Lung-Yu Liang
@lungyul.bsky.social
Reposted by Lung-Yu Liang
Very pleased to see our recent work on the evolution of complex eukaryotic cells from simple microbial ancestors is featured in this @nature.com News article. www.nature.com/articles/d41....
These bizarre, much-coveted microbes are revealing the origins of complex life
Researchers are racing to culture a menagerie of exotic organisms and finding lots of surprises along the way.
www.nature.com
September 16, 2026 at 2:06 PM
Very pleased to see our recent work on the evolution of complex eukaryotic cells from simple microbial ancestors is featured in this @nature.com News article. www.nature.com/articles/d41....
Reposted by Lung-Yu Liang
MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪
September 8, 2026 at 11:10 AM
MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪
Reposted by Lung-Yu Liang
Wonderful to share our new study! science.org/doi/10.1126/sc…
Patients can look well-controlled and still have epithelial death programs running. We found it in nascent IBD lesions on advanced therapy and it flagged who relapsed over 2–3 years. @WEHI_research @NHMR#ScienceResearchch
Patients can look well-controlled and still have epithelial death programs running. We found it in nascent IBD lesions on advanced therapy and it flagged who relapsed over 2–3 years. @WEHI_research @NHMR#ScienceResearchch
August 28, 2026 at 2:24 AM
Wonderful to share our new study! science.org/doi/10.1126/sc…
Patients can look well-controlled and still have epithelial death programs running. We found it in nascent IBD lesions on advanced therapy and it flagged who relapsed over 2–3 years. @WEHI_research @NHMR#ScienceResearchch
Patients can look well-controlled and still have epithelial death programs running. We found it in nascent IBD lesions on advanced therapy and it flagged who relapsed over 2–3 years. @WEHI_research @NHMR#ScienceResearchch
Reposted by Lung-Yu Liang
🤷🏻♀️ Idk why I have two Autoloader parts left over from this cryoEM build. Should keep them as spare parts I guess.
August 26, 2026 at 4:50 PM
🤷🏻♀️ Idk why I have two Autoloader parts left over from this cryoEM build. Should keep them as spare parts I guess.
Reposted by Lung-Yu Liang
Delighted that our story on chromatin architecture inside human cells is now published — the last chapter of my PhD. It was a pleasure working with @sergiocruzleon.bsky.social, @johannesbetz.bsky.social, and everyone involved. #teamtomo www.nature.com/articles/s41...
July 13, 2026 at 12:42 PM
Delighted that our story on chromatin architecture inside human cells is now published — the last chapter of my PhD. It was a pleasure working with @sergiocruzleon.bsky.social, @johannesbetz.bsky.social, and everyone involved. #teamtomo www.nature.com/articles/s41...
Reposted by Lung-Yu Liang
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
A Novel Pilus System in Candidate Phyla Radiation Bacteria
The Candidate Phyla Radiation (CPR) represents a bacterial superphylum estimated to include between 15–50% of all bacterial species, yet CPR bacteria remain challenging to culture and have been primar...
www.biorxiv.org
June 12, 2026 at 3:20 PM
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
Reposted by Lung-Yu Liang
PhD: defended ✅🎉 My work used in situ cryo-ET #teamtomo to investigate cellular machines from ribosome translation and HIV capsid at the nuclear pore to membrane association of vault, and the molecular architecture of heterochromatin. Huge thanks to @becklab.bsky.social. What a wonderful ride!
May 29, 2026 at 2:05 PM
PhD: defended ✅🎉 My work used in situ cryo-ET #teamtomo to investigate cellular machines from ribosome translation and HIV capsid at the nuclear pore to membrane association of vault, and the molecular architecture of heterochromatin. Huge thanks to @becklab.bsky.social. What a wonderful ride!
Reposted by Lung-Yu Liang
We have published a review on how contextual information can complement and enhance research using #cryoET .
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Context matters: A view on metadata analysis in cryo-electron tomography
Cryo-electron tomography (cryo-ET) enables the analysis of biological samples in situ, revealing the complex interplay that shapes (sub)cellular archi…
www.sciencedirect.com
May 28, 2026 at 8:57 AM
We have published a review on how contextual information can complement and enhance research using #cryoET .
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Lung-Yu Liang
🎉 @pseudokinase.bsky.social and Arthur Olson, two wonderful members of our Advisory Board, share their reflections and hopes for their fields in our special hashtag
#TIBSCelebrates50 series "Perspectives from the Advisory Board".
Keep up with the series at 👉 www.cell.com/trends/bioch...
#TIBSCelebrates50 series "Perspectives from the Advisory Board".
Keep up with the series at 👉 www.cell.com/trends/bioch...
April 21, 2026 at 3:43 PM
🎉 @pseudokinase.bsky.social and Arthur Olson, two wonderful members of our Advisory Board, share their reflections and hopes for their fields in our special hashtag
#TIBSCelebrates50 series "Perspectives from the Advisory Board".
Keep up with the series at 👉 www.cell.com/trends/bioch...
#TIBSCelebrates50 series "Perspectives from the Advisory Board".
Keep up with the series at 👉 www.cell.com/trends/bioch...
Reposted by Lung-Yu Liang
Out now in Nature Communications!
We show that Dictyostelium vaults associate with ER and NE membranes in situ and encapsulate ribosomes with defined orientations, shining new light on their cellular function! #TeamTomo #TeamMassSpec #ProtistsOnSky
www.nature.com/articles/s41...
We show that Dictyostelium vaults associate with ER and NE membranes in situ and encapsulate ribosomes with defined orientations, shining new light on their cellular function! #TeamTomo #TeamMassSpec #ProtistsOnSky
www.nature.com/articles/s41...
April 21, 2026 at 4:25 PM
Out now in Nature Communications!
We show that Dictyostelium vaults associate with ER and NE membranes in situ and encapsulate ribosomes with defined orientations, shining new light on their cellular function! #TeamTomo #TeamMassSpec #ProtistsOnSky
www.nature.com/articles/s41...
We show that Dictyostelium vaults associate with ER and NE membranes in situ and encapsulate ribosomes with defined orientations, shining new light on their cellular function! #TeamTomo #TeamMassSpec #ProtistsOnSky
www.nature.com/articles/s41...
Top effort by @sonjawelsch.bsky.social and co. Fantastic course
April 20, 2026 at 6:23 PM
Top effort by @sonjawelsch.bsky.social and co. Fantastic course
Reposted by Lung-Yu Liang
One of biggest mysteries in biology: how did complex eukaryotic cells evolve from simple microbes? ~1.8 billion years ago, an archaeal cell likely merged with a bacterium to form the first eukaryotic cell, but can we ever find direct evidence of this transformative event? 🦠 🚶♂️
April 12, 2026 at 1:58 PM
One of biggest mysteries in biology: how did complex eukaryotic cells evolve from simple microbes? ~1.8 billion years ago, an archaeal cell likely merged with a bacterium to form the first eukaryotic cell, but can we ever find direct evidence of this transformative event? 🦠 🚶♂️
Reposted by Lung-Yu Liang
Our new preprint on SMCHD1! We’ve shown SMCHD1’s ATPase activity is critical for function in vivo, and excitingly a new DNA binding domain neighbouring the ATPase domain activates the enzymatic function, which is important for normal chromatin binding.
urldefense.com/v3/__https:/...
urldefense.com/v3/__https:/...
February 6, 2026 at 7:57 AM
Our new preprint on SMCHD1! We’ve shown SMCHD1’s ATPase activity is critical for function in vivo, and excitingly a new DNA binding domain neighbouring the ATPase domain activates the enzymatic function, which is important for normal chromatin binding.
urldefense.com/v3/__https:/...
urldefense.com/v3/__https:/...
Reposted by Lung-Yu Liang
This is a cool study that you should all read. Full credit to the key agitator, Alexandra Gurzau, and noting not possible without amazing collaborators, and another fun effort for me, personally, with long time collab @marnieblewitt.bsky.social
Our new preprint on SMCHD1! We’ve shown SMCHD1’s ATPase activity is critical for function in vivo, and excitingly a new DNA binding domain neighbouring the ATPase domain activates the enzymatic function, which is important for normal chromatin binding.
urldefense.com/v3/__https:/...
urldefense.com/v3/__https:/...
February 6, 2026 at 8:13 AM
This is a cool study that you should all read. Full credit to the key agitator, Alexandra Gurzau, and noting not possible without amazing collaborators, and another fun effort for me, personally, with long time collab @marnieblewitt.bsky.social
Reposted by Lung-Yu Liang
📣 New paper alert! This is a story of molecular tricks that let spirochetes (spiral-shaped bacteria) drill through tissue. www.biorxiv.org/content/10.6...
February 5, 2026 at 2:19 PM
📣 New paper alert! This is a story of molecular tricks that let spirochetes (spiral-shaped bacteria) drill through tissue. www.biorxiv.org/content/10.6...
Reposted by Lung-Yu Liang
🚨Our preprint is out! doi.org/10.64898/202...
I'm really pleased to share that our work on resolving the molecular architecture of a condensate inside cells is available to read now on biorXiv. Thanks to a great team of co-authors for making this possible 🎉
I'm really pleased to share that our work on resolving the molecular architecture of a condensate inside cells is available to read now on biorXiv. Thanks to a great team of co-authors for making this possible 🎉
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
January 14, 2026 at 6:57 PM
🚨Our preprint is out! doi.org/10.64898/202...
I'm really pleased to share that our work on resolving the molecular architecture of a condensate inside cells is available to read now on biorXiv. Thanks to a great team of co-authors for making this possible 🎉
I'm really pleased to share that our work on resolving the molecular architecture of a condensate inside cells is available to read now on biorXiv. Thanks to a great team of co-authors for making this possible 🎉
Reposted by Lung-Yu Liang
Unsure how to gain your first peer review opportunity, or keen to improve your feedback? Catch up on our latest ECR webinar and gain practical tips from Biochemical Society Editors-in-Chief on writing and submitting a high-quality review!🧪 https://ow.ly/5pWZ50XNBJs
January 2, 2026 at 12:45 PM
Unsure how to gain your first peer review opportunity, or keen to improve your feedback? Catch up on our latest ECR webinar and gain practical tips from Biochemical Society Editors-in-Chief on writing and submitting a high-quality review!🧪 https://ow.ly/5pWZ50XNBJs
Reposted by Lung-Yu Liang
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
December 16, 2025 at 8:17 AM
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
Reposted by Lung-Yu Liang
Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET!
🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...
🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...
December 2, 2025 at 9:32 AM
Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET!
🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...
🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...
Reposted by Lung-Yu Liang
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Lung-Yu Liang
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
October 17, 2025 at 6:29 AM
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
Reposted by Lung-Yu Liang
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Dodonova Group – Organisational principles and 3D architecture of archaeal chromatin
www.embl.org
October 15, 2025 at 10:38 AM
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Reposted by Lung-Yu Liang
Fantastic new work from our researchers!
Check out their work on 🐯 cryoTIGER for cryoET 🐯
Check out their work on 🐯 cryoTIGER for cryoET 🐯
❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...
cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography - Communications Biology
Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.
www.nature.com
October 10, 2025 at 11:38 AM
Fantastic new work from our researchers!
Check out their work on 🐯 cryoTIGER for cryoET 🐯
Check out their work on 🐯 cryoTIGER for cryoET 🐯
Reposted by Lung-Yu Liang
We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!
lnkd.in/geXUApmK
lnkd.in/geXUApmK
September 10, 2025 at 2:23 PM
We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!
lnkd.in/geXUApmK
lnkd.in/geXUApmK
This is promised to be a great course!
We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
August 20, 2025 at 6:19 PM
This is promised to be a great course!