Agustín Mangiarotti
@mangiarotti.bsky.social
Assistant Researcher CIQUIBIC-CONICET Assistant Professor FCQ-UNC 🔬🧪🇦🇷
Biophysics of membranes & biomolecular condesates
Biophysics of membranes & biomolecular condesates
Reposted by Agustín Mangiarotti
Under a microscope, biomolecular condensates look like tiny droplets. But what exactly is inside them? 🧫
A new paper in Advanced Science presents a label-free approach combining Raman spectroscopy and spectral phasor analysis to map the chemical composition of biomolecular condensates in situ. ⬇️⬇️
A new paper in Advanced Science presents a label-free approach combining Raman spectroscopy and spectral phasor analysis to map the chemical composition of biomolecular condensates in situ. ⬇️⬇️
September 29, 2026 at 9:03 AM
Under a microscope, biomolecular condensates look like tiny droplets. But what exactly is inside them? 🧫
A new paper in Advanced Science presents a label-free approach combining Raman spectroscopy and spectral phasor analysis to map the chemical composition of biomolecular condensates in situ. ⬇️⬇️
A new paper in Advanced Science presents a label-free approach combining Raman spectroscopy and spectral phasor analysis to map the chemical composition of biomolecular condensates in situ. ⬇️⬇️
Reposted by Agustín Mangiarotti
Plasma membrane order maps functional diversity in immune cells @natchembio.nature.com @sciezgin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Plasma membrane order maps functional diversity in immune cells - Nature Chemical Biology
Cells undergo membrane remodeling in response to the environment to perform specific functions. Now, a cytometry-based method with immune cell biomarker analysis captures variations in plasma membrane...
www.nature.com
September 11, 2026 at 5:04 PM
Plasma membrane order maps functional diversity in immune cells @natchembio.nature.com @sciezgin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Agustín Mangiarotti
This review with Agu @mangiarotti.bsky.social 🙏on a topic close to my heart -membranes&condensates- came out some time ago.Only after receiving the printed issue,I realized it's on the journal cover. It does not have much to do with plants, but droplets on thin surfaces is kind of what it is about.
September 3, 2026 at 3:50 PM
This review with Agu @mangiarotti.bsky.social 🙏on a topic close to my heart -membranes&condensates- came out some time ago.Only after receiving the printed issue,I realized it's on the journal cover. It does not have much to do with plants, but droplets on thin surfaces is kind of what it is about.
New mini-review out ⚡🧬
Together with Natalia Wilke we critically compare the methods used to measure condensate electric properties, highlight the unexplored membrane-condensate interface and close with some open questions in the field.
doi.org/10.1016/j.bb...
Together with Natalia Wilke we critically compare the methods used to measure condensate electric properties, highlight the unexplored membrane-condensate interface and close with some open questions in the field.
doi.org/10.1016/j.bb...
August 9, 2026 at 1:06 AM
New mini-review out ⚡🧬
Together with Natalia Wilke we critically compare the methods used to measure condensate electric properties, highlight the unexplored membrane-condensate interface and close with some open questions in the field.
doi.org/10.1016/j.bb...
Together with Natalia Wilke we critically compare the methods used to measure condensate electric properties, highlight the unexplored membrane-condensate interface and close with some open questions in the field.
doi.org/10.1016/j.bb...
📢 Segunda Reunión Nacional de Condensados Biomoleculares y Organelas Sin Membrana
📍 Instituto Leloir
📅 27–28 agosto 2026
🎟️ Gratis
⚠️ Resúmenes hasta el 30 de julio → QR
#LLPS #Condensados #RNA
📍 Instituto Leloir
📅 27–28 agosto 2026
🎟️ Gratis
⚠️ Resúmenes hasta el 30 de julio → QR
#LLPS #Condensados #RNA
July 20, 2026 at 5:23 PM
📢 Segunda Reunión Nacional de Condensados Biomoleculares y Organelas Sin Membrana
📍 Instituto Leloir
📅 27–28 agosto 2026
🎟️ Gratis
⚠️ Resúmenes hasta el 30 de julio → QR
#LLPS #Condensados #RNA
📍 Instituto Leloir
📅 27–28 agosto 2026
🎟️ Gratis
⚠️ Resúmenes hasta el 30 de julio → QR
#LLPS #Condensados #RNA
Reposted by Agustín Mangiarotti
#Heat-triggered phospholipid flipping stabilizes plasma #membrane fluidity
www.nature.com/articles/s41...
#PlantScience @nature.com @natplants.nature.com @sciplant.bsky.social @plant-sci.bsky.social @plantmemories.bsky.social @trr341.bsky.social @planteditors.bsky.social @plantmorpho.bsky.social
www.nature.com/articles/s41...
#PlantScience @nature.com @natplants.nature.com @sciplant.bsky.social @plant-sci.bsky.social @plantmemories.bsky.social @trr341.bsky.social @planteditors.bsky.social @plantmorpho.bsky.social
July 3, 2026 at 11:29 AM
🧪🇦🇷 Excited to share our latest paper done together with Natalia Wilke, just out in Soft Matter!
The take-home message: anchor lipids deserve to be treated as active membrane components when interpreting protein- and condensate-membrane interactions.
doi.org/10.1039/D6SM...
The take-home message: anchor lipids deserve to be treated as active membrane components when interpreting protein- and condensate-membrane interactions.
doi.org/10.1039/D6SM...
NTA-Ni lipids affect membrane phase behavior and fluorescence of lipid-like dyes
The nitrilotriacetic acid group coordinated with nickel, NTA(Ni), is the standard chelator for purifying fusion proteins containing poly-histidine tags. The development of lipids with NTA(Ni) headgrou...
doi.org
May 15, 2026 at 9:15 PM
🧪🇦🇷 Excited to share our latest paper done together with Natalia Wilke, just out in Soft Matter!
The take-home message: anchor lipids deserve to be treated as active membrane components when interpreting protein- and condensate-membrane interactions.
doi.org/10.1039/D6SM...
The take-home message: anchor lipids deserve to be treated as active membrane components when interpreting protein- and condensate-membrane interactions.
doi.org/10.1039/D6SM...
Take a look at our lastest review: "Phase separation across membranes and condensates in cell organization and function," done together with @dimovalab.bsky.social now available in @nature.com Reviews Cell.Mol.Biol.
You can read the full review here:
doi.org/10.1038/s415...
@mpici.bsky.social
You can read the full review here:
doi.org/10.1038/s415...
@mpici.bsky.social
April 15, 2026 at 12:36 PM
Take a look at our lastest review: "Phase separation across membranes and condensates in cell organization and function," done together with @dimovalab.bsky.social now available in @nature.com Reviews Cell.Mol.Biol.
You can read the full review here:
doi.org/10.1038/s415...
@mpici.bsky.social
You can read the full review here:
doi.org/10.1038/s415...
@mpici.bsky.social
Reposted by Agustín Mangiarotti
How do biomolecular condensates🫧 interact with membranes? We show that dielectric permittivity contrast between coexisting phases directly governs condensate wetting behavior.
👉 preprint: bit.ly/4qBmVRx
Permittivity matters.🧪🫧
👉 preprint: bit.ly/4qBmVRx
Permittivity matters.🧪🫧
February 13, 2026 at 2:38 PM
How do biomolecular condensates🫧 interact with membranes? We show that dielectric permittivity contrast between coexisting phases directly governs condensate wetting behavior.
👉 preprint: bit.ly/4qBmVRx
Permittivity matters.🧪🫧
👉 preprint: bit.ly/4qBmVRx
Permittivity matters.🧪🫧
It was my pleasure to present at the SAIB Lipids Symposium for the first time. I had very enriching discussions about the role of membranes and condensates in cell biology!
November 9, 2025 at 6:40 PM
It was my pleasure to present at the SAIB Lipids Symposium for the first time. I had very enriching discussions about the role of membranes and condensates in cell biology!
Reposted by Agustín Mangiarotti
1/3 📢 New work from our lab 📢 We uncover a unifying dielectric principle for biomolecular condensates! 💦Contrary to intuition, we find that it is not a condensate’s absolute polarity, but the permittivity contrast with its surroundings, that governs its affinity for membranes. #GUV #condensates
August 6, 2025 at 3:36 PM
1/3 📢 New work from our lab 📢 We uncover a unifying dielectric principle for biomolecular condensates! 💦Contrary to intuition, we find that it is not a condensate’s absolute polarity, but the permittivity contrast with its surroundings, that governs its affinity for membranes. #GUV #condensates
Reposted by Agustín Mangiarotti
Join the Membrane Structure and Function Subgroup will be hosting a webinar on Tuesday, March 25 at 11:00 AM ET. The presentations will explore recent breakthroughs, foundational concepts, and future directions in membrane biophysics.
Register here: buff.ly/YOAPVID
Register here: buff.ly/YOAPVID
March 23, 2025 at 1:12 PM
Join the Membrane Structure and Function Subgroup will be hosting a webinar on Tuesday, March 25 at 11:00 AM ET. The presentations will explore recent breakthroughs, foundational concepts, and future directions in membrane biophysics.
Register here: buff.ly/YOAPVID
Register here: buff.ly/YOAPVID
Reposted by Agustín Mangiarotti
1/8 Exciting new work with Agu @mangiarotti.bsky.social @mpici.bsky.social ! 🚀 Our latest study explores how lipid packing and cholesterol regulate the interaction of biomolecular condensates with membranes. It turns out, it’s not just about membrane phase. Packing is the key! 🧵👇
rdcu.be/eelLq
rdcu.be/eelLq
Lipid packing and cholesterol content regulate membrane wetting and remodeling by biomolecular condensates
Nature Communications - Membrane lipid packing, influenced by cholesterol, lipid chain length, and saturation, regulates the affinity of biomolecular condensates, enhancing their interactions with...
rdcu.be
March 21, 2025 at 8:47 AM
1/8 Exciting new work with Agu @mangiarotti.bsky.social @mpici.bsky.social ! 🚀 Our latest study explores how lipid packing and cholesterol regulate the interaction of biomolecular condensates with membranes. It turns out, it’s not just about membrane phase. Packing is the key! 🧵👇
rdcu.be/eelLq
rdcu.be/eelLq