Kate Beckham
@kshbeckham.bsky.social
Royal Society University Research Fellow | NUAcT Fellow @ Newcastle University
Investigating mycobacterial transport systems
#structuralbiology #microbiology
Instagram @kshbeckham
lab website : https://beckham-lab-newcastle.github.io/
Investigating mycobacterial transport systems
#structuralbiology #microbiology
Instagram @kshbeckham
lab website : https://beckham-lab-newcastle.github.io/
Reposted by Kate Beckham
We finally built what I've always wanted: A cryoEM papers database that is updated continually, searchable, and categorized!
It's live right now at www.cryoarcana.com/cryoem-papers
It's live right now at www.cryoarcana.com/cryoem-papers
September 25, 2026 at 3:32 PM
We finally built what I've always wanted: A cryoEM papers database that is updated continually, searchable, and categorized!
It's live right now at www.cryoarcana.com/cryoem-papers
It's live right now at www.cryoarcana.com/cryoem-papers
Heading home after a great EMBO TB meeting in Paris. Always such an exciting meeting giving a great overview of what is happening in the field
@hrryflwr.bsky.social did a great job presenting his poster as well :D
#embocomplexinfections
@embo.org @lkremer1.bsky.social @figlegend.bsky.social
@hrryflwr.bsky.social did a great job presenting his poster as well :D
#embocomplexinfections
@embo.org @lkremer1.bsky.social @figlegend.bsky.social
September 18, 2026 at 12:09 PM
Heading home after a great EMBO TB meeting in Paris. Always such an exciting meeting giving a great overview of what is happening in the field
@hrryflwr.bsky.social did a great job presenting his poster as well :D
#embocomplexinfections
@embo.org @lkremer1.bsky.social @figlegend.bsky.social
@hrryflwr.bsky.social did a great job presenting his poster as well :D
#embocomplexinfections
@embo.org @lkremer1.bsky.social @figlegend.bsky.social
Reposted by Kate Beckham
Exciting Keystone TB Conference in London
Tuberculosis: Basic Science Addressing Clinical Needs
March 1–4, 2027
www.keystonesymposia.org/conferences/...
Tuberculosis: Basic Science Addressing Clinical Needs
March 1–4, 2027
www.keystonesymposia.org/conferences/...
September 17, 2026 at 8:10 PM
Exciting Keystone TB Conference in London
Tuberculosis: Basic Science Addressing Clinical Needs
March 1–4, 2027
www.keystonesymposia.org/conferences/...
Tuberculosis: Basic Science Addressing Clinical Needs
March 1–4, 2027
www.keystonesymposia.org/conferences/...
Reposted by Kate Beckham
Scientists have determined the highest-resolution protein structure obtained to date.
Using advanced X-ray crystallography techniques at EMBL Hamburg's P14 beamline, the team solved the structure of an archaeal protein at an astonishing 0.43 Ångström resolution.
www.embl.org/news/science...
Using advanced X-ray crystallography techniques at EMBL Hamburg's P14 beamline, the team solved the structure of an archaeal protein at an astonishing 0.43 Ångström resolution.
www.embl.org/news/science...
Every electron counts: most detailed protein structure to date revealed | EMBL
Researchers have used advanced X-ray crystallography methods to determine the structure of an archaeal protein at unprecedented resolution
www.embl.org
September 15, 2026 at 9:06 AM
Scientists have determined the highest-resolution protein structure obtained to date.
Using advanced X-ray crystallography techniques at EMBL Hamburg's P14 beamline, the team solved the structure of an archaeal protein at an astonishing 0.43 Ångström resolution.
www.embl.org/news/science...
Using advanced X-ray crystallography techniques at EMBL Hamburg's P14 beamline, the team solved the structure of an archaeal protein at an astonishing 0.43 Ångström resolution.
www.embl.org/news/science...
Reposted by Kate Beckham
Reposted by Kate Beckham
Apply to the EMBL Sabbatical Programme now! 📢
This is a great opportunity for senior scientists looking to expand their scientific horizons!
You could receive up to €15,000 and be based at any of EMBL’s six sites for 3 to 6 months.
📌 Deadline: 09 Oct 2026
🔗Apply here: bit.ly/sabbatical26
This is a great opportunity for senior scientists looking to expand their scientific horizons!
You could receive up to €15,000 and be based at any of EMBL’s six sites for 3 to 6 months.
📌 Deadline: 09 Oct 2026
🔗Apply here: bit.ly/sabbatical26
September 3, 2026 at 8:20 AM
Apply to the EMBL Sabbatical Programme now! 📢
This is a great opportunity for senior scientists looking to expand their scientific horizons!
You could receive up to €15,000 and be based at any of EMBL’s six sites for 3 to 6 months.
📌 Deadline: 09 Oct 2026
🔗Apply here: bit.ly/sabbatical26
This is a great opportunity for senior scientists looking to expand their scientific horizons!
You could receive up to €15,000 and be based at any of EMBL’s six sites for 3 to 6 months.
📌 Deadline: 09 Oct 2026
🔗Apply here: bit.ly/sabbatical26
Reposted by Kate Beckham
Keynote announced!
We're delighted to welcome Prof. Laura Spagnolo (University of Glasgow) as keynote speaker for the CCP4 Northern Structural Biology Meeting 2026
11–13 Nov | Newcastle
Free to attend
cc @lauraspagnolo.bsky.social
#StructuralBiology #CryoEM #CCP4
We're delighted to welcome Prof. Laura Spagnolo (University of Glasgow) as keynote speaker for the CCP4 Northern Structural Biology Meeting 2026
11–13 Nov | Newcastle
Free to attend
cc @lauraspagnolo.bsky.social
#StructuralBiology #CryoEM #CCP4
CCP4 Northern meeting 2026: Keynote Speaker Laura Spagnolo
CCP4 Northern meeting 2026 keynote speaker announced: Prof. Laura Spagnolo (Glasgow) will speak 11–13 Nov in Newcastle.
nusbf.ncl.ac.uk
August 19, 2026 at 3:20 PM
Keynote announced!
We're delighted to welcome Prof. Laura Spagnolo (University of Glasgow) as keynote speaker for the CCP4 Northern Structural Biology Meeting 2026
11–13 Nov | Newcastle
Free to attend
cc @lauraspagnolo.bsky.social
#StructuralBiology #CryoEM #CCP4
We're delighted to welcome Prof. Laura Spagnolo (University of Glasgow) as keynote speaker for the CCP4 Northern Structural Biology Meeting 2026
11–13 Nov | Newcastle
Free to attend
cc @lauraspagnolo.bsky.social
#StructuralBiology #CryoEM #CCP4
Reposted by Kate Beckham
Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself.
doi.org/10.1038/s415... 1/5
doi.org/10.1038/s415... 1/5
August 17, 2026 at 11:11 PM
Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself.
doi.org/10.1038/s415... 1/5
doi.org/10.1038/s415... 1/5
Reposted by Kate Beckham
New preprint out - Jenn’s hard work over the last few years collaborating with @jnb-lab.bsky.social, Overkleeft Lab in Leiden, Spencer Williams, Hannah Bridges at Cryosparc and @pmoyniha.bsky.social. Feat. her beautiful 1.5A cryo structure with a covalent inhibitor 😍. www.biorxiv.org/content/10.6...
August 15, 2026 at 9:02 AM
New preprint out - Jenn’s hard work over the last few years collaborating with @jnb-lab.bsky.social, Overkleeft Lab in Leiden, Spencer Williams, Hannah Bridges at Cryosparc and @pmoyniha.bsky.social. Feat. her beautiful 1.5A cryo structure with a covalent inhibitor 😍. www.biorxiv.org/content/10.6...
Reposted by Kate Beckham
Some very exciting news - cryo FIB-SEM instrumentation will soon be coming to the University of York cryo-EM facility, thanks to funding from @ukri.org BBSRC ALERT. This will enable technically demanding cryo-CLEM and in situ structural biology workflows for multiple projects ❄️🦠🧫
August 11, 2026 at 9:14 AM
Some very exciting news - cryo FIB-SEM instrumentation will soon be coming to the University of York cryo-EM facility, thanks to funding from @ukri.org BBSRC ALERT. This will enable technically demanding cryo-CLEM and in situ structural biology workflows for multiple projects ❄️🦠🧫
Reposted by Kate Beckham
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
Jobs - The University of York
jobs.york.ac.uk
August 10, 2026 at 8:33 PM
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
Reposted by Kate Beckham
Excited to share our latest work with Wonpil Im lab about the modeling of mycobacterial inner membrane using atomistic simulations, published in the @pubs.acs.org the Journal of Chemical Information and Modeling! Congratulations Hwayoung and Nate!
More details here: pubs.acs.org/jcisd8/artic...
More details here: pubs.acs.org/jcisd8/artic...
August 5, 2026 at 9:27 AM
Excited to share our latest work with Wonpil Im lab about the modeling of mycobacterial inner membrane using atomistic simulations, published in the @pubs.acs.org the Journal of Chemical Information and Modeling! Congratulations Hwayoung and Nate!
More details here: pubs.acs.org/jcisd8/artic...
More details here: pubs.acs.org/jcisd8/artic...
Reposted by Kate Beckham
From fuzzy to ridig
We are pleased to share a new paper entitled “Intrinsic flexibility of the Type VII secretion central pore is required for substrate translocation”, published now in www.biorxiv.org/content/10.6...
Great thanks to all contributing authors for their outstanding work.
We are pleased to share a new paper entitled “Intrinsic flexibility of the Type VII secretion central pore is required for substrate translocation”, published now in www.biorxiv.org/content/10.6...
Great thanks to all contributing authors for their outstanding work.
August 2, 2026 at 1:04 PM
From fuzzy to ridig
We are pleased to share a new paper entitled “Intrinsic flexibility of the Type VII secretion central pore is required for substrate translocation”, published now in www.biorxiv.org/content/10.6...
Great thanks to all contributing authors for their outstanding work.
We are pleased to share a new paper entitled “Intrinsic flexibility of the Type VII secretion central pore is required for substrate translocation”, published now in www.biorxiv.org/content/10.6...
Great thanks to all contributing authors for their outstanding work.
Happy to share our recent story on the Type VII secretion system.
Here were present new insights into the regulation of secretion mediated by the central pore. Thanks to all authors involved in the work. 🙂
Here were present new insights into the regulation of secretion mediated by the central pore. Thanks to all authors involved in the work. 🙂
August 3, 2026 at 8:53 PM
Happy to share our recent story on the Type VII secretion system.
Here were present new insights into the regulation of secretion mediated by the central pore. Thanks to all authors involved in the work. 🙂
Here were present new insights into the regulation of secretion mediated by the central pore. Thanks to all authors involved in the work. 🙂
Reposted by Kate Beckham
Please repost! #microsky🦠
The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x
Send CV and cover letter to: [email protected]
The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x
Send CV and cover letter to: [email protected]
scholar.google.com
July 23, 2026 at 9:04 PM
Please repost! #microsky🦠
The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x
Send CV and cover letter to: [email protected]
The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x
Send CV and cover letter to: [email protected]
Reposted by Kate Beckham
The EMBO workshop (March 2027) on marine microbial chemicals communication is open for abstract submission and registration (deadline 20th Oct 2026). The inaugural meeting in 2025 was fantastic and there are already some great speakers lined up, highly recommended. meetings.embo.org/event/27-mar...
Marine microbial chemical communication
This EMBO Workshop on Marine Microbial Chemical Communication will bring together researchers at the forefront of understanding the chemical crosstalk of microbial interactions in the ocean. As micr…
meetings.embo.org
July 22, 2026 at 2:57 PM
The EMBO workshop (March 2027) on marine microbial chemicals communication is open for abstract submission and registration (deadline 20th Oct 2026). The inaugural meeting in 2025 was fantastic and there are already some great speakers lined up, highly recommended. meetings.embo.org/event/27-mar...
Reposted by Kate Beckham
Our University Research Fellowships are now open for applications. This scheme provides outstanding early-career scientists with the opportunity to build an independent research careers and pursue cutting edge scientific research.
Find out more and apply now:
royalsociety.org/grants/unive...
Find out more and apply now:
royalsociety.org/grants/unive...
July 14, 2026 at 2:48 PM
Our University Research Fellowships are now open for applications. This scheme provides outstanding early-career scientists with the opportunity to build an independent research careers and pursue cutting edge scientific research.
Find out more and apply now:
royalsociety.org/grants/unive...
Find out more and apply now:
royalsociety.org/grants/unive...
Pleasure to host @gchojnowski.bsky.social here in Newcastle for a seminar and a cryo EM modelling building. Thanks Greg, we all learned a lot!
July 10, 2026 at 9:42 PM
Pleasure to host @gchojnowski.bsky.social here in Newcastle for a seminar and a cryo EM modelling building. Thanks Greg, we all learned a lot!
Reposted by Kate Beckham
Out Now! Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning #MicroSky
Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning
Nature Microbiology, Published online: 30 June 2026; doi:10.1038/s41564-026-02412-5Screening 1,572 compounds for mycomembrane permeation plus cheminformatic and machine learning analyses reveals features associated with improved permeation in the pathogen Mycobacterium tuberculosis and model organism M. smegmatis.
go.nature.com
July 1, 2026 at 2:12 AM
Out Now! Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning #MicroSky
Reposted by Kate Beckham
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications.
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
Open Positions
-
tiny.cc
March 29, 2026 at 11:22 AM
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications.
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
Reposted by Kate Beckham
Out after a lot of hard work from many people. When we first found arabinanase enzymes in mycobacteria we started looking into their roles in cell remodelling & pathogenesis. Did not expect to find that some species had weaponised them to kill competitors! Myco are endlessly surprising. #glycotime
New paper in collaboration with @proftracypalmer.bsky.social, @lislowe.bsky.social and many more. We show that mycobacteria produce Type VII secreted anti-bacterial protein toxins. Excited to explore this new area of mycobacterial biology. www.nature.com/articles/s41...
A Type VII-secreted toxin enables inter-mycobacterial competition - Nature Communications
Mycobacteria have not yet been reported to engage in interbacterial competition via secretion of proteinaceous toxins. Here, Benedict et al. show that some mycobacteria can use their type-VII secretio...
www.nature.com
June 25, 2026 at 6:26 AM
Out after a lot of hard work from many people. When we first found arabinanase enzymes in mycobacteria we started looking into their roles in cell remodelling & pathogenesis. Did not expect to find that some species had weaponised them to kill competitors! Myco are endlessly surprising. #glycotime
Reposted by Kate Beckham
Check out our latest T7SS toxin story. These reverse toxins aren’t as rare as we thought!
A novel reverse lipase toxin substrate of the Staphylococcus aureus type VII secretion system https://www.biorxiv.org/content/10.64898/2026.06.22.733114v1
June 24, 2026 at 5:08 AM
Check out our latest T7SS toxin story. These reverse toxins aren’t as rare as we thought!
Reposted by Kate Beckham
E subunit-enabled ENZYME YOGA. Structures of catalytically active, asymmetric, hybrid acyl-CoA carboxylase, essential in M. tuberculosis @edumullapudi.bsky.social & @matthiaswilmanns.bsky.social & Minh Thai.
www.nature.com/articles/s42...
see also Liang et al.
www.pnas.org/doi/10.1073/...
www.nature.com/articles/s42...
see also Liang et al.
www.pnas.org/doi/10.1073/...
Architecture of an asymmetric short chain/long chain hybrid acyl‑CoA carboxylase from Mycobacterium smegmatis - Communications Biology
Structural analysis of endogenously expressed proteins in Mycobacterium smegmatis reveals an asymmetric short-chain/long-chain hybrid acyl‑CoA carboxylase that comprises 16 subunits with (AccA3)4–AccE...
www.nature.com
June 11, 2026 at 7:21 PM
E subunit-enabled ENZYME YOGA. Structures of catalytically active, asymmetric, hybrid acyl-CoA carboxylase, essential in M. tuberculosis @edumullapudi.bsky.social & @matthiaswilmanns.bsky.social & Minh Thai.
www.nature.com/articles/s42...
see also Liang et al.
www.pnas.org/doi/10.1073/...
www.nature.com/articles/s42...
see also Liang et al.
www.pnas.org/doi/10.1073/...
Reposted by Kate Beckham
Our latest paper ‘Ecological context for bacterial natural products’ is now out in the Royal Society of Chemistry @natprodreports.rsc.org
International effort with @jonathanparra.bsky.social, Marla I Macias-Contreras & Dulce Guillen Matus #puravida #naturalproducts
pubs.rsc.org/en/Content/A...
International effort with @jonathanparra.bsky.social, Marla I Macias-Contreras & Dulce Guillen Matus #puravida #naturalproducts
pubs.rsc.org/en/Content/A...
Ecological context for bacterial natural products discovery
Covering: This review covers literature from 2015 to present.It is widely recognised that there is a significant gap between bacterial natural product potential and detected/described products. As suc...
pubs.rsc.org
June 11, 2026 at 3:33 PM
Our latest paper ‘Ecological context for bacterial natural products’ is now out in the Royal Society of Chemistry @natprodreports.rsc.org
International effort with @jonathanparra.bsky.social, Marla I Macias-Contreras & Dulce Guillen Matus #puravida #naturalproducts
pubs.rsc.org/en/Content/A...
International effort with @jonathanparra.bsky.social, Marla I Macias-Contreras & Dulce Guillen Matus #puravida #naturalproducts
pubs.rsc.org/en/Content/A...
Reposted by Kate Beckham
@agnese75.bsky.social's work is out. She shows that under iron starvation M. tuberculosis splits flux through the Krebs cycle and secretes metabolites, akin of fermentation. Why is this important? Metabolic flexibility is what makes it so hard to kill in vivo.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Mycobacterium tuberculosis partitions the Krebs cycle under iron starvation
elifesciences.org
June 4, 2026 at 12:25 PM
@agnese75.bsky.social's work is out. She shows that under iron starvation M. tuberculosis splits flux through the Krebs cycle and secretes metabolites, akin of fermentation. Why is this important? Metabolic flexibility is what makes it so hard to kill in vivo.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...