#CardiacMuscle
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rupress.org
Research News: @jgp.org study by Arooj Shahid, Mei Methawasin et al. (rupress.org/jgp/article/...) reveals sex-based differences in the contributors to diastolic stress in #cardiomyocytes from #HFpEF model mice. rupress.org/jgp/article/...

#CardiacMuscle
October 19, 2026 at 5:45 PM
jgp.org
Research News: JGP study by Arooj Shahid, Mei Methawasin et al. (rupress.org/jgp/article/...) reveals sex-based differences in the contributors to diastolic stress in #cardiomyocytes from #HFpEF model mice. rupress.org/jgp/article/...

#CardiacMuscle
October 19, 2026 at 5:02 PM
jgp.org
Chamber-specific regulation of #myofilament Ca²⁺ sensitivity by nNOSβ via #Troponin I phosphorylation: Predominance in the right ventricle. New study from Jae Won Kwon, Sung Joon Kim, Young Keul Jeon and colleagues (Seoul National University):
rupress.org/jgp/article/...

#CardiacMuscle
October 12, 2026 at 1:30 PM
jgp.org
Jae Won Kwon, Sung Joon Kim, Young Keul Jeon et al. show that myofilament-associated nNOS preferentially restrains right ventricular contraction by regulating Ca²⁺-binding affinity through #troponin I phosphorylation. rupress.org/jgp/article/...

#CardiacMuscle #CellularPhysiology
October 5, 2026 at 4:00 PM
rupress.org
In @jgp.org, Jae Won Kwon, Sung Joon Kim, Young Keul Jeon et al. show that myofilament-associated nNOS preferentially restrains right ventricular contraction by regulating Ca²⁺-binding affinity through #troponin I phosphorylation. rupress.org/jgp/article/...

#CardiacMuscle #CellularPhysiology
October 5, 2026 at 5:00 PM
jgp.org
Diastolic contributors in cardiomyocytes of a cardiometabolic HFpEF-like mouse model. New study from Arooj Shahid, Mei Methawasin (University of Missouri) and colleagues:
rupress.org/jgp/article/...

#CardiacMuscle
September 1, 2026 at 2:45 PM
jgp.org
Evolution, hibernation, and inactivation of voltage-gated Na channels. New Hypothesis from John S. Willis @universityofga.bsky.social:
rupress.org/jgp/article/...

#IonChannels #Biochemistry #Biophysics #MolecularPhysiology #CardiacMuscle
July 14, 2026 at 1:45 PM
jgp.org
Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles. New study from Manuel F. Muñoz, Fernando Santana @lfsantana68.bsky.social and colleagues @ucd-physiology.bsky.social rupress.org/jgp/article/...

#IonChannels #CardiacMuscle
April 7, 2026 at 7:30 PM
jgp.org
Muñoz, @lfsantana68.bsky.social et al. show that beat-locked cytosolic and mitochondrial ATP transients in sinoatrial node myocytes sort into high-gain, low-gain, or consumption-dominant modes aligned with superior–inferior vascular–mitochondrial gradients. rupress.org/jgp/article/...
#CardiacMuscle
March 31, 2026 at 4:00 PM
jgp.org
Titin's P-zone domains A164-167 are essential for thick filament structural arrangement. New study from Catherine Hoover Browne, Henk Granzier and colleagues @uarizona.bsky.social: rupress.org/jgp/article/...

#SkeletalMuscle #CardiacMuscle #MolecularPhysiology #CellularPhysiology #Titin
March 19, 2026 at 3:06 PM
jgp.org
Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere. New review from Angela C. Greenman, Willem de Lange, and J. Carter Ralphe @wiscpediatrics.bsky.social: rupress.org/jgp/article/...

#CardiacMuscle #Contraction #CellMotility #Biophysics
March 10, 2026 at 2:45 PM
jgp.org
AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic #bradycardia. New study from Luca M.G. Palloni, Dario DiFrancesco and colleagues (University of Milano): rupress.org/jgp/article/...

#MolecularPhysiology #CellularPhysiology #CardiacMuscle #SignalTransduction
February 13, 2026 at 2:45 PM
jgp.org
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/...

#Myofilaments #SkeletalMuscle #CardiacMuscle
February 4, 2026 at 3:45 PM
jgp.org
Review: @hesselanthony.bsky.social @crand22.bsky.social, Nguyen et al. provide useful tips and tricks for all those beginning their journey into permeabilized muscle fiber mechanics. rupress.org/jgp/article/...

#Myofilaments #SkeletalMuscle #CardiacMuscle
January 28, 2026 at 5:03 PM
jgp.org
Allosteric coupling of RyR calcium channels. Is it relevant to the [patho]physiology of heart and muscle? New review from Eduardo Rios (Rush University): rupress.org/jgp/article/...

#CardiacMuscle #SkeletalMuscle #ComputationalBiology #Biophysics
December 24, 2025 at 3:45 PM
jgp.org
Eduardo Rios reviews the relevance for physiology and pathophysiology of the synchronous gating of sarco-endoplasmic reticulum Ca²⁺ release channels, reported in bilayer reconstitution experiments. rupress.org/jgp/article/...

#Biophysics #CardiacMuscle #ComputationalBiology #SkeletalMuscle
December 17, 2025 at 5:15 PM
jgp.org
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility, say Alejandro Alvarez-Arce, David Barefield @barefieldlab.bsky.social and colleagues @loyolachicago.bsky.social: rupress.org/jgp/article/...

#Myofilaments #CardiacMuscle
November 26, 2025 at 3:45 PM
jgp.org
Regulation of voltage-sensing structures of Caᵥ1.2 calcium channel by the auxiliary β3-subunit. New study from Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, and Alan Neely (Universidad de Valparaíso): rupress.org/jgp/article/...

#Biophysics #CardiacMuscle #MembraneTransport #IonChannels
November 12, 2025 at 7:15 PM
jgp.org
Variability in reported midpoints of (in)activation of cardiac Ina. New study from Michael Clerx @michaelclerx.com, Paul Volders, and Gary Mirams @mirams.bsky.social @uniofnottingham.bsky.social: rupress.org/jgp/article/...

#ComputationalBiology #CardiacMuscle #CellularPhysiology #IonChannels
July 23, 2025 at 2:30 PM
jgp.org
Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affects ß-cardiac myosin activity, say Matvey Pilagov, Sonette Steczina, Ateeqa Naim, Neil Kad and colleagues @kent.ac.uk: rupress.org/jgp/article/...

#Myofilaments #CardiacMuscle
July 14, 2025 at 1:31 PM
jgp.org
Comparative mechanistic analysis of danicamtiv and omecamtiv mecarbil's in vivo cardiac effects. New study from Joshua Holmes and Julian Stelzer (Case Western Reserve University): rupress.org/jgp/article/...

#CardiacMuscle #Contraction #CellMotility #HeartFailure
June 25, 2025 at 2:56 PM
jgp.org
Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes, say Kerry McDonald and colleagues: rupress.org/jgp/article/...

#CardiacMuscle #Myofilaments #Contraction #CellMotility #Biophysics
March 31, 2025 at 2:48 PM
jgp.org
Regulation of loaded sarcomere shortening: McDonald et al. @Mizzou show that cardiac myosin binding protein-C regulates sarcomere-loaded shortening, especially at high loads, seemingly, by modulating cross-bridge availability rupress.org/jgp/article/...

#CardiacMuscle #Myofilaments
March 24, 2025 at 4:23 PM
jgp.org
Marfan-syndrome cardiomyocytes show excess of #titin isoform N2BA and extended sarcomeric M-band, say Dalma Kellermayer, Cristina Șulea, Miklós Kellermayer, Balázs Kiss and colleagues: rupress.org/jgp/article/...

#CardiacMuscle #Contraction #Myofilaments
March 17, 2025 at 2:06 PM
jgp.org
Novel Ca²⁺ wave mechanisms in cardiac myocytes revealed by multiscale Ca²⁺ release model, report Morris Vysma, James Welsh, and Derek Laver @uni-newcastle.bsky.social: rupress.org/jgp/article/...

#CardiacMuscle #ComputationalBiology #Biophysics #IntercellularSignaling
March 13, 2025 at 2:27 PM