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pregnancyimmunolab.bsky.social
Rizzuto lab
@pregnancyimmunolab.bsky.social
350 followers 350 following 12 posts
Studying fetomaternal tolerance since 2022 at Memorial Sloan Kettering Cancer Center.

http://therizzutolab.com
Posts Replies Media Videos
Reposted by Rizzuto lab
labwaggoner.bsky.social
A multiomic atlas of pregnancies with chronic placental inflammation links effector activation to preterm birth and regulatory resilience to term delivery
www.science.org/doi/10.1126/... @ngllab.bsky.social @washumedicine.bsky.social
October 8, 2026 at 1:44 AM
Reposted by Rizzuto lab
pollheimerlab.bsky.social
Proud and honored to share our new paper in @sciimmunology.bsky.social! Fibrinoid-associated neutrophils promote invasive placentation and shape neutrophil reprogramming at the maternal–fetal interface. @ailackner.bsky.social ial, @meduniwien.ac.at ien.ac.at
doi.org/10.1126/scii...
Fibrinoid-associated neutrophils promote invasive placentation and neutrophil reprogramming at the maternal-fetal interface
Neutrophils adopt a tissue-adapted state at the early maternal-fetal interface that supports trophoblast invasion.
doi.org
September 28, 2026 at 9:17 AM
Reposted by Rizzuto lab
natureportfolio.nature.com
A study in Nature Medicine shows that low levels of maternal serum ISM2 in early pregnancy may indicate increased risk of preeclampsia and fetal growth restriction. go.nature.com/4iaOReD #medsky 🧪
This is figure 4, which shows ISM2 regulates cell migration.
September 5, 2026 at 7:03 PM
Reposted by Rizzuto lab
nature.com
Adding albumin to popular antibody-based medicines helps to block their passage through the placenta

go.nature.com/4ikDmkB
To shield the fetus, link a protein to these drugs
Adding albumin to popular antibody-based medicines helps to block their passage through the placenta.
go.nature.com
August 20, 2026 at 10:22 AM
Reposted by Rizzuto lab
philippzross.com
Feels like something @devoevomed.bsky.social should know about: www.science.org/doi/10.1126/...
Reassessing the role of progesterone receptor isoforms PGR-A and PGR-B in female fertility
Progesterone is a critical reproductive hormone that acts via progesterone receptor transcriptional regulators. The short PGR-A isoform lacks a 164–amino acid amino-terminal region present in PGR-B th...
www.science.org
August 14, 2026 at 3:32 PM
Reposted by Rizzuto lab
science.org
A scientist is helping uncover the role of the immune system in endometriosis—while managing the disease herself.

Learn more: https://scim.ag/4oDvjAa #ScienceMagArchives
Pathways to pain: graphic illustrating the symptoms and mechanisms of endometriosis. Panel 1: diagram of the pelvic area showing common locations of lesions and cysts: the abdominal wall, the peritoneal membrane, the ovaries, between the uterus and rectum, and the vagina. Panel 2: Illustration of a reproductive system with endometriosis, showing locations of lesions and an ovarian cyst, as well as menstrual blood flowing out of the fallopian tube, which is thought to seed lesions. Panel 3: comparison of neutrophils in the menstrual effluent (ME) of women with endometriosis versus without; with endometriosis, the neutrophils have shrunken, many-lobed nuclei and vacuoles in their cytoplasm. Panel 4: Illustration of immune factors involved in endometriosis lesions: decreased natural killer cells, and increased neutrophils and macrophages.
August 2, 2026 at 8:18 PM
Reposted by Rizzuto lab
natrevimmunol.nature.com
ICYMI: Eosinophils shape barrier immunity during reproduction
Eosinophils shape barrier immunity during reproduction
Nature Reviews Immunology, Published online: 29 May 2026; doi:10.1038/s41577-026-01317-yEosinophils remodel the maternal intestine during pregnancy and lactation, promoting goblet cell differentiation and strengthening barrier immunity.
dlvr.it
May 31, 2026 at 9:04 AM
Reposted by Rizzuto lab
aussiastronomer.bsky.social
I went back to capture what the astronauts said in full when the clock was stopped at T-10 minutes and they were asked if they were go for launch:

This is Victor. We are going for our families.
This is Christina. We are going for our teammates.
This is Jeremy. We are going for all humanity.
April 1, 2026 at 10:47 PM
Reposted by Rizzuto lab
claireang.bsky.social
Excited to share my new preprint from the McKinley lab, where we explored regenerative mechanisms across menstruation and pregnancy! We thought specialized glands would regenerate everything.

We were wrong.

But the real mechanism turned out to be way cooler :) 🧪🧵
www.biorxiv.org/content/10.6...
www.biorxiv.org
March 12, 2026 at 4:38 PM
pregnancyimmunolab.bsky.social
This was so fun! Thank you so much to @cindyleifer.bsky.social and @microbetv.bsky.social for the opportunity to discuss pregnancy immunology ✨
microbetv.bsky.social Microbetv @microbetv.bsky.social · Mar 3
@cindyleifer.bsky.social talks with Gabrielle Rizzuto from Memorial Sloan Kettering Cancer Center about her work on the curious immunology of pregnancy and how a woman tolerates a genetically different baby but quickly rejects a mismatched organ donation.
Immune Booster 24: Tolerating pregnancy with Gabrielle Rizzuto
YouTube video by MicrobeTV
youtu.be
March 5, 2026 at 9:43 PM
Reposted by Rizzuto lab
anaccodo.bsky.social
I'm thrilled to share that the first paper from my PhD is out today in @cp-immunity.bsky.social!
Here, we investigated how phagocytes, such as macrophages, handle microplastics (MPs) during their normal functions.
www.sciencedirect.com/science/arti...
February 25, 2026 at 1:40 AM
Reposted by Rizzuto lab
jcstark.bsky.social
Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
www.nature.com
December 16, 2025 at 3:01 PM
Reposted by Rizzuto lab
carolynbertozzi.bskyverified.social
Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions
December 16, 2025 at 4:55 PM
Reposted by Rizzuto lab
scripps.edu
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
Scripps Research team identifies sugar molecules that trigger placental formation
ow.ly
November 8, 2025 at 12:25 AM
pregnancyimmunolab.bsky.social
“Rizz-ard of Oz: there’s no place like lab”
Happy Halloween! Thanks IGO for the annual party 🎃
October 31, 2025 at 5:39 PM
Reposted by Rizzuto lab
nycures.bsky.social
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/
September 4, 2025 at 4:32 PM
Reposted by Rizzuto lab
klebanofflab.bsky.social
🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social
CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit
Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...
rdcu.be
July 23, 2025 at 8:39 PM
pregnancyimmunolab.bsky.social
We are so proud of Mergim for passing his quals! Definitely warrants lollipops advertising his favorite model antigen.
June 25, 2025 at 9:27 PM
Reposted by Rizzuto lab
crick.ac.uk
Researchers at the Crick have found that pregnancy in mice leads to the irreversible growth of their small intestine.

www.crick.ac.uk/news/2025-03...
Pregnancy irreversibly remodels the mouse intestine
Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare ...
www.crick.ac.uk
March 19, 2025 at 4:44 PM
pregnancyimmunolab.bsky.social
Exciting news! To welcome our new lab members from the past year and reaffirm our commitment to women’s health and pregnancy immunology, we’ve launched our lab website. Check it out- and if this fascinating niche in immunology speaks to you, let’s connect! www.therizzutolab.com
The Rizzuto lab
www.therizzutolab.com
February 17, 2025 at 4:12 PM
pregnancyimmunolab.bsky.social
What determines the length of gestation? A short thread…

(1/5)
January 21, 2025 at 4:54 PM