do yall fw the sonic characters being 2-3 ft or do we like 4-5 ft better as the average ;riehjdri;agrp;k
September 27, 2026 at 5:53 AM
do yall fw the sonic characters being 2-3 ft or do we like 4-5 ft better as the average ;riehjdri;agrp;k
Excited to share work led by my PhD student Hayley McMorrow now published in @jclinical-invest.bsky.social. Hayley showed that GIP and GLP-1 receptor agonists rapidly inhibit AgRP neurons and that endogenous GIP is important for nutrient-mediated AgRP neuron inhibition. doi.org/10.1172/JCI1...
JCI -
Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice
doi.org
August 30, 2025 at 5:05 PM
Excited to share work led by my PhD student Hayley McMorrow now published in @jclinical-invest.bsky.social. Hayley showed that GIP and GLP-1 receptor agonists rapidly inhibit AgRP neurons and that endogenous GIP is important for nutrient-mediated AgRP neuron inhibition. doi.org/10.1172/JCI1...
Happy to share our preprint! We show that hypothalamic hunger-promoting AgRP neurons reflect proximity to food across different mazes in hungry mice. After mice discover food, AgRP activity decreases as they approach the food and increases as they move away.
Hunger neurons track available food locations during foraging and spatial memory recall https://www.biorxiv.org/content/10.64898/2026.07.28.741066v1
August 4, 2026 at 1:08 AM
Happy to share our preprint! We show that hypothalamic hunger-promoting AgRP neurons reflect proximity to food across different mazes in hungry mice. After mice discover food, AgRP activity decreases as they approach the food and increases as they move away.
I’m excited to share my latest paper
@cp-cellmetabolism.bsky.social. HakanK and I recorded from AgRP neurons continuously for 1 month and found some exciting things during ad lib feeding, fasting and on circadian timescales www.cell.com/cell-metabol....
@cp-cellmetabolism.bsky.social. HakanK and I recorded from AgRP neurons continuously for 1 month and found some exciting things during ad lib feeding, fasting and on circadian timescales www.cell.com/cell-metabol....
Acute and circadian feedforward regulation of agouti-related peptide hunger neurons
Douglass et al. employ long-term, continuous fiber photometry to uncover new modes of agouti-related peptide (AgRP) neuron regulation in ad libitum, fasted, and circadian conditions. AgRP neuron activity exhibits a circadian rhythm, which controls daily feeding patterns through a neural circuit from the suprachiasmatic nucleus via the dorsomedial hypothalamus.
www.cell.com
January 2, 2025 at 3:41 PM
I’m excited to share my latest paper
@cp-cellmetabolism.bsky.social. HakanK and I recorded from AgRP neurons continuously for 1 month and found some exciting things during ad lib feeding, fasting and on circadian timescales www.cell.com/cell-metabol....
@cp-cellmetabolism.bsky.social. HakanK and I recorded from AgRP neurons continuously for 1 month and found some exciting things during ad lib feeding, fasting and on circadian timescales www.cell.com/cell-metabol....
Nice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata. www.nytimes.com/2025/04/26/h...
What Nearly Brainless Rodents Know About Weight Loss and Hunger
www.nytimes.com
April 26, 2025 at 3:21 PM
Nice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata. www.nytimes.com/2025/04/26/h...
Our latest study
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
Brain sensing of metabolic state regulates circulating monocytes
Brain-initiated hunger signals control circulating monocyte dynamics.
www.science.org
April 7, 2025 at 2:33 PM
Our latest study
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
#BrainFunction #Diabetes
neurosciencenews.com/agrp-diabete...
#SharedFacts from #HealthScience #CellularReality
neurosciencenews.com/agrp-diabete...
#SharedFacts from #HealthScience #CellularReality
Surprising Diabetes Fix Found in the Brain - Neuroscience News
New research reveals that hyperactivity in a specific set of brain cells, AgRP neurons in the hypothalamus, plays a key role in type 2 diabetes—independent of obesity.
neurosciencenews.com
May 16, 2025 at 2:04 PM
The shift from parenting to foraging can be mimicked by stimulating AgRP neurons (with light!) that talk to the medial preoptic area (MPOA). AgRP neurons are inhibitory, so this suggests that there might be MPOA neurons that control both parenting and satiety downstream of AgRP.
July 30, 2025 at 4:35 PM
The shift from parenting to foraging can be mimicked by stimulating AgRP neurons (with light!) that talk to the medial preoptic area (MPOA). AgRP neurons are inhibitory, so this suggests that there might be MPOA neurons that control both parenting and satiety downstream of AgRP.
Congratulations to
@amdouglass.bsky.social and to the whole team, great work!...and glad to see our main findings were confirmed.
"Acute and circadian feedforward regulation of agouti-related peptide hunger neurons"
www.cell.com/cell-metabol...
@amdouglass.bsky.social and to the whole team, great work!...and glad to see our main findings were confirmed.
"Acute and circadian feedforward regulation of agouti-related peptide hunger neurons"
www.cell.com/cell-metabol...
Acute and circadian feedforward regulation of agouti-related peptide hunger neurons
Douglass et al. employ long-term, continuous fiber photometry to uncover new modes of agouti-related peptide (AgRP) neuron regulation in ad libitum, fasted, and circadian conditions. AgRP neuron activity exhibits a circadian rhythm, which controls daily feeding patterns through a neural circuit from the suprachiasmatic nucleus via the dorsomedial hypothalamus.
www.cell.com
December 23, 2024 at 5:24 PM
Congratulations to
@amdouglass.bsky.social and to the whole team, great work!...and glad to see our main findings were confirmed.
"Acute and circadian feedforward regulation of agouti-related peptide hunger neurons"
www.cell.com/cell-metabol...
@amdouglass.bsky.social and to the whole team, great work!...and glad to see our main findings were confirmed.
"Acute and circadian feedforward regulation of agouti-related peptide hunger neurons"
www.cell.com/cell-metabol...
Check out how the AgRP activity (green) is correlated with distance to food (magenta)!
August 4, 2026 at 1:10 AM
Check out how the AgRP activity (green) is correlated with distance to food (magenta)!
By identifying murine Agrp neurons as a target of LacPhe, the authors suggest this exercise-induced metabolite might have therapeutic benefits in various human diseases. www.nature.com/articles/s42...
Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice - Nature Metabolism
This study reveals neuronal targets of Lac-Phe in the hypothalamus that mediate its suppression of food intake.
www.nature.com
September 16, 2025 at 11:52 AM
By identifying murine Agrp neurons as a target of LacPhe, the authors suggest this exercise-induced metabolite might have therapeutic benefits in various human diseases. www.nature.com/articles/s42...
Successfully treating type 2 diabetes may involve focusing on brain neurons, rather than simply concentrating on obesity or insulin resistance, according to a study published today in the Journal of Clinical Investigation.neurons located in the hypothalamus, (AgRP) , is common in mice with diabetes.
May 26, 2025 at 3:19 PM
Successfully treating type 2 diabetes may involve focusing on brain neurons, rather than simply concentrating on obesity or insulin resistance, according to a study published today in the Journal of Clinical Investigation.neurons located in the hypothalamus, (AgRP) , is common in mice with diabetes.
MC4R regulates #BodyWeight at hypothalamic neuronal #cilia, but its levels are normally v low. @nachury.bsky.social &co show that MC4R accumulation is prevented via continuous ubiquitin- & β-arrestin-dependent exit from cilia, unless MC4R is inhibited by AgRP 🧪 @plosbiology.org plos.io/40MWUUz
![Top: MRAP2 facilitates the import of MC4R into cilia. Representative images of IMCD3-[MC4R3NG] (top row) or IMCD3-[MRAP23FLAG;MC4R3NG] (bottom row). Serum-starved cells were treated for 24 h with either HS014, AgRP, or vehicle, then fixed and stained for acetylated tubulin (acTub, magenta) and DNA (cyan). MC4R3NG was visualized through the intrinsic fluorescence of NG (yellow). The yellow and magenta channels are shifted to facilitate visualization of ciliary signals in the insets. Scale bars: 5 μm (main panel) and 1 μm (inset). Bottom: General and MC4R-specific models of regulated trafficking. Most ciliary GPCRs undergo exit once activated by their agonist. In the case of MC4R, exit is spontaneous in the absence of ligand and only in the presence of an inverse agonist does MC4R exit become interrupted. In both models, β-arrestin senses the activated state of the GPCR (agonist bound for most GPCRs, ligand free or agonist-bound for MC4R) and recruits the ubiquitination machinery to the activated GPCR. Unique to MC4R is that the receptor constitutively couples to β-arrestin. Once ubiquitinated, ciliary GPCRs are committed for retrieval back into the cell via TOM1L2 (dark purple) which endows the BBSome (pink) with the ability to recognize ubiquitin chains and move ubiquitinated proteins out of cilia.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreie3fepqrfc4e5tmfeb2jwquezqlsg5gosrgqe2qlaycqyxs5gntfu)
February 5, 2025 at 9:47 AM
MC4R regulates #BodyWeight at hypothalamic neuronal #cilia, but its levels are normally v low. @nachury.bsky.social &co show that MC4R accumulation is prevented via continuous ubiquitin- & β-arrestin-dependent exit from cilia, unless MC4R is inhibited by AgRP 🧪 @plosbiology.org plos.io/40MWUUz
The work builds off of an amazing result from Amber Alhadeff--
paper: www.cell.com/cell/fulltex...
essay: www.science.org/doi/full/10....
when mice are food-deprived, AgRP neurons projecting to parabrachial nucleus start releasing neuropeptide Y, and this mechanism suppresses pain-coping behavior.
paper: www.cell.com/cell/fulltex...
essay: www.science.org/doi/full/10....
when mice are food-deprived, AgRP neurons projecting to parabrachial nucleus start releasing neuropeptide Y, and this mechanism suppresses pain-coping behavior.
A Neural Circuit for the Suppression of Pain by a Competing Need State
Hunger suppresses responses to pain through an AgRP/NPY circuit.
www.cell.com
October 9, 2025 at 1:15 PM
The work builds off of an amazing result from Amber Alhadeff--
paper: www.cell.com/cell/fulltex...
essay: www.science.org/doi/full/10....
when mice are food-deprived, AgRP neurons projecting to parabrachial nucleus start releasing neuropeptide Y, and this mechanism suppresses pain-coping behavior.
paper: www.cell.com/cell/fulltex...
essay: www.science.org/doi/full/10....
when mice are food-deprived, AgRP neurons projecting to parabrachial nucleus start releasing neuropeptide Y, and this mechanism suppresses pain-coping behavior.
MC4R regulates #BodyWeight at hypothalamic neuronal #cilia, but its levels are normally v low. @nachury.bsky.social &co show that MC4R accumulation is prevented via continuous ubiquitin- & β-arrestin-dependent exit from cilia, unless MC4R is inhibited by AgRP 🧪 @plosbiology.org plos.io/40MWUUz
February 4, 2025 at 1:38 PM
MC4R regulates #BodyWeight at hypothalamic neuronal #cilia, but its levels are normally v low. @nachury.bsky.social &co show that MC4R accumulation is prevented via continuous ubiquitin- & β-arrestin-dependent exit from cilia, unless MC4R is inhibited by AgRP 🧪 @plosbiology.org plos.io/40MWUUz
🚨 New ⏰ 🔬 by Douglass et al show agouti-related peptide 🧠 (AgRP) hunger neurons follow a daily rhythm, regulating feeding patterns via a neural pathway connecting the SCN to the DMH 🍽️ 👉 www.sciencedirect.com/science/arti...
#Neuroscience #Physiology #Circadian
#Neuroscience #Physiology #Circadian
Acute and circadian feedforward regulation of agouti-related peptide hunger neurons
When food is freely available, eating occurs without energy deficit. While agouti-related peptide (AgRP) neurons are likely involved, their activation…
www.sciencedirect.com
December 25, 2024 at 4:28 PM
🚨 New ⏰ 🔬 by Douglass et al show agouti-related peptide 🧠 (AgRP) hunger neurons follow a daily rhythm, regulating feeding patterns via a neural pathway connecting the SCN to the DMH 🍽️ 👉 www.sciencedirect.com/science/arti...
#Neuroscience #Physiology #Circadian
#Neuroscience #Physiology #Circadian
AgRP Neuronal Suppression by Spontaneous Movement Encodes Exercise Reinforcement https://www.biorxiv.org/content/10.1101/2025.08.06.668910v1
August 9, 2025 at 11:15 PM
AgRP Neuronal Suppression by Spontaneous Movement Encodes Exercise Reinforcement https://www.biorxiv.org/content/10.1101/2025.08.06.668910v1
We then over-expressed Agouti in the MPOA of tolerant males and found that they became infanticidal! So what was Agouti doing? Inspired by work on a related peptide, AgRP, and a known connection between Agouti and obesity, we sought to determine if Agouti levels were tied to food availability. (6/8)
February 18, 2026 at 5:05 PM
We then over-expressed Agouti in the MPOA of tolerant males and found that they became infanticidal! So what was Agouti doing? Inspired by work on a related peptide, AgRP, and a known connection between Agouti and obesity, we sought to determine if Agouti levels were tied to food availability. (6/8)
AgRP Neuron Activity Predicts and Tracks the Glycemic Response to Oral Glucose https://www.biorxiv.org/content/10.64898/2026.04.01.715678v1
April 3, 2026 at 8:16 PM
AgRP Neuron Activity Predicts and Tracks the Glycemic Response to Oral Glucose https://www.biorxiv.org/content/10.64898/2026.04.01.715678v1
New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5
Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety
Nature Metabolism - Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.
rdcu.be
December 3, 2024 at 1:40 PM
New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5
🧠🍽️ "AgRP neurons integrate time-of-day information of past feeding experience with current metabolic needs to predict circadian feeding time"
🔗 www.nature.com/articles/s41...
#neuroskyence #feedingbehavior
🔗 www.nature.com/articles/s41...
#neuroskyence #feedingbehavior
AgRP neurons encode circadian feeding time - Nature Neuroscience
Sayar-Atasoy et al. monitored the activity of hypothalamic AgRP hunger neurons throughout the day and showed that these neurons anticipate meal time by integrating information about past circadian fee...
www.nature.com
November 15, 2023 at 2:39 PM
🧠🍽️ "AgRP neurons integrate time-of-day information of past feeding experience with current metabolic needs to predict circadian feeding time"
🔗 www.nature.com/articles/s41...
#neuroskyence #feedingbehavior
🔗 www.nature.com/articles/s41...
#neuroskyence #feedingbehavior
MC4R regulates #BodyWeight at hypothalamic neuronal #cilia, but its levels are normally v low. @nachury.bsky.social &co show that MC4R accumulation is prevented via continuous ubiquitin- & β-arrestin-dependent exit from cilia, unless MC4R is inhibited by AgRP 🧪 @plosbiology.org plos.io/40MWUUz
February 4, 2025 at 7:15 PM
MC4R regulates #BodyWeight at hypothalamic neuronal #cilia, but its levels are normally v low. @nachury.bsky.social &co show that MC4R accumulation is prevented via continuous ubiquitin- & β-arrestin-dependent exit from cilia, unless MC4R is inhibited by AgRP 🧪 @plosbiology.org plos.io/40MWUUz
Very cool new work by Jonny Kohl's lab on how hunger promotes infanticide dependent on the estrus cycle in mice.
When hungry, Agrp neurons in the hypothalamus arcuate release NPY onto the medial preoptic area, promoting an infanticide aggressive state
www.biorxiv.org/content/10.1...
When hungry, Agrp neurons in the hypothalamus arcuate release NPY onto the medial preoptic area, promoting an infanticide aggressive state
www.biorxiv.org/content/10.1...
December 6, 2024 at 2:29 PM
Very cool new work by Jonny Kohl's lab on how hunger promotes infanticide dependent on the estrus cycle in mice.
When hungry, Agrp neurons in the hypothalamus arcuate release NPY onto the medial preoptic area, promoting an infanticide aggressive state
www.biorxiv.org/content/10.1...
When hungry, Agrp neurons in the hypothalamus arcuate release NPY onto the medial preoptic area, promoting an infanticide aggressive state
www.biorxiv.org/content/10.1...
Hypothalamic GHSR neurons integrate an interoceptive state of energy need with external information to optimize changes in AgRP activity.
Ghrelin signaling is more than a feedback signal to increase AgRP activity.
So et al. #neuroskyence #interoception
www.sciencedirect.com/science/arti...
Ghrelin signaling is more than a feedback signal to increase AgRP activity.
So et al. #neuroskyence #interoception
www.sciencedirect.com/science/arti...
Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural ac...
The sensory detection of food and food cues suppresses Agouti related peptide (AgRP) neuronal activity prior to consumption with greatest suppression …
www.sciencedirect.com
October 27, 2023 at 1:52 PM
Hypothalamic GHSR neurons integrate an interoceptive state of energy need with external information to optimize changes in AgRP activity.
Ghrelin signaling is more than a feedback signal to increase AgRP activity.
So et al. #neuroskyence #interoception
www.sciencedirect.com/science/arti...
Ghrelin signaling is more than a feedback signal to increase AgRP activity.
So et al. #neuroskyence #interoception
www.sciencedirect.com/science/arti...