Daniel Hoces
@dhoces.bsky.social
Postdoc @Stanford. Engineering immune cells to enhance vaccine responses. Ph.D. @ETH_en | M.D. @CayetanoHeredia 🇵🇪 🇨🇭
Reposted by Daniel Hoces
ICYMI: Beyond the quick win: rebuilding the foundations of cancer immunotherapy
Beyond the quick win: rebuilding the foundations of cancer immunotherapy
Nature Reviews Immunology, Published online: 25 August 2026; doi:10.1038/s41577-026-01352-9Checkpoint inhibitors, CAR T cells and bispecific T cell engagers have demonstrated the transformative potential of cancer immunotherapy. However, progress has slowed as efforts have focused on replicating PD-(L)1 blockade successes, highlighting the need for deeper understanding of human cancer immunity.
dlvr.it
August 26, 2026 at 11:39 AM
ICYMI: Beyond the quick win: rebuilding the foundations of cancer immunotherapy
Reposted by Daniel Hoces
Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @stanforduniversity.bsky.social #Roth #Satpathy
www.cell.com/cell/fulltex... @stanforduniversity.bsky.social #Roth #Satpathy
August 19, 2026 at 4:50 PM
Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @stanforduniversity.bsky.social #Roth #Satpathy
www.cell.com/cell/fulltex... @stanforduniversity.bsky.social #Roth #Satpathy
Reposted by Daniel Hoces
Hope you enjoy this short piece, which came out yesterday. Some thoughts I’ve been musing on for a while about why adaptive immunity evolved. Read it for free at rdcu.be/fAO5P
August 19, 2026 at 11:24 AM
Hope you enjoy this short piece, which came out yesterday. Some thoughts I’ve been musing on for a while about why adaptive immunity evolved. Read it for free at rdcu.be/fAO5P
Reposted by Daniel Hoces
Pre-print alert 📰 🚨I’m very grateful and excited to share our new study : "Defective B cell tolerance in SLE lymph nodes underpins VH4-34 "clonal damnation" and PD-1+TOX+ autoreactive B cells expansion".
doi: doi.org/10.64898/202...
lnkd.in/eJwMTUEt
doi: doi.org/10.64898/202...
lnkd.in/eJwMTUEt
May 18, 2026 at 10:22 PM
Pre-print alert 📰 🚨I’m very grateful and excited to share our new study : "Defective B cell tolerance in SLE lymph nodes underpins VH4-34 "clonal damnation" and PD-1+TOX+ autoreactive B cells expansion".
doi: doi.org/10.64898/202...
lnkd.in/eJwMTUEt
doi: doi.org/10.64898/202...
lnkd.in/eJwMTUEt
Reposted by Daniel Hoces
🔬 We’re hiring again!
Looking for 1 #PhD student to join the #MSCA-DN TRANSCEND network 🧬
Project on unconventional #Tcells in #MultipleSclerosis with research exchanges in
🇩🇰 Klaus Eyer’s lab, Aarhus
🇳🇴 Victor Greiff’s lab, Oslo
⏳ Deadline: May 10
👉 euraxess.ec.europa.eu/jobs/403235
Looking for 1 #PhD student to join the #MSCA-DN TRANSCEND network 🧬
Project on unconventional #Tcells in #MultipleSclerosis with research exchanges in
🇩🇰 Klaus Eyer’s lab, Aarhus
🇳🇴 Victor Greiff’s lab, Oslo
⏳ Deadline: May 10
👉 euraxess.ec.europa.eu/jobs/403235
Open Call for 1 PhD Position at Università Vita-Salute San Raffaele in the frame of the MSCA Doctoral Network
Multiple sclerosis (MS), is an autoimmune disease of the central nervous system (CNS), characterized by demyelination and neuronal loss, along with immune cell brain infiltration and inflammation.
euraxess.ec.europa.eu
April 20, 2026 at 9:34 AM
🔬 We’re hiring again!
Looking for 1 #PhD student to join the #MSCA-DN TRANSCEND network 🧬
Project on unconventional #Tcells in #MultipleSclerosis with research exchanges in
🇩🇰 Klaus Eyer’s lab, Aarhus
🇳🇴 Victor Greiff’s lab, Oslo
⏳ Deadline: May 10
👉 euraxess.ec.europa.eu/jobs/403235
Looking for 1 #PhD student to join the #MSCA-DN TRANSCEND network 🧬
Project on unconventional #Tcells in #MultipleSclerosis with research exchanges in
🇩🇰 Klaus Eyer’s lab, Aarhus
🇳🇴 Victor Greiff’s lab, Oslo
⏳ Deadline: May 10
👉 euraxess.ec.europa.eu/jobs/403235
Reposted by Daniel Hoces
I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses
This study dissects the individual contributions of the different components of mRNA
vaccines to immune responses. Nucleoside-modified mRNA promotes the production of
type I interferons that act on de...
www.cell.com
December 16, 2025 at 5:40 PM
I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
Emma is an incredible mentor and scientist! Plus, Switzerland is a powerhouse of high-quality science. Don’t doubt to apply to this position.
1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!
We have an opening for a postdoctoral researcher in my group at the Botnar Institute for Immune Engineering in Basel, Switzerland. The project is aimed at developing novel mucosal adjuvants for application in oral vaccines. Deadline to apply 16.11.25! Please re-post 🔬🧬
join.com/companies/im...
join.com/companies/im...
November 10, 2025 at 12:36 AM
Emma is an incredible mentor and scientist! Plus, Switzerland is a powerhouse of high-quality science. Don’t doubt to apply to this position.
Reposted by Daniel Hoces
1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!
We have an opening for a postdoctoral researcher in my group at the Botnar Institute for Immune Engineering in Basel, Switzerland. The project is aimed at developing novel mucosal adjuvants for application in oral vaccines. Deadline to apply 16.11.25! Please re-post 🔬🧬
join.com/companies/im...
join.com/companies/im...
Botnar Institute of Immune Engineering - BIIE (Zürich): Postdoctoral Researcher (100%): Mechanisms of action of mucosal adjuvants
Botnar Institute of Immune Engineering - BIIE has a job opening for Postdoctoral Researcher (100%): Mechanisms of action of mucosal adjuvants in Zürich (published: 30.10.2025). Apply now or check the ...
join.com
November 9, 2025 at 10:41 PM
1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!
Reposted by Daniel Hoces
We are hiring! 🧫 🧬 🚀
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Botnar Institute of Immune Engineering - BIIE (Zürich): Doctoral studentships, Molecular Mucosal Immunology Group
Botnar Institute of Immune Engineering - BIIE has a job opening for Doctoral studentships, Molecular Mucosal Immunology Group in Zürich (published: 29.10.2025). Apply now or check the other available...
join.com
October 29, 2025 at 12:51 PM
We are hiring! 🧫 🧬 🚀
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Reposted by Daniel Hoces
Introducing SLAE, our new framework to represent all-atom protein structures with residue local chemical environment tokens!
SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)
SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)
October 9, 2025 at 5:36 PM
Introducing SLAE, our new framework to represent all-atom protein structures with residue local chemical environment tokens!
SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)
SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)
Reposted by Daniel Hoces
Excitability as a Design Principle in the Immune System https://www.biorxiv.org/content/10.1101/2025.08.31.673412v1
September 3, 2025 at 3:16 AM
Excitability as a Design Principle in the Immune System https://www.biorxiv.org/content/10.1101/2025.08.31.673412v1
Reposted by Daniel Hoces
LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice https://www.biorxiv.org/content/10.1101/2025.08.28.672860v1
September 3, 2025 at 4:16 AM
LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice https://www.biorxiv.org/content/10.1101/2025.08.28.672860v1
Reposted by Daniel Hoces
Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)
August 7, 2025 at 8:48 PM
Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)
Reposted by Daniel Hoces
Our new review article led by Jordan Kramer:
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
May 31, 2025 at 8:54 AM
Our new review article led by Jordan Kramer:
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Daniel Hoces
As promised, a 'skeet' -orial on our paper published last week !
Now online! Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
Robot-assisted analysis and theoretical modeling of TCR/CAR crosstalk enable the design of adoptive T cell therapies that maximize anti-tumor activity and minimize toxicity in healthy tissues.
dlvr.it
April 14, 2025 at 1:05 PM
As promised, a 'skeet' -orial on our paper published last week !
Reposted by Daniel Hoces
Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.
www.science.org
March 28, 2025 at 8:36 PM
Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Daniel Hoces
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
March 14, 2025 at 3:25 PM
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Reposted by Daniel Hoces
Our paper is finally out in @immunolcellbiol.bsky.social, think that transcription factor expression is all that? Well not if the genome is not prepared in a way to allow binding: here is a short 🧵1/
March 1, 2025 at 2:34 AM
Our paper is finally out in @immunolcellbiol.bsky.social, think that transcription factor expression is all that? Well not if the genome is not prepared in a way to allow binding: here is a short 🧵1/
Reposted by Daniel Hoces
1/ Ever wonder how a clearly brilliant person – someone great a math and engineering and company building – can display shockingly unintelligent thinking when it comes to politics? Neuroscience has the answer!
February 17, 2025 at 11:54 PM
1/ Ever wonder how a clearly brilliant person – someone great a math and engineering and company building – can display shockingly unintelligent thinking when it comes to politics? Neuroscience has the answer!
Reposted by Daniel Hoces
Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!
Interested in microbial #metabolism, #mucosalbiology and #UTI? Then check out the open postdoctoral position in the Mucosal Immunology Group at ETH Zurich! NB: All applications must go via the ETH job portal:
www.jobs.ethz.ch/job/view/JOP...
Closing date: 24th Feburary
🧪🧫🔬
www.jobs.ethz.ch/job/view/JOP...
Closing date: 24th Feburary
🧪🧫🔬
Postdoctoral researcher –Understanding bacterial metabolism in the urinary tract
www.jobs.ethz.ch
February 10, 2025 at 8:13 PM
Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!
Reposted by Daniel Hoces
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
January 16, 2025 at 8:10 AM
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
Reposted by Daniel Hoces
Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection
#Tpex
www.nature.com/articles/s41...
#Tpex
www.nature.com/articles/s41...
January 9, 2025 at 8:33 AM
Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection
#Tpex
www.nature.com/articles/s41...
#Tpex
www.nature.com/articles/s41...
Reposted by Daniel Hoces
Our work led by Anna Huhn is now published!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
January 4, 2025 at 4:28 PM
Our work led by Anna Huhn is now published!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
Reposted by Daniel Hoces
Happy New Year! Excited about our new study on a timed epigenetic switch controlling T cell and ILC lineage decisions in the thymus! In a nutshell: timing is everything.
The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n)
doi.org/10.1242/dev....
The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n)
doi.org/10.1242/dev....
A timed epigenetic switch balances T and ILC lineage proportions in the thymus
Highlighted Article: Delayed activation of the T-cell lineage commitment regulator Bcl11b in mouse thymic progenitors due to distal enhancer deletion reduces T-cell output and increases Zbtb16-driven ...
doi.org
January 3, 2025 at 7:21 PM
Happy New Year! Excited about our new study on a timed epigenetic switch controlling T cell and ILC lineage decisions in the thymus! In a nutshell: timing is everything.
The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n)
doi.org/10.1242/dev....
The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n)
doi.org/10.1242/dev....
Reposted by Daniel Hoces
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
January 4, 2025 at 12:34 AM
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...