Alström syndrome is a #cilia-related disorder caused by loss of ALMS1, a proximal #centriole protein. Thao P. Phan et al. @reitergroup.bsky.social show that ALMS1 protects centriole integrity to enable #centrosome-directed trafficking during cilia formation & maintenance rupress.org/jcb/article/...
November 2, 2026 at 6:01 PM
Alström syndrome is a #cilia-related disorder caused by loss of ALMS1, a proximal #centriole protein. Thao P. Phan et al. @reitergroup.bsky.social show that ALMS1 protects centriole integrity to enable #centrosome-directed trafficking during cilia formation & maintenance rupress.org/jcb/article/...
ALMS1 stabilizes the proximal centriole to drive transition zone assembly and ciliogenesis rupress.org/jcb/article-...
ALMS1 stabilizes the proximal centriole to drive transition zone assembly and ciliogenesis
Alström syndrome is a cilia-related disorder caused by loss of ALMS1, a proximal centriole protein. Phan et al. show that ALMS1 protects centriole integrit
rupress.org
November 2, 2026 at 4:27 PM
ALMS1 stabilizes the proximal centriole to drive transition zone assembly and ciliogenesis rupress.org/jcb/article-...
New research shows ~50% of human fertilized eggs arrest due to error-prone 2nd mitotic divisions. Stochastic centriole overduplication can be suppressed by PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
October 31, 2026 at 7:00 AM
Alström syndrome is a cilia-related disorder caused by loss of ALMS1, a proximal centriole protein. In @jcb.org, Phan et al @reitergroup.bsky.social show that ALMS1 protects centriole integrity to enable centrosome-directed trafficking during cilia formation & maintenance rupress.org/jcb/article/...
November 2, 2026 at 6:00 PM
Alström syndrome is a cilia-related disorder caused by loss of ALMS1, a proximal centriole protein. In @jcb.org, Phan et al @reitergroup.bsky.social show that ALMS1 protects centriole integrity to enable centrosome-directed trafficking during cilia formation & maintenance rupress.org/jcb/article/...
New research shows ~50% of fertilized human eggs arrest in pre-implantation due to error-prone 2nd mitotic divisions. PLK4 inhibition can reduce centriole overduplication! PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
November 2, 2026 at 10:00 PM
Authors published a paper in Biorxiv, they used Blender in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
CiliaBuilder2: a flexible ChimeraX bundle to visualize cilia and centriole structures in 3D
www.biorxiv.org
October 23, 2026 at 12:00 PM
Authors published a paper in Biorxiv, they used Blender in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
Introducing CiliaBuilder2, a ChimeraX bundle to generate cilia & centriole assembly from real structures (maps, pdbs).
Here's a hybrid sperm cilium (bovine sperm doublet microtubule PDB 9fqr & mouse sperm central pair PDB 9ijj)
Here's a hybrid sperm cilium (bovine sperm doublet microtubule PDB 9fqr & mouse sperm central pair PDB 9ijj)
October 20, 2026 at 11:30 AM
Introducing CiliaBuilder2, a ChimeraX bundle to generate cilia & centriole assembly from real structures (maps, pdbs).
Here's a hybrid sperm cilium (bovine sperm doublet microtubule PDB 9fqr & mouse sperm central pair PDB 9ijj)
Here's a hybrid sperm cilium (bovine sperm doublet microtubule PDB 9fqr & mouse sperm central pair PDB 9ijj)
50% of human fertilized eggs fail to develop due to error-prone 2nd mitotic divisions. Stochastic centriole overduplication plays a key role, but PLK4 inhibition can help! PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
October 21, 2026 at 3:00 AM
About 50% of human fertilized eggs arrest during pre-implantation. Key findings show that the second mitotic division is error-prone, with centriole overduplication being a major cause—this can be mitigated by… PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
October 23, 2026 at 8:00 AM
About 50% of human fertilized eggs arrest during pre-implantation. Key findings show that the second mitotic division is error-prone, with centriole overduplication being a major cause—this can be mitigated by… PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
CiliaBuilder2: a flexible ChimeraX bundle to visualize cilia and centriole structures in 3D https://www.biorxiv.org/content/10.64898/2026.10.15.759410v1
October 20, 2026 at 4:49 AM
CiliaBuilder2: a flexible ChimeraX bundle to visualize cilia and centriole structures in 3D https://www.biorxiv.org/content/10.64898/2026.10.15.759410v1
CiliaBuilder2: a flexible ChimeraX bundle to visualize cilia and centriole structures in 3D https://www.biorxiv.org/content/10.64898/2026.10.15.759410v1
October 20, 2026 at 4:49 AM
CiliaBuilder2: a flexible ChimeraX bundle to visualize cilia and centriole structures in 3D https://www.biorxiv.org/content/10.64898/2026.10.15.759410v1
About 50% of fertilized human eggs stall in pre-implantation. Key findings reveal that error-prone second mitotic divisions lead to this, linked to centriole overduplication, which PLK4 inhibition can reduce. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
October 18, 2026 at 12:00 PM
About 50% of fertilized human eggs stall in pre-implantation. Key findings reveal that error-prone second mitotic divisions lead to this, linked to centriole overduplication, which PLK4 inhibition can reduce. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
it's just, so cool.
October 12, 2026 at 1:50 AM
it's just, so cool.
We hope our in situ findings bring exciting new insights to the centriole & centrosome field! Would love to hear thoughts from the community: #Centriole #cryoET #InSituStructuralBiology @centriolelab.bsky.social @cellarchlab.com @computingcaitie.bsky.social @alanbrownhms.bsky.social
1/4 Following our 2023 ELI-TriScope work (@NatMethods), we’ve focused on the in situ architectures of native centrosomes & basal bodies (BBs).
October 10, 2026 at 1:28 AM
We hope our in situ findings bring exciting new insights to the centriole & centrosome field! Would love to hear thoughts from the community: #Centriole #cryoET #InSituStructuralBiology @centriolelab.bsky.social @cellarchlab.com @computingcaitie.bsky.social @alanbrownhms.bsky.social
~50% of human fertilized eggs arrest during pre-implantation. Imaging 150+ embryos reveals 2nd mitotic divisions are most error-prone, with centriole overduplication as a key factor that can be mitigated using… PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
October 11, 2026 at 6:00 AM
~50% of human fertilized eggs arrest during pre-implantation. Imaging 150+ embryos reveals 2nd mitotic divisions are most error-prone, with centriole overduplication as a key factor that can be mitigated using… PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
RRIDs were included in this in EMBO Reports paper. Thanks for making your methods matter! #BetterScience #OpenResearch #accelerateopenscience
McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation
Read the full paper: McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation
doi.org
October 8, 2026 at 7:04 AM
RRIDs were included in this in EMBO Reports paper. Thanks for making your methods matter! #BetterScience #OpenResearch #accelerateopenscience
50% of human fertilized eggs fail to develop due to error-prone second mitotic divisions. Stochastic centriole overduplication leads to arrest, effectively reduced by PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
October 7, 2026 at 6:00 AM
50% of human fertilized eggs fail to develop due to error-prone second mitotic divisions. Stochastic centriole overduplication leads to arrest, effectively reduced by PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪
Discover how the IDP ALMS1 influences centriole biogenesis! It catalyzes cartwheel formation by organizing CEP152 without becoming part of the structure itself. PMID:42380124, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74821-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1 | Nature Communications
Centriole biogenesis is viewed as a template-free physical transformation where a cartwheel scaffold emerges to guide centriole growth and subsequently disassembles; however, the mechanism underlying cartwheel dynamics remains obscure. Here, we identify the intrinsically disordered protein (IDP) ALMS1 as an external cofactor that causes a seed for cartwheel formation without itself incorporating into the seed structure. The cartwheel seed (CS) forms during interphase as dense composites of CEP152/CEP63 complexes, adopting a nanoscale ring from which the cartwheel grows. Upon mitotic entry, CSs undergo disassembly involving ALMS1, correlating with cartwheel disassembly. Hypomorph ALMS1 mutations trigger aberrant cartwheel expansion-shedding from its own grown centriole, in turn forming ectopic centrioles, leading to perpetual reciprocal amplification. ALMS1 depletion aborts CS assembly, whereas reintroducing ALMS1 initializes biogenesis anew, creating diverse yet heritable centriole arc
doi.org
October 5, 2026 at 10:00 PM
50% of fertilized eggs stall in early development, mainly due to error-prone 2nd mitotic divisions. Transient PLK4 inhibition reduces centriole overduplication, boosting efficiency. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
October 6, 2026 at 1:00 AM
50% of fertilized eggs stall in early development, mainly due to error-prone 2nd mitotic divisions. Transient PLK4 inhibition reduces centriole overduplication, boosting efficiency. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪
Bora, CEP192, and Cenexin selectively regulate Plk1 processes: Bora aids mitotic entry; CEP192 in centrosome maturation; Cenexin in centriole disengagement. Science! PMID:42380115, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75033-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Bora, CEP192 and Cenexin regulate distinct Plk1-dependent cell and centrosome cycle transitions | Nature Communications
Polo-like kinase 1 (Plk1) regulates multiple steps of the cell and centrosome cycle, including mitotic entry, DNA-damage recovery, centrosome maturation and centriole disengagement. Plk1 activity depends on several independent cofactors, such as the cytoplasmic Bora, and the centrosomal proteins Cep192 and Cenexin. However, whether these Plk1 coactivators differentially regulate the Plk1-dependent processes is unknown. Here, we show that each Plk1 coactivator controls different cell and centrosome cycle transitions in human cells. We find that Plk1 already acts in S-phase, where under the control of Cep192 and Aurora A it promotes replication origin firing. Bora is the main Plk1 activator driving mitotic entry, DNA-damage recovery and centrosome maturation in G2, while centriole disengagement is mainly regulated by Cep192 and Cenexin. Our results thus uncover a complex Plk1 activation regulatory network, in which distinct upstream activators dictate its activity in a context-dependent
doi.org
October 3, 2026 at 5:00 PM
~50% of fertilized human eggs arrest in pre-implantation. Key findings show 2nd mitotic divisions are error-prone; centriole overduplication can be suppressed by PLK4 inhib. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
September 29, 2026 at 7:00 PM
50% of human fertilized eggs arrest in pre-implantation due to error-prone second mitotic divisions. PLK4 inhibition reduces centriole overduplication, improving development. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
September 27, 2026 at 4:00 PM
50% of human fertilized eggs arrest in pre-implantation due to error-prone second mitotic divisions. PLK4 inhibition reduces centriole overduplication, improving development. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
50% of fertilized eggs stall in human pre-implantation. Imaging 150+ embryos shows the 2nd mitotic division has the highest errors. PLK4 inhibition can reduce centriole overduplication. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
September 25, 2026 at 9:00 AM
50% of fertilized eggs stall in human pre-implantation. Imaging 150+ embryos shows the 2nd mitotic division has the highest errors. PLK4 inhibition can reduce centriole overduplication. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪
~50% of fertilized human eggs stall in pre-implantation. Imaging 150+ eggs revealed error-prone 2nd mitotic divisions are key. Centriole overduplication can be reduced with PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
September 19, 2026 at 10:00 PM
~50% of fertilized human eggs stall in pre-implantation. Imaging 150+ eggs revealed error-prone 2nd mitotic divisions are key. Centriole overduplication can be reduced with PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky 🧪
New research reveals ~50% of fertilized human eggs fail at pre-implantation. Key insight: second mitotic divisions are highly error-prone. Stochastic centriole overduplication can be suppressed with PLK4… PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
September 15, 2026 at 11:00 AM
New research reveals ~50% of fertilized human eggs fail at pre-implantation. Key insight: second mitotic divisions are highly error-prone. Stochastic centriole overduplication can be suppressed with PLK4… PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #RNA 🧪