New paper in Ecosystems led by @biogeobob.bsky.social! Fun NSF-funded collaboration tracing the immediate & delayed whole-stream respiration of dissolved organic carbon using 13C-glucose & 13C-fescue leachate additions + 13C-DIC analyses w/ Michelle Baker & Stephen Plont. 💧🌎
April 2, 2026 at 10:51 PM
New paper in Ecosystems led by @biogeobob.bsky.social! Fun NSF-funded collaboration tracing the immediate & delayed whole-stream respiration of dissolved organic carbon using 13C-glucose & 13C-fescue leachate additions + 13C-DIC analyses w/ Michelle Baker & Stephen Plont. 💧🌎
1/For over a decade, we’ve been studying tumor metabolism in patients with non-small cell lung cancer
This long-term commitment allowed us to connect tumor metabolic features to patient outcomes
We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC
This long-term commitment allowed us to connect tumor metabolic features to patient outcomes
We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC
Now online in Cancer Discovery: High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients - by Ling Cai, Nia Hammond, Brandon Faubert, @rjdlab.bsky.social, and colleagues doi.org/10.1158/2159...
February 17, 2025 at 8:20 PM
1/For over a decade, we’ve been studying tumor metabolism in patients with non-small cell lung cancer
This long-term commitment allowed us to connect tumor metabolic features to patient outcomes
We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC
This long-term commitment allowed us to connect tumor metabolic features to patient outcomes
We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC
How do #circadian clocks regulate glucose processing? By integrating human metabolite profiling with isotope-tracing in #Drosophila, this study defines daily rhythms in #glucose utilization that are influenced by circadian timing @plosbiology.org 🧪 plos.io/3Olm1M1
April 20, 2026 at 8:05 AM
How do #circadian clocks regulate glucose processing? By integrating human metabolite profiling with isotope-tracing in #Drosophila, this study defines daily rhythms in #glucose utilization that are influenced by circadian timing @plosbiology.org 🧪 plos.io/3Olm1M1
How do #circadian clocks regulate glucose processing? By integrating human metabolite profiling with isotope-tracing in #Drosophila, this study defines daily rhythms in #glucose utilization that are influenced by circadian timing @plosbiology.org 🧪 plos.io/3Olm1M1
April 17, 2026 at 4:35 PM
How do #circadian clocks regulate glucose processing? By integrating human metabolite profiling with isotope-tracing in #Drosophila, this study defines daily rhythms in #glucose utilization that are influenced by circadian timing @plosbiology.org 🧪 plos.io/3Olm1M1
How do #circadian clocks regulate glucose processing? By integrating human metabolite profiling with isotope-tracing in #Drosophila, this study defines daily rhythms in #glucose utilization that are influenced by circadian timing @plosbiology.org 🧪 plos.io/3Olm1M1
April 17, 2026 at 1:05 PM
How do #circadian clocks regulate glucose processing? By integrating human metabolite profiling with isotope-tracing in #Drosophila, this study defines daily rhythms in #glucose utilization that are influenced by circadian timing @plosbiology.org 🧪 plos.io/3Olm1M1
Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism - Nature Metabolism
Tsyben et al. study the spatial distribution of labelled metabolites in glioblastoma samples from patients infused with 13C-glucose, using mass spectrometry imaging.
www.nature.com
May 25, 2025 at 6:27 AM
Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism
www.nature.com/articles/s42...
www.nature.com/articles/s42...
"Nerd-vana". A week of non-stop discussions about isotope tracing with expert faculty and enthusiastic trainees in Nashville.
Come for the 13C-glucose infusions, stay for the mechanical bull ride.
Come for the 13C-glucose infusions, stay for the mechanical bull ride.
November 21, 2024 at 12:48 AM
"Nerd-vana". A week of non-stop discussions about isotope tracing with expert faculty and enthusiastic trainees in Nashville.
Come for the 13C-glucose infusions, stay for the mechanical bull ride.
Come for the 13C-glucose infusions, stay for the mechanical bull ride.
Metabolomics and 13C labelled glucose tracing to identify carbon incorporation into aberrant cell membrane glycans in cancer #SciRep #MassSpec www.nature.com/articles/s42...
Metabolomics and 13C labelled glucose tracing to identify carbon incorporation into aberrant cell membrane glycans in cancer - Communications Biology
Stable isotope tracing reveals distinct glucose allocation to membrane glycans in genetically identical pancreatic cancer cells, showing how metabolic shifts impact glycosylation. This approach highli...
www.nature.com
November 27, 2024 at 7:22 PM
Metabolomics and 13C labelled glucose tracing to identify carbon incorporation into aberrant cell membrane glycans in cancer #SciRep #MassSpec www.nature.com/articles/s42...
2/The metabolic features we analyzed include isotope tracing with 13C-glucose (performed in patients and mice) and metabolomic profiling, evaluated over 6 passages in mice to assess both the fidelity and durability of PDX metabolic heterogeneity.
July 29, 2025 at 3:00 PM
2/The metabolic features we analyzed include isotope tracing with 13C-glucose (performed in patients and mice) and metabolomic profiling, evaluated over 6 passages in mice to assess both the fidelity and durability of PDX metabolic heterogeneity.
RESEARCH | A Tsyben, R Mair, KM Brindle (U Cambridge):
The spatial distribution of labelled metabolites in #glioblastoma samples from patients infused with 13C-glucose 🧠
www.nature.com/articles/s42... ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
The spatial distribution of labelled metabolites in #glioblastoma samples from patients infused with 13C-glucose 🧠
www.nature.com/articles/s42... ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism - Nature Metabolism
Tsyben et al. study the spatial distribution of labelled metabolites in glioblastoma samples from patients infused with 13C-glucose, using mass spectrometry imaging.
www.nature.com
June 20, 2025 at 3:14 PM
RESEARCH | A Tsyben, R Mair, KM Brindle (U Cambridge):
The spatial distribution of labelled metabolites in #glioblastoma samples from patients infused with 13C-glucose 🧠
www.nature.com/articles/s42... ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
The spatial distribution of labelled metabolites in #glioblastoma samples from patients infused with 13C-glucose 🧠
www.nature.com/articles/s42... ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Finally, congrats to @rjdlab.bsky.social for another exciting discovery in lung cancer metabolism and metastasis: aacrjournals.org/cancerdiscov...
High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients
Abstract. In patients with non–small cell lung cancer (NSCLC), the relationship between tumor metabolism and clinical outcomes is unknown. Here, 13C-labeled nutrients were intraoperatively infused int...
aacrjournals.org
February 23, 2025 at 6:36 AM
Finally, congrats to @rjdlab.bsky.social for another exciting discovery in lung cancer metabolism and metastasis: aacrjournals.org/cancerdiscov...
Microbial Carbon Accumulation Efficiency in Global Soils Resolved via 13C‐Glucose Amendment Experiments agupubs.onlinelibrary.wiley.com/doi/10.1029/... #jcampubs
June 5, 2025 at 4:46 PM
Microbial Carbon Accumulation Efficiency in Global Soils Resolved via 13C‐Glucose Amendment Experiments agupubs.onlinelibrary.wiley.com/doi/10.1029/... #jcampubs
8/In these PDX models, modest suppression of Complex I of the electron transport chain reduced 13C labeling in tumor-derived TCA cycle intermediates after infusion with 13C-glucose, as expected.
February 17, 2025 at 7:28 PM
8/In these PDX models, modest suppression of Complex I of the electron transport chain reduced 13C labeling in tumor-derived TCA cycle intermediates after infusion with 13C-glucose, as expected.
Metabolomics and 13C Labelled Glucose Tracing to Identify Carbon Incorporation into Aberrant Cell Membrane Glycans in Cancer https://www.biorxiv.org/content/10.1101/2024.04.08.588353v1
Metabolomics and 13C Labelled Glucose Tracing to Identify Carbon Incorporation into Aberrant Cell Membrane Glycans in Cancer https://www.biorxiv.org/content/10.1101/2024.04.08.588353v1
Cell membrane glycans contribute to immune recognition, signaling, and cellular adhesion and migrati
www.biorxiv.org
April 12, 2024 at 6:50 PM
Metabolomics and 13C Labelled Glucose Tracing to Identify Carbon Incorporation into Aberrant Cell Membrane Glycans in Cancer https://www.biorxiv.org/content/10.1101/2024.04.08.588353v1
Assessment of Glucose Metabolism In Vivo in the Human Frontal Lobe Using Interleaved 1H and 13C MRS at 7T: Toward Clinical Translation https://www.medrxiv.org/content/10.64898/2026.07.25.26358922v1
July 29, 2026 at 3:11 PM
Assessment of Glucose Metabolism In Vivo in the Human Frontal Lobe Using Interleaved 1H and 13C MRS at 7T: Toward Clinical Translation https://www.medrxiv.org/content/10.64898/2026.07.25.26358922v1
A study reveals complete glycolysis inside mitochondria, crucial for function. Confirmed by CoIP-MS and [U-¹³C] tracing; key in Retinitis Pigmentosa's pathogenesis. Insightful data! PMID:42120427, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-72988-3 #Medsky #Pharmsky #RNA #ASHG 🧪
Intra-mitochondrial glycolysis maintains mitochondrial function and underlies the pathogenesis of retinitis pigmentosa | Nature Communications
Glycolysis is classically defined as a cytoplasmic process. Here, in our investigation of mitochondrial dysfunction in Retinitis Pigmentosa (RP), we report the unexpected discovery of a complete and functional glycolytic pathway operating inside mitochondria. Through CoIP-MS, polysome profiling, and [U-13C] glucose isotope tracing, we demonstrate that key glycolytic enzymes are locally translated and metabolically active within the organelle. Mechanistically, we show that the VWA8-PHB2-GRP75 complex is responsible for anchoring these enzymes, thereby sustaining intra-mitochondrial glycolysis and preserving mitochondrial function by regulating NAD+ levels and reactive oxygen species (ROS) homeostasis. In vivo, Vwa8 knockout in both mice and zebrafish abolishes this metabolic safeguard, leading to RP-like phenotypes that can be partially rescued by reactivating mitochondrial glycolysis. Collectively, these findings redefine the spatial compartmentalization of glucose metabolism and estab
doi.org
June 15, 2026 at 6:00 PM
A study reveals complete glycolysis inside mitochondria, crucial for function. Confirmed by CoIP-MS and [U-¹³C] tracing; key in Retinitis Pigmentosa's pathogenesis. Insightful data! PMID:42120427, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-72988-3 #Medsky #Pharmsky #RNA #ASHG 🧪
2/This is the result of an 11-year effort to connect metabolic features of human NSCLC, obtained through clinical intra-operative 13C-glucose tracing, with overall and recurrence-free survival.
February 17, 2025 at 7:24 PM
2/This is the result of an 11-year effort to connect metabolic features of human NSCLC, obtained through clinical intra-operative 13C-glucose tracing, with overall and recurrence-free survival.
NEW in @GlobalChangeBio
Microbial Controls of Primed CO2 and CH4 Release From #Soils and Sediments Under #Warming
dx.doi.org/10.1111/gcb....
#SoilOrganicMatter #SoilOrganicCarbon #primingeffect #CO2 #CH4 #enzymes #GlobalChange #ClimateChange #GlobalWarming #nitrogen #13C-glucose #isotopes
Microbial Controls of Primed CO2 and CH4 Release From #Soils and Sediments Under #Warming
dx.doi.org/10.1111/gcb....
#SoilOrganicMatter #SoilOrganicCarbon #primingeffect #CO2 #CH4 #enzymes #GlobalChange #ClimateChange #GlobalWarming #nitrogen #13C-glucose #isotopes
June 9, 2026 at 1:40 PM
NEW in @GlobalChangeBio
Microbial Controls of Primed CO2 and CH4 Release From #Soils and Sediments Under #Warming
dx.doi.org/10.1111/gcb....
#SoilOrganicMatter #SoilOrganicCarbon #primingeffect #CO2 #CH4 #enzymes #GlobalChange #ClimateChange #GlobalWarming #nitrogen #13C-glucose #isotopes
Microbial Controls of Primed CO2 and CH4 Release From #Soils and Sediments Under #Warming
dx.doi.org/10.1111/gcb....
#SoilOrganicMatter #SoilOrganicCarbon #primingeffect #CO2 #CH4 #enzymes #GlobalChange #ClimateChange #GlobalWarming #nitrogen #13C-glucose #isotopes
I was lucky enough to be a part of this work. It has it all- new mouse models, clinically relevant metabolic phenotypes, pharmacology, mitochondrial biology, and some of the best scientists I have had the privilege to work with. Give it a gander! aacrjournals.org/cancerdiscov...
March 13, 2025 at 10:10 PM
I was lucky enough to be a part of this work. It has it all- new mouse models, clinically relevant metabolic phenotypes, pharmacology, mitochondrial biology, and some of the best scientists I have had the privilege to work with. Give it a gander! aacrjournals.org/cancerdiscov...
2/ We use intra-operative infusions of 13C-labeled nutrients, like glucose, to study tumors
We’ve learned a lot with this approach. We saw that tumor metabolism can be very heterogeneous and that tumors use a variety of nutrients. Even so-called “waste” products are recycled by lung tumors.
We’ve learned a lot with this approach. We saw that tumor metabolism can be very heterogeneous and that tumors use a variety of nutrients. Even so-called “waste” products are recycled by lung tumors.
February 17, 2025 at 8:22 PM
2/ We use intra-operative infusions of 13C-labeled nutrients, like glucose, to study tumors
We’ve learned a lot with this approach. We saw that tumor metabolism can be very heterogeneous and that tumors use a variety of nutrients. Even so-called “waste” products are recycled by lung tumors.
We’ve learned a lot with this approach. We saw that tumor metabolism can be very heterogeneous and that tumors use a variety of nutrients. Even so-called “waste” products are recycled by lung tumors.
& Dr. @faubert.bsky.social & team have a paper in @theaacr.bsky.social's Cancer Discovery about tumor metabolism in NSCLC doi.org/10.1158/2159...
High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients
Abstract. In patients with non–small cell lung cancer (NSCLC), the relationship between tumor metabolism and clinical outcomes is unknown. Here, 13C-labeled nutrients were intraoperatively infused int...
doi.org
February 19, 2025 at 7:09 PM
& Dr. @faubert.bsky.social & team have a paper in @theaacr.bsky.social's Cancer Discovery about tumor metabolism in NSCLC doi.org/10.1158/2159...
13C Stable Isotope Tracing-Based MFA Reveals the Contribution of Glucose to Glycolytic and TCA Fluxes and Its Application in Depression Research
Zhao, Linghu, Wang et al.
Analytical Chemistry
https://pubs.acs.org/doi/10.1021/acs.analchem.6c00087
#stableisotopes
Zhao, Linghu, Wang et al.
Analytical Chemistry
https://pubs.acs.org/doi/10.1021/acs.analchem.6c00087
#stableisotopes
13C Stable Isotope Tracing-Based MFA Reveals the Contribution of Glucose to Glycolytic and TCA Fluxes and Its Application in Depression Research
Abstract. Metabolomics is widely applied to dissect metabolic pathways and their correlations with biological phenotypes. Unlike genomics and proteomics, m
pubs.acs.org
September 2, 2026 at 7:02 PM
13C Stable Isotope Tracing-Based MFA Reveals the Contribution of Glucose to Glycolytic and TCA Fluxes and Its Application in Depression Research
Zhao, Linghu, Wang et al.
Analytical Chemistry
https://pubs.acs.org/doi/10.1021/acs.analchem.6c00087
#stableisotopes
Zhao, Linghu, Wang et al.
Analytical Chemistry
https://pubs.acs.org/doi/10.1021/acs.analchem.6c00087
#stableisotopes