Alström syndrome is a #cilia-related disorder caused by loss of ALMS1, a proximal #centriole protein. Thao P. Phan et al. @reitergroup.bsky.social show that ALMS1 protects centriole integrity to enable #centrosome-directed trafficking during cilia formation & maintenance rupress.org/jcb/article/...
November 2, 2026 at 6:01 PM
Alström syndrome is a #cilia-related disorder caused by loss of ALMS1, a proximal #centriole protein. Thao P. Phan et al. @reitergroup.bsky.social show that ALMS1 protects centriole integrity to enable #centrosome-directed trafficking during cilia formation & maintenance rupress.org/jcb/article/...
We next treated migrating T cells (no targets present) with thapsigargin to pharmacologically deplete ER calcium stores. Surprisingly, this was sufficient to drive organelle trafficking to the centrosome but not polarisation of the multi-organelle ensemble to the plasma membrane.
November 3, 2026 at 12:39 PM
We next treated migrating T cells (no targets present) with thapsigargin to pharmacologically deplete ER calcium stores. Surprisingly, this was sufficient to drive organelle trafficking to the centrosome but not polarisation of the multi-organelle ensemble to the plasma membrane.
Alström syndrome is a cilia-related disorder caused by loss of ALMS1, a proximal centriole protein. In @jcb.org, Phan et al @reitergroup.bsky.social show that ALMS1 protects centriole integrity to enable centrosome-directed trafficking during cilia formation & maintenance rupress.org/jcb/article/...
November 2, 2026 at 6:00 PM
Alström syndrome is a cilia-related disorder caused by loss of ALMS1, a proximal centriole protein. In @jcb.org, Phan et al @reitergroup.bsky.social show that ALMS1 protects centriole integrity to enable centrosome-directed trafficking during cilia formation & maintenance rupress.org/jcb/article/...
We next treated migrating T cells (no targets present) with thapsigargin to pharmacologically deplete ER calcium stores. Surprisingly, this was sufficient to drive organelle trafficking to the centrosome but not polarisation of the multi-organelle ensemble to the plasma membrane.
November 3, 2026 at 12:19 PM
We next treated migrating T cells (no targets present) with thapsigargin to pharmacologically deplete ER calcium stores. Surprisingly, this was sufficient to drive organelle trafficking to the centrosome but not polarisation of the multi-organelle ensemble to the plasma membrane.
We coin the phenomenon of Centrosome Organised Multi-organelle Ensemble Trafficking as COMET. We are now trying to determine how this process is regulated molecularly, whether it is shared in other immune cells and the role of organelle & their contacts in T cell killing.
November 3, 2026 at 12:39 PM
We coin the phenomenon of Centrosome Organised Multi-organelle Ensemble Trafficking as COMET. We are now trying to determine how this process is regulated molecularly, whether it is shared in other immune cells and the role of organelle & their contacts in T cell killing.
Model: after target recognition synaptic actin is depleted, the perinuclear ER polarises leading to an increase in early ER-PM contacts and ER stores are partially emptied. This drives organelle trafficking to the centrosome, and the multi-organelle ensemble then polarises to the synapse.
November 3, 2026 at 12:39 PM
Model: after target recognition synaptic actin is depleted, the perinuclear ER polarises leading to an increase in early ER-PM contacts and ER stores are partially emptied. This drives organelle trafficking to the centrosome, and the multi-organelle ensemble then polarises to the synapse.
We coin the phenomenon of Centrosome Organised Multi-organelle Ensemble Trafficking as COMET. We are now trying to determine how this process is regulated molecularly, whether it is shared in other immune cells and the role of organelle & their contacts in T cell killing.
November 3, 2026 at 12:19 PM
We coin the phenomenon of Centrosome Organised Multi-organelle Ensemble Trafficking as COMET. We are now trying to determine how this process is regulated molecularly, whether it is shared in other immune cells and the role of organelle & their contacts in T cell killing.
Model: after target recognition synaptic actin is depleted, the perinuclear ER polarises leading to an increase in early ER-PM contacts and ER stores are partially emptied. This drives organelle trafficking to the centrosome, and the multi-organelle ensemble then polarises to the synapse.
November 3, 2026 at 12:19 PM
Model: after target recognition synaptic actin is depleted, the perinuclear ER polarises leading to an increase in early ER-PM contacts and ER stores are partially emptied. This drives organelle trafficking to the centrosome, and the multi-organelle ensemble then polarises to the synapse.
The authors included RRIDs in their in Journal of Cell Biology paper! RRIDs improve reproducibility in scientific research. #RRID #STMpublishing #BetterScience
53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration
Read the full paper: 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration
doi.org
October 30, 2026 at 7:04 AM
The authors included RRIDs in their in Journal of Cell Biology paper! RRIDs improve reproducibility in scientific research. #RRID #STMpublishing #BetterScience
Leveraging our advances in multispectral live imaging we find a characteristic three-phase program of polarity: i) the perinuclear ER first polarises, ii) organelles then cluster around the centrosome at the cell rear and iii) this multi-organelle ensemble polarises as a single unit to the synapse.
November 3, 2026 at 12:19 PM
Leveraging our advances in multispectral live imaging we find a characteristic three-phase program of polarity: i) the perinuclear ER first polarises, ii) organelles then cluster around the centrosome at the cell rear and iii) this multi-organelle ensemble polarises as a single unit to the synapse.
The authors included RRIDs in their in eLife paper! RRIDs improve reproducibility in scientific research. #RRID #BetterScience #methodsmatter
53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis
Read the full paper: 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis
doi.org
October 30, 2026 at 7:02 AM
The authors included RRIDs in their in eLife paper! RRIDs improve reproducibility in scientific research. #RRID #BetterScience #methodsmatter
Leveraging our advances in multispectral live imaging we find a characteristic three-phase program of polarity: i) the perinuclear ER first polarises, ii) organelles then cluster around the centrosome at the cell rear and iii) this multi-organelle ensemble polarises as a single unit to the synapse.
November 3, 2026 at 12:39 PM
Leveraging our advances in multispectral live imaging we find a characteristic three-phase program of polarity: i) the perinuclear ER first polarises, ii) organelles then cluster around the centrosome at the cell rear and iii) this multi-organelle ensemble polarises as a single unit to the synapse.
The authors included RRIDs in their in Journal of Cell Biology paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #RRID #OpenScience
A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis
Read the full paper: A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis
doi.org
October 30, 2026 at 7:04 AM
The authors included RRIDs in their in Journal of Cell Biology paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #RRID #OpenScience
They said flies could develop without centrosomes. The embryos may beg to differ.
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
Centrosome Loss Alters Axonal and Muscle Development - preLights
They said flies could develop without centrosomes. The embryos may beg to differ.
prelights.biologists.com
October 21, 2026 at 12:13 PM
They said flies could develop without centrosomes. The embryos may beg to differ.
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
A preprint using: Mouse Anti-C-Nap1 Mo (RRID:AB_398896) from #BD was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #OpenScience
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways
www.biorxiv.org
October 20, 2026 at 12:00 PM
A preprint using: Mouse Anti-C-Nap1 Mo (RRID:AB_398896) from #BD was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #OpenScience
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways www.biorxiv.org/content/10.6...
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways
Centrosome cohesion mechanisms link the two interphase centrosomes into a single microtubule-organizing center that is closely associated with the Golgi apparatus. The contribution of cohesion mechani...
www.biorxiv.org
October 18, 2026 at 12:19 AM
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways www.biorxiv.org/content/10.6...
#bskyart #surrealism #iconoplasm #AIArt #AIArtist #AIArtwork #Alimages #GenArt #DigitalArt #AlArtGallery #AlGeneratedArt #creativeai #synthart #centrosome #quantum #sigil #abstractai
Sigil 7263 by Morisal on DeviantArt
Sigil 7263 — artwork by Morisal on DeviantArt. Published: 2026-10-18 · Likes: 0 · Views: 0 · Tags: digitalart, surreal, psychedelic, fractalart, abstract, magic, wallpaper, magick, quantum, sigil, wei...
www.deviantart.com
October 18, 2026 at 12:08 PM
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways https://www.biorxiv.org/content/10.64898/2026.10.15.759098v1
October 16, 2026 at 12:31 PM
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways https://www.biorxiv.org/content/10.64898/2026.10.15.759098v1
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways https://www.biorxiv.org/content/10.64898/2026.10.15.759098v1
October 16, 2026 at 12:31 PM
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways https://www.biorxiv.org/content/10.64898/2026.10.15.759098v1
Pericentrin contains internal adaptor-like sequences that activate dynein directly www.biorxiv.org/content/10.6...
Pericentrin contains internal adaptor-like sequences that activate dynein directly
Centrosome maturation, the rapid growth of the centrosome before cell division, prepares the cell for spindle assembly. Pericentrin (PCNT), a coiled-coil centrosomal protein, is transported to the cen...
www.biorxiv.org
October 15, 2026 at 2:34 PM
Pericentrin contains internal adaptor-like sequences that activate dynein directly www.biorxiv.org/content/10.6...
New paper! Advance Online & Open Access @ascbiology.bsky.social MBoC!
Drosophila Orb2 contributes to neural stem cell centrosome asymmetry and cell growth | Molecular Biology of the Cell
The deregulation of neural stem cell (NSC) homeostasis underlies neurodevelopmental
disorders and tumorigenesis. In the Drosophila larval brain, NSCs divide asymmetrically along an invariant...
nam11.safelinks.protection.outlook.com
October 14, 2026 at 8:21 PM
New paper! Advance Online & Open Access @ascbiology.bsky.social MBoC!
Drosophila Orb2 contributes to neural stem cell centrosome asymmetry and cell growth
#Drosophila
#Drosophila
Drosophila Orb2 contributes to neural stem cell centrosome asymmetry and cell growth
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
October 14, 2026 at 10:23 PM
Drosophila Orb2 contributes to neural stem cell centrosome asymmetry and cell growth
#Drosophila
#Drosophila
Proud of our work led by Andrew Mead in Nature Communications on apicoplast segregation in T. gondii. Also a wonderful co-submission with the Gubbels lab - together telling a great story of this new mechanism of organelle partitioning.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Identification and characterization of factors that govern apicoplast segregation in Toxoplasma gondii - Nature Communications
Here, Mead et al. identify two apicoplast proteins, APP1 and APP2, in T. gondii, which are critical for anchoring the apicoplast to the centrosome and segregation machinery thereby facilitating its in...
www.nature.com
October 10, 2026 at 6:02 PM
Proud of our work led by Andrew Mead in Nature Communications on apicoplast segregation in T. gondii. Also a wonderful co-submission with the Gubbels lab - together telling a great story of this new mechanism of organelle partitioning.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Modeling centrosome positioning by actin--microtubule crosstalk and actin anchoring at the cell membrane https://www.biorxiv.org/content/10.64898/2026.10.05.756642v1
October 9, 2026 at 3:47 PM
Modeling centrosome positioning by actin--microtubule crosstalk and actin anchoring at the cell membrane https://www.biorxiv.org/content/10.64898/2026.10.05.756642v1
We hope our in situ findings bring exciting new insights to the centriole & centrosome field! Would love to hear thoughts from the community: #Centriole #cryoET #InSituStructuralBiology @centriolelab.bsky.social @cellarchlab.com @computingcaitie.bsky.social @alanbrownhms.bsky.social
1/4 Following our 2023 ELI-TriScope work (@NatMethods), we’ve focused on the in situ architectures of native centrosomes & basal bodies (BBs).
October 10, 2026 at 1:28 AM
We hope our in situ findings bring exciting new insights to the centriole & centrosome field! Would love to hear thoughts from the community: #Centriole #cryoET #InSituStructuralBiology @centriolelab.bsky.social @cellarchlab.com @computingcaitie.bsky.social @alanbrownhms.bsky.social