#A1ar
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catfoodking.bsky.social
What? No they don’t.

Caffeine antagonizes adenosine A1 and A2A receptrs. No ADHD drugs work directly via adenosine receptors.

There’s been bit of speculation about interxns of A1AR or A2R and dopamine receptor heteromers, but don’t just make stuff up.

Science isn’t just vibes
May 30, 2024 at 11:44 AM
shihcheng.bsky.social
Explore the human A3 adenosine receptor through 3 distinct cryo-EM structures: endogenous agonist adenosine, agonist Piclidenoson, and antagonist LUF7602! PMID:40825947, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-62872-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor | Nature Communications
Adenosine receptors (ARs: A1AR, A2AAR, A2BAR, and A3AR) are crucial therapeutic targets; however, developing selective, efficacious drugs for them remains a significant challenge. Here, we present high-resolution cryo-electron microscopy (cryo-EM) structures of the human A3AR in three distinct functional states: bound to the endogenous agonist adenosine, the clinically relevant agonist Piclidenoson, and the covalent antagonist LUF7602. These structures, complemented by mutagenesis and pharmacological studies, reveal an A3AR activation mechanism that involves an extensive hydrogen bond network from the extracellular surface down to the orthosteric binding site. In addition, we identify a cryptic pocket that accommodates the N6-iodobenzyl group of Piclidenoson through a ligand-dependent conformational change of M1745.35. Our comprehensive structural and functional characterisation of A3AR advances our understanding of adenosine receptor pharmacology and establishes a foundation for devel
doi.org
September 29, 2025 at 8:10 AM
thebsline.bsky.social
Me and Rich Hofmann watched that Sixers' game last night so you don't have to... here's our recap on the @phlysports.bsky.social YouTube channel. And don't forget to stick around for the @kyleneubeck.bsky.social cameo near the end... www.youtube.com/watch?v=A1aR...
PHLY Sixers Postgame: Joel Embiid struggles in return as Sixers lose to Knicks
YouTube video by PHLY Sports
www.youtube.com
November 13, 2024 at 1:37 PM
runnindoe.bsky.social
Trump announces a deal for Hamas to disarm in Gaza, but many hurdles and uncertainty remain - The Associated Press

apple.news/A1ar-y0pLQ-u...
Trump announces a deal for Hamas to disarm in Gaza, but many hurdles and uncertainty remain — The Associated Press
President Donald Trump says a deal has been reached for Hamas to disarm and Israel to withdraw its forces from Gaza.
apple.news
July 31, 2026 at 9:12 AM
blala999.bsky.social
youtube.com/watch?v=a1AR...
White Farmers Now BEGGING Black Folks for Help as they LOOSING their Farms!
YouTube video by BLACK HISTORY IN PHOTOS!
youtube.com
June 8, 2026 at 4:22 AM
epsteinweb.bsky.social
EFTA01495995.jpg
#epsteinweb #efta01495995
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA01495995 | EFTA01495995 Primary Account: For the Period 311/11 to 3131111 JPMorgan Classic Business Checking JEGE INC c awil ;nitr 21. tWV.I. 41:49. ISMiordfrom COW MOVin•inalkeirsdron/ 003570586527 MAR 18 ',Mot ; tor TainANe.≤eporadoe Paellitearoll Twiti new owl n — Or— _ - - . in — _ 1$ ..•• -mane *Ma - rf R18 - N0000001378 S5.500.00 I a nw Amor COWOT lir 2ro. Mt* Isita.e.par Ii. WM a1AR 21 N0000001390 $15.023.50 MAR 21 .000000B91 $7,200.00 \I R 21 N0000001390 S15.023.50 SAR 21 KO00001391 87,200.00 Please note that you can view your historical check images online and easily enroll in &Delivery by going to wittily MorganOnline corn. J.P.Morgan Page 3 of 4 Confidential Treatment Requested by JPMorgan Chase JPM-SDNY-00019255 CONFIDENTIAL SDNY_GM_00288453 EFTA01495995
February 27, 2026 at 4:57 AM
just-me-deborah-g.bsky.social
A dessert idea for those getting snow.... I remember my mother making 'snow cream' after big snowfalls when I was a little girl. She made sure to select clean snow-- no yellow-stained snow, etc. LOL! www.youtube.com/watch?v=A1Ar...
Homemade Snow Ice Cream Recipe / Snow Cream
YouTube video by Living On A Dime To Grow Rich
www.youtube.com
January 24, 2026 at 11:13 PM
lokaalnieuws.bsky.social
Exclusief nieuwbouwproject Blank’O start verkoop

#A1ar #Belgischekust #BlankO #Blankenberge #duurzamearchitectuur #luxeappartementen #Nieuwbouwproject #POCRealEstate

Ontde
lokaalnieuws.online/exclusief-ni...
November 8, 2024 at 3:02 PM
gharrhome.bsky.social
♬ Anthem of the Unpriced Dawn: www.youtube.com/watch?v=A1ar... #AI​ #Song​ by #Suno​ #lyrics​ by #ChatGPT #music​ #newmusic​ 🆙 #game #changer SUNO P #AI #related and #new #style of #UTAU #vocaloid #ボーカロイド #music #音楽 #udio #kaiber #producer #entertainment 🌎 #global #community #news ❤️ ❧
Anthem of the Unpriced Dawn #AI​ #Song​ by #Suno​ #lyrics​ by #ChatGPT #music​ #newmusic​
YouTube video by Clive Dobson
www.youtube.com
December 12, 2025 at 4:22 AM
neurodaniela.bsky.social
Plenary talk by Rodrigo Cunha
“A cup of coffee to preserve memory? The role of the adenosine neuromodulation system”
Great overview on 1) the role of A2a receptor, 2) the differences between A2aR and NMDA and 3) A2a-A1aR interaction and 4) it’s dysregulation in disorders
January 12, 2025 at 12:32 PM
aftercapitalism.bsky.social
youtube.com/watch?v=A1ar...
Anthem of the Unpriced Dawn #AI​ #Song​ by #Suno​ #lyrics​ by #ChatGPT #music​ #newmusic​
YouTube video by Clive Dobson
youtube.com
December 12, 2025 at 3:01 AM
chelssicle.bsky.social
Choose 25 songs from the #kdrama OSTs that you love. One per day for 25 days, in no particular order. No explanations unless you feel inspired! No reviews. Just gifs or clips.

#kdramachallenge #kdramas #kdramaOST

Day 18: For You - BTOB
www.youtube.com/watch?v=A1aR...
February 22, 2025 at 1:37 AM