Shutt Lab
@mitomorph.bsky.social
Associate Professor at University of Calgary studying mitochondria.
We are delighted to share not one, but two new preprints on Mitofusin2 from recent PhD graduate Mashiat Zaman @mashiatzaman.bsky.social
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org
September 30, 2026 at 12:58 PM
We are delighted to share not one, but two new preprints on Mitofusin2 from recent PhD graduate Mashiat Zaman @mashiatzaman.bsky.social
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org/10.64898/202...
Reposted by Shutt Lab
What if mitochondria have a buddy to supply them with the right substrates at the right time?
Tune in this thursday, and our speaker
@nunoraimundo.bsky.social will tell you how mitochondria-lysosome crosstalk can be a tool when metabolism needs to be rewired.
See you there?
Tune in this thursday, and our speaker
@nunoraimundo.bsky.social will tell you how mitochondria-lysosome crosstalk can be a tool when metabolism needs to be rewired.
See you there?
September 28, 2026 at 8:05 PM
What if mitochondria have a buddy to supply them with the right substrates at the right time?
Tune in this thursday, and our speaker
@nunoraimundo.bsky.social will tell you how mitochondria-lysosome crosstalk can be a tool when metabolism needs to be rewired.
See you there?
Tune in this thursday, and our speaker
@nunoraimundo.bsky.social will tell you how mitochondria-lysosome crosstalk can be a tool when metabolism needs to be rewired.
See you there?
Congrats to superstar Mashiat Zaman @mashiatzaman.bsky.social, on the successful defense of his PhD thesis! Hopefully, you'll be hearing more about his work on MFN2 soon.
September 14, 2026 at 9:50 PM
Congrats to superstar Mashiat Zaman @mashiatzaman.bsky.social, on the successful defense of his PhD thesis! Hopefully, you'll be hearing more about his work on MFN2 soon.
Reposted by Shutt Lab
Are you working on mitochondria-related topics? We want to hear from you.
MITOchat slots open for applications.
Apply here: mitotalks.org
Deadline: September 17th, 2026
We want to see the MITOscoence of the future again!
Image
MITOchat slots open for applications.
Apply here: mitotalks.org
Deadline: September 17th, 2026
We want to see the MITOscoence of the future again!
Image
MITO talks online seminar series | mitochondria
MITOtalks: Online Seminar Series Focusing on Mitochondria
mitotalks.org
September 13, 2026 at 12:19 PM
Are you working on mitochondria-related topics? We want to hear from you.
MITOchat slots open for applications.
Apply here: mitotalks.org
Deadline: September 17th, 2026
We want to see the MITOscoence of the future again!
Image
MITOchat slots open for applications.
Apply here: mitotalks.org
Deadline: September 17th, 2026
We want to see the MITOscoence of the future again!
Image
Reposted by Shutt Lab
New preprint from our lab! We uncover how a subset of mitophagy proteins BNIP3 and NIX are repressed and protected from turnover, we think so that they can perform a surveillance role to detect mitochondrial dysfunction under basal conditions. t.co/4XKkd4LsFi
https://www.biorxiv.org/content/10.64898/2026.06.25.734517v1
t.co
June 29, 2026 at 3:55 PM
New preprint from our lab! We uncover how a subset of mitophagy proteins BNIP3 and NIX are repressed and protected from turnover, we think so that they can perform a surveillance role to detect mitochondrial dysfunction under basal conditions. t.co/4XKkd4LsFi
Reposted by Shutt Lab
Excited to have been able to collaborate with @labfriedman.bsky.social on this exciting new study that uncovers a new layer of regulation for BNIP3 and NIX!
New preprint from our lab! We uncover how a subset of mitophagy proteins BNIP3 and NIX are repressed and protected from turnover, we think so that they can perform a surveillance role to detect mitochondrial dysfunction under basal conditions. t.co/4XKkd4LsFi
https://www.biorxiv.org/content/10.64898/2026.06.25.734517v1
t.co
June 29, 2026 at 7:35 PM
Excited to have been able to collaborate with @labfriedman.bsky.social on this exciting new study that uncovers a new layer of regulation for BNIP3 and NIX!
Reposted by Shutt Lab
Really hyped to share our pre-print on mtDNA replication-fission !
@nanigrotjahn.bsky.social
(doi: doi.org/10.64898/202...)
🧵with details below ⤵️
@nanigrotjahn.bsky.social
(doi: doi.org/10.64898/202...)
🧵with details below ⤵️
ATAD3A structurally links mtDNA replication and mitochondrial fission
Mitochondrial function depends on the maintenance of its genome, and disruptions in copy number and distribution are hallmarks of mitochondrial disorders. Mitochondrial DNA (mtDNA) replication is spat...
doi.org
June 27, 2026 at 1:14 AM
Really hyped to share our pre-print on mtDNA replication-fission !
@nanigrotjahn.bsky.social
(doi: doi.org/10.64898/202...)
🧵with details below ⤵️
@nanigrotjahn.bsky.social
(doi: doi.org/10.64898/202...)
🧵with details below ⤵️
Reposted by Shutt Lab
Immunology Collection: MFN2 Q367H drives mtDNA release and inflammation, uncovering a new mechanism of MFN2-linked disease. @mitomorph.bsky.social
www.life-science-alliance.org/content/lsa-...
Read the full paper here: www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/lsa-...
Read the full paper here: www.life-science-alliance.org/content/8/6/...
June 10, 2026 at 3:06 PM
Immunology Collection: MFN2 Q367H drives mtDNA release and inflammation, uncovering a new mechanism of MFN2-linked disease. @mitomorph.bsky.social
www.life-science-alliance.org/content/lsa-...
Read the full paper here: www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/lsa-...
Read the full paper here: www.life-science-alliance.org/content/8/6/...
Reposted by Shutt Lab
Time-resolved tmFRET reveals GTP-coupled conformational changes in Mfn1 rupress.org/jcb/article-...
Time-resolved tmFRET reveals GTP-coupled conformational changes in Mfn1
Hurwitz et al. leverage a novel FRET-based approach to quantify conformational dynamics of Mfn1, a member of the dynamin superfamily that mediates mitochon
rupress.org
May 7, 2026 at 5:00 PM
Time-resolved tmFRET reveals GTP-coupled conformational changes in Mfn1 rupress.org/jcb/article-...
Reposted by Shutt Lab
Reposted by Shutt Lab
Super excited to present out work at @mitotalks.bsky.social this Thursday!! Hope to see you there!
We talk a lot about mitochondrial stress, but how about how do they keep themselves balanced? Good thing our speaker
@nieminm.bsky.social knows everything about that, and will tell all on the next MITOtalk. Usual time and place. See you there?
@nieminm.bsky.social knows everything about that, and will tell all on the next MITOtalk. Usual time and place. See you there?
March 3, 2026 at 11:46 PM
Super excited to present out work at @mitotalks.bsky.social this Thursday!! Hope to see you there!
Reposted by Shutt Lab
We are hiring!
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!
More about us: martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!
More about us: martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
January 28, 2026 at 1:35 PM
We are hiring!
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!
More about us: martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!
More about us: martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
Reposted by Shutt Lab
5 years of MITOtalks!
Feels like it was yesterday when @wanrooij20.bsky.social
and @nunoraimundo.bsky.social
opened the first MITOtalk to introduce
@frezzalab.bsky.social.
But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers.
Onwards and upwards!
Feels like it was yesterday when @wanrooij20.bsky.social
and @nunoraimundo.bsky.social
opened the first MITOtalk to introduce
@frezzalab.bsky.social.
But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers.
Onwards and upwards!
January 21, 2026 at 4:50 PM
5 years of MITOtalks!
Feels like it was yesterday when @wanrooij20.bsky.social
and @nunoraimundo.bsky.social
opened the first MITOtalk to introduce
@frezzalab.bsky.social.
But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers.
Onwards and upwards!
Feels like it was yesterday when @wanrooij20.bsky.social
and @nunoraimundo.bsky.social
opened the first MITOtalk to introduce
@frezzalab.bsky.social.
But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers.
Onwards and upwards!
Reposted by Shutt Lab
Really thrilled to have our work on mitochondrial presequence strength out today @jcb.org. We establish quantitative parameters to better define "strong" and "weak" presequences both in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a BBSB graduate student in my lab.
Yan, @ianofbristol.bsky.social, @nieminm.bsky.social et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. rupress.org/jcb/article/...
January 8, 2026 at 5:47 PM
Really thrilled to have our work on mitochondrial presequence strength out today @jcb.org. We establish quantitative parameters to better define "strong" and "weak" presequences both in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a BBSB graduate student in my lab.
Reposted by Shutt Lab
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
www.biorxiv.org
December 18, 2025 at 8:36 PM
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Reposted by Shutt Lab
We are hiring!. If you hold a PhD in natural science and are passionate about mitochondria, reach out!
December 12, 2025 at 12:38 PM
We are hiring!. If you hold a PhD in natural science and are passionate about mitochondria, reach out!
Reposted by Shutt Lab
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
Reposted by Shutt Lab
We have a new preprint! A major part of Taylor's PhD research is now available to read on bioRxiv: www.biorxiv.org/content/10.1...
Hyper-proliferation of Adipose Progenitors During Developmental Adipogenesis Programs Higher Adipocyte Number and Early-onset Obesity in Offspring Born to Obese Dams
Being born to a mother who was obese during pregnancy is one of the strongest predictors of early onset obesity and metabolic syndrome. To identify the developmental mechanism linking maternal obesity...
www.biorxiv.org
September 18, 2025 at 3:45 PM
We have a new preprint! A major part of Taylor's PhD research is now available to read on bioRxiv: www.biorxiv.org/content/10.1...
Reposted by Shutt Lab
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells https://www.biorxiv.org/content/10.1101/2025.06.23.660251v1
June 27, 2025 at 2:33 PM
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells https://www.biorxiv.org/content/10.1101/2025.06.23.660251v1
Thanks for including us in this exciting work! Looking forward to the next stages of this fun collaboration.
New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells
Pathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse as...
www.biorxiv.org
June 27, 2025 at 4:20 PM
Thanks for including us in this exciting work! Looking forward to the next stages of this fun collaboration.
Congrats to ShuttLab PhD student Mashiat Zaman @mashiatzaman.bsky.social on receiving an award for his short talk at the recent CSMB-PRinCE meeting in Ottawa
June 3, 2025 at 9:54 PM
Congrats to ShuttLab PhD student Mashiat Zaman @mashiatzaman.bsky.social on receiving an award for his short talk at the recent CSMB-PRinCE meeting in Ottawa
Reposted by Shutt Lab
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications
Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...
www.nature.com
June 1, 2025 at 1:16 AM
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
Reposted by Shutt Lab
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mitochondrial presequences harbor variable strengths to maintain organellar function
Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack ...
www.biorxiv.org
May 29, 2025 at 9:18 PM
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Shutt Lab
Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell
great work by Martin Picard
www.scientificamerican.com/article/why-...
great work by Martin Picard
www.scientificamerican.com/article/why-...
The Hidden Social Lives of Mitochondria
When these energy-giving organelles thrive, so do we
www.scientificamerican.com
May 22, 2025 at 4:41 AM
Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell
great work by Martin Picard
www.scientificamerican.com/article/why-...
great work by Martin Picard
www.scientificamerican.com/article/why-...
Reposted by Shutt Lab
Our Special Issue: Cell Biology of Mitochondria is complete.
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
May 15, 2025 at 2:32 PM
Our Special Issue: Cell Biology of Mitochondria is complete.
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria