This is why pts with severe inflammatory responses frequently have ⬇️ ADAMTS13!
ADAMTS13 is an important protease responsible for cleaving VWF. ⬆️ UL VWF leads to ⬆️
consumption of ADAMTS13.
⬇️ ADAMTS13 has been shown to be as predictive of mortality as APACHE 😳
10/n
ADAMTS13 is an important protease responsible for cleaving VWF. ⬆️ UL VWF leads to ⬆️
consumption of ADAMTS13.
⬇️ ADAMTS13 has been shown to be as predictive of mortality as APACHE 😳
10/n
a man in a suit is holding a lemon and says this is bad i mean bad bad
Alt: a man in a suit is holding a lemon and says this is bad i mean bad bad
media.tenor.com
November 15, 2024 at 5:20 PM
This is why pts with severe inflammatory responses frequently have ⬇️ ADAMTS13!
ADAMTS13 is an important protease responsible for cleaving VWF. ⬆️ UL VWF leads to ⬆️
consumption of ADAMTS13.
⬇️ ADAMTS13 has been shown to be as predictive of mortality as APACHE 😳
10/n
ADAMTS13 is an important protease responsible for cleaving VWF. ⬆️ UL VWF leads to ⬆️
consumption of ADAMTS13.
⬇️ ADAMTS13 has been shown to be as predictive of mortality as APACHE 😳
10/n
COVID-19 Stroke is Unique as the VWF/ADAMTS13 Axis Plays a Key Role in Thromboinflammatory Response
www.thailandmedical.news/news/covid-1...
www.thailandmedical.news/news/covid-1...
COVID-19 Stroke is Unique as the VWF/ADAMTS13 Axis Plays a Key Role in Thromboinflammatory Response - Thailand Medical News
www.thailandmedical.news
February 20, 2025 at 2:45 PM
COVID-19 Stroke is Unique as the VWF/ADAMTS13 Axis Plays a Key Role in Thromboinflammatory Response
www.thailandmedical.news/news/covid-1...
www.thailandmedical.news/news/covid-1...
Congenital #TTP is a rare disease caused by ADAMTS13 deficiency. A study of 9 pediatric patients treated with recombinant ADAMTS13 showed improved platelet counts, reduced LDH, and enhanced QOL with no adverse events.
#MedSky #HemeSky
www.jthjournal.org/article/S153...
#MedSky #HemeSky
www.jthjournal.org/article/S153...
December 13, 2024 at 6:07 PM
Congenital #TTP is a rare disease caused by ADAMTS13 deficiency. A study of 9 pediatric patients treated with recombinant ADAMTS13 showed improved platelet counts, reduced LDH, and enhanced QOL with no adverse events.
#MedSky #HemeSky
www.jthjournal.org/article/S153...
#MedSky #HemeSky
www.jthjournal.org/article/S153...
Very exciting talk on how VWF activity is dysregulated, as IL6 inhibits ADAMTS13 in ischemic stroke. After clot formation the vessels can reverses blood flow to protect the brain cells. @frederikdenorme.bsky.social #ISTH2025
June 23, 2025 at 1:56 PM
Very exciting talk on how VWF activity is dysregulated, as IL6 inhibits ADAMTS13 in ischemic stroke. After clot formation the vessels can reverses blood flow to protect the brain cells. @frederikdenorme.bsky.social #ISTH2025
SARS-CoV-2 Increases Plasma VWF Levels and Decreases ADAMTS13 Activity, Raising Risk and Worsening Outcomes of Stroke
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
SARS-CoV-2 Increases Plasma VWF Levels and Decreases ADAMTS13 Activity, Raising Risk and Worsening Outcomes of Stroke - Thailand Medical News
www.thailandmedical.news
January 12, 2025 at 3:23 AM
SARS-CoV-2 Increases Plasma VWF Levels and Decreases ADAMTS13 Activity, Raising Risk and Worsening Outcomes of Stroke
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
Recombinant ADAMTS13 should be the standard of care for patients with congenital TTP. FFP is an inferior product both in terms of efficacy and safety.
A paper in the journal Blood describes the experience from Japan in 14 patients.
lnkd.in/eXg345SD
A paper in the journal Blood describes the experience from Japan in 14 patients.
lnkd.in/eXg345SD
May 15, 2025 at 6:07 PM
Recombinant ADAMTS13 should be the standard of care for patients with congenital TTP. FFP is an inferior product both in terms of efficacy and safety.
A paper in the journal Blood describes the experience from Japan in 14 patients.
lnkd.in/eXg345SD
A paper in the journal Blood describes the experience from Japan in 14 patients.
lnkd.in/eXg345SD
Timon discussed how ADAMTS13 interacts with macrophage scavenger receptors #ISTH2025 @rcsi.bsky.social @jsodonnell.bsky.social
June 22, 2025 at 8:40 PM
Timon discussed how ADAMTS13 interacts with macrophage scavenger receptors #ISTH2025 @rcsi.bsky.social @jsodonnell.bsky.social
Recombinant ADAMTS13 proved safer and more effective than fresh frozen plasma for treating congenital TTP in Japanese patients.
by Sakai K, Hamamura A (...) Matsumoto M et 16 al. in Blood #MedSky
📖 read the article:
by Sakai K, Hamamura A (...) Matsumoto M et 16 al. in Blood #MedSky
📖 read the article:
Therapeutic switch from plasma to recombinant ADAMTS13 for patients with congenital TTP from Japanese real-world data
Key Points. Recombinant ADAMTS13 can supply ADAMTS13 more efficiently than plasma to patients with congenital thrombotic thrombocytopenic purpura.Therapeut
ashpublications.org
March 25, 2025 at 6:38 PM
Recombinant ADAMTS13 proved safer and more effective than fresh frozen plasma for treating congenital TTP in Japanese patients.
by Sakai K, Hamamura A (...) Matsumoto M et 16 al. in Blood #MedSky
📖 read the article:
by Sakai K, Hamamura A (...) Matsumoto M et 16 al. in Blood #MedSky
📖 read the article:
Pts can have ⬇️ platelet aggregation while other studies suggest ⬆️ ftn.
VWF is ⬆️. ADAMTS13 is ⬇️
2. Secondary hemostasis (fibrin clot formation)
The liver makes all procoagulants (except VWF & FVIII) + anticoagulants.
Levels ⬇️ in parallel to severity of LD.
3/n
VWF is ⬆️. ADAMTS13 is ⬇️
2. Secondary hemostasis (fibrin clot formation)
The liver makes all procoagulants (except VWF & FVIII) + anticoagulants.
Levels ⬇️ in parallel to severity of LD.
3/n
November 13, 2024 at 8:11 PM
Pts can have ⬇️ platelet aggregation while other studies suggest ⬆️ ftn.
VWF is ⬆️. ADAMTS13 is ⬇️
2. Secondary hemostasis (fibrin clot formation)
The liver makes all procoagulants (except VWF & FVIII) + anticoagulants.
Levels ⬇️ in parallel to severity of LD.
3/n
VWF is ⬆️. ADAMTS13 is ⬇️
2. Secondary hemostasis (fibrin clot formation)
The liver makes all procoagulants (except VWF & FVIII) + anticoagulants.
Levels ⬇️ in parallel to severity of LD.
3/n
Recombinant ADAMTS13 is also being explored.
Antifibrinolytics and PCCs are generally avoided due to risk of thrombosis.
20/n
Antifibrinolytics and PCCs are generally avoided due to risk of thrombosis.
20/n
November 15, 2024 at 5:20 PM
Recombinant ADAMTS13 is also being explored.
Antifibrinolytics and PCCs are generally avoided due to risk of thrombosis.
20/n
Antifibrinolytics and PCCs are generally avoided due to risk of thrombosis.
20/n
➡️ Inflammation and thrombosis play crucial roles in pancreatic necrosis. Targeting ADAMTS13 activity enhancement with the combination of PAD4 inhibition may better alleviate acute pancreatitis.
🔗 https://ow.ly/9xQ150ZQz46
🔗 https://ow.ly/9xQ150ZQz46
September 25, 2026 at 2:15 PM
➡️ Inflammation and thrombosis play crucial roles in pancreatic necrosis. Targeting ADAMTS13 activity enhancement with the combination of PAD4 inhibition may better alleviate acute pancreatitis.
🔗 https://ow.ly/9xQ150ZQz46
🔗 https://ow.ly/9xQ150ZQz46
Spacer-CUB interactions maintain the ADAMTS13 global latency to structurally constrain its proteolytic function. buff.ly/EcGPlCa #hemesky #thrombosisandhemostasis
April 30, 2025 at 2:04 PM
Spacer-CUB interactions maintain the ADAMTS13 global latency to structurally constrain its proteolytic function. buff.ly/EcGPlCa #hemesky #thrombosisandhemostasis
Excited to share our recent study in which we assessed whether iodinated radiocontrast media (as might be given for a CT scan) interferes with ADAMTS13 activity via the gold standard FRET method - it doesn’t, though read the open access paper for caveats. academic.oup.com/ajcp/advance...
Evaluating the potential for iodinated radiocontrast agents to interfere with ADAMTS13 activity testing via fluorescence resonance energy transfer methodology
AbstractObjectives. Fluorescence resonance energy transfer (FRET)–based ADAMTS13 activity assays are critical for the diagnosis of thrombotic thrombocytope
academic.oup.com
December 5, 2024 at 10:14 PM
Excited to share our recent study in which we assessed whether iodinated radiocontrast media (as might be given for a CT scan) interferes with ADAMTS13 activity via the gold standard FRET method - it doesn’t, though read the open access paper for caveats. academic.oup.com/ajcp/advance...
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare immune-mediated disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia, potentially causing life-threatening thrombosis.
Learn more in this Review. ja.ma/3H9b4tv
Learn more in this Review. ja.ma/3H9b4tv
August 12, 2025 at 3:20 PM
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare immune-mediated disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia, potentially causing life-threatening thrombosis.
Learn more in this Review. ja.ma/3H9b4tv
Learn more in this Review. ja.ma/3H9b4tv
🧪 Real-world study validates a new ADAMTS-13 assay: fast, reliable, and accurate for diagnosing and monitoring TTP. Strong performance at critical low activity levels makes it a valuable tool in clinical practice. #TTP #hematology #ADAMTS13 #labmedicine #MedSky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
May 22, 2025 at 2:05 PM
🧪 Real-world study validates a new ADAMTS-13 assay: fast, reliable, and accurate for diagnosing and monitoring TTP. Strong performance at critical low activity levels makes it a valuable tool in clinical practice. #TTP #hematology #ADAMTS13 #labmedicine #MedSky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
Prise en charge du purpura thrombotique thrombocytopénique congénital à l’ère de la protéine ADAMTS13 recombinante : recommandations du Centre de référence des microangiopathies thrombotiques (CNR-MAT)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Prise en charge du purpura thrombotique thrombocytopénique congénital à l’ère de la protéine ADAMTS13 recombinante : recommandations du Centre de référence des microangiopathies thrombotiques (CNR-MAT...
Thrombotic Thrombocytopenic Purpura (TTP) is a rare disease characterized by a severe deficiency of ADAMTS13, the specific protease that cleaves von W…
www.sciencedirect.com
February 5, 2025 at 7:02 AM
Prise en charge du purpura thrombotique thrombocytopénique congénital à l’ère de la protéine ADAMTS13 recombinante : recommandations du Centre de référence des microangiopathies thrombotiques (CNR-MAT)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
RTIs with S aureus or SARS-CoV-2 increase plasma VWF levels and decrease ADAMTS13 activity. buff.ly/sp9wvvW #hemesky #thrombosisandhemostasis #vascularbiology
April 1, 2025 at 2:02 PM
RTIs with S aureus or SARS-CoV-2 increase plasma VWF levels and decrease ADAMTS13 activity. buff.ly/sp9wvvW #hemesky #thrombosisandhemostasis #vascularbiology
Congratulations 👏👏 to @mimrobert.bsky.social for this very nice work 🗞
It seems worthy to look at anti-13 antibody during the follow-up of #iTTP . Maybe to guide anti-CD20 therapy ?
#Medsky
@amjh.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
It seems worthy to look at anti-13 antibody during the follow-up of #iTTP . Maybe to guide anti-CD20 therapy ?
#Medsky
@amjh.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
Anti‐ADAMTS13 Antibodies Trajectory is Associated With ADAMTS13 Recovery in Immune‐Mediated TTP
Anti-ADAMTS13 IgG antibodies titer trajectory from baseline to day 7–14 post-TPE as a reliable approach to identify iTTP patients at risk of late response to the triplet therapy regimen.
onlinelibrary.wiley.com
July 16, 2025 at 7:10 PM
Congratulations 👏👏 to @mimrobert.bsky.social for this very nice work 🗞
It seems worthy to look at anti-13 antibody during the follow-up of #iTTP . Maybe to guide anti-CD20 therapy ?
#Medsky
@amjh.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
It seems worthy to look at anti-13 antibody during the follow-up of #iTTP . Maybe to guide anti-CD20 therapy ?
#Medsky
@amjh.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
New Case Report from Éloïse Colliou and team demonstrate that administration of recombinant ADAMTS13 can treat congenital thrombotic thrombocytopenic purpura
Looking for more details? Check it out here www.rpthjournal.org/article/S247...
Looking for more details? Check it out here www.rpthjournal.org/article/S247...
www.rpthjournal.org
March 21, 2025 at 4:01 PM
New Case Report from Éloïse Colliou and team demonstrate that administration of recombinant ADAMTS13 can treat congenital thrombotic thrombocytopenic purpura
Looking for more details? Check it out here www.rpthjournal.org/article/S247...
Looking for more details? Check it out here www.rpthjournal.org/article/S247...
In #trauma-induced shock, a truncated and hyperactivated #ADAMTS13 circulates and is associated with #hyperfibrinolysis and #mortality
https://www.bjanaesthesia.org/article/S0007-0912(25)00582-3/fulltext
https://www.bjanaesthesia.org/article/S0007-0912(25)00582-3/fulltext
January 1, 2026 at 6:00 PM
In #trauma-induced shock, a truncated and hyperactivated #ADAMTS13 circulates and is associated with #hyperfibrinolysis and #mortality
https://www.bjanaesthesia.org/article/S0007-0912(25)00582-3/fulltext
https://www.bjanaesthesia.org/article/S0007-0912(25)00582-3/fulltext
5/1 Interaktion von Monozyten mit Blutplättchen fördert. Darüber hinaus fördert reduziertes ADAMTS13 bei Long-Covid-Patienten die Ansammlung ultragroßer vWF-Multimere, die die C3b-Bindung induzieren und den alternativen Weg der Komplementaktivierung stimulieren. Zusammen
January 31, 2025 at 12:37 PM
5/1 Interaktion von Monozyten mit Blutplättchen fördert. Darüber hinaus fördert reduziertes ADAMTS13 bei Long-Covid-Patienten die Ansammlung ultragroßer vWF-Multimere, die die C3b-Bindung induzieren und den alternativen Weg der Komplementaktivierung stimulieren. Zusammen
Preventing TTP relapse starts with the right monitoring.
In this clip from our webinar on TTP Diagnostics, we explore how early detection of ADAMTS13 activity changes can guide treatment and reduce risk of relapse.
🎥 Full webinar: youtu.be/Ol4wdCLZaok?...
#OnlyCells #TTP #Haematology #ADAMTS13
In this clip from our webinar on TTP Diagnostics, we explore how early detection of ADAMTS13 activity changes can guide treatment and reduce risk of relapse.
🎥 Full webinar: youtu.be/Ol4wdCLZaok?...
#OnlyCells #TTP #Haematology #ADAMTS13
May 21, 2025 at 12:28 PM
Preventing TTP relapse starts with the right monitoring.
In this clip from our webinar on TTP Diagnostics, we explore how early detection of ADAMTS13 activity changes can guide treatment and reduce risk of relapse.
🎥 Full webinar: youtu.be/Ol4wdCLZaok?...
#OnlyCells #TTP #Haematology #ADAMTS13
In this clip from our webinar on TTP Diagnostics, we explore how early detection of ADAMTS13 activity changes can guide treatment and reduce risk of relapse.
🎥 Full webinar: youtu.be/Ol4wdCLZaok?...
#OnlyCells #TTP #Haematology #ADAMTS13
Description: FDA is alerting patients, caregivers, & health care providers that Adzynma, a recombinant ADAMTS13 enzyme replacement therapy approved for cTTP, has been associated with the development of neutralizing antibodies (blocking antibodies) that can prevent the drug from working which can
September 24, 2026 at 5:00 AM
Description: FDA is alerting patients, caregivers, & health care providers that Adzynma, a recombinant ADAMTS13 enzyme replacement therapy approved for cTTP, has been associated with the development of neutralizing antibodies (blocking antibodies) that can prevent the drug from working which can
