#mRNADecay
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milofasken.bsky.social
#Ribosome #mRNADecay #RNA

academic.oup.com/nar/article/...
The ribosome as a platform to coordinate mRNA decay
Abstract. Messenger RNA (mRNA) homeostasis is a critical aspect of cellular function, involving the dynamic interplay between transcription and decay proce
academic.oup.com
February 9, 2025 at 4:34 PM
milofasken.bsky.social
Interesting!
#mRNADecay #DisorderedRegion #Yeast
April 24, 2025 at 11:42 AM
mamueller.bsky.social
Exicted to share our latest review in @narjournal.bsky.social on how the ribosome coordinates mRNA decay with a focus on structural advances in the field.

#ribosome #mRNAdecay #translation
The ribosome as a platform to coordinate mRNA decay
Abstract. Messenger RNA (mRNA) homeostasis is a critical aspect of cellular function, involving the dynamic interplay between transcription and decay proce
academic.oup.com
February 10, 2025 at 10:11 AM
milofasken.bsky.social
Cool! #m6A #tRNA #mRNADecay #RNA
tRNA modifications tune m6A-dependent mRNA decay: Cell www.cell.com/cell/fulltex...
tRNA modifications tune m6A-dependent mRNA decay
tRNA modifications functionally interact with m6A to regulate mRNA decay.
www.cell.com
May 2, 2025 at 4:28 PM
milofasken.bsky.social
Nice!
#RNAdecay #mRNAdecay #QualityControl #Cytoplasm #RNAsky #RNA

www.nature.com/articles/s41...
Cytoplasmic mRNA decay and quality control machineries in eukaryotes - Nature Reviews Genetics
In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and comment on implications for the de...
www.nature.com
February 6, 2025 at 6:14 PM
milofasken.bsky.social
#mRNADecay #Ribosome #Frameshift #Scerevisiae #NMD #CodonOptimality
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay: Molecular Cell www.cell.com/molecular-ce...
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay
Zhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay. This process, dependent on cod...
www.cell.com
May 19, 2025 at 12:21 PM
milofasken.bsky.social
#circRNA #NMD #EJC #mRNADecay #RNA

www.cell.com/molecular-ce...
Circular RNAs trigger nonsense-mediated mRNA decay
Boo and Shin et al. uncover that the EJC deposited onto circRNAs after back-splicing is spatially located near the 3′ UTR of mRNA through circRNA-mRNA interaction. The EJC on circRNA triggers NMD of the mRNA. Mechanistic studies reveal the roles of circNMD in apoptosis and its therapeutic potential for mRNA downregulation.
www.cell.com
December 14, 2024 at 4:43 PM
ibmp-cnrs.bsky.social
🚨 New discovery! 🚨 The exoribonuclease DXO1 joins XRN4 in co-translational mRNA decay, a key process in plant development & stress response. 🌱🔬
📖 Read more in #BMCPlantBio: bmcplantbiol.biomedcentral.com/articles/10....
#PlantScience #RNA #Arabidopsis #mRNAdecay
Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis - BMC Plant Biology
Background mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of th...
bmcplantbiol.biomedcentral.com
February 24, 2025 at 5:05 PM
michalra.bsky.social
7/
Bottom line:
* mRNA clearance is tempo-tuned to species and env. conditions
* 3′UTR motifs and poly(A) tails govern scalable mRNA decay
* QUANTA provides a quantitative framework to study mRNA turnover (and not just in embryos)
#mRNAdecay #zebrafish #mzt #compbio #devbio
August 5, 2025 at 8:23 PM
milofasken.bsky.social
#mRNA #Decapping #mRNADecay #Translation #Scerevisiae #GeneExpression

elifesciences.org/reviewed-pre...
Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways
elifesciences.org
December 12, 2024 at 5:24 PM