
840A BioVault!
aurorascientific.com/products/mus...
A portable chamber that takes your experiments from bench to beamline.
Reposted by Anthony Hessel, PhD
Ecstatic to see this launched! Thanks to our amazing partners @ambiotech.us, @hesselanthony.bsky.social and Khoi for their support throughout.
Aurora Scientific is proud to introduce our much-anticipated new product, built in partnership with @ambiotech.us:
840A BioVault!
aurorascientific.com/products/mus...
A portable chamber that takes your experiments from bench to beamline.
840A BioVault!
aurorascientific.com/products/mus...
A portable chamber that takes your experiments from bench to beamline.
March 11, 2026 at 2:16 PM
Ecstatic to see this launched! Thanks to our amazing partners @ambiotech.us, @hesselanthony.bsky.social and Khoi for their support throughout.
Reposted by Anthony Hessel, PhD
Greenman et al. review the role of cMyBP-C post-translational modifications in health & disease. During cardiovascular disease, oxidative stress may drive the inverse relationship btwn. phosphorylation & S-glutathionylation of cMyBP-C, identifying new therapeutic targets rupress.org/jgp/article/...
March 3, 2026 at 5:00 PM
Greenman et al. review the role of cMyBP-C post-translational modifications in health & disease. During cardiovascular disease, oxidative stress may drive the inverse relationship btwn. phosphorylation & S-glutathionylation of cMyBP-C, identifying new therapeutic targets rupress.org/jgp/article/...
Reposted by Anthony Hessel, PhD
We are proud to share that IMSI Co-Director Kiisa Nishikawa has been named the recipient of the 2026 SEB Bidder Lecture Award by the Society for Experimental Biology.
Please join us in congratulating her on this outstanding achievement.
#SEB2026 #ExperimentalBiology #ScientificAchievement #STEM
Please join us in congratulating her on this outstanding achievement.
#SEB2026 #ExperimentalBiology #ScientificAchievement #STEM
February 27, 2026 at 11:49 PM
We are proud to share that IMSI Co-Director Kiisa Nishikawa has been named the recipient of the 2026 SEB Bidder Lecture Award by the Society for Experimental Biology.
Please join us in congratulating her on this outstanding achievement.
#SEB2026 #ExperimentalBiology #ScientificAchievement #STEM
Please join us in congratulating her on this outstanding achievement.
#SEB2026 #ExperimentalBiology #ScientificAchievement #STEM
Reposted by Anthony Hessel, PhD
Our new project unveiling an integrative single-fiber framework that connect multi-omic cellular heterogeneity to molecular function in ICU-related muscle wasting! Congratulations to all authors especially Alexandra who led the whole project! Thank you to @lundbeckfonden.bsky.social for the support
www.biorxiv.org
February 17, 2026 at 3:54 PM
Our new project unveiling an integrative single-fiber framework that connect multi-omic cellular heterogeneity to molecular function in ICU-related muscle wasting! Congratulations to all authors especially Alexandra who led the whole project! Thank you to @lundbeckfonden.bsky.social for the support
Reposted by Anthony Hessel, PhD
There's exactly one normal man left on planet Earth.
Child at the podium: “A woo woo woo.”
Mamdani: That’s how I felt when we came up with this plan. Together, we will expand the idea of what is possible in our city—and what sounds and noises we can make at a press conference.
Mamdani: That’s how I felt when we came up with this plan. Together, we will expand the idea of what is possible in our city—and what sounds and noises we can make at a press conference.
February 6, 2026 at 5:12 AM
There's exactly one normal man left on planet Earth.
Reposted by Anthony Hessel, PhD
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
February 4, 2026 at 3:45 PM
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
Reposted by Anthony Hessel, PhD
New review from our partners Accelerated Muscle Biotechnologies (Anthony Hessel, PhD, Katelyn Manross, Khoi Nguyen), co-authored with our Chris Rand & Matthew Borkowski. #MusclePhysiology #CardiacResearch
Check it out:
https://bit.ly/a-primer-on-the-methods-of-skeletal-and-cardiac-muscle-mechanics
Check it out:
https://bit.ly/a-primer-on-the-methods-of-skeletal-and-cardiac-muscle-mechanics
February 2, 2026 at 3:00 PM
New review from our partners Accelerated Muscle Biotechnologies (Anthony Hessel, PhD, Katelyn Manross, Khoi Nguyen), co-authored with our Chris Rand & Matthew Borkowski. #MusclePhysiology #CardiacResearch
Check it out:
https://bit.ly/a-primer-on-the-methods-of-skeletal-and-cardiac-muscle-mechanics
Check it out:
https://bit.ly/a-primer-on-the-methods-of-skeletal-and-cardiac-muscle-mechanics
Reposted by Anthony Hessel, PhD
💪 NEW VIDEO:
Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work.
Rendered using @bradyajohnston.bsky.social 's molecular nodes
Model based on the incredible work of the @raunser-lab.bsky.social lab
Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work.
Rendered using @bradyajohnston.bsky.social 's molecular nodes
Model based on the incredible work of the @raunser-lab.bsky.social lab
January 31, 2026 at 3:00 PM
💪 NEW VIDEO:
Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work.
Rendered using @bradyajohnston.bsky.social 's molecular nodes
Model based on the incredible work of the @raunser-lab.bsky.social lab
Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work.
Rendered using @bradyajohnston.bsky.social 's molecular nodes
Model based on the incredible work of the @raunser-lab.bsky.social lab
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffraction experiments.
See LinkedIn post for details.
www.linkedin.com/posts/anthon...
See LinkedIn post for details.
www.linkedin.com/posts/anthon...
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray… | Anthon...
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffracti...
www.linkedin.com
January 29, 2026 at 10:10 AM
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffraction experiments.
See LinkedIn post for details.
www.linkedin.com/posts/anthon...
See LinkedIn post for details.
www.linkedin.com/posts/anthon...
Really happy about this paper getting published, where we muse on some of the finer aspects of the permeablized fiber mechanics technique. Have things you wished were covered? Go write one of these up to! Science is better when we all share our "institutional knowledge"!
Review: @hesselanthony.bsky.social @crand22.bsky.social, Nguyen et al. provide useful tips and tricks for all those beginning their journey into permeabilized muscle fiber mechanics. rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
January 28, 2026 at 7:43 PM
Really happy about this paper getting published, where we muse on some of the finer aspects of the permeablized fiber mechanics technique. Have things you wished were covered? Go write one of these up to! Science is better when we all share our "institutional knowledge"!
Anothee run at the P03 beamline PETRAIII complete. It was a exhausting run but we checked off all goals.
January 28, 2026 at 9:15 AM
Anothee run at the P03 beamline PETRAIII complete. It was a exhausting run but we checked off all goals.
Americans are supposed to be the good guys. It makes applying/enforcing laws harder but that is the burden of being the good guys. We rarely reach that ideal in practice but I will do all I can to support those who fight the good fight to bring us towards it. Protests comes in many ways. #NoKings
January 26, 2026 at 6:59 AM
Americans are supposed to be the good guys. It makes applying/enforcing laws harder but that is the burden of being the good guys. We rarely reach that ideal in practice but I will do all I can to support those who fight the good fight to bring us towards it. Protests comes in many ways. #NoKings
Reposted by Anthony Hessel, PhD
The National Institutes of Health has agreed to settle lawsuits over its handling of grant applications that conflicted with President Donald Trump’s directives. https://scim.ag/4jsQ7sc
After legal deal, NIH to review grant proposals frozen, denied, or withdrawn because of Trump directives
Agreement requires agency to evaluate hundreds of applications “in good faith” using its standard process
scim.ag
January 6, 2026 at 5:23 PM
The National Institutes of Health has agreed to settle lawsuits over its handling of grant applications that conflicted with President Donald Trump’s directives. https://scim.ag/4jsQ7sc
Reposted by Anthony Hessel, PhD
Our team at Københavns Universitet - University of Copenhagen will soon be looking for a postdoc with experience in AI-driven vHTS and cardiac sarcomere modeling. If interested please send me an email. Spread the word :-)
Ochala Group – University of Copenhagen
bmi.ku.dk
December 18, 2025 at 11:29 AM
Our team at Københavns Universitet - University of Copenhagen will soon be looking for a postdoc with experience in AI-driven vHTS and cardiac sarcomere modeling. If interested please send me an email. Spread the word :-)
Reposted by Anthony Hessel, PhD
First preprint from my PhD!
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
Piperine activates the thick filament of resting rat skeletal muscle, enhancing dynamic contractility in a fiber-type-dependent manner
Thick-filament activation, whereby myosin heads transition from an OFF to an ON state, is a key regulatory step in muscle contraction and a promising therapeutic target. The availability of ON-state m...
www.biorxiv.org
November 27, 2025 at 2:53 PM
First preprint from my PhD!
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
Reposted by Anthony Hessel, PhD
In February 2025, Aurora Scientific formed a strategic partnership with Accelerated Muscle Biotechnologies (AMB). Watch this video interview with Anthony Hessel, PhD and Khoi Nguyen, PhD from AMB, and our own Chris Rand to learn about our partnership!
https://bit.ly/asi-amb-partnership-interview
https://bit.ly/asi-amb-partnership-interview
November 26, 2025 at 12:36 PM
In February 2025, Aurora Scientific formed a strategic partnership with Accelerated Muscle Biotechnologies (AMB). Watch this video interview with Anthony Hessel, PhD and Khoi Nguyen, PhD from AMB, and our own Chris Rand to learn about our partnership!
https://bit.ly/asi-amb-partnership-interview
https://bit.ly/asi-amb-partnership-interview
Reposted by Anthony Hessel, PhD
New #PNASNews paper: Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging. #Myoblue tinyurl.com/y5rayxmz
Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging | PNAS
Skeletal muscle is essential for movement, respiration, and metabolism, with mTORC1
acting as a key regulator of protein synthesis and degradation....
tinyurl.com
November 25, 2025 at 3:40 PM
New #PNASNews paper: Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging. #Myoblue tinyurl.com/y5rayxmz
Reposted by Anthony Hessel, PhD
Our collaborative effort unravelled puzzling results warranted more research on the topic of myosin and cardiac chamber specificities @ucph.bsky.social
Cardiac Chamber‐Specific Regulation of Myosin Biochemical Super‐Relaxation and Auto‐Inhibition
The combination of Mant-ATP (2′-(or-3′)-O-(N-Methylanthraniloyl) Adenosine 5′-Triphosphate) chase experiments and all-atomistic molecular dynamics simulations, revealed that myosin auto-inhibition an...
faseb.onlinelibrary.wiley.com
November 22, 2025 at 12:57 PM
Our collaborative effort unravelled puzzling results warranted more research on the topic of myosin and cardiac chamber specificities @ucph.bsky.social