Excited to share our latest paper on wound healing. The research is the fruits of a fantastic collaboration between me, Dr Leah Vardy (A star Institute in Singapore) & UoM surgeon Prof Jason Wong and critical insight from amazing colleagues too🧪#ImmunoSky🧵
doi.org/10.1093/bjd/...
doi.org/10.1093/bjd/...
Keratinocyte arginase 1 regulates proinflammatory responses and drives re-epithelialization via lipocalin 2
Keratinocyte arginase 1 (ARG1) promotes anti-inflammatory and antimicrobial protection during re-epithelialization. Chronic skin wounds have a delay in wou
doi.org
July 22, 2025 at 3:06 PM
Excited to share our latest paper on wound healing. The research is the fruits of a fantastic collaboration between me, Dr Leah Vardy (A star Institute in Singapore) & UoM surgeon Prof Jason Wong and critical insight from amazing colleagues too🧪#ImmunoSky🧵
doi.org/10.1093/bjd/...
doi.org/10.1093/bjd/...
Arginase 1 Drives Liver Fat Production Through Unusual Mechanisms
www.thailandmedical.news/news/arginas...
www.thailandmedical.news/news/arginas...
Arginase 1 Drives Liver Fat Production Through Unusual Mechanisms - Thailand Medical News
www.thailandmedical.news
January 27, 2025 at 1:13 PM
Arginase 1 Drives Liver Fat Production Through Unusual Mechanisms
www.thailandmedical.news/news/arginas...
www.thailandmedical.news/news/arginas...
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis | Science Signaling www.science.org/doi/10.1126/... 🧪
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis
Macrophages perform repeated rounds of phagocytosis in response to an FDA-approved dopamine blocker.
www.science.org
April 15, 2025 at 7:41 PM
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis | Science Signaling www.science.org/doi/10.1126/... 🧪
Red blood cells from people with #T2D induce endothelial dysfunction through increased uptake of extracellular vesicles that transfer arginase-1 from RBCs to the endothelium to induce oxidative stress and endothelial dysfunction @jclinical-invest.bsky.social www.jci.org/articles/vie...
March 20, 2025 at 6:47 PM
Red blood cells from people with #T2D induce endothelial dysfunction through increased uptake of extracellular vesicles that transfer arginase-1 from RBCs to the endothelium to induce oxidative stress and endothelial dysfunction @jclinical-invest.bsky.social www.jci.org/articles/vie...
This is not the only study to show neutrophil dysfunction - this one was in severe covid-19 patients, not long covid however.
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
JCI Insight -
Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19
insight.jci.org
December 8, 2024 at 2:22 PM
This is not the only study to show neutrophil dysfunction - this one was in severe covid-19 patients, not long covid however.
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
November 7, 2025 at 7:30 PM
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
#ImmunoSky #MedSky
#drugrepurposing
#Inflammation: "Time to halt the #Dopamine rush"
An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis
Now @science.org signaling
#drugrepurposing
#Inflammation: "Time to halt the #Dopamine rush"
An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis
Now @science.org signaling
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis
Macrophages perform repeated rounds of phagocytosis in response to an FDA-approved dopamine blocker.
www.science.org
April 10, 2025 at 7:43 AM
#ImmunoSky #MedSky
#drugrepurposing
#Inflammation: "Time to halt the #Dopamine rush"
An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis
Now @science.org signaling
#drugrepurposing
#Inflammation: "Time to halt the #Dopamine rush"
An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis
Now @science.org signaling
we are delighted to announce that our study focusing on Macrophage Arginine Metabolism in Neuroinflammation has been published today in #NatureImmunology.
www.nature.com/articles/s41...
its time to celebrate 🍷🍻🥂
www.nature.com/articles/s41...
its time to celebrate 🍷🍻🥂
Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation - Nature Immunology
Kerndl and colleagues identify that arginase 1-expressing monocyte-derived cells mediate arginine catabolism and detrimental effects during experimental autoimmune encephalitis-triggered neuroinflamma...
www.nature.com
May 18, 2026 at 3:42 PM
we are delighted to announce that our study focusing on Macrophage Arginine Metabolism in Neuroinflammation has been published today in #NatureImmunology.
www.nature.com/articles/s41...
its time to celebrate 🍷🍻🥂
www.nature.com/articles/s41...
its time to celebrate 🍷🍻🥂
Mudskippers have evolved visual adaptations for seeing in air. Comparative genomics showed that certain vision-related genes, like aanat1a, LWS1 and LWS2, are lost or altered in P. schlosseri, aligning with its need for aerial vision #2025MMM doi.org/10.3390/ani8...
March 14, 2025 at 12:07 AM
Mudskippers have evolved visual adaptations for seeing in air. Comparative genomics showed that certain vision-related genes, like aanat1a, LWS1 and LWS2, are lost or altered in P. schlosseri, aligning with its need for aerial vision #2025MMM doi.org/10.3390/ani8...
Type 2 diabetes red blood cell-derived vesicles disrupt endothelial function by transferring arginase-1, causing oxidative stress.
by Collado A, Humoud R (...) Pernow J et 16 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/180900
by Collado A, Humoud R (...) Pernow J et 16 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/180900
May 24, 2025 at 2:06 AM
Type 2 diabetes red blood cell-derived vesicles disrupt endothelial function by transferring arginase-1, causing oxidative stress.
by Collado A, Humoud R (...) Pernow J et 16 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/180900
by Collado A, Humoud R (...) Pernow J et 16 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/180900
Just sent in the initial contact to pursue Arginase 1 & HIF1a inhibitor compassionate use in #longcovid #mecfs for one of the patients in the Amatica study
Very thankful we have physicians willing to pursue this
Will provide updates as the process evolves!
Very thankful we have physicians willing to pursue this
Will provide updates as the process evolves!
January 15, 2025 at 11:14 AM
Just sent in the initial contact to pursue Arginase 1 & HIF1a inhibitor compassionate use in #longcovid #mecfs for one of the patients in the Amatica study
Very thankful we have physicians willing to pursue this
Will provide updates as the process evolves!
Very thankful we have physicians willing to pursue this
Will provide updates as the process evolves!
Real-world pegzilarginase data in arginase 1 deficiency (n=16):
• ↓ plasma arginine by 3 months
• Most <200 μmol/L
• ↑ dietary protein intake with maintained control
• No new safety signals
Findings align with trial data.
doi.org/10.1002/jmd2...
• ↓ plasma arginine by 3 months
• Most <200 μmol/L
• ↑ dietary protein intake with maintained control
• No new safety signals
Findings align with trial data.
doi.org/10.1002/jmd2...
April 5, 2026 at 4:10 AM
Real-world pegzilarginase data in arginase 1 deficiency (n=16):
• ↓ plasma arginine by 3 months
• Most <200 μmol/L
• ↑ dietary protein intake with maintained control
• No new safety signals
Findings align with trial data.
doi.org/10.1002/jmd2...
• ↓ plasma arginine by 3 months
• Most <200 μmol/L
• ↑ dietary protein intake with maintained control
• No new safety signals
Findings align with trial data.
doi.org/10.1002/jmd2...
🚨 New from the Cantley lab in @asnpublications.bsky.social! Bharathan et al. found that arginase-1+ macrophages team up with myofibroblasts to drive IGF1-dependent tubule repair after AKI - highlighting an unexpected reparative role for activated myofibroblasts. 🔗⬇️
journals.lww.com/kidney360/ab...
journals.lww.com/kidney360/ab...
journals.lww.com
February 4, 2026 at 5:29 PM
🚨 New from the Cantley lab in @asnpublications.bsky.social! Bharathan et al. found that arginase-1+ macrophages team up with myofibroblasts to drive IGF1-dependent tubule repair after AKI - highlighting an unexpected reparative role for activated myofibroblasts. 🔗⬇️
journals.lww.com/kidney360/ab...
journals.lww.com/kidney360/ab...
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 #ARG1 #ARG2 #candesartan #metformin #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 #ARG1 #ARG2 #candesartan #metformin #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Qui, Tang and colleagues show how Dectin-1 signaling induces Arginase-1 / TGF-β AND and promotes profibrotic AMs via the Raf1-dependent pathway, bypassing CARD9 signaling and mono-macrophage chemotactic recruitment. [7/n]
bit.ly/4nyTzCS
bit.ly/4nyTzCS
Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis
Dectin-1 is known for its role in antifungal immunity, but its contribution to pulmonary
fibrosis remains poorly defined. Qiu et al. reveal that Dectin-1 signaling promotes
lung fibrosis by inducing A...
bit.ly
July 23, 2025 at 12:39 PM
Qui, Tang and colleagues show how Dectin-1 signaling induces Arginase-1 / TGF-β AND and promotes profibrotic AMs via the Raf1-dependent pathway, bypassing CARD9 signaling and mono-macrophage chemotactic recruitment. [7/n]
bit.ly/4nyTzCS
bit.ly/4nyTzCS
Oral L-arginine cures arginase 1-dependent chronic cutaneous leishmaniasis by redirecting the T helper cell response https://www.biorxiv.org/content/10.1101/2025.09.23.677696v1
September 25, 2025 at 11:17 PM
Oral L-arginine cures arginase 1-dependent chronic cutaneous leishmaniasis by redirecting the T helper cell response https://www.biorxiv.org/content/10.1101/2025.09.23.677696v1
Oral L-arginine cures arginase 1-dependent chronic cutaneous leishmaniasis by redirecting the T helper cell response https://www.biorxiv.org/content/10.1101/2025.09.23.677696v1
September 25, 2025 at 11:17 PM
Oral L-arginine cures arginase 1-dependent chronic cutaneous leishmaniasis by redirecting the T helper cell response https://www.biorxiv.org/content/10.1101/2025.09.23.677696v1
The authors included RRIDs in their in Oncogenesis paper! RRIDs improve reproducibility in scientific research. #RRID #methodsmatter #reproducibility
Alternatively activated macrophages cause DNA damage through an arginase 1-mediated bystander effect and promote epithelial cell transformation - Oncogenesis
Read the full paper: Alternatively activated macrophages cause DNA damage through an arginase 1-mediated bystander effect and promote epithelial cell transformation
doi.org
May 28, 2026 at 7:10 AM
The authors included RRIDs in their in Oncogenesis paper! RRIDs improve reproducibility in scientific research. #RRID #methodsmatter #reproducibility
RRIDs were included in this in Redox Biology paper. Thanks for making your methods matter! #RRID #methodsmatter #OpenResearch
Loss of erythrocyte arginase-1 impairs vasorelaxation due to endothelial GSNOR overexpression and denitrosylation of G protein subunits
Read the full paper: Loss of erythrocyte arginase-1 impairs vasorelaxation due to endothelial GSNOR overexpression and denitrosylation of G protein subunits
doi.org
May 7, 2026 at 7:00 AM
RRIDs were included in this in Redox Biology paper. Thanks for making your methods matter! #RRID #methodsmatter #OpenResearch
Link to publication ⬇️
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes
www.jci.org
March 26, 2025 at 2:36 PM
Link to publication ⬇️
www.jci.org/articles/vie...
www.jci.org/articles/vie...
First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours bmjoncology.bmj.com/content/3/1/... #hvhebron #onco [Text complet]
First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours
Objective The arginase inhibitor INCB001158 was evaluated for safety (primary endpoint) in locally advanced or metastatic solid tumours; pharmacokinetics, pharmacodynamics and efficacy were also asses...
bmjoncology.bmj.com
February 4, 2025 at 11:45 AM
First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours bmjoncology.bmj.com/content/3/1/... #hvhebron #onco [Text complet]
A preprint using: Arginase 1 Monoclona (RRID:AB_2734830) from @thermofishersci.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
www.biorxiv.org
November 4, 2025 at 3:42 PM
A preprint using: Arginase 1 Monoclona (RRID:AB_2734830) from @thermofishersci.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
RRID:AB_2722564 from @proteintech.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #ReproducibleResearch #accelerateopenscience #methodsmatter
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing Arginase 1 and continual efferocytosis
doi.org
October 18, 2025 at 7:00 AM
RRID:AB_2722564 from @proteintech.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #ReproducibleResearch #accelerateopenscience #methodsmatter
Our own Dr Sanchez Russo reports on 1st potential enzyme replacement therapy for arginase 1 deficiency, in a multi-center RCT. Sponsor: Aeglea Biotherapeutics. #GeneSky 🧬https://clinicaltrials.gov/study/NCT03921541 www.thelancet.com/journals/ecl...
January 22, 2024 at 2:33 PM
Our own Dr Sanchez Russo reports on 1st potential enzyme replacement therapy for arginase 1 deficiency, in a multi-center RCT. Sponsor: Aeglea Biotherapeutics. #GeneSky 🧬https://clinicaltrials.gov/study/NCT03921541 www.thelancet.com/journals/ecl...
A powerful JIMD study reports a cluster of severe arginase-1 deficiency in children from Mayotte & the Comoros, linked to a founder effect. Early diagnosis = normal outcomes; delayed diagnosis = high morbidity & mortality.
🔗 doi.org/10.1002/jimd...
🔗 doi.org/10.1002/jimd...
February 14, 2026 at 4:11 AM
A powerful JIMD study reports a cluster of severe arginase-1 deficiency in children from Mayotte & the Comoros, linked to a founder effect. Early diagnosis = normal outcomes; delayed diagnosis = high morbidity & mortality.
🔗 doi.org/10.1002/jimd...
🔗 doi.org/10.1002/jimd...