The November issue of JASN is now available online! Topics covered include:
- SGLT2i in a Mouse Model of ANCA-Associated Vasculitis
- Pregnancy and CKD Progression in ADPKD
- and more
kidney.pub/JASN-1126
#ASNJASN

#ASNJASN #Perspective: IgA vasculitis nephritis can range from mild urinary abnormalities to kidney failure, and current treatments often fail to prevent relapses. New therapies targeting B cells, APRIL/BLyS, and complement pathways may reshape care in the years ahead. kidney.pub/JASN1283

#ASNJASN: Kidney epithelial AKT links potassium homeostasis and metabolism. In mice, AKT loss caused potassium wasting and a shift toward ketone production while improving glucose tolerance and insulin sensitivity. #basicresearch kidney.pub/JASN1278

#ASNJASN: A kidney-protective immune cell? TREM2+ macrophages help limit diabetic kidney disease, with distinct resident and monocyte-derived populations playing unique roles. Loss of TREM2 impaired lipid clearance and worsened kidney injury. #BasicResearch #Nephrologyhttps://bit.ly/JASN1248//bit.ly/JASN1248" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">bit.ly/JASN1248

ADPKD is more than a cystic kidney disease. #Perspective in #ASNJASN highlights how metabolic and cardiovascular dysfunction may accelerate ADPKD progression, supporting a more holistic CKM approach to prevention, treatment, and patient care. #ADPKD kidney.pub/JASN1291 @cu-kidney.bsky.social

Published simultaneously with #KidneyWk, a #ASNJASN study found that in 2 phase 3 trials, upacicalcet significantly reduced intact parathyroid hormone levels vs placebo. Asymptomatic hypocalcemia was more frequent with upacicalcet, and symptomatic hypocalcemia was infrequent. kidney.pub/JASN1285

The 2026 #ASNJASN Trainee of the Year Award goes to Jianqing Liang, PhD, for her article “Tenascin C–Derived Peptide 6 Promotes De Novo Kidney Regeneration after Partial Nephrectomy in Axolotl,” which is freely available online until November 23. kidney.pub/JASN1066 #KidneyWk

One TAL, three cell types. Spatial transcriptomics revealed distinct TAL-α, TAL-β, and TAL-γ populations with unique molecular signatures and anatomical distributions, uncovering an unrecognized spatial architecture of the thick ascending limb in an #ASNJASN #researchletter. kidney.pub/JASN1290

New in #ASNJASN and simultaneously published with #KidneyWk: Study found empagliflozin 25 mg once daily for 12 months was safe & well-tolerated in adults with ADPKD at high risk for rapid progression. Those treated with empagliflozin had greater increase in kidney volume kidney.pub/JASN1271

Microplastics have been detected in human tissues, but what about patients on dialysis? Repeated exposure through dialysis circuits + reduced renal clearance may create vulnerability. A new #perspective outlines the unanswered questions and research priorities. kidney.pub/JASN1288 #ASNJASN

A #ASNJASN study published simultaneously with #KidneyWk found that mortality rates declined among patients initiating hemodialysis with a central venous catheter (CVC) over the past decade, with a reduction in absolute excess risk associated with continued CVC use. kidney.pub/JASN1293

What if we've been measuring the wrong outcomes? This #review in #ASNJASN highlights why dialysis innovation should focus less on surrogate targets and more on survival, symptoms, quality of life, equity, and value for patients. kidney.pub/JASN1286

As a 2026 top 5 #ASNJASN reviewer, Dr. Sandeep K. Mallipattu notes “Peer review is where scientific progress meets shared purpose. It’s an opportunity for the research community to challenge, refine, and strengthen one another’s work in service of knowledge we can trust.” #PRW2026

Why are some glomeruli more vulnerable than others? According to #basicresearch in #ASNJASN, Single-nucleus RNA-seq of 860K+ kidney nuclei identified juxtamedullary podocytes as hotspots of stress and senescence, showing location as key determinant of glomerular risk. kidney.pub/JASN1255

New #basicresearch in #ASNJASN suggests TSPO may drive CKD progression by disrupting mitochondrial metabolism. Blocking TSPO reduced kidney injury and fibrosis and improved cellular energy production in preclinical models, highlighting a potential new therapeutic target. kidney.pub/JASN1262

Could a routine urine test help track SGLT2 inhibitor use? In >45,000 patients, glucosuria after SGLT2 inhibitor initiation was associated with lower risks of death, heart failure hospitalization, and ESKD, suggesting it may be a simple marker of treatment exposure. #ASNJASN kidney.pub/JASN1252

We asked Volker Vallon, MD, FASN, one of the Top 5 #ASNJASN reviewers of 2026, for his thoughts on the benefits of peer review: “Peer review provides me with an opportunity to learn from my peers and provide them with critical and constructive feedback.” #PRW2026
@ucsdmedschool.bsky.social

This study in #ASNJASN provides evidence that iBox can be used fairly and accurately across racial groups, helping transplant teams make informed decisions while promoting more equitable post-transplant care. kidney.pub/JASN1247 @mannonmom.bsky.social

#Review in #ASNJASN: Human-based kidney models could improve drug safety testing, reduce animal use, and help researchers develop better treatments for kidney disease. kidney.pub/JASN1272 @azeloglu.bsky.social

Basic Research published in #ASNJASN identified a protein called ARL13B that helps drive cyst growth in PKD. In mice, blocking this protein reduced cyst growth and improved kidney health, suggesting it could be a possible target for future treatments. kidney.pub/JASN1238 @vansciver.bsky.social

Discussing peer review, Manuel Praga, MD, noted “the work of a reviewer for high-quality scientific journals like JASN is crucial for maintaining high standards of rigor, quality, originality, and independence. These values are even more essential today.” Top 5 #ASNJASN reviewer 2026. #PRW2026

#Perspective in #ASNJASN proposes supplementing eGFR-based kidney transplant referral with the Kidney Failure Risk Equation (KFRE) to better align referral timing with individual risk of kidney failure rather than a single laboratory threshold. kidney.pub/JASN1259

Authors of #ASNJASN #perspective propose a more individualized approach to treating severe hyponatremia, arguing that sodium correction rates should be tailored to patient-specific risks rather than governed by strict universal limits. kidney.pub/JASN1270 @sagarnigs.bsky.social

The October issue of JASN is now available online! Topics covered include:
- Neutrophil Extracellular Traps in Complement-Mediated TMA
- Medications Influencing Cystatin C Level
- and more
kidney.pub/JASN-1026
#ASNJASN

Could a novel CHAR T-cell therapy provide a targeted way to desensitize kidney transplant candidates with HLA-DQ antibodies? Read #BasicResearch #ASNJASN to find out. kidney.pub/JASN1244