Martin Kampmann
@kampmann.bsky.social
Professor at UCSF. Molecular/cellular mechanisms of brain disease. Functional Genomics. Diversity & Inclusion. 🏳️🌈 he/him
Very excited to share our new preprint:
Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling
Great team effort and collaboration, led by MD/PhD student @kunalshroff.bsky.social in my lab - read more details in his post below:
Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling
Great team effort and collaboration, led by MD/PhD student @kunalshroff.bsky.social in my lab - read more details in his post below:
I am so excited to share our new preprint!
www.biorxiv.org/cgi/content/...
This work uncovers a key molecular mechanism that control synapse-specific exposure of the canonical “eat-me” signal phosphatidylserine!
www.biorxiv.org/cgi/content/...
This work uncovers a key molecular mechanism that control synapse-specific exposure of the canonical “eat-me” signal phosphatidylserine!
Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling
Neuronal synapses are eliminated during brain development and disease through pruning by glial cells. Individual synapses are marked for engulfment by 'eat-me' signals, which include externalized phos...
www.biorxiv.org
June 30, 2026 at 10:04 PM
Very excited to share our new preprint:
Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling
Great team effort and collaboration, led by MD/PhD student @kunalshroff.bsky.social in my lab - read more details in his post below:
Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling
Great team effort and collaboration, led by MD/PhD student @kunalshroff.bsky.social in my lab - read more details in his post below:
Our paper is (finally) out in Cell today!
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
January 28, 2026 at 5:24 PM
Our paper is (finally) out in Cell today!
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
December 5, 2025 at 4:23 PM
Kampmann lab Halloween costume this year:
Revenge of the lab rats
(Including several KO mice)
Happy 👻🎃
Revenge of the lab rats
(Including several KO mice)
Happy 👻🎃
October 31, 2025 at 10:23 PM
Kampmann lab Halloween costume this year:
Revenge of the lab rats
(Including several KO mice)
Happy 👻🎃
Revenge of the lab rats
(Including several KO mice)
Happy 👻🎃
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
October 22, 2025 at 6:28 PM
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Apply by Oct 15 - please spread the word!
Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF05702
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF05702
September 16, 2025 at 1:50 PM
Apply by Oct 15 - please spread the word!
Reposted by Martin Kampmann
Find the CrAAVe-seq plasmid pAP215 here: www.addgene.org/217635/
Exciting work, thanks for sharing!
Exciting work, thanks for sharing!
September 5, 2025 at 5:59 PM
Find the CrAAVe-seq plasmid pAP215 here: www.addgene.org/217635/
Exciting work, thanks for sharing!
Exciting work, thanks for sharing!
Reposted by Martin Kampmann
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
@kampmann.bsky.social @ivlrose.bsky.social
www.nature.com/articles/s41...
@kampmann.bsky.social @ivlrose.bsky.social
www.nature.com/articles/s41...
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
www.nature.com
September 5, 2025 at 3:41 PM
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
@kampmann.bsky.social @ivlrose.bsky.social
www.nature.com/articles/s41...
@kampmann.bsky.social @ivlrose.bsky.social
www.nature.com/articles/s41...
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
www.nature.com
August 22, 2025 at 10:15 PM
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF05702
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF05702
July 23, 2025 at 10:51 PM
Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF05702
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF05702
Very honored to receive this year's Byers Award in Basic Science!
Huge thanks to my lab and our funders for enabling our research on Alzheimer's disease and related dementias.
www.ucsf.edu/news/2025/07...
Huge thanks to my lab and our funders for enabling our research on Alzheimer's disease and related dementias.
www.ucsf.edu/news/2025/07...
July 21, 2025 at 1:13 AM
Very honored to receive this year's Byers Award in Basic Science!
Huge thanks to my lab and our funders for enabling our research on Alzheimer's disease and related dementias.
www.ucsf.edu/news/2025/07...
Huge thanks to my lab and our funders for enabling our research on Alzheimer's disease and related dementias.
www.ucsf.edu/news/2025/07...
Farewell party for 4 great lab members, excited for their next adventures: Biswa Ramani (starting the Ramani Lab @ucsanfrancisco.bsky.social), @venushagan.bsky.social (PhD @ucsanfrancisco.bsky.social), Cristian Chavira (PhD @uwmadison.bsky.social), Kean Ehsani (Ramani lab). Thanks & best wishes
June 28, 2025 at 1:22 AM
Farewell party for 4 great lab members, excited for their next adventures: Biswa Ramani (starting the Ramani Lab @ucsanfrancisco.bsky.social), @venushagan.bsky.social (PhD @ucsanfrancisco.bsky.social), Cristian Chavira (PhD @uwmadison.bsky.social), Kean Ehsani (Ramani lab). Thanks & best wishes
Stand up for science - stand up for the NIH!
I just signed the support letter for the #BethesdaDeclaration.
Please consider signing as well:
www.standupforscience.net/bethesda-dec...
I just signed the support letter for the #BethesdaDeclaration.
Please consider signing as well:
www.standupforscience.net/bethesda-dec...
Bethesda Declaration — STAND UP FOR SCIENCE
Support NIH Staff Now!
www.standupforscience.net
June 10, 2025 at 3:23 AM
Stand up for science - stand up for the NIH!
I just signed the support letter for the #BethesdaDeclaration.
Please consider signing as well:
www.standupforscience.net/bethesda-dec...
I just signed the support letter for the #BethesdaDeclaration.
Please consider signing as well:
www.standupforscience.net/bethesda-dec...
Farewell to Emily Marzette. Thank you so much for your many contributions to the lab! We will miss you lots but are excited for you to start grad school at UCLA!
🎉
🎉
June 5, 2025 at 8:13 PM
Farewell to Emily Marzette. Thank you so much for your many contributions to the lab! We will miss you lots but are excited for you to start grad school at UCLA!
🎉
🎉
Reposted by Martin Kampmann
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes,
and neurons to investigate intercellular communication across different environmental
and genetic contexts. Transcr...
www.cell.com
June 5, 2025 at 12:49 AM
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Congratulations Rudra Bose, on passing your qualifying exam with flying colors!
🎉🎉🎉
#kampmannlabproud
🎉🎉🎉
#kampmannlabproud
April 22, 2025 at 12:44 AM
Congratulations Rudra Bose, on passing your qualifying exam with flying colors!
🎉🎉🎉
#kampmannlabproud
🎉🎉🎉
#kampmannlabproud
Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation
While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...
www.biorxiv.org
April 16, 2025 at 4:39 PM
Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Reposted by Martin Kampmann
As Trump & Musk tear down our federal science agencies & jeopardize U.S. global science leadership, CA needs to step up.
I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵
I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵
April 1, 2025 at 5:09 PM
As Trump & Musk tear down our federal science agencies & jeopardize U.S. global science leadership, CA needs to step up.
I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵
I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵
Congratulations Dr. @parkergrosjean.bsky.social! 🎓🎉🎉🎉
Thank you for your contributions to the Kampmann lab & UCSF - combining AI/ML with functional genomics to uncover regulators of neuronal activity.
We are missing you already - but excited for your next adventures at @insitro.bsky.social!
Thank you for your contributions to the Kampmann lab & UCSF - combining AI/ML with functional genomics to uncover regulators of neuronal activity.
We are missing you already - but excited for your next adventures at @insitro.bsky.social!
April 1, 2025 at 12:36 AM
Congratulations Dr. @parkergrosjean.bsky.social! 🎓🎉🎉🎉
Thank you for your contributions to the Kampmann lab & UCSF - combining AI/ML with functional genomics to uncover regulators of neuronal activity.
We are missing you already - but excited for your next adventures at @insitro.bsky.social!
Thank you for your contributions to the Kampmann lab & UCSF - combining AI/ML with functional genomics to uncover regulators of neuronal activity.
We are missing you already - but excited for your next adventures at @insitro.bsky.social!
Reposted by Martin Kampmann
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
March 5, 2025 at 4:54 PM
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
Excited for our iAssembloid work, led by @emmyli.bsky.social to be featured on the cover of today's issue of @cp-neuron.bsky.social
Our latest issue is out! www.cell.com/neuron/current
On the cover is an iAssembloid, a 3D co-culture of human iPSC-derived brain cell types, that Emmy Li & coll. combines with CRISPRi screening to elucidate neuron-glia interactions
Find the paper here: www.cell.com/neuron/fullt...
On the cover is an iAssembloid, a 3D co-culture of human iPSC-derived brain cell types, that Emmy Li & coll. combines with CRISPRi screening to elucidate neuron-glia interactions
Find the paper here: www.cell.com/neuron/fullt...
March 6, 2025 at 12:03 AM
Excited for our iAssembloid work, led by @emmyli.bsky.social to be featured on the cover of today's issue of @cp-neuron.bsky.social
Honored and grateful to receive the 2025 Bowes Biomedical Investigator Award - along with my friend, colleague and collaborator @annamolofskylab.bsky.social
😊🎉🎉🎉
www.ucsf.edu/news/2025/02...
😊🎉🎉🎉
www.ucsf.edu/news/2025/02...
How to Build Bold Thinking to Foster Scientific Breakthroughs
Martin Kampmann, PhD, and Anna Victoria Molofsky, MD, PhD, are the 2025 recipients of the Bowes Biomedical Investigator award, which supports scientists who take novel approaches and have the potentia...
www.ucsf.edu
March 6, 2025 at 12:00 AM
Honored and grateful to receive the 2025 Bowes Biomedical Investigator Award - along with my friend, colleague and collaborator @annamolofskylab.bsky.social
😊🎉🎉🎉
www.ucsf.edu/news/2025/02...
😊🎉🎉🎉
www.ucsf.edu/news/2025/02...
Reposted by Martin Kampmann
In this time of chaos - something good! We are excited to share our final (or near final) speaker list for the 3rd UCSF Full Circle Symposium 4/3-4/4 to highlight Native biologists! Please share the word and register to attend the webinar in person! More info: qbi.ucsf.edu/full-circle-...
March 5, 2025 at 8:59 PM
In this time of chaos - something good! We are excited to share our final (or near final) speaker list for the 3rd UCSF Full Circle Symposium 4/3-4/4 to highlight Native biologists! Please share the word and register to attend the webinar in person! More info: qbi.ucsf.edu/full-circle-...
Congratulations Dr. Olivia Teter! 🎓🎉🎉🎉
Thank you for your many contributions to the Kampmann lab - scientifically and socially. We will miss you lots.
All the best for your next adventure at Calico!
Thank you for your many contributions to the Kampmann lab - scientifically and socially. We will miss you lots.
All the best for your next adventure at Calico!
February 18, 2025 at 1:15 AM
Congratulations Dr. Olivia Teter! 🎓🎉🎉🎉
Thank you for your many contributions to the Kampmann lab - scientifically and socially. We will miss you lots.
All the best for your next adventure at Calico!
Thank you for your many contributions to the Kampmann lab - scientifically and socially. We will miss you lots.
All the best for your next adventure at Calico!