#ASCL1
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graycamplab.bsky.social
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
July 11, 2025 at 8:59 PM
drjnaidoo.bsky.social
Interesting paper identifies 3 subgrps of pulm carcinoid @jtoonline.bsky.social
- 3 subtypes by mRNA & 🇳🇱registry by IHC
- A1=OTP+/ASCL1+/HNF1A (53%)
- A2=OTP+/ASCL1/HNF1A+ (38%)
- B=OTP/ASCL1/HNF1A+ (9%)

Nxt step- assist tx selectn?
www.jto.org/article/S155...
#Oncsky #LCSM @oncoalert.bsky.social
www.jto.org
November 26, 2024 at 9:45 PM
devbiol.bsky.social
#DBfeature

Towards functional genetics in the European amphioxus: Efficient CRISPR/Cas9 editing reveals Ascl1/2.1 requirement for peripheral nervous system development

by Rafath Chowdhury, Agnès Roure, Sébastien Darras @rafathchowdhury.bsky.social
www.sciencedirect.com/science/arti...
CRISPR/Cas9 mediated mutagenesis of Bl-Ascl1/2.1 induces decrease of ESN in Branchiostoma lanceolatum
April 28, 2026 at 12:11 PM
robertazzarelli.bsky.social
Glad to share our review on Cell fate acquisition and reprogramming by ASCL1

Big shout out to Jethro Lundie-Brown, Francesca Puletti and Anna Philpott

Collaboration between @scicambridge.bsky.com @ucl.ac.uk @ucllifesciences.bsky.com School of Pharmacy

royalsocietypublishing.org/doi/10.1098/...
Cell fate acquisition and reprogramming by the proneural transcription factor ASCL1 | Open Biology
ASCL1 is a key member of the proneural basic helix-loop-helix (bHLH) transcription factor (TF) family and it plays diverse roles in nervous system development and maintenance. ASCL1 is also one of the...
royalsocietypublishing.org
June 19, 2025 at 6:16 PM
pmresearch-uhn.bsky.social
Circular RNA in aggressive tumours

Abundant circRMST molecules were found in aggressive prostate and lung cancers, interacting with transcription factors SOX2 & NKX2-1 to drive oncogene ASCL1 expression, reported by @pmresearch-uhn.bsky.social & @danafarber.bsky.social

www.cell.com/cancer-cell/...
April 17, 2025 at 3:48 PM
dev-journal.bsky.social
ASCL1 is a better chromatin remodeller when unphosphorylated

Read this Research Highlight showcasing work from Roberta Azzarelli (@robertazzarelli.bsky.social @ucllifesciences.bsky.social), Anna Philpott and colleagues:
https://journals.biologists.com/dev/article/151/24/e151_e2401/363434/
Figure 1 (C) Representative immunostaining images for Tubb3 (green) in ESCs in pluripotency, NE and MS after 48 h of WT or SA ASCL1 induction or in control cells. DAPI nuclear counterstain (blue). Scale bars: 100 μm.
December 17, 2024 at 4:29 PM
cp-molcell.bsky.social
Online Now: Distinct associations of pioneer factor Ascl1-E12a with nucleosomes drive changes in cell fate Online now:
Distinct associations of pioneer factor Ascl1-E12a with nucleosomes drive changes in cell fate
Zhou et al. reveal how the neural pioneer factor Ascl1-E12a engages nucleosomes through distinct interactions that together drive DNA unwrapping and repositioning. These mechanisms enable chromatin opening and efficient reprogramming to a neural fate, providing insight into how pioneer transcription factors overcome nucleosomal barriers to initiate cell fate transitions.
dlvr.it
June 12, 2026 at 11:33 AM
rafathchowdhury.bsky.social
Happy to share my last paper from my PhD work with the Deeva team! We establish new tools in European amphioxus: fertilized egg microinjection, F0 CRISPR/Cas9 mutagenesis & show Ascl1/2.1 is required for epidermal sensory neurons formation in amphioxus.
www.sciencedirect.com/science/arti...
Towards functional genetics in the European amphioxus: efficient CRISPR/Cas9 editing reveals Ascl1/2.1 requirement for peripheral nervous system development.
Amphioxus, or cephalochordates, have a key phylogenetic position among chordates and serve as pivotal invertebrate models for investigating the evolut…
www.sciencedirect.com
August 18, 2025 at 3:18 PM
cp-molcell.bsky.social
Distinct associations of pioneer factor Ascl1-E12a with nucleosomes drive changes in cell fate
Distinct associations of pioneer factor Ascl1-E12a with nucleosomes drive changes in cell fate
Zhou et al. reveal how the neural pioneer factor Ascl1-E12a engages nucleosomes through distinct interactions that together drive DNA unwrapping and repositioning. These mechanisms enable chromatin opening and efficient reprogramming to a neural fate, providing insight into how pioneer transcription factors overcome nucleosomal barriers to initiate cell fate transitions.
dlvr.it
July 4, 2026 at 3:19 PM
cp-cellreports.bsky.social
Retraction Notice to: ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
Retraction Notice to: ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
(Cell Reports 42, 112937; August 29, 2023)
dlvr.it
August 19, 2025 at 7:50 PM
dev-journal.bsky.social
Read the #OpenAccess Research Article 'Distinct proliferative and neuronal programmes of chromatin binding and gene activation by ASCL1 are cell cycle stage-specific' here:
journals.biologists.com/dev/article/...
Distinct proliferative and neuronal programmes of chromatin binding and gene activation by ASCL1 are cell cycle stage-specific
Highlighted Article: ASCL1 binds to distinct targets in different cell cycle phases, controlling the switch from division to differentiation in neuroblastic cells in response to G1 lengthening.
journals.biologists.com
June 30, 2025 at 9:47 AM
prelights.bsky.social
How do progenitor cells in the brain give rise to such a diverse range of cell types?

Jethro Lundie-Brown discusses a #preprint @sumrubayin.bsky.social showing that ASCL1 & FOXO1 work together to create inhibitory neurons from bipotent progenitors
#preLight⬇️
prelights.biologists.com/highlights/a...
A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum - preLights
How do progenitor cells in the brain give rise to such a diverse range of cell types? ASCL1 and FOXO1 work together to create inhibitory neurons from bipotent progenitors
prelights.biologists.com
May 16, 2025 at 10:19 AM
robertazzarelli.bsky.social
And the interview here 🫣

journals.biologists.com/dev/article/...
The people behind the papers – Roberta Azzarelli and Anna Philpott
ASCL1 is a pioneer factor that can reprogram somatic cells to produce neurons. Preventing ASCL1 from being phosphorylated appears to enhance its reprogramming abilities, but the reason for this is unc...
journals.biologists.com
December 12, 2024 at 7:26 PM
abireland.bsky.social
Delighted our new work is posted for the world to see! We discover the #basalcell as a likely #SCLC origin that unlocks plasticity towards all fates observed in human tumors—even the POU2F3+ state that has been so “tuft” to model and treat. Check it out! www.biorxiv.org/content/10.1...
Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer
Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine cancers, including small cell lun...
www.biorxiv.org
November 16, 2024 at 7:07 PM
prelights.bsky.social
ASCL1 can’t always make neurons alone…

In this 2‑minute #Short, jethrolb.bsky.social explains how chromatin priming and co‑factors shape cell fate decisions in embryonic stem cells. #StemCells #DevBio

www.youtube.com/shorts/UB2es...
spotLights Ep 20: Jethro on pioneer factors & neuronal lineage specification #science #biology
YouTube video by The Company of Biologists
www.youtube.com
May 21, 2026 at 11:22 AM
evodevo-papers.bsky.social
Towards functional genetics in the European amphioxus: Efficient CRISPR/Cas9 editing reveals Ascl1/2.1 requirement for peripheral nervous system development https://pubmed.ncbi.nlm.nih.gov/40825449/ #EvoDevo
September 11, 2025 at 1:00 PM
drwilliamhill.bsky.social
More data highlighting how cell of origin and lineage plasticity may alter lung cancer phenotype. Elegant story exploring basal cells in SCLC www.biorxiv.org/content/10.1...
Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer
Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine cancers, including small cell lun...
www.biorxiv.org
November 18, 2024 at 11:22 AM
biorxiv-biophys.bsky.social
PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1 https://www.biorxiv.org/content/10.64898/2026.05.11.724289v1
May 14, 2026 at 12:49 PM
biorxivpreprint.bsky.social
PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1 https://www.biorxiv.org/content/10.64898/2026.05.11.724289v1
May 14, 2026 at 12:49 PM
tbertalab.bsky.social
Proud to be part of this exciting study from our fantastic collaborator Prof. Chul-Kyu Park (Gachon University) about how the transcription factors Ascl1 and Lhx6 could help treat diabetic neuropathic pain by modulating GABAergic peripheral neurons. Link: pubmed.ncbi.nlm.nih.gov/39741412/
Modulation of Pain Sensitivity by Ascl1- and Lhx6-Dependent GABAergic Neuronal Function in Streptozotocin-Diabetic Mice - PubMed
Painful diabetic neuropathy commonly affects the peripheral nervous system in individuals with diabetes. However, the pathological processes and mechanisms underlying diabetic neuropathic pain remain ...
pubmed.ncbi.nlm.nih.gov
January 6, 2025 at 10:51 PM
biorxiv-neursci.bsky.social
Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells https://www.biorxiv.org/content/10.1101/2025.08.21.671552v1
August 25, 2025 at 3:15 PM
natcomms.nature.com
FOXA2, regulated by ASCL1, promotes multi-site metastasis in small cell lung cancer by inducing a fetal neuroendocrine gene expression program doi.org/10.1038/s414...
May 27, 2025 at 4:41 PM
sethblackshaw.bsky.social
Some of our favorite "universal" late-stage factors, such as Nfia/b/x and Notch pathway genes, don't do this in Ascl1+ progenitors. Many of factors involved in regionalization in posterior hypothalamus -- such as Irx3/5, Sim1 -- are selectively active in early Neurog2+ progenitors. Unclear why./20
January 12, 2025 at 4:10 PM
sethblackshaw.bsky.social
This also gives us an opportunity to see how temporal patterning is controlled across diverse progenitor subtypes. Comparing primary progenitors vs. neurogenic Ascl1+ and Neurog2+ progenitors we see some early-stage factors, such as Lin28b and Hmga1, which are also seen elsewhere in the CNS./19
January 12, 2025 at 4:04 PM
vhio.bsky.social
🔬 #NuageTherapeutics obtains €2.7M from @ageinves.bsky.social to develope NTX-A, a innovative therapy targeting the ASCL1-driven #LungCancer.
In partnership with 
@cniostopcancer.bsky.social, @embl.org and #VHIO.

➡️ https://linke.to/NuageTherapeuticsVHIO

@mmalumbres.bsky.social
December 3, 2025 at 11:03 AM