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🎂Our 5-YEAR ANNIVERSARY Issue is now ONLINE!
@NatureCancer

Find it here:
www.nature.com/natcancer/vo...

Features:
⭐️Reviews and opinion pieces
⭐️Research articles
on key developments in #cancerresearch and #oncology
January 30, 2025 at 4:31 PM
erictopol.bsky.social
How explainable, multimodal #AI of real world cancer patient data has the potential to increase accuracy of prognosis and optimize treatment
www.nature.com/articles/s43...
@NatureCancer open-access
Decoding pan-cancer treatment outcomes using multimodal real-world data and explainable artificial intelligence - Nature Cancer
Keyl et al. present an explainable artificial intelligence model-based real-world data analysis from over 15,000 patients across 38 cancer types, identified key prognostic marker interactions, and con...
www.nature.com
January 30, 2025 at 4:39 PM
danieljdrucker.bsky.social
GLP-1 medicines might stimulate cell proliferation in some GLP-1R+ cell types, while exerting direct and indirect effects on the Tumour MicroEnvironment. It will take time to see the overall impact on #obesity associated cancer. Free to read @NatureCancer rdcu.be/eZlv0
January 16, 2026 at 11:13 AM
natcancer.nature.com
⭐Check out this Comment published in the 2025 year-in-review @NatureCancer Focus Issue

✏️By Michelle Monje & Frank Winkler

'Key developments in the cancer neuroscience field'

🔗 www.nature.com/articles/s43...
December 15, 2025 at 12:31 PM
syedaahmad5.bsky.social
Metastatic patterns stratify patients with pancreatic cancer ⁦‪@NatureCancer‬⁩

www.nature.com/articles/s43...
Metastatic patterns stratify patients with pancreatic cancer - Nature Cancer
Patients with lung-metastatic pancreatic ductal adenocarcinoma survive longer than those with liver metastases. A study now leverages real-world data to identify distinct molecular and immune profiles...
www.nature.com
February 9, 2025 at 3:27 PM
annagolebiewska.bsky.social
Can immunotherapy ever work in #glioblastoma?

In a new #NatureCancer review, we share our perspective on current limitations and future directions:
www.nature.com/articles/s43...

#NORLUX, #LIH , @fnr.lu #TELEVIE, @glioresolve.bsky.social, @michael-platten.bsky.social
Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity - Nature Cancer
In this Review, Golebiewska and colleagues summarize the main features of the immunosuppressive microenvironment in glioblastoma (GBM) and discuss how different therapeutic approaches reshape GBM immu...
www.nature.com
January 8, 2026 at 1:29 PM
klebanofflab.bsky.social
🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social
CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit
Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...
rdcu.be
July 23, 2025 at 8:39 PM
scinews.bsky.social
An antibody–toxin conjugate targeting the ‘don’t eat me’ signal CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy. #NatureCancer

www.nature.com/articles/s43...
An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy - Nature Cancer
Schrank et al. report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models.
www.nature.com
February 28, 2025 at 12:15 AM
cedric-blanpain.bsky.social
I am delighted to share our new study uncovering the role of innate immunity in regulating cell plasticity and reprograming of prostate tumor initiating cells published in
@NatureCancer
. Congrats
@ChenJiang919
and
@yura__song
, the first authors,
www.nature.com/articles/s43...
Innate immunity and the NF-κB pathway control prostate stem cell plasticity, reprogramming and tumor initiation - Nature Cancer
Blanpain and colleagues delineate lineage reprogramming following PTEN deletion in different prostate cancer-originating cells, demonstrating that in basal cells the NF-κB pathway and innate immunity ...
www.nature.com
June 23, 2025 at 1:23 PM
mattmuscleguy.bsky.social
New #NatureCancer paper: Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia. #Myoblue tinyurl.com/yhjx4sjt
Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer
Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...
tinyurl.com
May 26, 2025 at 4:46 PM
stevensalzberg.bsky.social
Happy to share this free link to our new paper on the perils of trying to find microbes in human cancers, which appeared today in NatureCancer. Co-authors include Nobel laureate
Barry Marshall, ancient DNA Eske Willerslev, @niranjantw.bsky.social, Jacques Neefjes, @rafalab.bsky.social: rdcu.be/e4IaU
Setting higher standards for reports of microbial species in human cancers
Nature Cancer - Nagarajan and colleagues overview the current challenges in microbiome analyses from human cancer samples and discuss the optimal practices for improving the standards of reporting...
rdcu.be
February 19, 2026 at 1:27 PM
natcancer.nature.com
Resource article now online @NatureCancer
'An organoid library unveils subtype-specific IGF-1 dependency via a YAP–AP1 axis in human small cell lung cancer'

✏️By Toshiro Sato & colleagues
📎https://www.nature.com/articles/s43018-025-00945-y?utm_source=bluesky&utm_medium=social&utm_campaign=natcancer
May 6, 2025 at 12:20 PM
teamjjtueb.bsky.social
🚀New paper alert and a great way to start the year for Philip and #TeamJJ!🚀 Our paper on enhancing T cell anti-tumor potency through CAR-adapted PIK3CD base editing is now out in Nature Cancer. For more details visit: www.nature.com/articles/s43...

#TeamJJ #NatureCancer #iFIT #CARTcells
CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency - Nature Cancer
By performing a CAR-adapted base-editing screen of phosphatidylinositol-3-kinase delta (PI3Kδ, PIK3CD), Bucher et al. identify mutations affecting endogenous PI3K–AKT signaling that enhances CAR T cel...
www.nature.com
January 6, 2026 at 10:17 AM
natcancer.nature.com
Article now published @NatureCancer !

'Cryoablation plus sintilimab and lenvatinib in advanced or metastatic intrahepatic cholangiocarcinoma: a phase 2 trial'

✒️By Ye Li, Peng Wang and colleagues

🔗 www.nature.com/articles/s43...
Cryoablation plus sintilimab and lenvatinib in advanced or metastatic intrahepatic cholangiocarcinoma: a phase 2 trial - Nature Cancer
Wang and colleagues report the clinical results and immunological correlates of a phase 2 clinical trial of cryoablation plus lenvatinib and sintilimab in persons with advanced or metastatic intrahepa...
www.nature.com
November 19, 2025 at 11:45 AM
sjcenos.bsky.social
The Northcott group introduced M-PACT, a next-generation AI classifier using DNA methylation from liquid biopsies.
M-PACT overcomes challenges arising from low levels of DNA for accurate classification and monitoring of tumor microenvironment and evolution. #NatureCancer
tinyurl.com/36duu9az
Classifying pediatric brain tumors by liquid biopsy using artificial intelligence
See how M-PACT, an AI-powered algorithm can sift through ctDNA in cerebrospinal fluid and molecularly classify tumors based on their DNA methylation pattern
tinyurl.com
March 4, 2026 at 8:39 PM
lpodsiadlowski.bsky.social
Transmissible cancer in marine mussels. On depth study this week on the cover of @NatureCancer
Nature Cancer - Transmissible marine cancer evolution
Transmissible leukemia-like cancer in the marine species Cerastoderma edule and Mya arenaria is characterized by long-term tolerance as well as genomic...
www.nature.com
November 28, 2023 at 8:26 AM
natcancer.nature.com
New article published @NatureCancer !

'Spatiotemporal control of SMARCA5 by a MAPK–RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration'

✏️By Charles David, Mo Chen and colleagues

🔗 www.nature.com/articles/s43...
Spatiotemporal control of SMARCA5 by a MAPK–RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration - Nature Cancer
Han et al. show that SMARCA5 is required for the sustained expression of genes required for malignancy in pancreatic cells with mutant KRAS. Inhibiting SMARCA5 activity prevents malignant transformati...
www.nature.com
November 19, 2025 at 11:47 AM
natcancer.nature.com
Resource article published now @NatureCancer

'Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity'

✒️By Qiu Wu, Chenfei Wang and colleagues

🔗 www.nature.com/articles/s43...
Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity - Nature Cancer
Han et al. present TabulaTIME, a multicancer scRNA-seq resource, and report enrichment of extracellular matrix-related CTHRC1+ cancer-associated fibroblasts in proximity to SLPI+ macrophages, creating...
www.nature.com
August 29, 2025 at 9:11 AM
ciccarellilab.bsky.social
We have two open positions for #computationalbiologists to work on:
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
February 19, 2025 at 6:08 PM
carmeloferrai.bsky.social
Impressive study from the lab of Thomas R. Cox on the development & deployment of a novel anti-fibrotic in pancreatic cancer has just been published (OpenAccess) in @NatureCancer | → nature.com/articles/s4301… ← | @TCox_Lab @GarvanInstitute #extracellularmatrix #ECM #cancer
September 26, 2023 at 7:28 AM
natcancer.nature.com
⭐️New Article ONLINE at NatureCancer !

Concurrent inhibition of tumor growth and metastasis by a lipidated nanophotosensitizer tracing and disabling tumor extracellular vesicles

✏️By Xiaorui Wang and colleagues

🔗 www.nature.com/articles/s43...
Concurrent inhibition of tumor growth and metastasis by a lipidated nanophotosensitizer tracing and disabling tumor extracellular vesicles - Nature Cancer
Wang and colleagues describe the design and characterization of lipidated nanophotosensitizers, promoting photodynamic suppression of primary tumor growth and inhibition of metastasis by disabling tum...
www.nature.com
June 30, 2025 at 9:36 AM
mdc-berlin.bsky.social
Multiple #myeloma, a form of bone marrow cancer, can progress very aggressively. #mdcBerlin researchers now show for the first time at the #proteogenomic level how previously incurable forms can be recognized early and thus treated. 👇 #NatureCancer #ChariteBerlin #BIH
Multiple myeloma: Early detection of aggressive tumors
Berlin researchers and their partners describe how aggressive variants of multiple myeloma can be detected early. Their comprehensive study in “Nature Cancer” shows how changes in genetic material aff...
www.mdc-berlin.de
June 28, 2024 at 12:31 PM
mtmdphd.bsky.social
Crowdsourcing a crisis response for COVID-19 in oncology [Apr 21, 2020] @ADesaiMD @hemoncwarner @NicoleKuderer @mtmdphd @corrie_painter @gary_lyman @GlopesMd @NatureCancer ow.ly/wuyD30qzDyS #CCC19 #COVID19nCANCER @COVID19nCCC
March 10, 2025 at 5:47 PM
mtmdphd.bsky.social
Crowdsourcing a crisis response for COVID-19 in oncology [Apr 21, 2020] @ADesaiMD @hemoncwarner @NicoleKuderer @mtmdphd @corrie_painter @gary_lyman @GlopesMd @NatureCancer ow.ly/wuyD30qzDyS #CCC19 #COVID19nCANCER @COVID19nCCC
Crowdsourcing a crisis response for COVID-19 in oncology - Nature Cancer
Crowdsourcing efforts are currently underway to collect and analyze data from patients with cancer who are affected by the COVID-19 pandemic. These community-led initiatives will fill key knowledge ga...
ow.ly
February 14, 2025 at 1:32 PM
mtmdphd.bsky.social
Crowdsourcing a crisis response for COVID-19 in oncology [Apr 21, 2020] @ADesaiMD @hemoncwarner @NicoleKuderer @mtmdphd @corrie_painter @gary_lyman @GlopesMd @NatureCancer ow.ly/wuyD30qzDyS #CCC19 #COVID19nCANCER @COVID19nCCC
Crowdsourcing a crisis response for COVID-19 in oncology - Nature Cancer
Crowdsourcing efforts are currently underway to collect and analyze data from patients with cancer who are affected by the COVID-19 pandemic. These community-led initiatives will fill key knowledge ga...
ow.ly
November 19, 2024 at 1:10 PM