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wemakemolecules.bsky.social
We make molecules!
@wemakemolecules.bsky.social
100 followers 130 following 18 posts
The Yeast Natural Products lab, we love fungi and chemistry.
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Reposted by We make molecules!
tomas-strucko.bsky.social
Black yeasts are efficient heterologous hosts for the production of a wide range of fungal polyketides

doi.org/10.1038/s415...
Black yeasts are efficient heterologous hosts for the production of a wide range of fungal polyketides - Nature Chemical Biology
Here, the authors establish and validate two black yeasts as heterologous hosts for fungal polyketide discovery and production, combining the metabolic robustness of filamentous Aspergillus species wi...
doi.org
August 7, 2026 at 12:09 PM
Reposted by We make molecules!
natchembio.nature.com
Black yeasts are efficient heterologous hosts for the production of a wide range of fungal polyketides

www.nature.com/articles/s41...
Black yeasts are efficient heterologous hosts for the production of a wide range of fungal polyketides - Nature Chemical Biology
Here, the authors establish and validate two black yeasts as heterologous hosts for fungal polyketide discovery and production, combining the metabolic robustness of filamentous Aspergillus species wi...
www.nature.com
August 12, 2026 at 1:56 PM
wemakemolecules.bsky.social
Check out this news and views by Tahir Ali and Elizabeth Skellam featuring our research on black yeast hosts for natural products heterologous production.
www.nature.com/articles/s41...
Black yeasts emerge as hosts for fungal polyketide production - Nature Chemical Biology
Fungal polyketides represent a treasure trove of industrially relevant compounds, yet sustainable high-level production can be challenging. Black yeasts have emerged as promising heterologous hosts fo...
www.nature.com
August 7, 2026 at 1:52 AM
wemakemolecules.bsky.social
Fungal natural products Heterologous production: fast, easy, cheap.
Introducing BLACK YEASTS 🍄
Fast to engineer, capable of expressing complex fungal biosynthetic pathways, and ready to accelerate natural product discovery.
Check the paper 🧪
www.nature.com/articles/s41...
#SyntheticBiology #fung
Black yeasts are efficient heterologous hosts for the production of a wide range of fungal polyketides - Nature Chemical Biology
Here, the authors establish and validate two black yeasts as heterologous hosts for fungal polyketide discovery and production, combining the metabolic robustness of filamentous Aspergillus species wi...
www.nature.com
August 4, 2026 at 11:40 PM
wemakemolecules.bsky.social
Dr. Kevin Yin and the @keaslinglab.bsky.social team engineered polyketide synthases to produce designer polycyclopropanated fuels with improved freezing points and energy density
www.nature.com/articles/s41...
🚀🧬

#SyntheticBiology #Biofuels #MetabolicEngineering #AviationFuel
Polyketide synthase-based controlled synthesis of polycyclopropanated fuel molecules - Nature Communications
To be practically useful, sustainable aviation fuels need a suitable energy density and freezing point. Here the authors explore an iterative polyketide synthase family, leading to engineered biosynth...
www.nature.com
June 1, 2026 at 3:36 PM
Reposted by We make molecules!
sciencex.bsky.social
Genetic analysis of Hypocreales fungi has uncovered thousands of previously unknown natural compounds, highlighting new possibilities for sustainable, eco-friendly crop protection. doi.org/hb2vsw
Scientists unlock fungi's secret chemistry, offering a greener path to crop protection
Pesky pests can wreak havoc on plants by chewing leaves, boring into stems, and sucking sap from trees. Beyond the direct damage, they also spread harmful bacteria, viruses, and fungi that can infect and ultimately kill the crops.
phys.org
May 7, 2026 at 5:20 PM
wemakemolecules.bsky.social
Looking for new biopesticides? or active ingredients for pest control? Check out this research briefing on our recent paper on Hypocreales and their chemistry
www.nature.com/articles/s41...
Surveying hypocrealean fungi to identify biocontrol agents - Nature Chemical Biology
Hypocrealean fungi are the most important source of fungal and insect pest biocontrol agents. By integrating phylogenomics, metabolomics and synthetic biology, we surveyed the biosynthetic capabilitie...
www.nature.com
April 28, 2026 at 12:35 PM
Reposted by We make molecules!
natchembio.nature.com
Hypocrealean fungi form symbiotic relationships with plants while antagonizing pests. A survey of 5221 of their biosynthetic gene clusters reveals that ~80% encode unknown products, which could have potential for pest control

www.nature.com/articles/s41...
A biosynthetic survey of hypocrealean biocontrol fungi - Nature Chemical Biology
Crop losses from pests threaten global food security. Here, the authors survey the biosynthetic repertoire of hypocrealean fungi, identifying over 5,200 biosynthetic gene clusters, most encoding unkno...
www.nature.com
April 23, 2026 at 3:57 PM
wemakemolecules.bsky.social
We lose up to 40% of crops to pests. Fungal-based crop protection can help. The challenge? We barely know the chemicals fungi use to protect plants. Check out our paper on their biosynthetic potential. Led by Dr Ana Calheiros de Carvalho of YNP Lab + BRIGHT Biofoundry
www.nature.com/articles/s41...
A biosynthetic survey of hypocrealean biocontrol fungi - Nature Chemical Biology
Crop losses from pests threaten global food security. Here, the authors survey the biosynthetic repertoire of hypocrealean fungi, identifying over 5,200 biosynthetic gene clusters, most encoding unkno...
www.nature.com
April 16, 2026 at 9:44 AM
Reposted by We make molecules!
natprodreports.rsc.org
🔓Take a look at this #OpenAccess Highlight article from Pablo Cruz-Morales & co. @wemakemolecules.bsky.social discussing synthetic biology for heterologous expression and engineering of fungal polyketide synthases #secmet #natprod

📍 @dtu.dk
Synthetic biology for heterologous expression and engineering of fungal polyketide synthases
Covering: up to 2025Polyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products. Their biosynthetic features offer significant opportunities to create a…
pubs.rsc.org
March 20, 2026 at 12:43 PM
Reposted by We make molecules!
natmicrobiol.nature.com
Read the associated news and views:

Microbial chocolatiers of fine flavour 🍫

by Pablo Cruz-Morales

www.nature.com/articles/s41...
August 18, 2025 at 3:37 PM
wemakemolecules.bsky.social
Climate change is stressing our forests, fungal allies may turn into pathogens. Are we ready for this?
Don’t miss this call to action for new model organisms & functional studies in forest pathogens. By Anne Oostlander and col. at TU Braunschweig and FABI
nph.onlinelibrary.wiley.com/doi/full/10....
May 12, 2025 at 2:21 PM
wemakemolecules.bsky.social
Our biosynthetic survey of biocontrol fungi is out now!
lnkd.in/dJbyis5f
Dr. Ana Calheiros de Carvalho combined analytical chemistry, post-genomics and Synbio to catalog and discover lots of natural products. Data release in the next few days:

Check our preprint for details ⚗️ 🍄 🥰 🌽
March 10, 2025 at 10:26 AM
wemakemolecules.bsky.social
Our PhD student Adrian Gadar López and the Black Yeast Natural Products team made fungal PKS Heterologous Expression easy! Check out the preprint.
www.researchsquare.com/article/rs-6...
#wemakemolecules #blackyeast #NNF_BRIGHT
Black yeasts are efficient heterologous hosts of a wide range of fungal polyketides
Fungal natural products, including polyketides, are a rich source of bioactive molecules. Their biosynthetic enzymes are encoded within biosynthetic gene clusters, which are often activated by specifi...
www.researchsquare.com
February 20, 2025 at 4:06 PM
Reposted by We make molecules!
thombooth.bsky.social
getphylo is finally official! Build phylogenetic trees directly from genbank files - at breakneck speed! I'd like to thank everyone who provided feedback and encourage you to continue. Improving getphylo doesn't stop now the paper is out!
1/5
🧪
bmcbioinformatics.biomedcentral.com/articles/10....
getphylo: rapid and automatic generation of multi-locus phylogenetic trees - BMC Bioinformatics
Background The increasing amount of genomic data calls for tools that can create genome-scale phylogenies quickly and efficiently. Existing tools rely on large reference databases or require lengthy d...
bmcbioinformatics.biomedcentral.com
January 22, 2025 at 11:31 AM
Reposted by We make molecules!
tilmweber.bsky.social
Have a look at our latest study on large-scale #Streptomyces BGC mining / pangenome analysis: genomebiology.biomedcentral.com/articles/10....
January 15, 2025 at 1:01 PM
wemakemolecules.bsky.social
Feeding 9 billion people will take lots of creativity and the best scientists. Check how Dr. Loes van Dam is working on new fungal foods are DTU biosustain. #DTU_BRIGHT
www.euronews.com/health/2025/...
Fungi oysters: Inside the Danish lab producing next alternative food
At a Technical University of Denmark lab, researchers are exploring the potential for fungi to be used as meat and seafood replacements.
www.euronews.com
January 9, 2025 at 1:40 AM
Reposted by We make molecules!
tilmweber.bsky.social
Are you working with #streptomycetes? Then you may be interested in trying our new #StreptoCAD platform: StreptoCAD is an open-source software
toolbox automating genome engineering
workflows in streptomycetes. www.biorxiv.org/content/10.1...
StreptoCAD: An open-source software toolbox automating genome engineering workflows in streptomycetes
Streptomycetes hold immense potential for discovering novel bioactive molecules for applications in medicine or sustainable agriculture. However, high-throughput exploration is hampered by the current...
www.biorxiv.org
January 7, 2025 at 2:16 PM
wemakemolecules.bsky.social
Diplodia sapinea a pine endophyte lives a harmless life until the tree is dying... Climate change is stressing trees and turning harmless fungi into pathogens. How? It is not clear, new tools to study them are needed, check work by Anne Oostlander of TU Braunschweig journals.plos.org/plosone/arti...
Development of a molecular genetics and cell biology toolbox for the filamentous fungus Diplodia sapinea
Diplodia sapinea (Fr.) Fuckel is a widespread fungal pathogen affecting conifers worldwide. Infections can lead to severe symptoms, such as shoot blight, canker, tree death, or blue stain in harvested...
journals.plos.org
January 7, 2025 at 4:11 PM
wemakemolecules.bsky.social
The perfect molecule doesn't exist... Until Dr Ana Calheiros de Carvalho find it with her metabologenomics workflow for biocontrol molecules! Check it out poster #81 #NP2025 San Diego #DTU_BRIGHT
January 7, 2025 at 4:45 AM
wemakemolecules.bsky.social
N.R.P.S. will stand for No Resistant Pest will Stand after Dr Carolina Cano-Prieto engineer them with her SynBio tools. Poster 38 #NP2025 #DTU_BRIGHT #sustainableagriculture
January 7, 2025 at 4:31 AM
wemakemolecules.bsky.social
Saccharomyces Fans are scared of this black yeast! Check out how our PhD student Adrian Gadar-Lopez and his black yeast makes bioproducts like gangbusters. Poster #37 #NP2025 #DTU_BRIGHT #clickbait
January 7, 2025 at 3:56 AM
wemakemolecules.bsky.social
Do you dream of making polyketides advanced materials with polyketide synthases? Check our PhD student Sidharth Jayachandran's poster at #NP2025 San Diego #OMG #DTU_BRIGHT
January 7, 2025 at 3:43 AM
Reposted by We make molecules!
kblin.bsky.social
The #antiSMASH beta is now live on the website. There’s some minor updates and maybe a bug fix out two separating us from what will be in the final release. Please let up know if you run into any bugs.
Thanks to all the contributors for getting us past 100 detection rules and all the other updates
December 17, 2024 at 9:47 PM
Reposted by We make molecules!
biorxiv-synthbio.bsky.social
StreptoCAD: An open-source software toolbox automating genome engineering workflows in streptomycetes https://www.biorxiv.org/content/10.1101/2024.12.19.629370v1
December 20, 2024 at 1:05 PM