Tralokinumab for AD was associated with sustained improvements in disease severity and no new safety signals at 12 months in a real-life study.

Presentation highlights EVO301’s clear therapeutic signal, favorable safety and tolerability profile, and reinforces IL-18 inhibition as a…...

Discover free, up-to-date clinical references for atopic dermatitis at Healio. Our content informs physicians, aiding in making confident point-of-care decisions.

Retrospective data show ocular adverse events are rare with dupilumab, though risk for conjunctivitis is elevated in atopic dermatitis.

Learn how to manage childhood eczema in Central Texas. Expert tips on toddler dry patches, summer flare-ups, daily skincare, and natural itch relief.

Dupilumab use among pediatric patients with moderate to severe AD is associated with a meaningful increase in weight percentiles.

Ivarmacitinib was associated with improved atopic dermatitis symptoms among adolescents and adults.

Pediatric patients with moderate to severe AD may have a reduced mean height and increased mean weight when compared with the general population.

A study of infants has identified distinct skin microbiome patterns that appear before and after the onset of atopic diseases, suggesting that early microbial changes could eventually help identify children at increased risk. The research, published online July 17 in Allergy, examined more than 1,000 skin swab samples collected from 429 infants at 2 to 3 months of age, before diagnosis, and again at 12 months, after diagnosis in affected children. Researchers used deep shotgun metagenomic sequencing to investigate microbial differences associated with atopic dermatitis (AD), food sensitization (FS), food allergy (FA), combinations of these conditions, and FLG mutation status. The findings showed that skin microbiome profiles varied according to the specific atopic phenotype. Staphylococcus epidermidis was more abundant in infants who developed AD without food allergy or sensitization. In contrast, infants with both AD and food allergy had lower levels of Staphylococcus hominis and Lactococcus species, along with higher levels of Dermacoccus nishinomiyaensis and Malassezia slooffiae. Early skin dysbiosis, particularly an enrichment of Staphylococcus species at 2 to 3 months, was associated with the subsequent development of AD accompanied by food sensitization or food allergy, but not with AD alone. Infants carrying FLG mutations also showed additional microbiome differences among those with AD, including lower levels of Streptococcus species and higher levels of M. slooffiae. Strain-level analyses provided evidence of sharing of some AD-associated microbes between mothers and infants, while microbial genome-wide association analyses identified species-specific genes associated with AD severity. The researchers noted that detecting microbiome differences before clinical disease develops could potentially support the future development of early biomarkers. However, the findings describe associations and do not establish that the identified microbes directly cause atopic disease.

Adults who adhere to healthy habits regarding alcohol consumption, smoking cessation, sleep, and physical activity have a lower risk for incident AD.

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Both patients and health care providers regard the use of telemedicine for the management of systemic therapies for psoriasis and AD as positive.