Emiliano Sotelo
@jemilianosf.bsky.social
PhD student @crg.eu Interested in #bioinformatics #genomics #generegulation #transposons #evolution #popgen
Reposted by Emiliano Sotelo
NEXT WEEK: Científico Latino's NYC Workshop Series on "Applying to Graduate School and Writing a Strong Personal Statement" on 10/14 at 4pm.
Sign-up here: cientificolatino.com/nyc-workshop...
All attendees will be eligible for a fee waiver at Stony Brook University.
#CientificoLatino #PhDReady
Sign-up here: cientificolatino.com/nyc-workshop...
All attendees will be eligible for a fee waiver at Stony Brook University.
#CientificoLatino #PhDReady
October 7, 2026 at 4:51 PM
NEXT WEEK: Científico Latino's NYC Workshop Series on "Applying to Graduate School and Writing a Strong Personal Statement" on 10/14 at 4pm.
Sign-up here: cientificolatino.com/nyc-workshop...
All attendees will be eligible for a fee waiver at Stony Brook University.
#CientificoLatino #PhDReady
Sign-up here: cientificolatino.com/nyc-workshop...
All attendees will be eligible for a fee waiver at Stony Brook University.
#CientificoLatino #PhDReady
Reposted by Emiliano Sotelo
An other example of the value and beauty of fundamental biology research: we don’t always know what kind of future applications will be made possible by a basic discovery. This work in a single-celled alga open the doors to optigenetics 💡🧬
Peter Hegemann and Georg Nagel – awarded the 2026 medicine prize – discovered a remarkable protein, channelrhodopsin, in a single-celled alga.
Hegemann wondered how Chlamydomonas, a single-celled alga, is able to swim towards a light source.
Hegemann wondered how Chlamydomonas, a single-celled alga, is able to swim towards a light source.
October 5, 2026 at 11:27 AM
An other example of the value and beauty of fundamental biology research: we don’t always know what kind of future applications will be made possible by a basic discovery. This work in a single-celled alga open the doors to optigenetics 💡🧬
Reposted by Emiliano Sotelo
Thrilled to see this published today!
Truly special because we made the initial discovery >15 yrs ago!
We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic!
www.science.org/doi/10.1126/...
🧵1/n
Truly special because we made the initial discovery >15 yrs ago!
We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic!
www.science.org/doi/10.1126/...
🧵1/n
Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates
Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...
www.science.org
September 24, 2026 at 7:00 PM
Thrilled to see this published today!
Truly special because we made the initial discovery >15 yrs ago!
We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic!
www.science.org/doi/10.1126/...
🧵1/n
Truly special because we made the initial discovery >15 yrs ago!
We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic!
www.science.org/doi/10.1126/...
🧵1/n
Reposted by Emiliano Sotelo
The CRG's 2027 PhD call is now open! We have multiple, fully-funded positions across fifteen different research groups. Successful candidates will spend four years pursuing cutting-edge questions at our labs in Barcelona. Deadline is 22 November. www.crg.eu/en/content/t...
September 21, 2026 at 3:16 PM
The CRG's 2027 PhD call is now open! We have multiple, fully-funded positions across fifteen different research groups. Successful candidates will spend four years pursuing cutting-edge questions at our labs in Barcelona. Deadline is 22 November. www.crg.eu/en/content/t...
Reposted by Emiliano Sotelo
The 4DN Center for 3D Structure and Physics of the Genome proudly presents: "Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation". www.biorxiv.org/content/10.6...
September 19, 2026 at 1:50 AM
The 4DN Center for 3D Structure and Physics of the Genome proudly presents: "Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation". www.biorxiv.org/content/10.6...
Reposted by Emiliano Sotelo
It was great working with students Kun and Ryan and
@hannahlong.bsky.social, combing the literature to try and find examples of bona fide disease-causing variants in non-coding elements - promoters, enhancers and silencers.
www.nature.com/articles/s41...
@hannahlong.bsky.social, combing the literature to try and find examples of bona fide disease-causing variants in non-coding elements - promoters, enhancers and silencers.
www.nature.com/articles/s41...
Mechanisms underlying disease-causing variants in promoters and enhancers - Nature Genetics
This Review discusses how rare-disease-causing variants in the noncoding genome impact gene regulation, why these examples are so few and how new approaches could accelerate discovery of noncoding var...
www.nature.com
September 8, 2026 at 10:06 AM
It was great working with students Kun and Ryan and
@hannahlong.bsky.social, combing the literature to try and find examples of bona fide disease-causing variants in non-coding elements - promoters, enhancers and silencers.
www.nature.com/articles/s41...
@hannahlong.bsky.social, combing the literature to try and find examples of bona fide disease-causing variants in non-coding elements - promoters, enhancers and silencers.
www.nature.com/articles/s41...
Reposted by Emiliano Sotelo
Our paper is now out in the @isme-microbes.bsky.social Journal (and selected as editor's choice)! We use an ecological framework to analyze the distribution of small transposable elements in over 30,000 prokaryotic genomes, characterizing their genomic niche doi.org/10.1093/isme...
September 7, 2026 at 2:32 PM
Our paper is now out in the @isme-microbes.bsky.social Journal (and selected as editor's choice)! We use an ecological framework to analyze the distribution of small transposable elements in over 30,000 prokaryotic genomes, characterizing their genomic niche doi.org/10.1093/isme...
Reposted by Emiliano Sotelo
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
September 3, 2026 at 8:09 PM
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
Reposted by Emiliano Sotelo
Finally - the 🧵!
So, the piRNA pathway defends the animal germline from transposons. But most of what we know comes from narrow developmental windows like late oogenesis, where it's easiest to study.
We asked if the pathway is the same across development.
It is not!
/+
So, the piRNA pathway defends the animal germline from transposons. But most of what we know comes from narrow developmental windows like late oogenesis, where it's easiest to study.
We asked if the pathway is the same across development.
It is not!
/+
We watched piRNAs and transposons across development, saw them dance tightly and wrote a paper about it.
It's so cool to see it online and we will make a thread about it all very soon. Stay tuned :-)
It's so cool to see it online and we will make a thread about it all very soon. Stay tuned :-)
A developmental switch in the piRNA pathway ensures stage-specific transposon silencing https://www.biorxiv.org/content/10.64898/2026.08.28.747770v1
September 2, 2026 at 3:10 PM
Finally - the 🧵!
So, the piRNA pathway defends the animal germline from transposons. But most of what we know comes from narrow developmental windows like late oogenesis, where it's easiest to study.
We asked if the pathway is the same across development.
It is not!
/+
So, the piRNA pathway defends the animal germline from transposons. But most of what we know comes from narrow developmental windows like late oogenesis, where it's easiest to study.
We asked if the pathway is the same across development.
It is not!
/+
Reposted by Emiliano Sotelo
1/11 We are excited to share Dynema, a new method for efficient genome-wide mapping of reproducible, context-dependent eQTLs at true single-cell resolution w/
@soumya-boston.bsky.social and @aparnanathan
biorxiv.org/content/10.6... tldr it finds reproducible eQTLs quickly and accurately!
@soumya-boston.bsky.social and @aparnanathan
biorxiv.org/content/10.6... tldr it finds reproducible eQTLs quickly and accurately!
Efficient genome-wide mapping of reproducible, context-dependent eQTLs at single-cell resolution
Single-cell technologies enable linking disease-risk variants to gene regulatory effects in specific cell-state contexts. However, most so called "single-cell eQTL" studies use a "pseudobulking" strat...
biorxiv.org
August 31, 2026 at 3:42 PM
1/11 We are excited to share Dynema, a new method for efficient genome-wide mapping of reproducible, context-dependent eQTLs at true single-cell resolution w/
@soumya-boston.bsky.social and @aparnanathan
biorxiv.org/content/10.6... tldr it finds reproducible eQTLs quickly and accurately!
@soumya-boston.bsky.social and @aparnanathan
biorxiv.org/content/10.6... tldr it finds reproducible eQTLs quickly and accurately!
Reposted by Emiliano Sotelo
Multi-member gene families of cell-surface proteins can contribute to complex circuit assembly. This study in #Drosophila reveals that 2 conserved families are expressed combinatorially in olfactory #circuits, suggesting roles as neuronal tags for brain patterning.
🧪 #AcademicSky
plos.io/3UFJTfZ
🧪 #AcademicSky
plos.io/3UFJTfZ
August 30, 2026 at 12:20 PM
Multi-member gene families of cell-surface proteins can contribute to complex circuit assembly. This study in #Drosophila reveals that 2 conserved families are expressed combinatorially in olfactory #circuits, suggesting roles as neuronal tags for brain patterning.
🧪 #AcademicSky
plos.io/3UFJTfZ
🧪 #AcademicSky
plos.io/3UFJTfZ
Reposted by Emiliano Sotelo
How do nuclear compartments form inside cell nuclei? We show RNA glues certain loci together to form a nuclear compartment. This involves special GC-rich regions of highly expressed genes that also associate with nuclear speckles, but interactions between these loci are independent of speckles!
Formation of an RNA-mediated nuclear compartment https://www.biorxiv.org/content/10.64898/2026.08.20.746005v1
August 24, 2026 at 3:41 PM
How do nuclear compartments form inside cell nuclei? We show RNA glues certain loci together to form a nuclear compartment. This involves special GC-rich regions of highly expressed genes that also associate with nuclear speckles, but interactions between these loci are independent of speckles!
Reposted by Emiliano Sotelo
Sequence-to-function deep learning decodes human cis-regulatory evolution https://www.biorxiv.org/content/10.64898/2026.08.24.746818v1
August 28, 2026 at 7:35 AM
Sequence-to-function deep learning decodes human cis-regulatory evolution https://www.biorxiv.org/content/10.64898/2026.08.24.746818v1
Reposted by Emiliano Sotelo
It’s still genetic… www.brainfacts.org/diseases-and...
Understanding the Genetics of Autism
“The genetics underpinning autism is extremely complex. But the evidence for primarily genetic causation is overwhelming…” writes Kevin Mitchell.
www.brainfacts.org
August 10, 2026 at 9:31 PM
It’s still genetic… www.brainfacts.org/diseases-and...
Help us untangle repetitive genomic variants! 🧬
We’re looking for an undergrad/master's intern (4 months, Spring 2027) with Python & Bash skills to map regulatory sequences in structural variants in the Bernardo Rodriguez Martin lab.
Details & apply: tinyurl.com/mtkknphc
#TEsky
We’re looking for an undergrad/master's intern (4 months, Spring 2027) with Python & Bash skills to map regulatory sequences in structural variants in the Bernardo Rodriguez Martin lab.
Details & apply: tinyurl.com/mtkknphc
#TEsky
Centre for Genomic Regulation Website
tinyurl.com
August 11, 2026 at 10:08 AM
Help us untangle repetitive genomic variants! 🧬
We’re looking for an undergrad/master's intern (4 months, Spring 2027) with Python & Bash skills to map regulatory sequences in structural variants in the Bernardo Rodriguez Martin lab.
Details & apply: tinyurl.com/mtkknphc
#TEsky
We’re looking for an undergrad/master's intern (4 months, Spring 2027) with Python & Bash skills to map regulatory sequences in structural variants in the Bernardo Rodriguez Martin lab.
Details & apply: tinyurl.com/mtkknphc
#TEsky
Reposted by Emiliano Sotelo
Happy to share this release of some new long-read genomes in @genomebiolevol.bsky.social! We hope that subspecies-specific, quality genomes will enable better profiling of variation underlying phenotypic differences in Heliconius, mitigating bias from using a relative's genome as the reference 1/3
@a-mack-s.bsky.social @evolvwing.bsky.social et al. generate deep-coverage PacBio long-read data from five Heliconius, recovering high genome contiguity, quality, and completeness scores.
🔗 doi.org/10.1093/gbe/evag171
#societyjournal #genome
🔗 doi.org/10.1093/gbe/evag171
#societyjournal #genome
de novo Assembly of five Highly Contiguous Heliconius Butterfly Genomes With Long-Read Sequencing Alone
Abstract. Rapidly decreasing costs of sequencing whole genomes have caused a boom in genomic resources for many species. However, many key nonmodel systems
doi.org
August 3, 2026 at 3:04 PM
Happy to share this release of some new long-read genomes in @genomebiolevol.bsky.social! We hope that subspecies-specific, quality genomes will enable better profiling of variation underlying phenotypic differences in Heliconius, mitigating bias from using a relative's genome as the reference 1/3
Reposted by Emiliano Sotelo
Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com
Led by @crisnava.bsky.social and @seanamontgomery.bsky.social
www.nature.com/articles/s41...
Some highlights below
Led by @crisnava.bsky.social and @seanamontgomery.bsky.social
www.nature.com/articles/s41...
Some highlights below
Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics
This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...
www.nature.com
August 3, 2026 at 9:08 AM
Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com
Led by @crisnava.bsky.social and @seanamontgomery.bsky.social
www.nature.com/articles/s41...
Some highlights below
Led by @crisnava.bsky.social and @seanamontgomery.bsky.social
www.nature.com/articles/s41...
Some highlights below
Reposted by Emiliano Sotelo
Our manuscript on the co-option of TEs as cerebellar CREs is now officially published in @natcomms.nature.com!
Huge thanks to @kaessmannlab.bsky.social @marisepp.bsky.social, and @ioansarr.bsky.social for the fantastic collaboration throughout this project!
www.nature.com/articles/s41...
Huge thanks to @kaessmannlab.bsky.social @marisepp.bsky.social, and @ioansarr.bsky.social for the fantastic collaboration throughout this project!
www.nature.com/articles/s41...
July 30, 2026 at 9:30 AM
Our manuscript on the co-option of TEs as cerebellar CREs is now officially published in @natcomms.nature.com!
Huge thanks to @kaessmannlab.bsky.social @marisepp.bsky.social, and @ioansarr.bsky.social for the fantastic collaboration throughout this project!
www.nature.com/articles/s41...
Huge thanks to @kaessmannlab.bsky.social @marisepp.bsky.social, and @ioansarr.bsky.social for the fantastic collaboration throughout this project!
www.nature.com/articles/s41...
Reposted by Emiliano Sotelo
New article!: The Origins and Evolution of Writing
www.annualreviews.org/content/jour... 🧵1/
www.annualreviews.org/content/jour... 🧵1/
The Origins and Evolution of Writing
For centuries, scholars have debated the etiology and evolution of writing. The most persistent concerns relate to the relationship between writing and social organization, linguistic structure, and c...
www.annualreviews.org
July 28, 2026 at 4:57 AM
New article!: The Origins and Evolution of Writing
www.annualreviews.org/content/jour... 🧵1/
www.annualreviews.org/content/jour... 🧵1/
Reposted by Emiliano Sotelo
"This trimodal platform enables a comprehensive understanding of the relationships among gene expression, morphological diversity, and functional properties of single neurons"
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Multimodal imaging of gene expression, morphology, and activity of the same neuron
This study establishes an imaging-based multimodal characterization (IMC) platform
to link in vivo activity, whole-brain morphology, and spatial gene expression in the
same cortical projection neurons...
www.cell.com
July 27, 2026 at 1:04 PM
"This trimodal platform enables a comprehensive understanding of the relationships among gene expression, morphological diversity, and functional properties of single neurons"
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Emiliano Sotelo
You can now make chord diagrams in #ggplot2 🎉
Here's a short blog introducing the 'ggchord2' package and showing you how to make chord diagrams 📊
Link: nrennie.rbind.io/blog/chord-d...
#RStats #DataViz #RLadies
Here's a short blog introducing the 'ggchord2' package and showing you how to make chord diagrams 📊
Link: nrennie.rbind.io/blog/chord-d...
#RStats #DataViz #RLadies
Chord diagrams in R with ggchord2 – Nicola Rennie
Chord diagrams can be used to show relationships or flows between and within categories. This blog post introduces ggchord2, a new package that makes it possible to create them using ggplto2 in R.
nrennie.rbind.io
July 13, 2026 at 1:04 PM
You can now make chord diagrams in #ggplot2 🎉
Here's a short blog introducing the 'ggchord2' package and showing you how to make chord diagrams 📊
Link: nrennie.rbind.io/blog/chord-d...
#RStats #DataViz #RLadies
Here's a short blog introducing the 'ggchord2' package and showing you how to make chord diagrams 📊
Link: nrennie.rbind.io/blog/chord-d...
#RStats #DataViz #RLadies
Reposted by Emiliano Sotelo
How has natural selection shaped admixed human populations in Mexico? Catch Ram Gonzalez-Buenfil's presentation [B337] at #SMBE2026 to find out!
June 30 at 6pm @ 2nd floor Arkaden 6
@ramgonzalezb.bsky.social
June 30 at 6pm @ 2nd floor Arkaden 6
@ramgonzalezb.bsky.social
June 30, 2026 at 3:46 AM
How has natural selection shaped admixed human populations in Mexico? Catch Ram Gonzalez-Buenfil's presentation [B337] at #SMBE2026 to find out!
June 30 at 6pm @ 2nd floor Arkaden 6
@ramgonzalezb.bsky.social
June 30 at 6pm @ 2nd floor Arkaden 6
@ramgonzalezb.bsky.social
Reposted by Emiliano Sotelo
Very excited to finally share my PhD! 🎉
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish
Loss of the conserved splicing factor for neuronal microexons disrupts neuromodulatory signaling and drives hyperarousal.
www.science.org
June 28, 2026 at 4:37 PM
Very excited to finally share my PhD! 🎉
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Reposted by Emiliano Sotelo
(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack:
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec):
www.biorxiv.org/content/10.6...
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec):
www.biorxiv.org/content/10.6...
June 22, 2026 at 3:32 PM
(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack:
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec):
www.biorxiv.org/content/10.6...
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec):
www.biorxiv.org/content/10.6...
Reposted by Emiliano Sotelo
🎉 #Preprint alert!
Excited to share this new study from our postdoc Carsten Hain on centromeres!
www.biorxiv.org/content/10.6...
This work presents HORoSCOPE, a computational framework that infers centromere architecture and size directly from short-read sequencing data.
(1/3)
Excited to share this new study from our postdoc Carsten Hain on centromeres!
www.biorxiv.org/content/10.6...
This work presents HORoSCOPE, a computational framework that infers centromere architecture and size directly from short-read sequencing data.
(1/3)
June 15, 2026 at 1:59 PM
🎉 #Preprint alert!
Excited to share this new study from our postdoc Carsten Hain on centromeres!
www.biorxiv.org/content/10.6...
This work presents HORoSCOPE, a computational framework that infers centromere architecture and size directly from short-read sequencing data.
(1/3)
Excited to share this new study from our postdoc Carsten Hain on centromeres!
www.biorxiv.org/content/10.6...
This work presents HORoSCOPE, a computational framework that infers centromere architecture and size directly from short-read sequencing data.
(1/3)