Sachin Kotak
@spindlebehavior.bsky.social
Cell Biologist interested in fundamental cell division processes working @iiscbangalore
Pinned
Can light build centrosome-like activity? 💡🔬
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
Can light build centrosome-like activity? 💡🔬
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
September 15, 2026 at 2:34 PM
Can light build centrosome-like activity? 💡🔬
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
Reposted by Sachin Kotak
Proud of two covers from India this year in JCB....both so beautiful, @rpadinjat.bsky.social and @spindlebehavior.bsky.social
📣 Help choose @jcb.org's cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Voting closes on Wednesday, December 31 👉 www.surveymonkey.com/r/JCB2025Cov...
#CellBio2025 #ScienceArt
#CellBio2025 #ScienceArt
December 6, 2025 at 2:48 PM
Proud of two covers from India this year in JCB....both so beautiful, @rpadinjat.bsky.social and @spindlebehavior.bsky.social
Happy to see our work on how Aurora A kinase orchestrates nuclear organization by regulating the material properties of spindle pole–localized NuMA at mitotic exit featured on the cover. Grateful to the students for creating this beautiful image!
In ISSUE 23
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
December 4, 2025 at 10:34 AM
Happy to see our work on how Aurora A kinase orchestrates nuclear organization by regulating the material properties of spindle pole–localized NuMA at mitotic exit featured on the cover. Grateful to the students for creating this beautiful image!
Reposted by Sachin Kotak
New Aurora A kinase role in maintaining proper nuclear shape organization at mitotic exit:
NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes
Sachin Kotak @spindlebehavior.bsky.social et al
www.embopress.org/doi/full/10....
NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes
Sachin Kotak @spindlebehavior.bsky.social et al
www.embopress.org/doi/full/10....
September 19, 2025 at 7:49 AM
New Aurora A kinase role in maintaining proper nuclear shape organization at mitotic exit:
NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes
Sachin Kotak @spindlebehavior.bsky.social et al
www.embopress.org/doi/full/10....
NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes
Sachin Kotak @spindlebehavior.bsky.social et al
www.embopress.org/doi/full/10....
Happy to share our work in @embojournal 👉 shorturl.at/zXNyn
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
September 13, 2025 at 5:14 AM
Happy to share our work in @embojournal 👉 shorturl.at/zXNyn
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
Reposted by Sachin Kotak
It’s happening on the 15th!!
#centrosome, #microtubules, #centromere, #mitosis, #cellbiology
@kaustuvsanyal.bsky.social
@viji-draviam.bsky.social
@spindlebehavior.bsky.social
#centrosome, #microtubules, #centromere, #mitosis, #cellbiology
@kaustuvsanyal.bsky.social
@viji-draviam.bsky.social
@spindlebehavior.bsky.social
July 9, 2025 at 4:09 PM
It’s happening on the 15th!!
#centrosome, #microtubules, #centromere, #mitosis, #cellbiology
@kaustuvsanyal.bsky.social
@viji-draviam.bsky.social
@spindlebehavior.bsky.social
#centrosome, #microtubules, #centromere, #mitosis, #cellbiology
@kaustuvsanyal.bsky.social
@viji-draviam.bsky.social
@spindlebehavior.bsky.social
Reposted by Sachin Kotak
The cover of @jcb.org's July issue (rupress.org/jcb/issue/22...) shows a confocal timelapse imaging of #Celegans one-cell embryo expressing fluorescently labeled plasma membrane, microtubules, chromosomes, and ZEN-4, a plus-end directed kinesin motor protein (Adhikary et al. doi.org/10.1083/jcb....)
July 7, 2025 at 2:04 PM
The cover of @jcb.org's July issue (rupress.org/jcb/issue/22...) shows a confocal timelapse imaging of #Celegans one-cell embryo expressing fluorescently labeled plasma membrane, microtubules, chromosomes, and ZEN-4, a plus-end directed kinesin motor protein (Adhikary et al. doi.org/10.1083/jcb....)