Poorly differentiated GEP carcinomas should be treated as adenocarcinomas - Udhayvir Grewal
@ugrewalmd.bsky.social
oncodaily.com/opinion/udha...
#Cancer #CancerTreatment #CancerResearch #Adenocarcinomas #GIOncology #Medicine #Health #Oncology #OncoDaily
@ugrewalmd.bsky.social
oncodaily.com/opinion/udha...
#Cancer #CancerTreatment #CancerResearch #Adenocarcinomas #GIOncology #Medicine #Health #Oncology #OncoDaily
Udhayvir Grewal: Poorly differentiated GEP carcinomas should be treated as adenocarcinomas - OncoDaily
Udhayvir Grewal: Poorly differentiated GEP carcinomas should be treated as adenocarcinomas / adenocarcinomas, cancer, gastroenteropancreatic carcinoma, GEP
oncodaily.com
March 13, 2025 at 9:11 PM
Poorly differentiated GEP carcinomas should be treated as adenocarcinomas - Udhayvir Grewal
@ugrewalmd.bsky.social
oncodaily.com/opinion/udha...
#Cancer #CancerTreatment #CancerResearch #Adenocarcinomas #GIOncology #Medicine #Health #Oncology #OncoDaily
@ugrewalmd.bsky.social
oncodaily.com/opinion/udha...
#Cancer #CancerTreatment #CancerResearch #Adenocarcinomas #GIOncology #Medicine #Health #Oncology #OncoDaily
my happy place is visualizing Cheryl Hines being ravaged by cervical adenocarcinomas while a grisly goblin offers her alkaline water and contempt
February 27, 2025 at 6:37 AM
my happy place is visualizing Cheryl Hines being ravaged by cervical adenocarcinomas while a grisly goblin offers her alkaline water and contempt
📚 In Annals of Oncology, we investigated the 10% of lung adenocarcinomas with “mucinous histology”
examining the natural history, co-occurring DNA alterations, and outcomes to treatment
www.sciencedirect.com/science/arti...
🧵 Some highlights in our in our 🌎 🌍 multiCtr cohort:
#lcsm
examining the natural history, co-occurring DNA alterations, and outcomes to treatment
www.sciencedirect.com/science/arti...
🧵 Some highlights in our in our 🌎 🌍 multiCtr cohort:
#lcsm
January 14, 2025 at 3:27 PM
📚 In Annals of Oncology, we investigated the 10% of lung adenocarcinomas with “mucinous histology”
examining the natural history, co-occurring DNA alterations, and outcomes to treatment
www.sciencedirect.com/science/arti...
🧵 Some highlights in our in our 🌎 🌍 multiCtr cohort:
#lcsm
examining the natural history, co-occurring DNA alterations, and outcomes to treatment
www.sciencedirect.com/science/arti...
🧵 Some highlights in our in our 🌎 🌍 multiCtr cohort:
#lcsm
The OncoAlert 🚨Newsletter NOW OUT Covering September November 28-Dec 5, 2024
REGISTER AT www.OncoAlert360.com OR https://buff.ly/48Xpgz0
✅FDA Approves Duvalumab in #SCLC 🫁🇺🇸
✅FDA ACCELERATED APPROVAL TO
ZENOCUTUZUMAB-ZBCO IN #NSCLC 🫁
✅Lung adenocarcinomas with mucinous & more
REGISTER AT www.OncoAlert360.com OR https://buff.ly/48Xpgz0
✅FDA Approves Duvalumab in #SCLC 🫁🇺🇸
✅FDA ACCELERATED APPROVAL TO
ZENOCUTUZUMAB-ZBCO IN #NSCLC 🫁
✅Lung adenocarcinomas with mucinous & more
December 5, 2024 at 2:40 PM
The OncoAlert 🚨Newsletter NOW OUT Covering September November 28-Dec 5, 2024
REGISTER AT www.OncoAlert360.com OR https://buff.ly/48Xpgz0
✅FDA Approves Duvalumab in #SCLC 🫁🇺🇸
✅FDA ACCELERATED APPROVAL TO
ZENOCUTUZUMAB-ZBCO IN #NSCLC 🫁
✅Lung adenocarcinomas with mucinous & more
REGISTER AT www.OncoAlert360.com OR https://buff.ly/48Xpgz0
✅FDA Approves Duvalumab in #SCLC 🫁🇺🇸
✅FDA ACCELERATED APPROVAL TO
ZENOCUTUZUMAB-ZBCO IN #NSCLC 🫁
✅Lung adenocarcinomas with mucinous & more
Never-Smoker lung cancers are all adenocarcinomas, which is now the most dominant of the 4 sub-types globally.
Air pollution and unnecessary CT scans are causes.
Air pollution and unnecessary CT scans are causes.
February 4, 2025 at 5:05 AM
Never-Smoker lung cancers are all adenocarcinomas, which is now the most dominant of the 4 sub-types globally.
Air pollution and unnecessary CT scans are causes.
Air pollution and unnecessary CT scans are causes.
Nature research paper: Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma
go.nature.com/4oUHIPb
go.nature.com/4oUHIPb
Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma - Nature
Lung adenocarcinomas bearing the ID2 mutational signature display increased LINE-1 retrotransposon activity, which contributes to their fast evolutionary dynamics and aggressive phenotype.
go.nature.com
December 15, 2025 at 9:40 AM
Nature research paper: Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma
go.nature.com/4oUHIPb
go.nature.com/4oUHIPb
New open access review article in this month's Modern Pathology: Claudin-18.2 Immunohistochemical Evaluation in Gastric and Gastroesophageal Junction Adenocarcinomas to Direct Targeted Therapy: A Practical Approach
www.modernpathology.org/article/S089...
www.modernpathology.org/article/S089...
November 25, 2024 at 7:55 PM
New open access review article in this month's Modern Pathology: Claudin-18.2 Immunohistochemical Evaluation in Gastric and Gastroesophageal Junction Adenocarcinomas to Direct Targeted Therapy: A Practical Approach
www.modernpathology.org/article/S089...
www.modernpathology.org/article/S089...
MATTERHORN manuscript published today in the New England Journal of Medicine. #ASCO25 www.nejm.org/doi/full/10....
Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer | NEJM
Perioperative FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) is a standard therapy for resectable gastric and gastroesophageal junction adenocarcinomas, but recurrence rates remain hig...
www.nejm.org
June 1, 2025 at 8:29 PM
MATTERHORN manuscript published today in the New England Journal of Medicine. #ASCO25 www.nejm.org/doi/full/10....
As a nurse I despair at conspiracy theories about anybody hiding a Stage 4 cancer . It’s a rotten diagnosis and often patients have vague symptoms and pts and families are devastated by this worst possible scenario
Neuroendocrine prostatic cancer is a different kettle of fish to Adenocarcinomas .
Neuroendocrine prostatic cancer is a different kettle of fish to Adenocarcinomas .
May 19, 2025 at 2:23 AM
As a nurse I despair at conspiracy theories about anybody hiding a Stage 4 cancer . It’s a rotten diagnosis and often patients have vague symptoms and pts and families are devastated by this worst possible scenario
Neuroendocrine prostatic cancer is a different kettle of fish to Adenocarcinomas .
Neuroendocrine prostatic cancer is a different kettle of fish to Adenocarcinomas .
#OtrasBuenasNoticias
«El equipo del doctor Mariano Barbacid, con financiación de la Fundación Cris contra el Cáncer, ha logrado "la desaparición completa de adenocarcinomas ductales de páncreas en modelos animales"
¡El cáncer de páncreas más común!
«El equipo del doctor Mariano Barbacid, con financiación de la Fundación Cris contra el Cáncer, ha logrado "la desaparición completa de adenocarcinomas ductales de páncreas en modelos animales"
¡El cáncer de páncreas más común!
El científico Mariano Barbacid logra eliminar el cáncer de páncreas más común en modelos animales
El científico Mariano Barbacid logra eliminar el cáncer de páncreas más común en modelos animales
Es "la primera vez que se logra una curación completa" en modelos experimentales
dozz.es
January 28, 2026 at 6:45 AM
#OtrasBuenasNoticias
«El equipo del doctor Mariano Barbacid, con financiación de la Fundación Cris contra el Cáncer, ha logrado "la desaparición completa de adenocarcinomas ductales de páncreas en modelos animales"
¡El cáncer de páncreas más común!
«El equipo del doctor Mariano Barbacid, con financiación de la Fundación Cris contra el Cáncer, ha logrado "la desaparición completa de adenocarcinomas ductales de páncreas en modelos animales"
¡El cáncer de páncreas más común!
Que no te pase nada no quiere decir que no haya gluten. Soy celíaco asintomático, rara vez me sienta algo mal y no creo que sea por el gluten. Pero si mi cuerpo batalla contra el gluten eso se traducirá en pérdida de vellosidades, pólipos, linfomas, adenocarcinomas...
January 21, 2026 at 10:01 AM
Que no te pase nada no quiere decir que no haya gluten. Soy celíaco asintomático, rara vez me sienta algo mal y no creo que sea por el gluten. Pero si mi cuerpo batalla contra el gluten eso se traducirá en pérdida de vellosidades, pólipos, linfomas, adenocarcinomas...
From @nabalabuic.bsky.social
In-depth proteomic profiling of the extracellular matrix of pancreatic ductal adenocarcinomas identifies signatures correlating with lymphocyte infiltration
www.biorxiv.org/content/10.1...
In-depth proteomic profiling of the extracellular matrix of pancreatic ductal adenocarcinomas identifies signatures correlating with lymphocyte infiltration
www.biorxiv.org/content/10.1...
In-depth proteomic profiling of the extracellular matrix of pancreatic ductal adenocarcinomas identifies signatures correlating with lymphocyte infiltration
The extracellular matrix (ECM) is a complex assembly of proteins surrounding cells. It is a critical component of the tumor microenvironment that plays an active role in tumor progression and modulati...
www.biorxiv.org
September 3, 2025 at 6:58 AM
From @nabalabuic.bsky.social
In-depth proteomic profiling of the extracellular matrix of pancreatic ductal adenocarcinomas identifies signatures correlating with lymphocyte infiltration
www.biorxiv.org/content/10.1...
In-depth proteomic profiling of the extracellular matrix of pancreatic ductal adenocarcinomas identifies signatures correlating with lymphocyte infiltration
www.biorxiv.org/content/10.1...
#Medsky🧪 #oncosky #pharmasky #drugdevelopment #publichealth HER2 receptors are overexpressed in a range of solid malignant tumours that often have poor survival rates, incl GI cancers, gastric/gastroesophageal adenocarcinomas , biliary tract cancer & #breastcancer . Inhibiting the HER2 pathway
April 27, 2025 at 3:59 AM
#Medsky🧪 #oncosky #pharmasky #drugdevelopment #publichealth HER2 receptors are overexpressed in a range of solid malignant tumours that often have poor survival rates, incl GI cancers, gastric/gastroesophageal adenocarcinomas , biliary tract cancer & #breastcancer . Inhibiting the HER2 pathway
key line from study: "Approximately half of adenocarcinomas have an actionable alteration for which US Food and Drug Administration (FDA)–approved therapy became available within the past 2 decades."
The speed and scope of new therapies is amazing. I take a genetic drug every day.
The speed and scope of new therapies is amazing. I take a genetic drug every day.
May 18, 2026 at 1:04 PM
key line from study: "Approximately half of adenocarcinomas have an actionable alteration for which US Food and Drug Administration (FDA)–approved therapy became available within the past 2 decades."
The speed and scope of new therapies is amazing. I take a genetic drug every day.
The speed and scope of new therapies is amazing. I take a genetic drug every day.
Is this mRNA pancreatic cancer vaccine for primarily adenocarcinomas, or P-Nets?
February 21, 2025 at 10:27 PM
Is this mRNA pancreatic cancer vaccine for primarily adenocarcinomas, or P-Nets?
Exacto. Los adenocarcinomas de mama de en torno a los 50 se suelen detectar mejor con mamografía. Los de la mujer joven se ven mejor con eco, pero en caso de imposibilidad de hacer mano, la eco es bastante aceptable. Y la RMN la hostia.
July 11, 2025 at 10:30 PM
Exacto. Los adenocarcinomas de mama de en torno a los 50 se suelen detectar mejor con mamografía. Los de la mujer joven se ven mejor con eco, pero en caso de imposibilidad de hacer mano, la eco es bastante aceptable. Y la RMN la hostia.
Marty Makary has been involved in exactly one clinical trial relevant to the charge of FDA. He was one of 36 authors. (see below)
Vinay Prasad has never led or coauthored an RCT.
Neither has Tracy Hoeg.
This is the team leading the FDA.
What could go wrong?
aacrjournals.org/clincancerre...
Vinay Prasad has never led or coauthored an RCT.
Neither has Tracy Hoeg.
This is the team leading the FDA.
What could go wrong?
aacrjournals.org/clincancerre...
Vaccine-Induced Intratumoral Lymphoid Aggregates Correlate with Survival Following Treatment with a Neoadjuvant and Adjuvant Vaccine in Patients with Resectable Pancreatic Adenocarcinoma
AbstractPurpose:. Immunotherapy is currently ineffective for nearly all pancreatic ductal adenocarcinomas (PDAC), largely due to its tumor microenvironment (TME) that lacks antigen-experienced T effec...
aacrjournals.org
May 6, 2025 at 8:36 PM
Marty Makary has been involved in exactly one clinical trial relevant to the charge of FDA. He was one of 36 authors. (see below)
Vinay Prasad has never led or coauthored an RCT.
Neither has Tracy Hoeg.
This is the team leading the FDA.
What could go wrong?
aacrjournals.org/clincancerre...
Vinay Prasad has never led or coauthored an RCT.
Neither has Tracy Hoeg.
This is the team leading the FDA.
What could go wrong?
aacrjournals.org/clincancerre...
Lung cancers can use two different mechanisms to evade KRAS-inhibiting #drugs
Some tumor cells develop resistance by amplifying the #KRAS gene, while others change their tumor type, #MIT researchers have found
#Cancer #Genetics #Health #Science
Some tumor cells develop resistance by amplifying the #KRAS gene, while others change their tumor type, #MIT researchers have found
#Cancer #Genetics #Health #Science
Lung cancers can use two different mechanisms to evade KRAS-inhibiting drugs
MIT researchers identified a way that lung tumor cells become resistant to drugs called KRAS inhibitors, which are often used to treat lung adenocarcinomas. The findings could help scientists discover...
news.mit.edu
October 3, 2026 at 7:45 PM
We are happy to present a new paper on gastric tumour evolution in response to peri-operative chemotherapy. www.biorxiv.org/content/10.1... 🧵 1/6
Tumor clone dynamics in gastro-esophageal cancer organoids reveal a non-genetic memory of neoadjuvant chemotherapy via downregulation of NFκB signaling
Adenocarcinomas of the gastroesophageal junction exhibit genetic and non-genetic heterogeneity that impact clinical outcomes, though the underlying mechanisms behind drug resistance remain poorly unde...
www.biorxiv.org
July 31, 2025 at 6:28 AM
We are happy to present a new paper on gastric tumour evolution in response to peri-operative chemotherapy. www.biorxiv.org/content/10.1... 🧵 1/6
AIS - adenocarcinoma in situ
MIA - minimally invasive adenocarcinoma
Note that not all adenocarcinomas are your textbook spiculated or lobulated mass. Some invasive mucinous and lepidic subtype adenocarcinomas can mimic consolidation - and can have air bronchograms!
MIA - minimally invasive adenocarcinoma
Note that not all adenocarcinomas are your textbook spiculated or lobulated mass. Some invasive mucinous and lepidic subtype adenocarcinomas can mimic consolidation - and can have air bronchograms!
November 25, 2024 at 11:42 PM
AIS - adenocarcinoma in situ
MIA - minimally invasive adenocarcinoma
Note that not all adenocarcinomas are your textbook spiculated or lobulated mass. Some invasive mucinous and lepidic subtype adenocarcinomas can mimic consolidation - and can have air bronchograms!
MIA - minimally invasive adenocarcinoma
Note that not all adenocarcinomas are your textbook spiculated or lobulated mass. Some invasive mucinous and lepidic subtype adenocarcinomas can mimic consolidation - and can have air bronchograms!
new out in Nature this week www.nature.com/articles/s41...
Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma - Nature
Lung adenocarcinomas bearing the ID2 mutational signature display increased LINE-1 retrotransposon activity, which contributes to their fast evolutionary dynamics and aggressive phenotype.
www.nature.com
December 13, 2025 at 11:15 AM
new out in Nature this week www.nature.com/articles/s41...
FDA approves first HER2 × HER3 bispecific antibody tinyurl.com/2nart3rs
The FDA has granted accelerated approval to Merus’s zenocutuzumab (Bizengri) for pancreatic adenocarcinomas and non-small-cell lung cancers carrying NRG1 gene fusions
The FDA has granted accelerated approval to Merus’s zenocutuzumab (Bizengri) for pancreatic adenocarcinomas and non-small-cell lung cancers carrying NRG1 gene fusions
December 19, 2024 at 4:46 PM
FDA approves first HER2 × HER3 bispecific antibody tinyurl.com/2nart3rs
The FDA has granted accelerated approval to Merus’s zenocutuzumab (Bizengri) for pancreatic adenocarcinomas and non-small-cell lung cancers carrying NRG1 gene fusions
The FDA has granted accelerated approval to Merus’s zenocutuzumab (Bizengri) for pancreatic adenocarcinomas and non-small-cell lung cancers carrying NRG1 gene fusions
👏El doctor Barbacid está a punto de lograr los 3,5 millones de euros que necesita para la lucha contra el cáncer de páncreas en humanos ver.20m.es/21hbz1
El doctor Barbacid está a punto de lograr los 3,5 millones de euros que necesita para la lucha contra el cáncer de páncreas en humanos
El científico e investigador logró la desaparición completa de adenocarcinomas ductales de páncreas en ratones y ahora busca financiación para lograr hacerlo en pacientes humanos.
ver.20m.es
February 10, 2026 at 6:09 PM
👏El doctor Barbacid está a punto de lograr los 3,5 millones de euros que necesita para la lucha contra el cáncer de páncreas en humanos ver.20m.es/21hbz1