Darya Yanushko (Dasha)
@yanushkod.bsky.social
PhD,
cancer plasticity & tumor microenvironment
cancer plasticity & tumor microenvironment
Pinned
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
Cell Death & Disease - p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
rdcu.be
Extremely happy to share that a part of my PhD project just got published in Cell Death and Disease rdcu.be/d7x68
In this work, we uncover how prostate tumor microenvironment drives tumor cell plasticity
In this work, we uncover how prostate tumor microenvironment drives tumor cell plasticity
Reposted by Darya Yanushko (Dasha)
Big progress vs cancer, folks.
The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done.
The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done.
June 2, 2026 at 12:53 AM
Big progress vs cancer, folks.
The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done.
The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done.
🚨paper alert 🚨 Our manuscript on targeting hypoxic signaling in metastatic and castration-resistant prostate cancer is out in @springernature.com Cell Death & Disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
HIF1 inhibition targets tumoral and myeloid cells, and is a promising therapy for metastatic castration-resistant prostate cancer - Cell Death & Disease
Cell Death & Disease - HIF1 inhibition targets tumoral and myeloid cells, and is a promising therapy for metastatic castration-resistant prostate cancer
www.nature.com
March 30, 2026 at 7:45 AM
🚨paper alert 🚨 Our manuscript on targeting hypoxic signaling in metastatic and castration-resistant prostate cancer is out in @springernature.com Cell Death & Disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Darya Yanushko (Dasha)
Sad to hear about the passing of John Gurdon, a titan and pioneer of developmental biology and much more. Winner of the Nobel Prize in Medicine or Physiology, shared with Shinya Yamanaka, who actually was inspired by his work
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 4:41 PM
Sad to hear about the passing of John Gurdon, a titan and pioneer of developmental biology and much more. Winner of the Nobel Prize in Medicine or Physiology, shared with Shinya Yamanaka, who actually was inspired by his work
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Reposted by Darya Yanushko (Dasha)
Are 90% of cancer-related deaths due to metastasis? Apparently the overuse of this percentage in reviews has created confusion and questioning of whether this is true. The answer, which is as always cancer type dependent, may be in these references that also people claim they cannot find.
September 28, 2025 at 4:39 PM
Are 90% of cancer-related deaths due to metastasis? Apparently the overuse of this percentage in reviews has created confusion and questioning of whether this is true. The answer, which is as always cancer type dependent, may be in these references that also people claim they cannot find.
Reposted by Darya Yanushko (Dasha)
Thrilled to share our recent study on prostate immune landscape 🎉 #Prostate #Cancer #Macrophages #Neutrophils. doi.org/10.1080/2162... Thanks to my amazing group at @ciml.bsky.social @inserm.fr Despoina Pervizou & Joanna De Chiara 🔥 Thanks to our great collaborators @igbmc.bsky.social 🙏🏻
Characterization of the immune landscape in healthy mouse prostate and during prostate cancer progression
The immune landscape of healthy prostate and its alterations during prostate cancer (PCa) progression remain poorly characterized. Using scRNA-sequencing and multiparametric flow-cytometry analysis...
doi.org
September 28, 2025 at 9:06 AM
Thrilled to share our recent study on prostate immune landscape 🎉 #Prostate #Cancer #Macrophages #Neutrophils. doi.org/10.1080/2162... Thanks to my amazing group at @ciml.bsky.social @inserm.fr Despoina Pervizou & Joanna De Chiara 🔥 Thanks to our great collaborators @igbmc.bsky.social 🙏🏻
Excited to announce that I defended my PhD thesis, culminating the last 4 years of work in the @igbmc.bsky.social . A heartfelt thank you to my supervisor @metzgerlab.bsky.social , the jury members @mariannakruithof.bsky.social @marinelab.bsky.social and all those who supported me along the way.
September 26, 2025 at 9:48 PM
Excited to announce that I defended my PhD thesis, culminating the last 4 years of work in the @igbmc.bsky.social . A heartfelt thank you to my supervisor @metzgerlab.bsky.social , the jury members @mariannakruithof.bsky.social @marinelab.bsky.social and all those who supported me along the way.
Reposted by Darya Yanushko (Dasha)
As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
July 17, 2025 at 7:26 PM
As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
An avant-première presentation of a new study by @marinelab.bsky.social at the #EACR2025 on immunosuppressive NK cells in melanoma
June 18, 2025 at 11:02 AM
An avant-première presentation of a new study by @marinelab.bsky.social at the #EACR2025 on immunosuppressive NK cells in melanoma
See you tomorrow at the #EACR2025 poster session to discuss about hypoxia and myeloid cells in prostate cancer! @helloeacr.bsky.social
June 16, 2025 at 8:45 PM
See you tomorrow at the #EACR2025 poster session to discuss about hypoxia and myeloid cells in prostate cancer! @helloeacr.bsky.social
Reposted by Darya Yanushko (Dasha)
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
The transition from benign to malignant growth is a pivotal yet poorly understood step in cancer progression that marks the shift from a pathologically inert condition to a clinically lethal disease. ...
www.biorxiv.org
June 13, 2025 at 11:08 AM
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
got to see it irl :) great talk of @ardemp.bskyverified.social at @unistra.fr
May 26, 2025 at 10:17 AM
got to see it irl :) great talk of @ardemp.bskyverified.social at @unistra.fr
I will once again run for cancer research, this time with @fondationarc.bsky.social for Paris half-marathon 2026!
Je cours pour la Fondation ARC le 8 mars 2026, vous pouvez soutenir ma course en faisant un don pour la recherche sur le cancer:
semi-paris.dossards-solidaires.org/fundraisers/...
Je cours pour la Fondation ARC le 8 mars 2026, vous pouvez soutenir ma course en faisant un don pour la recherche sur le cancer:
semi-paris.dossards-solidaires.org/fundraisers/...
Mon Semi-Marathon pour la recherche sur le cancer !
Chers amis, cher réseau,Je me lance le défi de courir le Semi de Paris 2026, que j'aimerais courir avec un Dossard Solidaire pour la Fondation ARC, pour la recherche sur le cancer.Cette association so...
semi-paris.dossards-solidaires.org
May 16, 2025 at 5:43 PM
I will once again run for cancer research, this time with @fondationarc.bsky.social for Paris half-marathon 2026!
Je cours pour la Fondation ARC le 8 mars 2026, vous pouvez soutenir ma course en faisant un don pour la recherche sur le cancer:
semi-paris.dossards-solidaires.org/fundraisers/...
Je cours pour la Fondation ARC le 8 mars 2026, vous pouvez soutenir ma course en faisant un don pour la recherche sur le cancer:
semi-paris.dossards-solidaires.org/fundraisers/...
Great time at the CRCL symposium! It was a real pleasure to present our work (available here lnkd.in/dS254Hrz ) and to discuss. Thank you for such a warm welcome and for the poster prize by @fondationarc.bsky.social!
January 31, 2025 at 3:18 PM
Great time at the CRCL symposium! It was a real pleasure to present our work (available here lnkd.in/dS254Hrz ) and to discuss. Thank you for such a warm welcome and for the poster prize by @fondationarc.bsky.social!
Reposted by Darya Yanushko (Dasha)
on this paper in Nature Medicine www.nature.com/articles/s41...
Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial - Nature Medicine
This proof-of-concept phase 1 trial shows that the size of circulating tumor cell clusters (which can promote metastatic spread) can be reduced by treatment with the Na+/K+ ATPase inhibitor digoxin in...
www.nature.com
January 30, 2025 at 7:55 AM
on this paper in Nature Medicine www.nature.com/articles/s41...
Extremely happy to share that a part of my PhD project just got published in Cell Death and Disease rdcu.be/d7x68
In this work, we uncover how prostate tumor microenvironment drives tumor cell plasticity
In this work, we uncover how prostate tumor microenvironment drives tumor cell plasticity
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
Cell Death & Disease - p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
rdcu.be
January 26, 2025 at 1:03 PM
Extremely happy to share that a part of my PhD project just got published in Cell Death and Disease rdcu.be/d7x68
In this work, we uncover how prostate tumor microenvironment drives tumor cell plasticity
In this work, we uncover how prostate tumor microenvironment drives tumor cell plasticity
Reposted by Darya Yanushko (Dasha)
"Adaptations of #neutrophils in #cancer"
Ng et al, 2025
A great new review on these fascinating immune cells!
In the first #Immunity issue of this year - with lots of other amazing immunology 🧪 check it out 🤩
@cp-immunity.bsky.social
www.cell.com/immunity/iss...
www.cell.com/immunity/abs...
Ng et al, 2025
A great new review on these fascinating immune cells!
In the first #Immunity issue of this year - with lots of other amazing immunology 🧪 check it out 🤩
@cp-immunity.bsky.social
www.cell.com/immunity/iss...
www.cell.com/immunity/abs...
January 14, 2025 at 6:51 PM
"Adaptations of #neutrophils in #cancer"
Ng et al, 2025
A great new review on these fascinating immune cells!
In the first #Immunity issue of this year - with lots of other amazing immunology 🧪 check it out 🤩
@cp-immunity.bsky.social
www.cell.com/immunity/iss...
www.cell.com/immunity/abs...
Ng et al, 2025
A great new review on these fascinating immune cells!
In the first #Immunity issue of this year - with lots of other amazing immunology 🧪 check it out 🤩
@cp-immunity.bsky.social
www.cell.com/immunity/iss...
www.cell.com/immunity/abs...
Reposted by Darya Yanushko (Dasha)
Finally out our work showing the specific inhibition of melanoma-lineage identity genes using a new generation of ecteinascidin. Kudos to the only one Frédéric Coin and collaborators!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity - Nature Communications
Super-enhancers (SEs) drive specific gene expression programmes underlying different cancer cell states offering opportunities for therapeutic targeting. Here, the authors suggest targeting SE-depende...
www.nature.com
January 9, 2025 at 2:33 AM
Finally out our work showing the specific inhibition of melanoma-lineage identity genes using a new generation of ecteinascidin. Kudos to the only one Frédéric Coin and collaborators!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Darya Yanushko (Dasha)
Now online in Cancer Discovery: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion - by @cishak.bsky.social, Sajid Marhon, @daniel-decarvalho.bsky.social, and colleagues @pmresearch-uhn.bsky.social @mdanderson.bsky.social doi.org/10.1158/2159...
January 7, 2025 at 4:26 PM
Now online in Cancer Discovery: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion - by @cishak.bsky.social, Sajid Marhon, @daniel-decarvalho.bsky.social, and colleagues @pmresearch-uhn.bsky.social @mdanderson.bsky.social doi.org/10.1158/2159...
Reposted by Darya Yanushko (Dasha)
Lovely Christmas party with the group after such an amazing year! 🎄🎅Hope the best is to come next year Thanks to the Secret Santa 😜
December 19, 2024 at 10:38 PM
Lovely Christmas party with the group after such an amazing year! 🎄🎅Hope the best is to come next year Thanks to the Secret Santa 😜
First publication here! 😄 It was a great pleasure to present my work at the annual meeting of the ARTP, loved the questions session :) @metzgerlab.bsky.social
November 20, 2024 at 9:40 AM
First publication here! 😄 It was a great pleasure to present my work at the annual meeting of the ARTP, loved the questions session :) @metzgerlab.bsky.social
Reposted by Darya Yanushko (Dasha)
Great little starter pack from @ravimadan.bsky.social go.bsky.app/ANw3D3j
Prostate Cancer
Join the conversation
go.bsky.app
November 18, 2024 at 5:36 PM
Great little starter pack from @ravimadan.bsky.social go.bsky.app/ANw3D3j