Mayank Sharma
@mayankdu.bsky.social
Jr. Group Leader/Lecturer @ETH Zürich, Plant Cell Biology #chloroplasts #starchbiosynthesis #membraneremodeling #mitochondria (tweets=my opinion)
Pinned
Mayank Sharma
@mayankdu.bsky.social
· Oct 14
Hot off the press, first PI paper 🎉. Reporting a novel protein (VIA1) involved in thylakoid membrane biogenesis. VIA1 (similar to ESCRT-II) and bind to chloroplast ESCRT-III (VIPP1). Showing a direct role of VIPP1 in thylakoid biogenesis.
@cp-cellreports.bsky.social
tinyurl.com/msrepdna
@cp-cellreports.bsky.social
tinyurl.com/msrepdna
Reposted by Mayank Sharma
New PEC story 🌱 led by PhD cand Susi with amazing collabs Grimm, Hause & Robatzek labs! We patch-clamped isolated plastids to show that PECs mediate rapid cation flux across the IE. PECs relay Ca²⁺ signals into plastids & link Ca²⁺ to JA-mediated defense. #plantscience www.pnas.org/doi/10.1073/...
August 29, 2026 at 7:07 PM
New PEC story 🌱 led by PhD cand Susi with amazing collabs Grimm, Hause & Robatzek labs! We patch-clamped isolated plastids to show that PECs mediate rapid cation flux across the IE. PECs relay Ca²⁺ signals into plastids & link Ca²⁺ to JA-mediated defense. #plantscience www.pnas.org/doi/10.1073/...
Congratulations to Susanne, Henning @kunzlab.bsky.social and the team on this exciting new publication in @pnas.org 🎉🌱
Insightful work connecting plastid ion channels, Ca+ signalling, hormone biology, and plant immunity! 👏
doi.org/10.1073/pnas...
Insightful work connecting plastid ion channels, Ca+ signalling, hormone biology, and plant immunity! 👏
doi.org/10.1073/pnas...
PLASTID ENVELOPE ION CHANNELS (PEC1/2) link Ca2+ and jasmonic acid signaling in plant cells | PNAS
Plants constantly encounter adverse environmental interactions. One organelle is particularly
specialized in stress signaling and phytohormone synt...
doi.org
August 29, 2026 at 3:40 PM
Congratulations to Susanne, Henning @kunzlab.bsky.social and the team on this exciting new publication in @pnas.org 🎉🌱
Insightful work connecting plastid ion channels, Ca+ signalling, hormone biology, and plant immunity! 👏
doi.org/10.1073/pnas...
Insightful work connecting plastid ion channels, Ca+ signalling, hormone biology, and plant immunity! 👏
doi.org/10.1073/pnas...
Reposted by Mayank Sharma
Dry seeds are not waiting to build mitochondria—they come pre-packaged with cristae and full respiratory complexes. ⚡️🌱🌱🌱
Check out the updated growth-and-division model in @currentbiology.bsky.social
doi.org/10.1016/j.cu...
Check out the updated growth-and-division model in @currentbiology.bsky.social
doi.org/10.1016/j.cu...
August 13, 2026 at 7:51 PM
Dry seeds are not waiting to build mitochondria—they come pre-packaged with cristae and full respiratory complexes. ⚡️🌱🌱🌱
Check out the updated growth-and-division model in @currentbiology.bsky.social
doi.org/10.1016/j.cu...
Check out the updated growth-and-division model in @currentbiology.bsky.social
doi.org/10.1016/j.cu...
Reposted by Mayank Sharma
Our single-cell atlas paper made the cover 🎉 image by @lbmountain.bsky.social, showing the mature Brachy epidermis in all its beauty. #GoBrachy: yellow is lignin, and blue is cell wall autofluorescence.
July 13, 2026 at 7:52 PM
Our single-cell atlas paper made the cover 🎉 image by @lbmountain.bsky.social, showing the mature Brachy epidermis in all its beauty. #GoBrachy: yellow is lignin, and blue is cell wall autofluorescence.
Reversible chromatin remodeling enables Prosopis cineraria survival under recurrent heat extremes. https://www.biorxiv.org/content/10.64898/2026.07.17.734425v1
July 21, 2026 at 11:27 AM
Reposted by Mayank Sharma
Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ESCRT-III assembles around mis-segregated DNA to protect genome stability - Nature Structural & Molecular Biology
The authors show that persistent ultrafine DNA bridges become coated by membranes and the ESCRT-III proteins CHMP1B and IST1, which protect the genome within from damage.
www.nature.com
July 15, 2026 at 9:36 AM
Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mayank Sharma
1st insights into protein synthesis accuracy of plant organelles: www.pnas.org/doi/full/10.... Thx to terrific colabs @ifink-lab.bsky.social @organelledchaos.bsky.social & many others from @pullman.wsu.edu @hhu.de @uni-muenster.de
@unihalle.bsky.social funds by @dfg.de #GoPMF #plantscience #biology
@unihalle.bsky.social funds by @dfg.de #GoPMF #plantscience #biology
June 4, 2026 at 7:33 AM
1st insights into protein synthesis accuracy of plant organelles: www.pnas.org/doi/full/10.... Thx to terrific colabs @ifink-lab.bsky.social @organelledchaos.bsky.social & many others from @pullman.wsu.edu @hhu.de @uni-muenster.de
@unihalle.bsky.social funds by @dfg.de #GoPMF #plantscience #biology
@unihalle.bsky.social funds by @dfg.de #GoPMF #plantscience #biology
Reposted by Mayank Sharma
Hi #plantscience peeps, please check out our revised manuscript version under: www.biorxiv.org/content/10.6...
April 14, 2026 at 9:11 AM
Hi #plantscience peeps, please check out our revised manuscript version under: www.biorxiv.org/content/10.6...
Reposted by Mayank Sharma
New preprint 🚀 ❄️
We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows
✔️ improved grid stability
✔️ reduced handling
✔️ robust vitrification (🦠 🧫 🧠)
A step toward routine HPF for complex samples
#teamtomo
We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows
✔️ improved grid stability
✔️ reduced handling
✔️ robust vitrification (🦠 🧫 🧠)
A step toward routine HPF for complex samples
#teamtomo
April 22, 2026 at 6:18 AM
New preprint 🚀 ❄️
We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows
✔️ improved grid stability
✔️ reduced handling
✔️ robust vitrification (🦠 🧫 🧠)
A step toward routine HPF for complex samples
#teamtomo
We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows
✔️ improved grid stability
✔️ reduced handling
✔️ robust vitrification (🦠 🧫 🧠)
A step toward routine HPF for complex samples
#teamtomo
Reposted by Mayank Sharma
New paper out from the Synoxys lab!
We asked an important question: what if plants sensed oxygen like animals do? what if we swapped the O2 sensing across? We built the system to find out. 🧵
www.nature.com/articles/s41...
#plantscience
@syno2xis.bsky.social @beagiuntoli.bsky.social @biology.ox.ac.uk
We asked an important question: what if plants sensed oxygen like animals do? what if we swapped the O2 sensing across? We built the system to find out. 🧵
www.nature.com/articles/s41...
#plantscience
@syno2xis.bsky.social @beagiuntoli.bsky.social @biology.ox.ac.uk
a poster for indiana jones and the last crusade with a man in a hat
ALT: a poster for indiana jones and the last crusade with a man in a hat
media.tenor.com
April 19, 2026 at 7:28 PM
New paper out from the Synoxys lab!
We asked an important question: what if plants sensed oxygen like animals do? what if we swapped the O2 sensing across? We built the system to find out. 🧵
www.nature.com/articles/s41...
#plantscience
@syno2xis.bsky.social @beagiuntoli.bsky.social @biology.ox.ac.uk
We asked an important question: what if plants sensed oxygen like animals do? what if we swapped the O2 sensing across? We built the system to find out. 🧵
www.nature.com/articles/s41...
#plantscience
@syno2xis.bsky.social @beagiuntoli.bsky.social @biology.ox.ac.uk
Reposted by Mayank Sharma
At long last, the Chlamy chloroplast ribosome hat 🎩 (now renamed the arm 💪) is here to say hello👋! We first spotted this extended structure in green algae a decade ago, and @florentwaltz.bsky.social did beautiful work bringing it into focus! #CryoEM ❄️ #TeamTomo 🔬 #PlantScience 🌾 #ProtistsOnSky 🧪
Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
February 10, 2026 at 1:53 PM
At long last, the Chlamy chloroplast ribosome hat 🎩 (now renamed the arm 💪) is here to say hello👋! We first spotted this extended structure in green algae a decade ago, and @florentwaltz.bsky.social did beautiful work bringing it into focus! #CryoEM ❄️ #TeamTomo 🔬 #PlantScience 🌾 #ProtistsOnSky 🧪
Reposted by Mayank Sharma
Plz read our study by @lmumuenchen.bsky.social PhD cand. Lorenz. He describes chloroplast ionomes for several 🌱species & shows how plastid iron can be massively increased. Terrific help by peers from @ruhr-uni-bochum.de, @mizzouid.bsky.social and @uni-saarland.de academic.oup.com/plcell/artic...
The chloroplast ionome shines light on the dynamics of organellar iron homeostasis
Loss of chloroplast iron (Fe) ferritin storage leads to Fe re-shuttling into the vacuole and reduced leaf tissue Fe content.
academic.oup.com
February 2, 2026 at 8:16 AM
Plz read our study by @lmumuenchen.bsky.social PhD cand. Lorenz. He describes chloroplast ionomes for several 🌱species & shows how plastid iron can be massively increased. Terrific help by peers from @ruhr-uni-bochum.de, @mizzouid.bsky.social and @uni-saarland.de academic.oup.com/plcell/artic...
Reposted by Mayank Sharma
Plz check out our preprint in which we investigate the role of KEA1 in #chlamy, a monoplastid algae. KO mutant vs WT comparison across the green linage reveals conserved but also novel insights in part linked to the mono plastid bottleneck. Thx to many terrific collabs 👇 doi.org/10.64898/202...
December 9, 2025 at 8:15 PM
Plz check out our preprint in which we investigate the role of KEA1 in #chlamy, a monoplastid algae. KO mutant vs WT comparison across the green linage reveals conserved but also novel insights in part linked to the mono plastid bottleneck. Thx to many terrific collabs 👇 doi.org/10.64898/202...
Reposted by Mayank Sharma
Now online in its final version. Plz surf to doi.org/10.1111/tpj....
November 12, 2025 at 9:29 PM
Now online in its final version. Plz surf to doi.org/10.1111/tpj....
Reposted by Mayank Sharma
1/ Preprint alert:
🌾 The developing leaf of the wild grass Brachypodium distachyon at single-cell resolution
👉 doi.org/10.1101/2025...
A 70k-cell single-cell RNA-seq atlas of the developing grass leaf—from the shoot meristem to mature leaf tissues. @cerealcell.bsky.social @lbmountain.bsky.social
🌾 The developing leaf of the wild grass Brachypodium distachyon at single-cell resolution
👉 doi.org/10.1101/2025...
A 70k-cell single-cell RNA-seq atlas of the developing grass leaf—from the shoot meristem to mature leaf tissues. @cerealcell.bsky.social @lbmountain.bsky.social
November 5, 2025 at 12:32 PM
1/ Preprint alert:
🌾 The developing leaf of the wild grass Brachypodium distachyon at single-cell resolution
👉 doi.org/10.1101/2025...
A 70k-cell single-cell RNA-seq atlas of the developing grass leaf—from the shoot meristem to mature leaf tissues. @cerealcell.bsky.social @lbmountain.bsky.social
🌾 The developing leaf of the wild grass Brachypodium distachyon at single-cell resolution
👉 doi.org/10.1101/2025...
A 70k-cell single-cell RNA-seq atlas of the developing grass leaf—from the shoot meristem to mature leaf tissues. @cerealcell.bsky.social @lbmountain.bsky.social
Reposted by Mayank Sharma
Hi all @plantsciencedbg.bsky.social members and other 🌽community folks, #MBP2026 🌱 is no open for registration. Please 🏄♀️ to: www.pflanzen-molekularbiologie.de/en/conferenc...
Conference
Conference "Molecular Biology of Plants", annual meeting of the Section Plant Physiology and Molecular Biology in the DBG
www.pflanzen-molekularbiologie.de
October 28, 2025 at 10:19 AM
Hi all @plantsciencedbg.bsky.social members and other 🌽community folks, #MBP2026 🌱 is no open for registration. Please 🏄♀️ to: www.pflanzen-molekularbiologie.de/en/conferenc...
Reposted by Mayank Sharma
Hey #TeamTomo …would you like to try some 🍦ICECREAM!? Our @unibas.ch colleagues over at the @ivandokmanic.bsky.social lab have developed a stunningly effective tool to de-noise and de-wedge your tomograms. The contrast and details will give you brain freeze! 🍨❄️🤯
Please try, we need feedback 🧪🧶🧬🔬
Please try, we need feedback 🧪🧶🧬🔬
Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧
Icecream: High-Fidelity Equivariant Cryo-Electron Tomography
Cryo-electron tomography (cryo-ET) visualizes 3D cellular architecture in near-native states. Recent deep-learning methods (CryoCARE, IsoNet, DeepDeWedge, CryoLithe) improve denoising and artifact cor...
www.biorxiv.org
October 23, 2025 at 5:57 PM
Hey #TeamTomo …would you like to try some 🍦ICECREAM!? Our @unibas.ch colleagues over at the @ivandokmanic.bsky.social lab have developed a stunningly effective tool to de-noise and de-wedge your tomograms. The contrast and details will give you brain freeze! 🍨❄️🤯
Please try, we need feedback 🧪🧶🧬🔬
Please try, we need feedback 🧪🧶🧬🔬
Reposted by Mayank Sharma
October 21, 2025 at 7:32 AM
Concluded the teaching for this semester. 🧑🏫 The greatest feeling is to transfer the knowledge. 💡
October 17, 2025 at 11:59 AM
Concluded the teaching for this semester. 🧑🏫 The greatest feeling is to transfer the knowledge. 💡
Reposted by Mayank Sharma
What else I am offering
• My services for transforming PhD theses into Thesis Glossies with Thesis & Zo
• And not to forget my blogs about recent plant science articles under Plant & Zo
• My services for transforming PhD theses into Thesis Glossies with Thesis & Zo
• And not to forget my blogs about recent plant science articles under Plant & Zo
October 17, 2025 at 7:26 AM
What else I am offering
• My services for transforming PhD theses into Thesis Glossies with Thesis & Zo
• And not to forget my blogs about recent plant science articles under Plant & Zo
• My services for transforming PhD theses into Thesis Glossies with Thesis & Zo
• And not to forget my blogs about recent plant science articles under Plant & Zo
Reposted by Mayank Sharma
Reposted by Mayank Sharma
So, we all know that VIPP1 (the Very Important Protein in Plants) is the "photosynthetic ESCRT-III", required for the biogenesis and maintenance of light-harvesting thylakoids. But what about ESCRT-II, you say? ...Meet VIA1! Congrats @mayankdu.bsky.social on your lab's first paper! #PlantScience 🧪 🌾
Hot off the press, first PI paper 🎉. Reporting a novel protein (VIA1) involved in thylakoid membrane biogenesis. VIA1 (similar to ESCRT-II) and bind to chloroplast ESCRT-III (VIPP1). Showing a direct role of VIPP1 in thylakoid biogenesis.
@cp-cellreports.bsky.social
tinyurl.com/msrepdna
@cp-cellreports.bsky.social
tinyurl.com/msrepdna
October 14, 2025 at 12:30 PM
So, we all know that VIPP1 (the Very Important Protein in Plants) is the "photosynthetic ESCRT-III", required for the biogenesis and maintenance of light-harvesting thylakoids. But what about ESCRT-II, you say? ...Meet VIA1! Congrats @mayankdu.bsky.social on your lab's first paper! #PlantScience 🧪 🌾
Hot off the press, first PI paper 🎉. Reporting a novel protein (VIA1) involved in thylakoid membrane biogenesis. VIA1 (similar to ESCRT-II) and bind to chloroplast ESCRT-III (VIPP1). Showing a direct role of VIPP1 in thylakoid biogenesis.
@cp-cellreports.bsky.social
tinyurl.com/msrepdna
@cp-cellreports.bsky.social
tinyurl.com/msrepdna
October 14, 2025 at 9:40 AM
Hot off the press, first PI paper 🎉. Reporting a novel protein (VIA1) involved in thylakoid membrane biogenesis. VIA1 (similar to ESCRT-II) and bind to chloroplast ESCRT-III (VIPP1). Showing a direct role of VIPP1 in thylakoid biogenesis.
@cp-cellreports.bsky.social
tinyurl.com/msrepdna
@cp-cellreports.bsky.social
tinyurl.com/msrepdna
Reposted by Mayank Sharma
New work from the Synoxys lab!
About how does a plant’s habitat, whether growing in water, drylands, or typical soils, shape the evolution of its oxygen-sensing machinery.
Indulge!
#plantscience
#ISPLORE2025JP
About how does a plant’s habitat, whether growing in water, drylands, or typical soils, shape the evolution of its oxygen-sensing machinery.
Indulge!
#plantscience
#ISPLORE2025JP
Thrilled to make my first post here 🌱 Right after presenting at #ISPLORE2025JP, where I shared our work on how anatomy & habitat shaped the oxygen-sensing machinery of angiosperms. Please check out our new preprint www.biorxiv.org/content/10.1...
September 23, 2025 at 11:24 PM
New work from the Synoxys lab!
About how does a plant’s habitat, whether growing in water, drylands, or typical soils, shape the evolution of its oxygen-sensing machinery.
Indulge!
#plantscience
#ISPLORE2025JP
About how does a plant’s habitat, whether growing in water, drylands, or typical soils, shape the evolution of its oxygen-sensing machinery.
Indulge!
#plantscience
#ISPLORE2025JP