The first structure of a cold-active arginase reveals a modest reduction in structural rigidity associated with cold adaptation #ColdActiveEnzymes #Arginases #XRayCrystallography doi.org/10.1107/S205...
June 10, 2026 at 1:35 PM
The first structure of a cold-active arginase reveals a modest reduction in structural rigidity associated with cold adaptation #ColdActiveEnzymes #Arginases #XRayCrystallography doi.org/10.1107/S205...
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Interestingly, irbesartan, and candesartan extend a healthy lifespan in heart failure patients, and improve cognitive function in patients."
"Interestingly, irbesartan, and candesartan extend a healthy lifespan in heart failure patients, and improve cognitive function in patients."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Interestingly, irbesartan, and candesartan extend a healthy lifespan in heart failure patients, and improve cognitive function in patients."
"Interestingly, irbesartan, and candesartan extend a healthy lifespan in heart failure patients, and improve cognitive function in patients."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"We found metformin and isavuconazole are non-selective to both the arginases based on binding energies, protein-ligand interaction, and molecular dynamics."
"We found metformin and isavuconazole are non-selective to both the arginases based on binding energies, protein-ligand interaction, and molecular dynamics."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"We found metformin and isavuconazole are non-selective to both the arginases based on binding energies, protein-ligand interaction, and molecular dynamics."
"We found metformin and isavuconazole are non-selective to both the arginases based on binding energies, protein-ligand interaction, and molecular dynamics."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Notably, the amino-rich, metformin forms multiple hydrogen bonds in the binding site with arginase and contributes to complex stability (Figure 5)."
"Notably, the amino-rich, metformin forms multiple hydrogen bonds in the binding site with arginase and contributes to complex stability (Figure 5)."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Notably, the amino-rich, metformin forms multiple hydrogen bonds in the binding site with arginase and contributes to complex stability (Figure 5)."
"Notably, the amino-rich, metformin forms multiple hydrogen bonds in the binding site with arginase and contributes to complex stability (Figure 5)."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Interestingly, isavuconazole and metformin remained in the binding site of both arginase for 50 ns, potentially suggesting non-selective arginase binding, thus reinforcing our molecular docking results that isavuconazole and metformin are non-selective."
"Interestingly, isavuconazole and metformin remained in the binding site of both arginase for 50 ns, potentially suggesting non-selective arginase binding, thus reinforcing our molecular docking results that isavuconazole and metformin are non-selective."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Interestingly, isavuconazole and metformin remained in the binding site of both arginase for 50 ns, potentially suggesting non-selective arginase binding, thus reinforcing our molecular docking results that isavuconazole and metformin are non-selective."
"Interestingly, isavuconazole and metformin remained in the binding site of both arginase for 50 ns, potentially suggesting non-selective arginase binding, thus reinforcing our molecular docking results that isavuconazole and metformin are non-selective."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"This limits, our earlier results which show irbesartan selectivity towards ARG2, and both irbesartan and candesartan could potentially favor ARG1."
"This limits, our earlier results which show irbesartan selectivity towards ARG2, and both irbesartan and candesartan could potentially favor ARG1."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"This limits, our earlier results which show irbesartan selectivity towards ARG2, and both irbesartan and candesartan could potentially favor ARG1."
"This limits, our earlier results which show irbesartan selectivity towards ARG2, and both irbesartan and candesartan could potentially favor ARG1."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"In comparison, candesartan and irbesartan remained in the binding site of ARG2 less than 37 ns and 13 ns, respectively, suggesting they are selective for ARG1."
"In comparison, candesartan and irbesartan remained in the binding site of ARG2 less than 37 ns and 13 ns, respectively, suggesting they are selective for ARG1."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"In comparison, candesartan and irbesartan remained in the binding site of ARG2 less than 37 ns and 13 ns, respectively, suggesting they are selective for ARG1."
"In comparison, candesartan and irbesartan remained in the binding site of ARG2 less than 37 ns and 13 ns, respectively, suggesting they are selective for ARG1."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Remarkably, candesartan and irbesartan occupied the binding site of ARG1 for the entire length of the simulation (50 ns)."
"Remarkably, candesartan and irbesartan occupied the binding site of ARG1 for the entire length of the simulation (50 ns)."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Remarkably, candesartan and irbesartan occupied the binding site of ARG1 for the entire length of the simulation (50 ns)."
"Remarkably, candesartan and irbesartan occupied the binding site of ARG1 for the entire length of the simulation (50 ns)."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Most notable are the antihypertensive drugs candesartan, irbesartan, indapamide, and amiloride, the antiemetic rolapitant, the anti-angina ivabradine, and the antidiabetic metformin which have minimal side effects."
"Most notable are the antihypertensive drugs candesartan, irbesartan, indapamide, and amiloride, the antiemetic rolapitant, the anti-angina ivabradine, and the antidiabetic metformin which have minimal side effects."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Most notable are the antihypertensive drugs candesartan, irbesartan, indapamide, and amiloride, the antiemetic rolapitant, the anti-angina ivabradine, and the antidiabetic metformin which have minimal side effects."
"Most notable are the antihypertensive drugs candesartan, irbesartan, indapamide, and amiloride, the antiemetic rolapitant, the anti-angina ivabradine, and the antidiabetic metformin which have minimal side effects."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Remarkably, half of the top 30 potential drugs are used clinically to lower blood pressure and treat cancer, infection, kidney disease, and Parkinson’s disease thus partially validating our virtual screen."
"Remarkably, half of the top 30 potential drugs are used clinically to lower blood pressure and treat cancer, infection, kidney disease, and Parkinson’s disease thus partially validating our virtual screen."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Remarkably, half of the top 30 potential drugs are used clinically to lower blood pressure and treat cancer, infection, kidney disease, and Parkinson’s disease thus partially validating our virtual screen."
"Remarkably, half of the top 30 potential drugs are used clinically to lower blood pressure and treat cancer, infection, kidney disease, and Parkinson’s disease thus partially validating our virtual screen."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"The potential arginase ligands are classified into three categories: (1) Non-selective, (2) ARG1 selective, and (3) ARG2 selective."
"The evaluated potential arginase ligands are then compared with their clinical use."
"The potential arginase ligands are classified into three categories: (1) Non-selective, (2) ARG1 selective, and (3) ARG2 selective."
"The evaluated potential arginase ligands are then compared with their clinical use."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"The potential arginase ligands are classified into three categories: (1) Non-selective, (2) ARG1 selective, and (3) ARG2 selective."
"The evaluated potential arginase ligands are then compared with their clinical use."
"The potential arginase ligands are classified into three categories: (1) Non-selective, (2) ARG1 selective, and (3) ARG2 selective."
"The evaluated potential arginase ligands are then compared with their clinical use."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs."
"Arginase type 1 ( #ARG1) is a cytosolic enzyme, and arginase type 2 ( #ARG2) is a mitochondrial one."
"Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs."
"Arginase type 1 ( #ARG1) is a cytosolic enzyme, and arginase type 2 ( #ARG2) is a mitochondrial one."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs."
"Arginase type 1 ( #ARG1) is a cytosolic enzyme, and arginase type 2 ( #ARG2) is a mitochondrial one."
"Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs."
"Arginase type 1 ( #ARG1) is a cytosolic enzyme, and arginase type 2 ( #ARG2) is a mitochondrial one."
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 #ARG1 #ARG2 #candesartan #metformin #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...
pmc.ncbi.nlm.nih.gov
February 19, 2025 at 5:28 PM
Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 #ARG1 #ARG2 #candesartan #metformin #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
🧪for insights about an ancient, multitasking and still not fully understood enzyme family read “Biochemistry, pharmacology, and in vivo function of arginases - Pharmacological Reviews “https://pharmrev.aspetjournals.org/article/S0031-6997%2824%2911615-8/fulltext
Biochemistry, pharmacology, and in vivo function of arginases
The enzyme arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea.
The 2 existing isoforms Arg1 and Arg2 exhibit different cellular localizations and
metabolic functions. Arginase a...
pharmrev.aspetjournals.org
January 18, 2025 at 10:46 AM
🧪for insights about an ancient, multitasking and still not fully understood enzyme family read “Biochemistry, pharmacology, and in vivo function of arginases - Pharmacological Reviews “https://pharmrev.aspetjournals.org/article/S0031-6997%2824%2911615-8/fulltext