🌟Facts about Lipodystrophies:
Congenital generalized lipodystrophy (CGL)
#CGL #Lipodystrophy #RareDiseases #MedicalEducation #GeneticDisorders #Endocrinology #MetabolicDisorders #AGPAT2 #BSCL2
Congenital generalized lipodystrophy (CGL)
#CGL #Lipodystrophy #RareDiseases #MedicalEducation #GeneticDisorders #Endocrinology #MetabolicDisorders #AGPAT2 #BSCL2
October 26, 2026 at 10:21 PM
🌟Facts about Lipodystrophies:
Congenital generalized lipodystrophy (CGL)
#CGL #Lipodystrophy #RareDiseases #MedicalEducation #GeneticDisorders #Endocrinology #MetabolicDisorders #AGPAT2 #BSCL2
Congenital generalized lipodystrophy (CGL)
#CGL #Lipodystrophy #RareDiseases #MedicalEducation #GeneticDisorders #Endocrinology #MetabolicDisorders #AGPAT2 #BSCL2
liver RNAseq in the CD model is fascinating
the G3P-ChREBP program turns on key genes for de novo lipogenesis including PKLR, ACLY, ACACA, FASN (directing synthesis of the fatty acids that will be linked to G3P & the enzymes like AGPAT2 that link them to G3P)
the G3P-ChREBP program turns on key genes for de novo lipogenesis including PKLR, ACLY, ACACA, FASN (directing synthesis of the fatty acids that will be linked to G3P & the enzymes like AGPAT2 that link them to G3P)
December 29, 2024 at 5:13 AM
liver RNAseq in the CD model is fascinating
the G3P-ChREBP program turns on key genes for de novo lipogenesis including PKLR, ACLY, ACACA, FASN (directing synthesis of the fatty acids that will be linked to G3P & the enzymes like AGPAT2 that link them to G3P)
the G3P-ChREBP program turns on key genes for de novo lipogenesis including PKLR, ACLY, ACACA, FASN (directing synthesis of the fatty acids that will be linked to G3P & the enzymes like AGPAT2 that link them to G3P)
The authors included RRIDs in their in iScience paper! RRIDs improve reproducibility in scientific research. #OpenResearch #OpenScience #reproducibility
The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis
Read the full paper: The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis
doi.org
April 25, 2026 at 7:00 AM
The authors included RRIDs in their in iScience paper! RRIDs improve reproducibility in scientific research. #OpenResearch #OpenScience #reproducibility
#RecentlyPublished AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
ift.tt/3r9FilB
ift.tt/3r9FilB
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December 5, 2024 at 3:08 AM
#RecentlyPublished AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
ift.tt/3r9FilB
ift.tt/3r9FilB
Two patients with congenital generalized lipodystrophy type 1 due to a variant in AGPAT2 (c.589-2A→G) who had been receiving insulin and metreleptin were switched to tirzepatide and were successfully weaned off other therapy. Read the full correspondence: nej.md/40Rznmz
#MedSky #EndoSky
#MedSky #EndoSky
Tirzepatide for Congenital Generalized Lipodystrophy | NEJM
Two patients with congenital generalized lipodystrophy type 1 due to a variant in
AGPAT2 (c.589-2A→G) who had been receiving insulin and metreleptin were switched to
tirzepatide and were successful...
nej.md
January 30, 2025 at 5:35 PM
Two patients with congenital generalized lipodystrophy type 1 due to a variant in AGPAT2 (c.589-2A→G) who had been receiving insulin and metreleptin were switched to tirzepatide and were successfully weaned off other therapy. Read the full correspondence: nej.md/40Rznmz
#MedSky #EndoSky
#MedSky #EndoSky
Gpat3 Knockout Attenuates Adipose Loss and Steatohepatitis in Agpat2-Deficient Mice
Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00069-6/fulltext
Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00069-6/fulltext
June 17, 2026 at 7:25 PM
Gpat3 Knockout Attenuates Adipose Loss and Steatohepatitis in Agpat2-Deficient Mice
Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00069-6/fulltext
Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00069-6/fulltext
#ArticleinPress: Gpat3 Knockout Attenuates Adipose Loss and Steatohepatitis in Agpat2-Deficient Mice
Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00069-6/fulltext
Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00069-6/fulltext
May 8, 2026 at 7:42 PM
#ArticleinPress: Gpat3 Knockout Attenuates Adipose Loss and Steatohepatitis in Agpat2-Deficient Mice
Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00069-6/fulltext
Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00069-6/fulltext
AGPAT2 acts at the crossroads of lipid biosynthesis and DRP1-mediated ER morphogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
AGPAT2 acts at the crossroads of lipid biosynthesis and DRP1-mediated ER morphogenesis - Nature Communications
The endoplasmic reticulum (ER) is the major site for lipid synthesis, yet the role of lipids in ER morphogenesis remains elusive. Here, Adachi et al. identify the ER-resident enzyme AGPAT2, which bind...
www.nature.com
December 12, 2025 at 4:34 PM
AGPAT2 acts at the crossroads of lipid biosynthesis and DRP1-mediated ER morphogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...