Adenine (A), cytosine (C), guanine (G), and thymine (T), 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC).
May 15, 2026 at 2:39 PM
Adenine (A), cytosine (C), guanine (G), and thymine (T), 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC).
Those amazing #phages 🦠 figured out 5mC chemistry before we did:
📄 Out today in @MolecularCell we describe a 5mC-selective #deaminase family in environmental phage genomes with broad applications for #5base #sequencing
#epigenetics #DNAmethylation #genomics #NGS 🧬🧪
www.cell.com/molecular-ce...
📄 Out today in @MolecularCell we describe a 5mC-selective #deaminase family in environmental phage genomes with broad applications for #5base #sequencing
#epigenetics #DNAmethylation #genomics #NGS 🧬🧪
www.cell.com/molecular-ce...
April 20, 2026 at 6:19 AM
Those amazing #phages 🦠 figured out 5mC chemistry before we did:
📄 Out today in @MolecularCell we describe a 5mC-selective #deaminase family in environmental phage genomes with broad applications for #5base #sequencing
#epigenetics #DNAmethylation #genomics #NGS 🧬🧪
www.cell.com/molecular-ce...
📄 Out today in @MolecularCell we describe a 5mC-selective #deaminase family in environmental phage genomes with broad applications for #5base #sequencing
#epigenetics #DNAmethylation #genomics #NGS 🧬🧪
www.cell.com/molecular-ce...
June 12, 2026 at 10:32 PM
A biochemical curiosity: it is much more straightforward to go enzymatically from 5mC > T than it is to go from 5mC > C
Those amazing #phages 🦠 figured out 5mC chemistry before we did:
📄 Out today in @MolecularCell we describe a 5mC-selective #deaminase family in environmental phage genomes with broad applications for #5base #sequencing
#epigenetics #DNAmethylation #genomics #NGS 🧬🧪
www.cell.com/molecular-ce...
📄 Out today in @MolecularCell we describe a 5mC-selective #deaminase family in environmental phage genomes with broad applications for #5base #sequencing
#epigenetics #DNAmethylation #genomics #NGS 🧬🧪
www.cell.com/molecular-ce...
April 20, 2026 at 10:06 AM
A biochemical curiosity: it is much more straightforward to go enzymatically from 5mC > T than it is to go from 5mC > C
www.biorxiv.org/content/10.1...
Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
December 9, 2024 at 2:12 PM
www.biorxiv.org/content/10.1...
Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
Not only the 5 nucleobases... but the meteorite contains 5mC. So epigenetics existed even before genetics. Something for you @maxvcg.bsky.social
January 29, 2025 at 6:18 PM
Not only the 5 nucleobases... but the meteorite contains 5mC. So epigenetics existed even before genetics. Something for you @maxvcg.bsky.social
February’s playlist is here. I still believe in love, what about you?
open.spotify.com/playlist/5mc...
open.spotify.com/playlist/5mc...
February 20, 2025 at 9:32 PM
February’s playlist is here. I still believe in love, what about you?
open.spotify.com/playlist/5mc...
open.spotify.com/playlist/5mc...
kurwa to post sprzed 5mc a sie podniecilem ze fura wrocil
July 23, 2025 at 11:23 AM
kurwa to post sprzed 5mc a sie podniecilem ze fura wrocil
Epinoma (EpiAmp) open.substack.com/pub/albertvi...
Company profile Epinoma (EpiAmp)
Introducing 5mC-preserving amplification
open.substack.com
September 2, 2025 at 4:09 PM
Epinoma (EpiAmp) open.substack.com/pub/albertvi...
Spatial 5mC-seq offers nonbiased spatiotemporal analysis of the genome-wide methylome at single cell resolution.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial 5mC-seq profiling of embryos and decidua after implantation in mammals - Nature Methods
Spatial 5mC-seq enables nonbiased, spatiotemporal analysis of the genome-wide methylome at a single-cell resolution.
www.nature.com
May 4, 2026 at 6:30 PM
Spatial 5mC-seq offers nonbiased spatiotemporal analysis of the genome-wide methylome at single cell resolution.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chaetognaths have lost gene body methylation and shifted #5mC back to Transposable Elements. This reversion to the ancestral state is coupled with a simplification of DNMT3 architecture. We posit that trans-splicing might compensate.
It is an honour to have contributed to this 20y struggle ⛰️.
It is an honour to have contributed to this 20y struggle ⛰️.
After nearly twenty years in the making, our attempt at understanding what makes the chaetognath phylum so unique has finally been published! www.nature.com/articles/s41...
with #LauraPiovani @dariagavr.bsky.social @alexdemendoza.bsky.social @chemamd.bsky.social and others /1
with #LauraPiovani @dariagavr.bsky.social @alexdemendoza.bsky.social @chemamd.bsky.social and others /1
The genomic origin of the unique chaetognath body plan - Nature
Genomic, single-cell transcriptomic and epigenetic analyses show that chaetognaths, following extensive gene loss in the gnathiferan lineage, relied on newly evolved genes and lineage-specific tandem ...
www.nature.com
August 14, 2025 at 7:53 AM
Chaetognaths have lost gene body methylation and shifted #5mC back to Transposable Elements. This reversion to the ancestral state is coupled with a simplification of DNMT3 architecture. We posit that trans-splicing might compensate.
It is an honour to have contributed to this 20y struggle ⛰️.
It is an honour to have contributed to this 20y struggle ⛰️.
TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
August 5, 2025 at 5:11 PM
TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
Why 5meC and not 5mC?
September 16, 2025 at 3:35 AM
Why 5meC and not 5mC?
Epigenetic memory that couples 5mC and H3K9 methylation, enables chromatin state inheritance across lifetimes and evolution. New excellent review by @hitenmadhani.bsky.social highlights inheritance mechanisms including roles for histone chaperones and nucleosome recycling. tinyurl.com/42ddhj4a
December 24, 2024 at 2:37 PM
Epigenetic memory that couples 5mC and H3K9 methylation, enables chromatin state inheritance across lifetimes and evolution. New excellent review by @hitenmadhani.bsky.social highlights inheritance mechanisms including roles for histone chaperones and nucleosome recycling. tinyurl.com/42ddhj4a
LIGOU O ALARME DUM CARRO VSFFFFFFFFFFFFFFFFF 5RTJÇL~54REJ0E/P´5MÇ,J5LMÇ
December 31, 2024 at 7:24 PM
LIGOU O ALARME DUM CARRO VSFFFFFFFFFFFFFFFFF 5RTJÇL~54REJ0E/P´5MÇ,J5LMÇ
📊 | Charts Diário Spotify Global
TIVEMOS UM AUMENTO, ARMY!
FAÇAM STREAM em SEVEN só falta mais 1 posição para entrarmos no TOP40 no Spotify Global 🔥🔥🔥
#41 (+9) Seven — 2.368.178 (+139.135)
🎧 : open.spotify.com/playlist/5Mc...
TIVEMOS UM AUMENTO, ARMY!
FAÇAM STREAM em SEVEN só falta mais 1 posição para entrarmos no TOP40 no Spotify Global 🔥🔥🔥
#41 (+9) Seven — 2.368.178 (+139.135)
🎧 : open.spotify.com/playlist/5Mc...
September 19, 2024 at 2:11 PM
📊 | Charts Diário Spotify Global
TIVEMOS UM AUMENTO, ARMY!
FAÇAM STREAM em SEVEN só falta mais 1 posição para entrarmos no TOP40 no Spotify Global 🔥🔥🔥
#41 (+9) Seven — 2.368.178 (+139.135)
🎧 : open.spotify.com/playlist/5Mc...
TIVEMOS UM AUMENTO, ARMY!
FAÇAM STREAM em SEVEN só falta mais 1 posição para entrarmos no TOP40 no Spotify Global 🔥🔥🔥
#41 (+9) Seven — 2.368.178 (+139.135)
🎧 : open.spotify.com/playlist/5Mc...
cmon man not the box legendary
twitch.tv/tietuesday
A lil 5MC after! And a lil bit of Pokemon (real) after that!
twitch.tv/tietuesday
A lil 5MC after! And a lil bit of Pokemon (real) after that!
June 26, 2026 at 8:59 PM
cmon man not the box legendary
twitch.tv/tietuesday
A lil 5MC after! And a lil bit of Pokemon (real) after that!
twitch.tv/tietuesday
A lil 5MC after! And a lil bit of Pokemon (real) after that!
Koschei KSC-5MC. 75 pounds of death per second on 65 tons of engine and steel. One of my all time faves despite being skeptical of it at first.
#battletech #miniature #painting
#battletech #miniature #painting
September 10, 2025 at 2:29 PM
Koschei KSC-5MC. 75 pounds of death per second on 65 tons of engine and steel. One of my all time faves despite being skeptical of it at first.
#battletech #miniature #painting
#battletech #miniature #painting
Nanopore duplex sequencing reveals patterns of asymmetric states of 5hmC and 5mC in the medaka brain genome. #AsymetricMethylation #5hmC #5mC #MedakaGenome #Nanopore #LongRead #Sequencing @biorxiv-genomic.bsky.social 🧬 🖥️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 29, 2025 at 8:31 AM
Nanopore duplex sequencing reveals patterns of asymmetric states of 5hmC and 5mC in the medaka brain genome. #AsymetricMethylation #5hmC #5mC #MedakaGenome #Nanopore #LongRead #Sequencing @biorxiv-genomic.bsky.social 🧬 🖥️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
An overview of nanopore sequencing for pangenomes and hemi-hydroxymethylation in medaka fish brains by @ewanbirney.bsky.social
Presenting results showing biased 5hmC/5mC hemimethylation at splice sites, and increased skewed hemimethylation across repetitive sequences.
Presenting results showing biased 5hmC/5mC hemimethylation at splice sites, and increased skewed hemimethylation across repetitive sequences.
February 23, 2025 at 11:08 PM
An overview of nanopore sequencing for pangenomes and hemi-hydroxymethylation in medaka fish brains by @ewanbirney.bsky.social
Presenting results showing biased 5hmC/5mC hemimethylation at splice sites, and increased skewed hemimethylation across repetitive sequences.
Presenting results showing biased 5hmC/5mC hemimethylation at splice sites, and increased skewed hemimethylation across repetitive sequences.
Excited to share the first of 2 new papers diving into functions of UHRF1 ubiquitin ligase activity. Here, a connection to the support of 5mC maintenance in regions of low CpG density. These same regions are prone to 5mC loss in cancer. A potential mechanistic link to PMD formation. #epigenetics
UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation
Abstract. The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. The model posits that nucleosomal engagement throu
academic.oup.com
December 1, 2024 at 3:13 PM
Excited to share the first of 2 new papers diving into functions of UHRF1 ubiquitin ligase activity. Here, a connection to the support of 5mC maintenance in regions of low CpG density. These same regions are prone to 5mC loss in cancer. A potential mechanistic link to PMD formation. #epigenetics
September 27, 2024 at 2:26 AM
#SpatialOmics
Spatial-DMT
Co-profiling spatial #DNAMethylome #Transcriptome🤠
Enzymatic Methyl-seq (pooling 5mC 5hmC)
>100k CpG, >1k gene per 10-μm pixel
Mapping mCG & mCH & transcription factors
@dengyanxiang.bsky.social bioRxiv 2025
www.biorxiv.org/content/10.1...
Spatial-DMT
Co-profiling spatial #DNAMethylome #Transcriptome🤠
Enzymatic Methyl-seq (pooling 5mC 5hmC)
>100k CpG, >1k gene per 10-μm pixel
Mapping mCG & mCH & transcription factors
@dengyanxiang.bsky.social bioRxiv 2025
www.biorxiv.org/content/10.1...
July 9, 2025 at 11:46 AM
#SpatialOmics
Spatial-DMT
Co-profiling spatial #DNAMethylome #Transcriptome🤠
Enzymatic Methyl-seq (pooling 5mC 5hmC)
>100k CpG, >1k gene per 10-μm pixel
Mapping mCG & mCH & transcription factors
@dengyanxiang.bsky.social bioRxiv 2025
www.biorxiv.org/content/10.1...
Spatial-DMT
Co-profiling spatial #DNAMethylome #Transcriptome🤠
Enzymatic Methyl-seq (pooling 5mC 5hmC)
>100k CpG, >1k gene per 10-μm pixel
Mapping mCG & mCH & transcription factors
@dengyanxiang.bsky.social bioRxiv 2025
www.biorxiv.org/content/10.1...
A DNA break-5mC cycle activates transposable elements in Arabidopsis | PNAS www.pnas.org/doi/abs/10.1...
A DNA break-5mC cycle activates transposable elements in Arabidopsis | PNAS
Plant genomic and epigenomic integrity are perpetually threatened by exogenous and
endogenous DNA damage. However, the interplay between DNA damage...
www.pnas.org
July 14, 2026 at 2:32 AM
A DNA break-5mC cycle activates transposable elements in Arabidopsis | PNAS www.pnas.org/doi/abs/10.1...
An interesting link between 5mC and m6A; when #epigenetics meets #epitranscriptomics!
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation
Beyond its role as RNA m6A writer, METTL3-METTL14 can mediate 5mC deposition on DNA
by recruiting the DNA methyltransferase DNMT1 to chromatin. The two marks co-orchestrate
the expression of key genes...
www.cell.com
January 19, 2025 at 8:29 AM
An interesting link between 5mC and m6A; when #epigenetics meets #epitranscriptomics!
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...