Emmanuel Beaurepaire
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ebeaurepaire.bsky.social
Emmanuel Beaurepaire
@ebeaurepaire.bsky.social
Biomicroscopist
@laboptbio.bsky.social @CNRS.bsky.social Polytechnique
https://lob.ip-paris.fr
Reposted by Emmanuel Beaurepaire
Preprint is out! Our BakingTray software turns a 2-photon microscope into a serial-section tomography system for automated whole-organ imaging. ~€35k to convert an existing scope. 11 systems worldwide, >7,000 samples at SWC alone #neuroskyence #microscopy www.biorxiv.org/content/10.6...
October 4, 2026 at 9:18 AM
@stelladees.bsky.social et al.'s work on THG in pigments is featured in #Scilight @aip.bsky.social
🔹 doi.org/10.1063/10.0...
September 12, 2026 at 1:07 PM
A nice study by @laboptbio.bsky.social colleagues V.Abdelsayed, P.Mahou,G.Latour,MC.Schanne-Klein and collaborators in J.Ramella-Roman's group at FIU.
They use polarized SHG to analyze the reorganization of cervix collagen matric during gestation in mice.
Congrats Vaky & co!
doi.org/10.1063/5.03...
Advanced optical polarimetric microscopy reveals spatio-temporal dynamics of cervix remodeling during gestation
Polarimetric microscopy is a powerful tool for assessing fiber orientation and reorganization during various biological processes. Collagen fiber remodeling in
doi.org
September 4, 2026 at 11:25 AM
Resonant third harmonic generation in biological pigments
Dees et al, APL Photonics 2026 doi.org/10.1063/5.03...
A new article from @laboptbio.bsky.social microscopy unit @cnrs.fr @inserm.fr @xpolytechnique.bsky.social @ipparis.bsky.social
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Resonant third harmonic generation in biological pigments
Third harmonic generation (THG) microscopy provides label-free structural contrast of biological tissues. While the THG process can be enhanced by electronic tr
doi.org
August 25, 2026 at 9:13 AM
Reposted by Emmanuel Beaurepaire
A new paper from the LOB microscopy unit on high-speed multiphoton light-sheet imaging has been published in Optica. We achieved kilohertz frame rates by enhancing the signal-to-photodamage ratio during live imaging. doi.org/10.1364/OPTI...
Radware Captcha Page
doi.org
June 10, 2026 at 3:28 PM
Reposted by Emmanuel Beaurepaire
🚀 KiloHz two photon live imaging #MultiphotonMicroscopy @laboptbio.bsky.social
Two-photon light-sheet live imaging at kilohertz frame rate using birefringence-based pulse splitting
#LightSheetMicroscopy #Bioimaging #Photonics #Microscopy #Zebrafish
Article is available here: doi.org/10.1364/OPTI...
June 5, 2026 at 3:54 PM
Reposted by Emmanuel Beaurepaire
Caroline Boudoux, Professor at @polymtl.bsky.social and entrepreneur will give the next LOB seminar: "It Goes without Saying: Taking the Guesswork of Your PhD in Engineering"
See you on April 17th at 11AM in Amphi Becquerel.

lob.ip-paris.fr/en/events/se...
Seminar of Caroline Boudoux - Professor at Polytechnique Montréa et an entrepreneure (Castor Optics)
11:00am, Ecole Polytechnique, Amphi Becquerel
lob.ip-paris.fr
April 7, 2026 at 2:40 PM
Reposted by Emmanuel Beaurepaire
An INSERM CHAIR (tenure track position) has just been opened in the Laboratoire d'Optique et Biosciences (LOB) (INSERM U1182) in @xpolytechnique.bsky.social / @ipparis.bsky.social
@inserm.fr
Deadline to apply : September 2.
pro.inserm.fr/wp-content/u...
March 25, 2026 at 2:09 PM
Reposted by Emmanuel Beaurepaire
Our paper “Label-free nonlinear microscopy probes cellular metabolism and myelin dynamics in live tissue” is published in @commsbio.nature.com, thanks to an exciting collaboration between @laboptbio.bsky.social and @institutducerveau.bsky.social
www.nature.com/articles/s42...
Label-free nonlinear microscopy probes cellular metabolism and myelin dynamics in live tissue - Communications Biology
Multimodal label-free nonlinear microscopy and advanced image analysis map single-cell metabolism and myelin dynamics in live cerebellar tissue during demyelination, supporting research in neuroinflam...
www.nature.com
January 7, 2026 at 4:27 PM
Reposted by Emmanuel Beaurepaire
(2025/10/08) Congratulations to @chiarastringari.bsky.social on the defense of her Habilitation à Diriger les Recherches (HDR) "Label-free multimodal non-linear optical microscopy for functional imaging of living tissues" !
October 9, 2025 at 9:50 AM
Reposted by Emmanuel Beaurepaire
Hey, it's out!
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:
July 24, 2025 at 10:04 AM
Multiscale characterization of myelin distribution with polarized THG microscopy
Morizet et al, Optica 2025 doi.org/10.1364/OPTI...

@laboptbio.bsky.social @institutducerveau.bsky.social @cnrs.fr ‪‪ @ip-paris.bsky.social @inserm.fr
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July 16, 2025 at 1:39 PM
Reposted by Emmanuel Beaurepaire
Congratulations to @caporalclement.bsky.social on his brilliant defence of his PhD thesis, entitled 'Quantitative Analysis of Large Volume Imaging in Developmental Neurobiology' !
July 1, 2025 at 10:05 AM
Reposted by Emmanuel Beaurepaire
Two postdoc positions in the lab within the ERC Synergy project "Chronology" in collaboration with S. Ostojic, M. Jazayeri and V. van Wassenhove @virginievanw.bsky.social . Two focuses: sound sequences representations across the brain & novel all-optical technology. Contact: [email protected]
June 15, 2025 at 8:20 AM
Reposted by Emmanuel Beaurepaire
🆕 We're hiring! We're looking for postdoc 🎓 candidates to work at the intersaction of bioimage analysis 🖥️🔬, tissue biomechanics 🧫, and neuroscience 🧠.

👉 Application deadline: 2025/06/02
👉 Duration: July 2025 - December 2026 (for now)

Come work with us! 🤗

dipc.ehu.eus/en/dipc/join...
Joint Postdoctoral Position in Biophysics – Bioimage Analysis / AI / Neuroscience
dipc.ehu.eus
May 13, 2025 at 12:45 PM
Reposted by Emmanuel Beaurepaire
Congratulations to Stella Dees for defending her thesis on "Multicontrast 3P-microscopy for biological tissue imaging"
April 9, 2025 at 9:28 AM
Reposted by Emmanuel Beaurepaire
Congratulation to Giulia Galante for her thesis defense about the "Characterization and physico-chemical monitoring of collagen degradation in parchments by polarization-resolved multiphoton microscopy!
April 7, 2025 at 3:55 PM
Reposted by Emmanuel Beaurepaire
See you on Friday February 21st for the @eurobioimaging.bsky.social Virtual Pub on "Fluorescence Lifetime Microscopy (FLIM) for label-free metabolic imaging of living tissues"!
#FLIM #labelfree #microscopy #metabolism

You can register online here!
www.eurobioimaging.eu/events/flim-...
February 13, 2025 at 1:34 PM
Reposted by Emmanuel Beaurepaire
Do you need to analyze your FLIM data with open source software?
The #Virtual #I2K2024 workshop on "Interactive #phasor analysis of #FLIM data using FLUTE" given by Bahar Asadipour is online. www.youtube.com/watch?v=q7W1...
#FLUTE can analyze data of most commercial cards
github.com/LaboratoryOp...
Interactive phasor analysis of FLIM data using FLUTE
YouTube video by I2K Conference
www.youtube.com
February 13, 2025 at 9:49 AM
Un poste d’ingénieur en analyse d’images est ouvert en mobilité pour rejoindre @laboptbio.bsky.social à @polytechniqueparis.bsky.social (Palaiseau). Poste IR ouvert aux IE de la fonction publique et IR @cnrs.bsky.social. Deadline: 20/02. Lien (concours 508): profilsdemplois.cnrs.fr/ords/afipprd...
January 22, 2025 at 11:35 AM
An image analysis engineer position is open for mobility to join @laboptbio.bsky.social at @polytechniqueparis.bsky.social ky.social in Palaiseau. IR position open to civil service IEs and CNRS IRs. Deadline: 20/02. Link (position #508): profilsdemplois.cnrs.fr/ords/afipprd...
January 22, 2025 at 11:17 AM