👉 Out now @NatureRevGenet: we CAN and we SHOULD do more to enable #genomic data sharing! 🧬🌏
👉Best practice examples and 12 actions we can all take together
👉 https://rdcu.be/dWfsu
@GA4GH @AusGenomics @GenomicsEngland @NHSgms @AllofUsResearch @uk_biobank @ukfuturehealth
👉Best practice examples and 12 actions we can all take together
👉 https://rdcu.be/dWfsu
@GA4GH @AusGenomics @GenomicsEngland @NHSgms @AllofUsResearch @uk_biobank @ukfuturehealth
December 20, 2024 at 11:03 AM
👉 Out now @NatureRevGenet: we CAN and we SHOULD do more to enable #genomic data sharing! 🧬🌏
👉Best practice examples and 12 actions we can all take together
👉 https://rdcu.be/dWfsu
@GA4GH @AusGenomics @GenomicsEngland @NHSgms @AllofUsResearch @uk_biobank @ukfuturehealth
👉Best practice examples and 12 actions we can all take together
👉 https://rdcu.be/dWfsu
@GA4GH @AusGenomics @GenomicsEngland @NHSgms @AllofUsResearch @uk_biobank @ukfuturehealth
www.biorxiv.org/content/10.1...
📄 New preprint alert! 📄
@helenyslin.bsky.social benchmarked polygenic scores (PGS) using genotyping arrays vs whole-genome sequencing (WGS) across traits & populations in @AllofUsResearch. What’s the best approach? The answer is… it depends! 🧵⬇️
📄 New preprint alert! 📄
@helenyslin.bsky.social benchmarked polygenic scores (PGS) using genotyping arrays vs whole-genome sequencing (WGS) across traits & populations in @AllofUsResearch. What’s the best approach? The answer is… it depends! 🧵⬇️
Differential performance of polygenic prediction across traits and populations depending on genotype discovery approach
Polygenic scores (PGS) are widely used for estimating genetic predisposition to complex traits by aggregating the effects of common variants into a single measure. They hold promise in identifying ind...
www.biorxiv.org
March 20, 2025 at 2:53 PM
www.biorxiv.org/content/10.1...
📄 New preprint alert! 📄
@helenyslin.bsky.social benchmarked polygenic scores (PGS) using genotyping arrays vs whole-genome sequencing (WGS) across traits & populations in @AllofUsResearch. What’s the best approach? The answer is… it depends! 🧵⬇️
📄 New preprint alert! 📄
@helenyslin.bsky.social benchmarked polygenic scores (PGS) using genotyping arrays vs whole-genome sequencing (WGS) across traits & populations in @AllofUsResearch. What’s the best approach? The answer is… it depends! 🧵⬇️
Several of us #PatientsUseAI folks are super tickled by the idea of #OurNotes!
cc @gracecordovano.bsky.social @hugooc.bsky.social , @kosherfrog.bsky.social
cc @gracecordovano.bsky.social @hugooc.bsky.social , @kosherfrog.bsky.social
Hugo Campos (@hugooc.bsky.social)
Research Partner #AllofUsResearch Program, Nutrition for Precision Health, #PCORI THRIVE Trial, #CardiacRhythm #HCM patient, #GenAI for Universal Health Equity.
HugoOC.Bsky.social
December 3, 2024 at 7:54 PM
Several of us #PatientsUseAI folks are super tickled by the idea of #OurNotes!
cc @gracecordovano.bsky.social @hugooc.bsky.social , @kosherfrog.bsky.social
cc @gracecordovano.bsky.social @hugooc.bsky.social , @kosherfrog.bsky.social
The GTEx V10 has been released. Compared to release V8, V10 has 12% more RNA-seq samples and 23% more samples used for eQTL analyses. V10 release includes new smallRNA-seq data from 16,760 tissue samples, including gene expression counts and cis-QTLs: buff.ly/4eMQb1V
#UKBiobank #AllofUsResearch
#UKBiobank #AllofUsResearch
November 23, 2024 at 8:19 PM
The GTEx V10 has been released. Compared to release V8, V10 has 12% more RNA-seq samples and 23% more samples used for eQTL analyses. V10 release includes new smallRNA-seq data from 16,760 tissue samples, including gene expression counts and cis-QTLs: buff.ly/4eMQb1V
#UKBiobank #AllofUsResearch
#UKBiobank #AllofUsResearch
Researchers looked at @AllofUsResearch data to see how type 2 diabetes could affect a person's health over time. They found 8 subgroups of type 2 diabetes, each with its own genetic patterns.
Read more: http://allof-us.org/DNApatterns #AllofUsInclusion #JoinAllofUs
Read more: http://allof-us.org/DNApatterns #AllofUsInclusion #JoinAllofUs
January 28, 2025 at 9:55 PM
Researchers looked at @AllofUsResearch data to see how type 2 diabetes could affect a person's health over time. They found 8 subgroups of type 2 diabetes, each with its own genetic patterns.
Read more: http://allof-us.org/DNApatterns #AllofUsInclusion #JoinAllofUs
Read more: http://allof-us.org/DNApatterns #AllofUsInclusion #JoinAllofUs
Genomics, race, & ethics clean-up in aisle..or figures 1-5. #AllOfUSResearch #ScientificMisconduct
Human genomic researchers need to stop using biased methods (population sampling, racial/ethnicity definitions, & problematic statistical models like UMAP) to misrepresent human diversity.
Human genomic researchers need to stop using biased methods (population sampling, racial/ethnicity definitions, & problematic statistical models like UMAP) to misrepresent human diversity.
Genomic data in the All of Us Research Program - Nature
A study describes the release of clinical-grade whole-genome sequence data for 245,388 diverse participants by the All of Us Research Program and characterizes the properties of the dataset.
www.nature.com
February 20, 2024 at 10:21 PM
Genomics, race, & ethics clean-up in aisle..or figures 1-5. #AllOfUSResearch #ScientificMisconduct
Human genomic researchers need to stop using biased methods (population sampling, racial/ethnicity definitions, & problematic statistical models like UMAP) to misrepresent human diversity.
Human genomic researchers need to stop using biased methods (population sampling, racial/ethnicity definitions, & problematic statistical models like UMAP) to misrepresent human diversity.
On Wednesday 9/30/26 at 3 pm CT, Huiding Chen defends his dissertation, "Synthetic Sampling Weights for Volunteer-Based National Biobanks: Global Calibration, Subgroup Calibration, and Software." All are welcome and encouraged to attend. www.vanderbilt.edu/biostatistic... #RStats #AllOfUsResearch
Huiding Chen dissertation defense
Synthetic Sampling Weights for Volunteer-Based National Biobanks: Global Calibration, Subgroup Calibration, and Software Volunteer-based biobanks provide unprecedented opportunities for biomedical res...
www.vanderbilt.edu
September 28, 2026 at 7:41 PM
On Wednesday 9/30/26 at 3 pm CT, Huiding Chen defends his dissertation, "Synthetic Sampling Weights for Volunteer-Based National Biobanks: Global Calibration, Subgroup Calibration, and Software." All are welcome and encouraged to attend. www.vanderbilt.edu/biostatistic... #RStats #AllOfUsResearch
We also see large increases in within-family predictive power when we construct PGIs in the #AllOfUsResearch data using the GRMA summary stats relative to sibGWAS.
May 19, 2026 at 2:22 AM
We also see large increases in within-family predictive power when we construct PGIs in the #AllOfUsResearch data using the GRMA summary stats relative to sibGWAS.
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
September 14, 2026 at 5:03 PM
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
Previous infection with a common childhood virus could carry clues about lifelong health.
A recent Nature paper describes a novel method used to analyze genetic and health data from 750,000 people, including 245,000 AllofUsResearch program participants, to learn why some people develop certain
A recent Nature paper describes a novel method used to analyze genetic and health data from 750,000 people, including 245,000 AllofUsResearch program participants, to learn why some people develop certain
Population-scale sequencing resolves determinants of persistent EBV DNA - Nature
Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...
www.nature.com
February 9, 2026 at 9:49 PM
Previous infection with a common childhood virus could carry clues about lifelong health.
A recent Nature paper describes a novel method used to analyze genetic and health data from 750,000 people, including 245,000 AllofUsResearch program participants, to learn why some people develop certain
A recent Nature paper describes a novel method used to analyze genetic and health data from 750,000 people, including 245,000 AllofUsResearch program participants, to learn why some people develop certain
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
August 28, 2026 at 6:15 PM
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
September 4, 2026 at 6:02 PM
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
Happy to be speaking at the NIH @AllofUsResearch Online Outreach Event this Monday. Join us if you're a researcher thinking of using data from 633,000+ participants (EHR, genomics, and soon proteomics + transcriptomics!).
📅 June 29, 1:00-2:00 PM ET
🔗 bit.ly/AllofUsDiabetes
📅 June 29, 1:00-2:00 PM ET
🔗 bit.ly/AllofUsDiabetes
June 26, 2026 at 8:59 PM
Happy to be speaking at the NIH @AllofUsResearch Online Outreach Event this Monday. Join us if you're a researcher thinking of using data from 633,000+ participants (EHR, genomics, and soon proteomics + transcriptomics!).
📅 June 29, 1:00-2:00 PM ET
🔗 bit.ly/AllofUsDiabetes
📅 June 29, 1:00-2:00 PM ET
🔗 bit.ly/AllofUsDiabetes
New study reveals ATRNL1's key role in atrial fibrillation. Using single-nuclei RNA-seq, researchers identified its impact on cardiac conduction. Could ATRNL1 be the next therapeutic target for AF? doi.org/10.1038/s414...
#genetics #AF #UKBiobank #AllofUsResearch #GenomicsEngland #scRNAseq
#genetics #AF #UKBiobank #AllofUsResearch #GenomicsEngland #scRNAseq
November 20, 2024 at 6:12 AM
New study reveals ATRNL1's key role in atrial fibrillation. Using single-nuclei RNA-seq, researchers identified its impact on cardiac conduction. Could ATRNL1 be the next therapeutic target for AF? doi.org/10.1038/s414...
#genetics #AF #UKBiobank #AllofUsResearch #GenomicsEngland #scRNAseq
#genetics #AF #UKBiobank #AllofUsResearch #GenomicsEngland #scRNAseq
Eisen: "This paper from @AllofUsResearch needs to be retracted by @nature immediately. Under pretext of inclusivity it features a scientifically invalid representation of genetic diversity and race that is going to feature in racist literature for decades."
February 20, 2024 at 7:58 PM
Eisen: "This paper from @AllofUsResearch needs to be retracted by @nature immediately. Under pretext of inclusivity it features a scientifically invalid representation of genetic diversity and race that is going to feature in racist literature for decades."
Ok, on to the science!
Our first one was led by Noah Fields, who used the @AllofUsResearch cohort to ID 1,496 cancer patients with 3+ affected relatives but no recognized pathogenic variant.
www.medrxiv.org/content/10.6...
3/15
Our first one was led by Noah Fields, who used the @AllofUsResearch cohort to ID 1,496 cancer patients with 3+ affected relatives but no recognized pathogenic variant.
www.medrxiv.org/content/10.6...
3/15
Diverse mediators of cancer predisposition uncovered by germline whole genome sequencing of unexplained familial cancers
Cancer frequently clusters in families due to shared environment and genetics. However, many familial cancer cases lack a clinically recognized pathogenic germline variant (PGV). We analyzed germline ...
www.medrxiv.org
July 10, 2026 at 6:31 PM
Ok, on to the science!
Our first one was led by Noah Fields, who used the @AllofUsResearch cohort to ID 1,496 cancer patients with 3+ affected relatives but no recognized pathogenic variant.
www.medrxiv.org/content/10.6...
3/15
Our first one was led by Noah Fields, who used the @AllofUsResearch cohort to ID 1,496 cancer patients with 3+ affected relatives but no recognized pathogenic variant.
www.medrxiv.org/content/10.6...
3/15
After nearly seven years as Chief Executive Officer of the #AllofUsResearch Program at the #NIH, Josh Denny, M.D., M.S., will step down on Oct. 31, 2026, to accept a new leadership post at the University of Chicago #UChicago #UofC.
#JoshDenny
www.nih.gov/about-nih/ni...
#JoshDenny
www.nih.gov/about-nih/ni...
Statement on the departure of NIH’s All of Us Research Program CEO Dr. Josh Denny
After nearly seven years as Chief Executive Officer of the All of Us Research Program at the National Institutes of Health, Josh Denny, M.D., M.S., will step down on Oct. 31, 2026, to accept a new lea...
www.nih.gov
September 17, 2026 at 12:43 PM
After nearly seven years as Chief Executive Officer of the #AllofUsResearch Program at the #NIH, Josh Denny, M.D., M.S., will step down on Oct. 31, 2026, to accept a new leadership post at the University of Chicago #UChicago #UofC.
#JoshDenny
www.nih.gov/about-nih/ni...
#JoshDenny
www.nih.gov/about-nih/ni...
A phenome-wide association study of methylated GC-rich repeats identifies a GCC repeat expansion in AFF3 associated with intellectual disability - Nature Genetics
#UKBiobank #AllofUsResearch #GenomicsEngland
#UKBiobank #AllofUsResearch #GenomicsEngland
A phenome-wide association study of methylated GC-rich repeats identifies a GCC repeat expansion in AFF3 associated with intellectual disability - Nature Genetics
Phenome-wide analysis in the UK Biobank identifies GC-rich tandem repeat expansions associated with a range of traits, including a GCC expansion in AFF3 contributing to intellectual disability.
buff.ly
November 20, 2024 at 8:14 AM
A phenome-wide association study of methylated GC-rich repeats identifies a GCC repeat expansion in AFF3 associated with intellectual disability - Nature Genetics
#UKBiobank #AllofUsResearch #GenomicsEngland
#UKBiobank #AllofUsResearch #GenomicsEngland
After nearly seven years as Chief Executive Officer of the #AllofUsResearch Program at the #NIH, Josh Denny, M.D., M.S., will step down on Oct. 31, 2026, to accept a new leadership post at the @UofC .
#JoshDenny
www.nih.gov/about-nih/ni...
#JoshDenny
www.nih.gov/about-nih/ni...
Statement on the departure of NIH’s All of Us Research Program CEO Dr. Josh Denny
After nearly seven years as Chief Executive Officer of the All of Us Research Program at the National Institutes of Health, Josh Denny, M.D., M.S., will step down on Oct. 31, 2026, to accept a new lea...
www.nih.gov
September 17, 2026 at 12:39 PM
After nearly seven years as Chief Executive Officer of the #AllofUsResearch Program at the #NIH, Josh Denny, M.D., M.S., will step down on Oct. 31, 2026, to accept a new leadership post at the @UofC .
#JoshDenny
www.nih.gov/about-nih/ni...
#JoshDenny
www.nih.gov/about-nih/ni...
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
September 11, 2026 at 4:24 AM
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
August 21, 2026 at 4:45 PM
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
August 17, 2026 at 7:01 PM
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
August 14, 2026 at 1:16 AM
Upcoming USASP webinar: Perceived Healthcare Discrimination and Pain Severity: Insights from the All of Us Research Program
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
📅 September 16, 2026
⏰ 12–1 PM EST
Register here: [https://buff.ly/g6DQ31C]
#PainResearch #HealthEquity #HealthDisparities #PainScience #AllofUsResearch #USASP
So exciting to see such a diverse cohort of data being made available to researchers. Congrats to the entire @AllofUsResearch team. https://x.com/AndreaRamirezMD/status/1268198971421478912
March 8, 2025 at 5:03 PM
So exciting to see such a diverse cohort of data being made available to researchers. Congrats to the entire @AllofUsResearch team. https://x.com/AndreaRamirezMD/status/1268198971421478912