Natural variation modifies centromere proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana biorxiv.org/content/10.1... new work from us on centromere inheritance and organisation @matt-naish.bsky.social @plantevolution.bsky.social @genomeevolution.bsky.social
January 6, 2025 at 7:43 AM
Natural variation modifies centromere proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana biorxiv.org/content/10.1... new work from us on centromere inheritance and organisation @matt-naish.bsky.social @plantevolution.bsky.social @genomeevolution.bsky.social
we can debate some middle titles, but Telomere verse 1 and 2 and Centromere cannot be moved!
1. Telomere ver1
2. Inversion
3. Repeat
4. Centromere
5. Transposon
6. Viral incorporation
7. Telomere ver2
I'm etither playing the triangle or writhing on the ground in a chromosome suit, both good
1. Telomere ver1
2. Inversion
3. Repeat
4. Centromere
5. Transposon
6. Viral incorporation
7. Telomere ver2
I'm etither playing the triangle or writhing on the ground in a chromosome suit, both good
September 29, 2026 at 4:38 PM
we can debate some middle titles, but Telomere verse 1 and 2 and Centromere cannot be moved!
1. Telomere ver1
2. Inversion
3. Repeat
4. Centromere
5. Transposon
6. Viral incorporation
7. Telomere ver2
I'm etither playing the triangle or writhing on the ground in a chromosome suit, both good
1. Telomere ver1
2. Inversion
3. Repeat
4. Centromere
5. Transposon
6. Viral incorporation
7. Telomere ver2
I'm etither playing the triangle or writhing on the ground in a chromosome suit, both good
Centromere evolution isn't a sudden switch!
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
January 17, 2025 at 11:17 AM
Centromere evolution isn't a sudden switch!
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
Very proud to have our latest work now online in
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
Heterochromatin boundaries maintain centromere position, size and number - Nature Structural & Molecular Biology
Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.
www.nature.com
November 27, 2025 at 9:58 PM
Very proud to have our latest work now online in
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
An atlas of eukaryotic centromere architecture reveals recurrent evolutionary dynamics https://www.biorxiv.org/content/10.64898/2026.09.17.752431v1
September 23, 2026 at 6:31 PM
An atlas of eukaryotic centromere architecture reveals recurrent evolutionary dynamics https://www.biorxiv.org/content/10.64898/2026.09.17.752431v1
Nature research paper: Progressive coevolution of the yeast centromere and kinetochore
go.nature.com/4rtOuhu
go.nature.com/4rtOuhu
Progressive coevolution of the yeast centromere and kinetochore - Nature
Thousands of centromeres were identified and tracked across two major fungal clades, showing that new centromeres spread progressively and that the kinetochore acts as a filter to determine which new centromere variants are tolerated.
go.nature.com
December 3, 2025 at 2:14 PM
Nature research paper: Progressive coevolution of the yeast centromere and kinetochore
go.nature.com/4rtOuhu
go.nature.com/4rtOuhu
Our latest collaboration with Ron Biggs and John Marko at Northwestern is in the wild. Surprising centromere resistance to deformation even in the absence of most core centromere proteins. With @elinehendrix.bsky.social, Kousik Sundararajan and Mina Sun. #centromere www.biorxiv.org/content/10.1...
Independence of centromeric and pericentromeric chromatin stability on CCAN components
The chromatin of the centromere provides the assembly site for the mitotic kinetochore that couples microtubule attachment and force production to chromosome movement in mitosis. The chromatin of the ...
www.biorxiv.org
December 20, 2024 at 4:58 PM
Our latest collaboration with Ron Biggs and John Marko at Northwestern is in the wild. Surprising centromere resistance to deformation even in the absence of most core centromere proteins. With @elinehendrix.bsky.social, Kousik Sundararajan and Mina Sun. #centromere www.biorxiv.org/content/10.1...
Our new paper on the rapid evolution of centromeres in Drosophila is out! 🚀 Discover how transposable elements and satellite DNAs shape centromere dynamics and drive karyotype evolution over short timescales. @amlarracuente.bsky.social 🌟 Check it out here: journals.plos.org/plosbiology/...
Turnover of retroelements and satellite DNA drives centromere reorganization over short evolutionary timescales in Drosophila
Centromeres reside in rapidly evolving, repeat-rich genomic regions, despite their essential function in chromosome segregation. This study of centromere evolution over short evolutionary timescales i...
journals.plos.org
November 21, 2024 at 10:02 PM
Our new paper on the rapid evolution of centromeres in Drosophila is out! 🚀 Discover how transposable elements and satellite DNAs shape centromere dynamics and drive karyotype evolution over short timescales. @amlarracuente.bsky.social 🌟 Check it out here: journals.plos.org/plosbiology/...
So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍
The mighty yeast reveals what we believe are general principles of centromere evolution!
Behind the curtain: communities.springernature.com/posts/counti...
#MEvoSky 🧪🌎
The mighty yeast reveals what we believe are general principles of centromere evolution!
Behind the curtain: communities.springernature.com/posts/counti...
#MEvoSky 🧪🌎
November 27, 2025 at 9:21 AM
So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍
The mighty yeast reveals what we believe are general principles of centromere evolution!
Behind the curtain: communities.springernature.com/posts/counti...
#MEvoSky 🧪🌎
The mighty yeast reveals what we believe are general principles of centromere evolution!
Behind the curtain: communities.springernature.com/posts/counti...
#MEvoSky 🧪🌎
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Happy to share our Tansley insight published in @newphyt.bsky.social
nph.onlinelibrary.wiley.com/doi/epdf/10....
#plantscience #chromosome #centromere #meiosis
nph.onlinelibrary.wiley.com/doi/epdf/10....
#plantscience #chromosome #centromere #meiosis
Centromere diversity and its evolutionary impacts on plant karyotypes and plant reproduction
You have to enable JavaScript in your browser's settings in order to use the eReader.
nph.onlinelibrary.wiley.com
January 7, 2025 at 8:22 AM
Happy to share our Tansley insight published in @newphyt.bsky.social
nph.onlinelibrary.wiley.com/doi/epdf/10....
#plantscience #chromosome #centromere #meiosis
nph.onlinelibrary.wiley.com/doi/epdf/10....
#plantscience #chromosome #centromere #meiosis
📢 Three new #bioRxiv preprints from our team on holocentric chromosomes.
Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
January 21, 2026 at 2:45 PM
📢 Three new #bioRxiv preprints from our team on holocentric chromosomes.
Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
New work on Drosophila centromere evolution led by the amazing @cecilecourret.bsky.social!Thanks to all coauthors and collaborators in the @centromellone.bsky.social lab.
Our new paper on the rapid evolution of centromeres in Drosophila is out! 🚀 Discover how transposable elements and satellite DNAs shape centromere dynamics and drive karyotype evolution over short timescales. @amlarracuente.bsky.social 🌟 Check it out here: journals.plos.org/plosbiology/...
Turnover of retroelements and satellite DNA drives centromere reorganization over short evolutionary timescales in Drosophila
Centromeres reside in rapidly evolving, repeat-rich genomic regions, despite their essential function in chromosome segregation. This study of centromere evolution over short evolutionary timescales i...
journals.plos.org
November 21, 2024 at 10:34 PM
New work on Drosophila centromere evolution led by the amazing @cecilecourret.bsky.social!Thanks to all coauthors and collaborators in the @centromellone.bsky.social lab.
New Article: "Pan-centromere landscape and dynamic evolution in Brassica plants" rdcu.be/eLtOL
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
October 17, 2025 at 10:23 AM
New Article: "Pan-centromere landscape and dynamic evolution in Brassica plants" rdcu.be/eLtOL
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
📢ONLINE @natgenet.nature.com
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 5, 2025 at 12:32 PM
📢ONLINE @natgenet.nature.com
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Progressive coevolution of the yeast centromere and kinetochore
🤩
@helsenjana.bsky.social @gautamdey.bsky.social
Progressive coevolution of the yeast centromere and kinetochore
🤩
@helsenjana.bsky.social @gautamdey.bsky.social
Progressive coevolution of the yeast centromere and kinetochore - Nature
Thousands of centromeres were identified and tracked across two major fungal clades, showing that new centromeres spread progressively and that the kinetochore acts as a filter to determine which new ...
www.nature.com
November 27, 2025 at 6:22 PM
www.nature.com/articles/s41...
Progressive coevolution of the yeast centromere and kinetochore
🤩
@helsenjana.bsky.social @gautamdey.bsky.social
Progressive coevolution of the yeast centromere and kinetochore
🤩
@helsenjana.bsky.social @gautamdey.bsky.social
Beyond providing insight into the centromere paradox, this work demonstrates that complete chromosome reconstruction is now possible from wild-caught flies, opening new opportunities for population, functional, and quantitative genomics in Drosophila.
Preprint here: www.biorxiv.org/content/10.6...
Preprint here: www.biorxiv.org/content/10.6...
A conserved architectural domain shapes centromere evolution in Drosophila
Centromeres ensure faithful chromosome segregation despite being embedded within rapidly evolving repetitive DNA, a contradiction known as the centromere paradox. While centromere identity is defined ...
www.biorxiv.org
July 27, 2026 at 4:40 PM
Beyond providing insight into the centromere paradox, this work demonstrates that complete chromosome reconstruction is now possible from wild-caught flies, opening new opportunities for population, functional, and quantitative genomics in Drosophila.
Preprint here: www.biorxiv.org/content/10.6...
Preprint here: www.biorxiv.org/content/10.6...
Cool paper on evolutionary constraints and trajectories shaping point centromere evolution in budding yeasts by @helsenjana.bsky.social @gautamdey.bsky.social @gsherloc.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Centromeres evolve progressively through selection at the kinetochore interface
During mitosis, stable but dynamic interactions between the centromere DNA and kinetochore complex enable accurate and efficient chromosome segregation. Even though many proteins of the kinetochore ar...
www.biorxiv.org
January 17, 2025 at 1:25 PM
Cool paper on evolutionary constraints and trajectories shaping point centromere evolution in budding yeasts by @helsenjana.bsky.social @gautamdey.bsky.social @gsherloc.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Our paper on a centromere-enriched retroelement is out! link.springer.com/article/10.1... Congratulations to all the authors! Comments and reposts welcome and appreciated 🧬🔬
Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape - Genome Biology
Background Centromeres depend on chromatin containing the conserved histone H3 variant CENP-A for function and inheritance, while the role of centromeric DNA repeats remains unclear. Retroelements are...
link.springer.com
November 18, 2024 at 5:50 PM
Our paper on a centromere-enriched retroelement is out! link.springer.com/article/10.1... Congratulations to all the authors! Comments and reposts welcome and appreciated 🧬🔬
An atlas of eukaryotic centromere architecture reveals recurrent evolutionary dynamics https://www.biorxiv.org/content/10.64898/2026.09.17.752431v1
September 23, 2026 at 6:31 PM
An atlas of eukaryotic centromere architecture reveals recurrent evolutionary dynamics https://www.biorxiv.org/content/10.64898/2026.09.17.752431v1
We seem to be in the golden age of centromere biology
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:41 PM
We seem to be in the golden age of centromere biology
I am thrilled to share our new review on holocentric chromosomes. It was a lot of fun to write it together with Ines Drinnenberg!
Same but different: Centromere regulations in holocentric insects and plants doi.org/10.1016/j.ce...
Same but different: Centromere regulations in holocentric insects and plants doi.org/10.1016/j.ce...
February 21, 2025 at 9:17 AM
I am thrilled to share our new review on holocentric chromosomes. It was a lot of fun to write it together with Ines Drinnenberg!
Same but different: Centromere regulations in holocentric insects and plants doi.org/10.1016/j.ce...
Same but different: Centromere regulations in holocentric insects and plants doi.org/10.1016/j.ce...
The fritillary is back - love that chequerboard pattern! Reminds me of a centromere dot plot 😁
March 6, 2025 at 1:24 PM
The fritillary is back - love that chequerboard pattern! Reminds me of a centromere dot plot 😁
A centromere but not just a centromere: structure and evolution of a selfish chromosomal supergene in monkeyflowers www.biorxiv.org/content/10.6...
www.biorxiv.org
March 6, 2026 at 8:27 PM
A centromere but not just a centromere: structure and evolution of a selfish chromosomal supergene in monkeyflowers www.biorxiv.org/content/10.6...
I’m tenured! Thank you so much to everyone here, mentors, lab mates, colleagues, and the meiosis/centromere community for your support. This achievement was made possible by all the hard work by my amazing lab members over the past 6 years!🥳
April 21, 2026 at 9:34 PM
I’m tenured! Thank you so much to everyone here, mentors, lab mates, colleagues, and the meiosis/centromere community for your support. This achievement was made possible by all the hard work by my amazing lab members over the past 6 years!🥳