Douaa Moussalem
@douaam.bsky.social
Post-doc researcher in the lab of Dr. Jianjun Chen in California, United states
Former post-doc researcher in the lab of Dr. Martine Simonelig in Montpellier, France
#Development #RNA_modification #Blood_cell #embryogenesis
Lebanon, France, United states
Former post-doc researcher in the lab of Dr. Martine Simonelig in Montpellier, France
#Development #RNA_modification #Blood_cell #embryogenesis
Lebanon, France, United states
Pinned
Douaa Moussalem
@douaam.bsky.social
· May 1
Frontiers | Two Isoforms of serpent Containing Either One or Two GATA Zinc Fingers Provide Functional Diversity During Drosophila Development
GATA transcription factors play crucial roles in various developmental processes in organisms ranging from flies to humans. In mammals, GATA factors are char...
www.frontiersin.org
Reposted by Douaa Moussalem
Save the date for @CellPressEvents Functional RNAs and join researchers from around the world to explore the latest advances in RNA biology, regulation, technology, and therapeutics.
📅 October 25–27, 2027
📍 Geneva, Switzerland
🔗 http://dlvr.it/TVZp9w
#CPSRNAS2027
📅 October 25–27, 2027
📍 Geneva, Switzerland
🔗 http://dlvr.it/TVZp9w
#CPSRNAS2027
September 21, 2026 at 4:49 PM
Save the date for @CellPressEvents Functional RNAs and join researchers from around the world to explore the latest advances in RNA biology, regulation, technology, and therapeutics.
📅 October 25–27, 2027
📍 Geneva, Switzerland
🔗 http://dlvr.it/TVZp9w
#CPSRNAS2027
📅 October 25–27, 2027
📍 Geneva, Switzerland
🔗 http://dlvr.it/TVZp9w
#CPSRNAS2027
Reposted by Douaa Moussalem
METTL3 promotes cell-cycle progression via activation of transcriptional elongation
METTL3 promotes cell-cycle progression via activation of transcriptional elongation
Akçaöz-Alasar et al. reveal that the mitotic kinase CDK1 phosphorylates the m6A methyltransferase METTL3, which then methylates 7SK RNA to release P-TEFb and promote RNA polymerase II clearance during mitosis, ensuring proper chromosome segregation.
dlvr.it
August 24, 2026 at 11:32 AM
METTL3 promotes cell-cycle progression via activation of transcriptional elongation
Reposted by Douaa Moussalem
Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!
Biomolecular condensates at the nuclear pore basket maintain global chromatin organization https://www.biorxiv.org/content/10.1101/2025.07.18.665545v1
July 21, 2025 at 5:52 PM
Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!
Reposted by Douaa Moussalem
#Pseudouridine #RNA avoids immune detection through impaired endolysosomal processing and TLR engagement: Cell www.cell.com/cell/fulltex...
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection.
However, modified nucleosides common in self-RNA—most notably pseudouridine—evade
recognition. This study finds t...
www.cell.com
July 1, 2025 at 8:09 PM
#Pseudouridine #RNA avoids immune detection through impaired endolysosomal processing and TLR engagement: Cell www.cell.com/cell/fulltex...
Reposted by Douaa Moussalem
Our editors write:
- "RNA modification: A new m6A reader complex" rdcu.be/d6uG1
A highlight of this paper in @embojournal.bsky.social :
"ALBA proteins facilitate cytoplasmic YTHDF-mediated reading of m6A in Arabidopsis"
www.embopress.org/doi/full/10....
- "RNA modification: A new m6A reader complex" rdcu.be/d6uG1
A highlight of this paper in @embojournal.bsky.social :
"ALBA proteins facilitate cytoplasmic YTHDF-mediated reading of m6A in Arabidopsis"
www.embopress.org/doi/full/10....
January 16, 2025 at 6:01 PM
Our editors write:
- "RNA modification: A new m6A reader complex" rdcu.be/d6uG1
A highlight of this paper in @embojournal.bsky.social :
"ALBA proteins facilitate cytoplasmic YTHDF-mediated reading of m6A in Arabidopsis"
www.embopress.org/doi/full/10....
- "RNA modification: A new m6A reader complex" rdcu.be/d6uG1
A highlight of this paper in @embojournal.bsky.social :
"ALBA proteins facilitate cytoplasmic YTHDF-mediated reading of m6A in Arabidopsis"
www.embopress.org/doi/full/10....
In my PhD paper published in Front. Cell Dev. in 2022, i show that GATA factor Serpent (Srp) is required for fly fertility, as eggs laid by females mutant for srp are devoid of structures generated by ovarian follicle cells such as micropyle and chorion.
Recently, in 2025, it got published by
Recently, in 2025, it got published by
May 22, 2025 at 11:36 PM
In my PhD paper published in Front. Cell Dev. in 2022, i show that GATA factor Serpent (Srp) is required for fly fertility, as eggs laid by females mutant for srp are devoid of structures generated by ovarian follicle cells such as micropyle and chorion.
Recently, in 2025, it got published by
Recently, in 2025, it got published by
Reposted by Douaa Moussalem
Cool! #m6A #tRNA #mRNADecay #RNA
tRNA modifications tune m6A-dependent mRNA decay: Cell www.cell.com/cell/fulltex...
tRNA modifications tune m6A-dependent mRNA decay: Cell www.cell.com/cell/fulltex...
tRNA modifications tune m6A-dependent mRNA decay
tRNA modifications functionally interact with m6A to regulate mRNA decay.
www.cell.com
May 2, 2025 at 4:28 PM
Cool! #m6A #tRNA #mRNADecay #RNA
tRNA modifications tune m6A-dependent mRNA decay: Cell www.cell.com/cell/fulltex...
tRNA modifications tune m6A-dependent mRNA decay: Cell www.cell.com/cell/fulltex...