Kim et al. show that obesity-associated TGF-β1 establishes a persistent adipocyte transcriptional memory that sustains asprosin production. In mice, this persistent hormonal state promotes weight rega...

Kim et al. show that obesity-associated TGF-β1 establishes a persistent adipocyte transcriptional memory that sustains asprosin production. In mice, this persistent hormonal state promotes weight…

Liu, Z. et al. identify protein tyrosine phosphatase receptor F (Ptprf) as the receptor for the glucogenic hormone Asprosin. Genetic ablation and overexpression demonstrate the essential role of Ptprf...

Liu, Z. et al. identify protein tyrosine phosphatase receptor F (Ptprf) as the receptor for the glucogenic hormone Asprosin. Genetic ablation and overexpression demonstrate the essential role of Ptprf in mediating Asprosin-induced hyperglycemia. These findings establish the conserved Asprosin-Ptprf axis as a promising therapeutic target for diabetes and obesity.

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d8284524e101"> <b>Objective</b> To investigate whether there is abnormal expression of serum asprosin i...

Aberrant autophagy mediated by AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/unc-51 like kinase 1 (ULK1) pathway (a canonical autophagy pathway) plays important roles in dia...

Two enduring biological mysteries have remained unsolved for decades: why almost everyone who loses weight gains it back, no matter how they lost it, and why obesity passes from mother to child at rates that diet and environment cannot explain.

How AAV vectors and a newly identified hormone connected basic mechanism to translational relevance in metabolic and neural regulation. AAV vectors for basic research have become a versatile tool to…

Nature Reviews Endocrinology, Published online: 09 January 2026; doi:10.1038/s41574-025-01228-3During fasting, the liver produces fuel under the control of several hormonal and metabolic cues. In this Review, the authors outline the effects of the cues (glucagon, glucocorticoids, growth hormone, adrenaline, free fatty acids, asprosin and GP73) that are known to directly signal to hepatocytes under fasting conditions.

Nature Reviews Endocrinology, Published online: 09 January 2026; doi:10.1038/s41574-025-01228-3During fasting, the liver produces fuel under the control of several hormonal and metabolic cues. In this Review, the authors outline the effects of the cues (glucagon, glucocorticoids, growth hormone, adrenaline, free fatty acids, asprosin and GP73) that are known to directly signal to hepatocytes under fasting conditions.

Kim et al. show that obesity-associated TGF-β1 establishes a persistent adipocyte transcriptional memory that sustains asprosin production. In mice, this persistent hormonal state promotes weight regain after weight loss and increases offspring susceptibility to obesity, identifying the TGF-β1-asprosin-Ptprd axis as a potential therapeutic target.

Read the full paper: Adipose TGFβ-asprosin memory promotes obesity relapse and offspring obesity susceptibility

Read the full paper: Asprosin expression and its role in regulating proliferation, cell cycle, and apoptosis in mouse hippocampal HT-22 cells

Researchers at the University of California, Irvine Joe C. Wen School of Population & Public Health have identified how the hormone asprosin influences long-term weight change among postmenopausal women in the United States. The findings suggest that the fasting-induced hormone may play a significant role in shaping body composition and long-term weight stability, offering a promising target for tailored obesity prevention strategies.

Researchers at the University of California, Irvine Joe C. Wen School of Population & Public Health have identified how the hormone asprosin influences long-term weight change among postmenopausal women in the United States.