Elizabeth Lee Hazen y Rachel Fuller Brown. Fungicida. Química. Microbiología. Nistatina. Candida albicans. Cryptococcus neoformans. Streptomyces noursei.

In a collaboration, researchers from the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures and the Helmholtz Center for Infection Research (HZI) have discovered two previously unknown natural products.

Base editors are useful tools that allow genetic engineers to precisely change single bases in an organism's genome. Most base editors catalyze transition mutations (e.g., A-to-G or C to-T). Transvers...

Abstract. Analysis of the genome of Streptomyces aizunensis NRRL B-11277 indicated its potential to produce a compound of novel and highly predictable stru

Abstract. Okgyeamides A–C (1–3), cyclic pentapeptides with a YPWIP sequence and distinct Tyr–Trp C–C and C–N cross-links, were isolated from cave-derived S

Conseil de pôle A2F, flash talk, Cyril Bontemps (Dynamic) et Rodnay Sormani (IAM) -'Criblage d’Antifongiques produit par Streptomyces ciblant la voie TOR (CASTOR)' Ajouté par : Vincent Jeannot

Alma Joslyn Whiffen-Barksdale. Cicloheximida. Agente antifúngico y antibacteriano. Streptomyces griseus. Achlya bisexualis.

Cytochrome P450 (CYP) enzymes with peroxygenase activity can use H2O2 as the sole oxidant which is beneficial for biocatalytic applications. We investigated the peroxygenase activity of CYP105D18 from Streptomyces laurentii. The modification of the acid-...

Although thousands of microbial specialized metabolites have been identified, the ecological functions of most remain unknown. Naphthocyclinones are aromatic polyketide antibiotics discovered more than five decades ago, yet their biological role has remained elusive. Investigating the microbial community of the oligolectic ivy bee (Colletes hederae), a bacterial community that included several Streptomyces species and members of the class Bacilli was recovered from fermented nest provisions. One Streptomyces isolate, B-004T (DSM 121525T = LMG 34598T), was identified as representing a novel species based on polyphasic taxonomic studies, for which the name Streptomyces hederae sp. nov. is proposed. This strain showed potent antibacterial activity against co-isolated Gram-positive bacteria as well as Paenibacillus larvae, the causative agent of American foulbrood. Bioassay-guided fractionation coupled with liquid chromatography-mass spectrometry analysis led to the identification of naphthocyclinone congeners as the active metabolites. Whole-genome sequencing and genome mining revealed a type II polyketide synthase biosynthetic gene cluster closely related to that of the characterized naphthocyclinone pathway. Targeted deletion of the cluster-encoded ketosynthase gene (B-004_07360) abolished naphthocyclinone production and resulted in the complete loss of antibacterial activity, whereas heterologous overexpression of the Streptomyces antibiotic regulatory protein gene papR2 significantly increased antibiotic production, confirming the function of the naphthocyclinone biosynthetic gene cluster. Furthermore, naphthocyclinone biosynthesis was found to be induced by sympatric bacterial isolates from bee nests. Together, our findings provide the first evidence for an ecological function of naphthocyclinones as mediators of bacterial competition in wild bee nests and highlight their potential as antimicrobial substances against P. larvae.

We report the isolation and characterization of six novel phages infecting Streptomyces, including a satellite-helper system. Additionally, this work highl

#FEMSmicroBlog: Phage research developments and how bacterial predators help solve challenges in infectious diseases and advance biology.

Guided by these metagenomic observations, the team isolated and screened microorganisms from rice rhizosphere soil enriched by the rotation. P-11