Pedro Escoll
@pescoll.bsky.social
How the metabolic crosstalk between pathogenic bacteria and host cells impacts infection? @pasteur.fr
Pinned
Pedro Escoll
@pescoll.bsky.social
· Sep 4
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
Reposted by Pedro Escoll
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
September 4, 2026 at 8:14 AM
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
Reposted by Pedro Escoll
Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages https://www.biorxiv.org/content/10.64898/2026.09.03.749052v1
September 4, 2026 at 2:20 AM
Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages https://www.biorxiv.org/content/10.64898/2026.09.03.749052v1
Reposted by Pedro Escoll
Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.03.749052v1
https://www.biorxiv.org/content/10.64898/2026.09.03.749052v1
September 4, 2026 at 4:00 AM
Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.03.749052v1
https://www.biorxiv.org/content/10.64898/2026.09.03.749052v1
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
September 4, 2026 at 8:14 AM
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
New paper from the team in Plos Pathogens @plos.org
: providing macrophages with preferred nutrients lets Salmonella replicate even without its Type III Secretion Systems (T3SS). Work by Francisco Garcia-Rodriguez & Paula Martinez, with @kamovalenz.bsky.social and @joaquinbernal.bsky.social 🧵1/9
: providing macrophages with preferred nutrients lets Salmonella replicate even without its Type III Secretion Systems (T3SS). Work by Francisco Garcia-Rodriguez & Paula Martinez, with @kamovalenz.bsky.social and @joaquinbernal.bsky.social 🧵1/9
July 10, 2026 at 9:49 AM
New paper from the team in Plos Pathogens @plos.org
: providing macrophages with preferred nutrients lets Salmonella replicate even without its Type III Secretion Systems (T3SS). Work by Francisco Garcia-Rodriguez & Paula Martinez, with @kamovalenz.bsky.social and @joaquinbernal.bsky.social 🧵1/9
: providing macrophages with preferred nutrients lets Salmonella replicate even without its Type III Secretion Systems (T3SS). Work by Francisco Garcia-Rodriguez & Paula Martinez, with @kamovalenz.bsky.social and @joaquinbernal.bsky.social 🧵1/9
Our last paper is out at IAI @asm.org . With @cbuch.bsky.social, at @pasteur.fr . Congrats Francisco & Paula !
Mitochondrial Complex I emerges as a common energetic checkpoint distinguishing virulent from secretion-deficient bacteria during Legionella and Salmonella infection of human macrophages.
Mitochondrial Complex I emerges as a common energetic checkpoint distinguishing virulent from secretion-deficient bacteria during Legionella and Salmonella infection of human macrophages.
March 2, 2026 at 6:39 AM
Our last paper is out at IAI @asm.org . With @cbuch.bsky.social, at @pasteur.fr . Congrats Francisco & Paula !
Mitochondrial Complex I emerges as a common energetic checkpoint distinguishing virulent from secretion-deficient bacteria during Legionella and Salmonella infection of human macrophages.
Mitochondrial Complex I emerges as a common energetic checkpoint distinguishing virulent from secretion-deficient bacteria during Legionella and Salmonella infection of human macrophages.
Reposted by Pedro Escoll
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
October 17, 2025 at 1:47 AM
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵
October 16, 2025 at 12:55 PM
New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵
Reposted by Pedro Escoll
Extracellular ATP is an environmental cue in bacteria
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Extracellular ATP is an environmental cue in bacteria
Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes
and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular
ATP reprograms the tra...
www.cell.com
October 11, 2025 at 11:59 AM
Extracellular ATP is an environmental cue in bacteria
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Reposted by Pedro Escoll
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA
Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...
forum.image.sc
October 7, 2025 at 12:39 PM
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
Reposted by Pedro Escoll
New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr
September 5, 2025 at 2:08 PM
New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr
Reposted by Pedro Escoll
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1
September 18, 2025 at 4:58 PM
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Reposted by Pedro Escoll
🟢 The Institut Pasteur goes green for Mitochondrial Disease Awareness Week! 🟢
These rare diseases affect 1 in 5,000 people. Mitochondria, the “powerhouses” of our cells, are also thought to play a role in Alzheimer's disease.
Research today, cure tomorrow. 🔬 #WorldMitoWeek2025
These rare diseases affect 1 in 5,000 people. Mitochondria, the “powerhouses” of our cells, are also thought to play a role in Alzheimer's disease.
Research today, cure tomorrow. 🔬 #WorldMitoWeek2025
September 17, 2025 at 9:11 AM
🟢 The Institut Pasteur goes green for Mitochondrial Disease Awareness Week! 🟢
These rare diseases affect 1 in 5,000 people. Mitochondria, the “powerhouses” of our cells, are also thought to play a role in Alzheimer's disease.
Research today, cure tomorrow. 🔬 #WorldMitoWeek2025
These rare diseases affect 1 in 5,000 people. Mitochondria, the “powerhouses” of our cells, are also thought to play a role in Alzheimer's disease.
Research today, cure tomorrow. 🔬 #WorldMitoWeek2025
Reposted by Pedro Escoll
Hydrogen sulfide production distinguishes Salmonella from close relatives, but its biological significance remains obscure. This study uncovers the secret: Salmonella uses hydrogen sulfide production as a weapon to outcompete E. coli and gain a foothold in the gut.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
September 13, 2025 at 6:32 PM
Hydrogen sulfide production distinguishes Salmonella from close relatives, but its biological significance remains obscure. This study uncovers the secret: Salmonella uses hydrogen sulfide production as a weapon to outcompete E. coli and gain a foothold in the gut.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Pedro Escoll
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
www.science.org
September 6, 2025 at 9:35 AM
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr
September 5, 2025 at 2:08 PM
New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr
Reposted by Pedro Escoll
Complex-I Preserves Mitochondrial Polarization during Infection of Human Macrophages by Secretion-competent Bacteria https://www.biorxiv.org/content/10.1101/2025.09.04.674018v1
September 5, 2025 at 3:17 AM
Complex-I Preserves Mitochondrial Polarization during Infection of Human Macrophages by Secretion-competent Bacteria https://www.biorxiv.org/content/10.1101/2025.09.04.674018v1
Reposted by Pedro Escoll
That concludes GRC Salmonella 2025. What a fantastic meeting it was - topnotch science, great discussions and a wonderful spirit. I am proud to be part of this amazing scientific community.
August 8, 2025 at 12:58 PM
That concludes GRC Salmonella 2025. What a fantastic meeting it was - topnotch science, great discussions and a wonderful spirit. I am proud to be part of this amazing scientific community.
Reposted by Pedro Escoll
A Salmonella T3SS-2 mutant grows fine in spleen macrophages, contradicting tissue culture dogma (PMID: 23236281). This observation was largely ignored, but adding certain carbon sources rescues growth in cultured macrophages, hinting that T3SS-2 may be doing something entirely different in vivo.
New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with @kamovalenz.bsky.social
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems https://www.biorxiv.org/content/10.1101/2025.05.15.653970v1
August 9, 2025 at 12:18 AM
A Salmonella T3SS-2 mutant grows fine in spleen macrophages, contradicting tissue culture dogma (PMID: 23236281). This observation was largely ignored, but adding certain carbon sources rescues growth in cultured macrophages, hinting that T3SS-2 may be doing something entirely different in vivo.
Reposted by Pedro Escoll
Shigella-trained pro-inflammatory macrophages protect zebrafish from secondary infection
@cgmargarida.bsky.social
@cgmargarida.bsky.social
Shigella-trained pro-inflammatory macrophages protect zebrafish from secondary infection
Shigella-trained pro-inflammatory macrophages protect zebrafish from secondary infection
Trained immunity enhances host innate defenses against secondary infections. Gomes et al. innovate zebrafish infection models to investigate Shigella-induced training, demonstrating that Shigella epigenetically reprograms macrophages to be pro-inflammatory and promote antibacterial responses.
dlvr.it
May 2, 2025 at 2:41 PM
Shigella-trained pro-inflammatory macrophages protect zebrafish from secondary infection
@cgmargarida.bsky.social
@cgmargarida.bsky.social
Reposted by Pedro Escoll
New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with @kamovalenz.bsky.social
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems https://www.biorxiv.org/content/10.1101/2025.05.15.653970v1
May 16, 2025 at 8:04 AM
New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with @kamovalenz.bsky.social
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
Reposted by Pedro Escoll
New study reveals that Salmonella can replicate inside macrophages even without its T3SSs, if the nutrient conditions are right! Metabolic heterogeneity of host cells is a game-changer in bacterial replication dynamics. #MicroSky
✍️ @pescoll.bsky.social and coll. @pasteur.fr
📖 shorturl.at/a9a06
✍️ @pescoll.bsky.social and coll. @pasteur.fr
📖 shorturl.at/a9a06
May 17, 2025 at 6:41 AM
New study reveals that Salmonella can replicate inside macrophages even without its T3SSs, if the nutrient conditions are right! Metabolic heterogeneity of host cells is a game-changer in bacterial replication dynamics. #MicroSky
✍️ @pescoll.bsky.social and coll. @pasteur.fr
📖 shorturl.at/a9a06
✍️ @pescoll.bsky.social and coll. @pasteur.fr
📖 shorturl.at/a9a06
Reposted by Pedro Escoll
Our latest paper is out! Congratulations to @leaswistak.bsky.social et al for this amazing #cryoET work that elucidates the initial stages of #T3SS dependent vacuolar damage during #Shigella infection. We will do a deep-dive later! journals.plos.org/plosbiology/...
May 6, 2025 at 1:06 PM
Our latest paper is out! Congratulations to @leaswistak.bsky.social et al for this amazing #cryoET work that elucidates the initial stages of #T3SS dependent vacuolar damage during #Shigella infection. We will do a deep-dive later! journals.plos.org/plosbiology/...
Reposted by Pedro Escoll
Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems https://www.biorxiv.org/content/10.1101/2025.05.15.653970v1
May 16, 2025 at 4:17 AM
Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems https://www.biorxiv.org/content/10.1101/2025.05.15.653970v1
New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with @kamovalenz.bsky.social
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems https://www.biorxiv.org/content/10.1101/2025.05.15.653970v1
May 16, 2025 at 8:04 AM
New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with @kamovalenz.bsky.social
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV