#Alphagenome
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philipcball.bsky.social
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 30, 2026 at 9:47 AM
timkellogg.me
AlphaFold Atlas: an exhaustive database of every nucleotide variant in the human body, and its effects as predicted by Google’s models

available for free

deepmind.google/blog/alphage...
AlphaGenome Atlas: Molecular predictions for 9 Billion human DNA variants
Explore AlphaGenome Atlas, a catalogue predicting the molecular effects and AVI scores for 9 billion single-nucleotide variants across the human genome.
deepmind.google
September 8, 2026 at 5:47 PM
avsecz.bsky.social
Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind
June 25, 2025 at 2:29 PM
kamounlab.bsky.social
On this day, 3 years ago, we released #AlphaGenome

The rest is history…
April 1, 2026 at 6:55 AM
dschthan.bsky.social
ist ja alles schön und gut aber “alphagenome” klingt so unfassbar nazi coded
riffreporter.bsky.social RiffReporter @riffreporter.bsky.social · Jan 29
Googles #KI „Alphagenome“ soll Licht in den bislang „dunklen“ Teil des menschlichen Erbguts bringen – mit Potenzial für neue Therapeutika. Warum sich Forschrïnnen dennoch nicht nur Hoffnungen, sondern auch Sorge machen, erklärt @christian-j-meier.bsky.social.
Alphagenome: Googles neue KI erschließt das „dunkle Genom“
Das KI-Modell Alphagenome ermöglicht Vorhersagen über Genfunktionen und könnte die Entwicklung neuer Therapien voranbringen. Manche aber haben Bedenken.
www.riffreporter.de
January 29, 2026 at 6:10 PM
nature.com
Nature research paper: Advancing regulatory variant effect prediction with AlphaGenome

go.nature.com/3LT1Und
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect prediction and enables comprehensive genomic analysis.
go.nature.com
February 3, 2026 at 5:06 PM
kamounlab.bsky.social
Exactly one year ago, we released #AlphaGenome

The rest is history…
April 1, 2024 at 10:57 AM
erictopol.bsky.social
Today @nature.com, it's #AlphaGenome, to decipher and determine functionality of the regulatory (very challenging) variants in our genome.
Another big step of AI for advancing life science
nature.com/articles/s41...
January 28, 2026 at 4:19 PM
biorxiv-bioinfo.bsky.social
AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model https://www.biorxiv.org/content/10.1101/2025.06.25.661532v1
June 28, 2025 at 12:47 AM
nature.com
AI model AlphaGenome forecasts the consequences of altering every single DNA letter in the human genome

go.nature.com/4xQ7ZDK
DeepMind’s new genome ‘atlas’ charts effects of all 9 billion human gene mutations
AI model AlphaGenome forecasts the consequences of altering every single DNA letter in the human genome.
go.nature.com
September 8, 2026 at 2:31 PM
sashagusevposts.bsky.social
Cool work from AlphaGenome ( storage.googleapis.com/deepmind-med... ). Interesting how challenging it still is to predict even just the direction of distal QTLs.
June 25, 2025 at 5:54 PM
suragnair.bsky.social
Excited to share Nona: a unifying multimodal masking framework for functional genomics.

Models for DNA have evolved along separate paths: sequence-to-function (AlphaGenome), language models (Evo2), and generative models (DDSM).

Can these be unified under a single paradigm? 1/15
November 10, 2025 at 9:01 PM
natureportfolio.nature.com
A paper in Nature presents AlphaGenome, a deep learning model that can predict the function of long DNA sequences, up to one million base pairs. The tool can predict how DNA sequence variations affect different biological processes. go.nature.com/4t5JQa7 🧬 🧪
This is figure 1, which shows AlphaGenome model architecture, training regimes and comprehensive evaluation performance.
February 4, 2026 at 2:19 AM
stephenturner.us
AlphaGenome deepmind.google/discover/blo... 🧬🖥️🧪
API: github.com/google-deepm...
Docs: www.alphagenomedocs.com
Community: www.alphagenomecommunity.com
June 25, 2025 at 4:53 PM
tagesschau.bsky.social
AlphaGenome verbessert unser Verständnis der Gene#Genetik#DNA#KI
AlphaGenome verbessert unser Verständnis der Gene
Die neue KI AlphaGenome entschlüsselt, wie Gene gesteuert werden - ein Durchbruch für die Forschung
www.tagesschau.de
January 28, 2026 at 4:35 PM
nature.com
AI model AlphaGenome forecasts the consequences of altering every single DNA letter in the human genome

go.nature.com/4A4XlKN
DeepMind’s new genome ‘atlas’ charts effects of all 9 billion human gene mutations
Nature - AI model AlphaGenome forecasts the consequences of altering every single DNA letter in the human genome.
go.nature.com
September 12, 2026 at 9:02 AM
natureportfolio.nature.com
A paper in Nature presents AlphaGenome, a deep learning model that can predict the function of long DNA sequences, up to one million base pairs. The tool can predict how DNA sequence variations affect different biological processes. go.nature.com/4t5JQa7 🧬 🧪
This is figure 1, which shows AlphaGenome model architecture, training regimes and comprehensive evaluation performance.
January 28, 2026 at 11:29 PM
technologyreview.com
First came AlphaFold. Now comes AlphaGenome for DNA.
Google’s new AI will help researchers understand how our genes work
First came AlphaFold. Now comes AlphaGenome for DNA.
www.technologyreview.com
June 25, 2025 at 3:37 PM
spectrum.ieee.org
The team at Google DeepMind behind AlphaFold has now released #AlphaGenome, a tool for exploring the 98% of #DNA that does not encode for proteins. spectrum.ieee.org/alphagenome-...
February 18, 2026 at 8:30 PM
carlzimmer.com
I wrote today about AlphaGenome, Google DeepMind's AI for DNA. It's powerful, experts told me, but it won't solve the mysteries of the genome overnight. Gift link: nyti.ms/4k5NFIl
nyti.ms
January 28, 2026 at 4:44 PM
annizlab.bsky.social
AlphaGenome is out! Input 1 Mb DNA -> predict gene expression, transcription initiation, chromatin accessibility, histone modifications, transcription factor binding, chromatin contact maps, ..., up to single-base-pair resolution! Trained on human and mouse data 🧪🧬🖥️🦠✨
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
February 11, 2026 at 5:40 AM
nature.com
Hackathons using AlphaGenome and other AI models are hunting down the genetic causes of devastating conditions that have evaded diagnosis

go.nature.com/3OeX5oM
How DeepMind's genome AI could help solve rare disease mysteries
Hackathons using AlphaGenome and other AI models are hunting down the genetic causes of devastating conditions that have evaded diagnosis.
go.nature.com
January 30, 2026 at 12:01 PM
avsecz.bsky.social
AlphaGenome is out in @nature.com today along with model weights! 🧬

📄 Paper: www.nature.com/articles/s41...

💻 Weights: github.com/google-deepm...

Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc
January 28, 2026 at 9:02 PM
manuelacasasoli.bsky.social
Read about AlphaGenome, a unified #DNA sequence model, "takes as input 1 Mb of DNA sequence and predicts thousands of functional genomic tracks up to single-base-pair resolution across diverse modalities."
🧪 #Science #Biology #AI
1 www.nature.com/articles/s41...
2 deepmind.google.com/science/alph...
Image Source: https://deepmind.google/blog/alphagenome-ai-for-better-understanding-the-genome/ Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API. https://deepmind.google.com/science/alphagenome/
January 28, 2026 at 5:16 PM