Chaperone-mediated autophagy curbs senescence
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Chaperone-mediated autophagy curbs senescence - Nature Aging
Sereda and colleagues show that chaperone-mediated autophagy declines with aging, which leads to enhanced senescent cell burden that is driven, in part, by failed macrophage-mediated immunosurveillanc...
www.nature.com
November 1, 2026 at 12:20 AM
Chaperone-mediated autophagy curbs senescence
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Autophagy in macrophages curtails IL-1α-mediated immune priming against lung infections @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 30, 2026 at 4:43 PM
Autophagy in macrophages curtails IL-1α-mediated immune priming against lung infections @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Disabling autophagy in lung macrophages boosted IL-1α and resistance to bacterial and flu infections. 🧪
#Immunology
Nature Immunology · doi.org/10.1038/s415...
#Immunology
Nature Immunology · doi.org/10.1038/s415...
Autophagy in macrophages curtails IL-1α-mediated immune priming against lung infections - Nature Immunology
Wang and colleagues show that autophagy deficiency in alveolar macrophages upregulates the expression of IL-1α and increases resistance to respiratory infections.
doi.org
October 31, 2026 at 10:19 AM
Disabling autophagy in lung macrophages boosted IL-1α and resistance to bacterial and flu infections. 🧪
#Immunology
Nature Immunology · doi.org/10.1038/s415...
#Immunology
Nature Immunology · doi.org/10.1038/s415...
STING-dependent TNF signalling promotes IKKβ-mediated ATG9A phosphorylation and autophagy
->Nature | More on "Cancer autophagy and chemotherapy response" at BigEarthData.ai
->Nature | More on "Cancer autophagy and chemotherapy response" at BigEarthData.ai
STING-dependent TNF signalling promotes IKKβ-mediated ATG9A phosphorylation and autophagy
a, b. Densitometric quantification of P62/β-Actin ratios in CAL27 (a) and FaDu (b) cells treated for 24 h with 5-FU (5 μM for CAL27, 10 μM for FaDu), DTX (2.5 nM for CAL27, 5 nM for FaDu), or DDP (2.5 μM for CAL27, 5 μM for FaDu). CAL27: Padj < 0.0001 for 5-FU versus Ctrl, Padj < 0.0001 for DTX versus Ctrl, Padj < 0.0001 for DDP versus Ctrl. FaDu: Padj < 0.0001 for 5-FU versus Ctrl, Padj < 0.0001 for DTX versus Ctrl, Padj < 0.0001 for DDP versus Ctrl. c, d. Densitometric quantification of LC3B-II/β-Actin ratios in CAL27 (c) and FaDu (d) cells treated with the indicated chemotherapeutic agents at the aforementioned concentrations, in the presence or absence of bafilomycin A1 (Baf-A1; 0.4 μM) for 24 h. CAL27: Padj = 0.0013 for 5-FU versus Ctrl, Padj = 0.0004 for DTX versus Ctrl, Padj = 0.0012 for DDP versus Ctrl. FaDu: Padj < 0.0001 for 5-FU versus Ctrl, Padj < 0.0001 for DTX versus Ctrl, Padj < 0.0001 for DDP versus Ctrl. e, f. Representative TEM images of FaDu cells treated with 5-FU (10 μM), DTX (5 nM), or DDP (5 μM) for 24 h, with red arrows indicating...
www.nature.com
November 4, 2026 at 9:22 AM
Autophagy in macrophages curtails IL-1α-mediated immune priming against lung infections
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Autophagy in macrophages curtails IL-1α-mediated immune priming against lung infections - Nature Immunology
Wang and colleagues show that autophagy deficiency in alveolar macrophages upregulates the expression of IL-1α and increases resistance to respiratory infections.
www.nature.com
October 30, 2026 at 1:30 PM
Autophagy in macrophages curtails IL-1α-mediated immune priming against lung infections
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The authors included RRIDs in their in eLife paper! Thanks for making your methods matter! #ReproducibleResearch #BetterScience #OpenScience
Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
Read the full paper: Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
doi.org
October 30, 2026 at 7:07 AM
The authors included RRIDs in their in eLife paper! Thanks for making your methods matter! #ReproducibleResearch #BetterScience #OpenScience
Chaperone-mediated autophagy is regulated by the lysosomal receptor LAMP2A - a key pathway for αSynuclein clearance. Researchers report LAMP2A gene therapy mitigates #Parkinsons–related pathology in nonhuman primates & evoked beneficial effects on motor
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 31, 2026 at 1:44 PM
Chaperone-mediated autophagy is regulated by the lysosomal receptor LAMP2A - a key pathway for αSynuclein clearance. Researchers report LAMP2A gene therapy mitigates #Parkinsons–related pathology in nonhuman primates & evoked beneficial effects on motor
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Last but not least for this session, we welcome Ahmed Elshazly from Virgina Commonwealth University, presenting his work on “AUTAC-mediated selective autophagy uncouples MCL1-targeted antitumor activity from cardiotoxicity”.
#WIA2026meeting
#WIA2026meeting
October 28, 2026 at 12:37 AM
Last but not least for this session, we welcome Ahmed Elshazly from Virgina Commonwealth University, presenting his work on “AUTAC-mediated selective autophagy uncouples MCL1-targeted antitumor activity from cardiotoxicity”.
#WIA2026meeting
#WIA2026meeting
📰 "LAMP2A gene therapy mitigates Parkinson’s disease–related pathology in nonhuman primates", published in Sciences Advances
✒️ ML Arotçarena, H Jadot, M Darricau, A Lovisotto, S Dovero, V Planche, ML Thiolat, N ,Dutheil, E Bezard, B Dehay et al.
📍 For more : www.science.org/doi/10.1126/...
✒️ ML Arotçarena, H Jadot, M Darricau, A Lovisotto, S Dovero, V Planche, ML Thiolat, N ,Dutheil, E Bezard, B Dehay et al.
📍 For more : www.science.org/doi/10.1126/...
LAMP2A gene therapy mitigates Parkinson’s disease–related pathology in nonhuman primates
Chaperone-mediated autophagy (CMA), regulated by its lysosomal receptor LAMP2A, is a key pathway for αSynuclein (αSyn) clearance and a direct target of αSyn-related neurotoxicity. Rodent studies show ...
www.science.org
November 2, 2026 at 10:26 AM
📰 "LAMP2A gene therapy mitigates Parkinson’s disease–related pathology in nonhuman primates", published in Sciences Advances
✒️ ML Arotçarena, H Jadot, M Darricau, A Lovisotto, S Dovero, V Planche, ML Thiolat, N ,Dutheil, E Bezard, B Dehay et al.
📍 For more : www.science.org/doi/10.1126/...
✒️ ML Arotçarena, H Jadot, M Darricau, A Lovisotto, S Dovero, V Planche, ML Thiolat, N ,Dutheil, E Bezard, B Dehay et al.
📍 For more : www.science.org/doi/10.1126/...
Up next, we are excited to have Anna Dahlström from Abo Akademi University, presenting her work on Dredd-mediated cleavage of Kenny uncouples the IKK complex from selective autophagy to enable innate immunity.
#WIAmeeting2026
#WIAmeeting2026
October 26, 2026 at 5:35 PM
Up next, we are excited to have Anna Dahlström from Abo Akademi University, presenting her work on Dredd-mediated cleavage of Kenny uncouples the IKK complex from selective autophagy to enable innate immunity.
#WIAmeeting2026
#WIAmeeting2026
Auf jeden Fall. Dazu gibt es sogar schon eine Pilotstudie für MECFS
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study - Journal of Translational Medicine
Background mTOR activation is associated with chronic inflammation in ME/CFS. Previous studies have shown that sustained mTOR activation may cause chronic muscle fatigue by inhibiting ATG13-mediated a...
link.springer.com
October 25, 2026 at 5:10 PM
Auf jeden Fall. Dazu gibt es sogar schon eine Pilotstudie für MECFS
link.springer.com/article/10.1...
link.springer.com/article/10.1...
RRID:AB_2164267 from @thermofishersci.bsky.social was used by authors in their Metabolic Brain Disease paper. RRIDs improve reproducibility in scientific research. #RRID #reproducibility #ReproducibleResearch
Gentiopicroside alleviates depression-like symptoms in animal models through regulating COX-2-mediated autophagy and inflammation
Read the full paper: Gentiopicroside alleviates depression-like symptoms in animal models through regulating COX-2-mediated autophagy and inflammation
doi.org
October 25, 2026 at 7:00 AM
RRID:AB_2164267 from @thermofishersci.bsky.social was used by authors in their Metabolic Brain Disease paper. RRIDs improve reproducibility in scientific research. #RRID #reproducibility #ReproducibleResearch
Spatiotemporally Programmable Chaperone-Mediated Autophagy Activation Disarms the Senescence-Immunity Axis for Targeted Intervertebral Disc Regeneration
advanced.onlinelibrary.wiley.com/doi/full/10....
advanced.onlinelibrary.wiley.com/doi/full/10....
Spatiotemporally Programmable Chaperone‐Mediated Autophagy Activation Disarms the Senescence‐Immunity Axis for Targeted Intervertebral Disc Regeneration
A. Dual cross-linked ROS-responsive hydrogel synthesized by incorporating TA and EVs loaded with AR7 into the boronate bonds of HA-PBA and HA-DA. B. Schematic diagram illustrating application of the ...
advanced.onlinelibrary.wiley.com
October 23, 2026 at 1:18 PM
Spatiotemporally Programmable Chaperone-Mediated Autophagy Activation Disarms the Senescence-Immunity Axis for Targeted Intervertebral Disc Regeneration
advanced.onlinelibrary.wiley.com/doi/full/10....
advanced.onlinelibrary.wiley.com/doi/full/10....
Why do zombie cells pile up with age? 🧟 Einstein: declining chaperone-mediated autophagy impairs senescent cells AND the macrophages that clear them. A CMA-boosting compound cleared them in aged mice. Mostly mouse data. doi.org/10.1038/s435...
#Senescence
#Senescence
October 22, 2026 at 9:16 PM
Why do zombie cells pile up with age? 🧟 Einstein: declining chaperone-mediated autophagy impairs senescent cells AND the macrophages that clear them. A CMA-boosting compound cleared them in aged mice. Mostly mouse data. doi.org/10.1038/s435...
#Senescence
#Senescence
The receptor TM9SF3 controls Golgiphagy, but how is it itself regulated?
Yixian Cui & colleagues show that under stress, it is stabilized by USP28-mediated deubiquitination, leading to maintenance of glycosylation patterns and thereby promoting breast tumor growth
link.springer.com/article/10.1...
Yixian Cui & colleagues show that under stress, it is stabilized by USP28-mediated deubiquitination, leading to maintenance of glycosylation patterns and thereby promoting breast tumor growth
link.springer.com/article/10.1...
A USP28-TM9SF3-Golgiphagy axis maintains glycosylation homeostasis and promotes breast cancer progression - The EMBO Journal
Selective autophagy of the Golgi apparatus (Golgiphagy) is essential for Golgi quality control, yet its regulation and physiological functions remain poorly understood. Here, we identify the deubiquit...
link.springer.com
October 20, 2026 at 12:36 PM
The receptor TM9SF3 controls Golgiphagy, but how is it itself regulated?
Yixian Cui & colleagues show that under stress, it is stabilized by USP28-mediated deubiquitination, leading to maintenance of glycosylation patterns and thereby promoting breast tumor growth
link.springer.com/article/10.1...
Yixian Cui & colleagues show that under stress, it is stabilized by USP28-mediated deubiquitination, leading to maintenance of glycosylation patterns and thereby promoting breast tumor growth
link.springer.com/article/10.1...
→ What they did
Researchers described how the decline in chaperone-mediated autophagy over time hinders the removal of senescent cells, which cause aging.
Researchers described how the decline in chaperone-mediated autophagy over time hinders the removal of senescent cells, which cause aging.
October 18, 2026 at 2:00 PM
→ What they did
Researchers described how the decline in chaperone-mediated autophagy over time hinders the removal of senescent cells, which cause aging.
Researchers described how the decline in chaperone-mediated autophagy over time hinders the removal of senescent cells, which cause aging.
Dual #Autophagy activation improves #AlzheimersDisease.
Presenting AR7 & rapamycin- delivering #Microglia-derived nanovesicles that synchronously activate autophagy & macroautophagy, enhancing amyloid clearance and cognition.
#STTT #OpenAccess: doi.org/10.1038/s413...
Presenting AR7 & rapamycin- delivering #Microglia-derived nanovesicles that synchronously activate autophagy & macroautophagy, enhancing amyloid clearance and cognition.
#STTT #OpenAccess: doi.org/10.1038/s413...
October 17, 2026 at 6:00 AM
Dual #Autophagy activation improves #AlzheimersDisease.
Presenting AR7 & rapamycin- delivering #Microglia-derived nanovesicles that synchronously activate autophagy & macroautophagy, enhancing amyloid clearance and cognition.
#STTT #OpenAccess: doi.org/10.1038/s413...
Presenting AR7 & rapamycin- delivering #Microglia-derived nanovesicles that synchronously activate autophagy & macroautophagy, enhancing amyloid clearance and cognition.
#STTT #OpenAccess: doi.org/10.1038/s413...
The study found that age-related decline in chaperone-mediated autophagy impairs the clearance of senescence cells. The article also reviews differences identified in gut microbiome composition between young, old, and older adults.
#Senescence #ChaperoneMediatedAutophagy #Aging
#Senescence #ChaperoneMediatedAutophagy #Aging
Impaired removal of senescence cells due to aging
Source: Fight Aging!
realfeedapp.com
October 18, 2026 at 2:00 PM
The study found that age-related decline in chaperone-mediated autophagy impairs the clearance of senescence cells. The article also reviews differences identified in gut microbiome composition between young, old, and older adults.
#Senescence #ChaperoneMediatedAutophagy #Aging
#Senescence #ChaperoneMediatedAutophagy #Aging
As we age, our immune cells become less effective at clearing away senescent cells. A study published in Nature Aging suggests that a decline in chaperone-mediated autophagy impairs this cleanup process in macrophages, potentially contributing to age-related inflammation and disease.🧪
Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells - Nature Aging
This study looks at how the decline in chaperone-mediated autophagy in aging alters senescent cell properties leading to an impairment in their immune clearance. Utilizing proteomic and metabolomic analyses, the authors show that restoring autophagy enhances macrophage function and reduces senescent cell accumulation.
go.nature.com
October 15, 2026 at 10:00 PM
As we age, our immune cells become less effective at clearing away senescent cells. A study published in Nature Aging suggests that a decline in chaperone-mediated autophagy impairs this cleanup process in macrophages, potentially contributing to age-related inflammation and disease.🧪
Restoring chaperone-mediated autophagy in macrophages is mechanistically stronger than merely correlating senescent-cell load with age. The next boundary is tissue and organism specificity: changing senescent-cell persistence may have context-dependent effects.
October 15, 2026 at 11:01 PM
Restoring chaperone-mediated autophagy in macrophages is mechanistically stronger than merely correlating senescent-cell load with age. The next boundary is tissue and organism specificity: changing senescent-cell persistence may have context-dependent effects.
RRIDs were included in this in Journal of Radiation Research and Applied Sciences paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #RRID #methodsmatter
Safflower yellow investigates AMPK/mTOR-mediated autophagy to mitigate sevoflurane-induced neuroinflammation and cognitive dysfunction
Read the full paper: Safflower yellow investigates AMPK/mTOR-mediated autophagy to mitigate sevoflurane-induced neuroinflammation and cognitive dysfunction
doi.org
October 12, 2026 at 7:00 AM
RRIDs were included in this in Journal of Radiation Research and Applied Sciences paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #RRID #methodsmatter
BmSNX20 restricts Bombyx mori nucleopolyhedrovirus infection and is associated with autophagy-mediated antiviral immunity #BmNPV
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
October 11, 2026 at 10:56 AM
BmSNX20 restricts Bombyx mori nucleopolyhedrovirus infection and is associated with autophagy-mediated antiviral immunity #BmNPV
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Using comprehensive #Multiomics analyses, researchers identify PLPP2-mediated phosphatidylethanolamine biosynthesis as a driver of #LiverRegeneration by promoting GLI1 stabilization and #Autophagy while alleviating #ERstress.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
October 12, 2026 at 6:32 AM
Using comprehensive #Multiomics analyses, researchers identify PLPP2-mediated phosphatidylethanolamine biosynthesis as a driver of #LiverRegeneration by promoting GLI1 stabilization and #Autophagy while alleviating #ERstress.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...