full video here!!
youtu.be/CydT3swcIn8
youtu.be/CydT3swcIn8
Estimate Bestimate | GameJungle S2E4
YouTube video by illegal melon
youtu.be
October 13, 2026 at 10:40 AM
full video here!!
youtu.be/CydT3swcIn8
youtu.be/CydT3swcIn8
As a marginalised AGI safety designer - current bestimate; it's less likely to cause our immediate extinction, but more likely to be stupid yet recursive, switch off the Internet for people and recruit a bunch of human sycophants to build its 3rd rate vision.
Could go either way for other species.
Could go either way for other species.
September 19, 2026 at 4:16 AM
As a marginalised AGI safety designer - current bestimate; it's less likely to cause our immediate extinction, but more likely to be stupid yet recursive, switch off the Internet for people and recruit a bunch of human sycophants to build its 3rd rate vision.
Could go either way for other species.
Could go either way for other species.
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/CansuDincer/...
May 20, 2025 at 3:30 PM
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/CansuDincer/...
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments https://www.biorxiv.org/content/10.1101/2025.05.19.654892v1
May 20, 2025 at 3:47 AM
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments https://www.biorxiv.org/content/10.1101/2025.05.19.654892v1
If you are fancy to test, please check the below repository:
📂 GitHub: github.com/CansuDincer/...
📂 GitHub: github.com/CansuDincer/...
GitHub - CansuDincer/BEstimate: BEstimate, a Python module that systematically analyses guide RNA (gRNA) targetable sites across given sequences for given Base Editors, and functional and clinical eff...
BEstimate, a Python module that systematically analyses guide RNA (gRNA) targetable sites across given sequences for given Base Editors, and functional and clinical effects of the potential edits o...
github.com
May 22, 2025 at 1:21 PM
If you are fancy to test, please check the below repository:
📂 GitHub: github.com/CansuDincer/...
📂 GitHub: github.com/CansuDincer/...
BEstimate enables the identification of gRNAs, generating variants on reference and mutant sequences, correcting pathogenic variants for therapeutic development, and extensive annotation of the base editing libraries for pre- and post-experiment interpretation.
May 22, 2025 at 1:21 PM
BEstimate enables the identification of gRNAs, generating variants on reference and mutant sequences, correcting pathogenic variants for therapeutic development, and extensive annotation of the base editing libraries for pre- and post-experiment interpretation.
With BEstimate you can:
✅ Fully customise Cas enzymes, base editors & PAMs
✅ Design libraries for reference or mutated sequences
✅ Find gRNAs reverting the alterations
✅ Annotate functional, structural & clinical impacts
✅ Retrieve real-time data via Ensembl & UniProt APIs
✅ Fully customise Cas enzymes, base editors & PAMs
✅ Design libraries for reference or mutated sequences
✅ Find gRNAs reverting the alterations
✅ Annotate functional, structural & clinical impacts
✅ Retrieve real-time data via Ensembl & UniProt APIs
May 22, 2025 at 1:21 PM
With BEstimate you can:
✅ Fully customise Cas enzymes, base editors & PAMs
✅ Design libraries for reference or mutated sequences
✅ Find gRNAs reverting the alterations
✅ Annotate functional, structural & clinical impacts
✅ Retrieve real-time data via Ensembl & UniProt APIs
✅ Fully customise Cas enzymes, base editors & PAMs
✅ Design libraries for reference or mutated sequences
✅ Find gRNAs reverting the alterations
✅ Annotate functional, structural & clinical impacts
✅ Retrieve real-time data via Ensembl & UniProt APIs
🚨 Excited to share our latest preprint!
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments https://www.biorxiv.org/content/10.1101/2025.05.19.654892v1
May 22, 2025 at 1:21 PM
🚨 Excited to share our latest preprint!
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor
BITCOIN Enters BUY ZONE. Peak Not There Yet.
#Bitcoin can still hit $150K minimum (bestimate) up to $200K (See BTC 1W Chart)
🧐 Historically (see BTC Halving to ATH Table), Bitcoin tends to hit its cycle peak between 12 to 18 months post-halving—roughly 365 to 550 days.
#Bitcoin can still hit $150K minimum (bestimate) up to $200K (See BTC 1W Chart)
🧐 Historically (see BTC Halving to ATH Table), Bitcoin tends to hit its cycle peak between 12 to 18 months post-halving—roughly 365 to 550 days.
August 26, 2025 at 2:20 AM
BITCOIN Enters BUY ZONE. Peak Not There Yet.
#Bitcoin can still hit $150K minimum (bestimate) up to $200K (See BTC 1W Chart)
🧐 Historically (see BTC Halving to ATH Table), Bitcoin tends to hit its cycle peak between 12 to 18 months post-halving—roughly 365 to 550 days.
#Bitcoin can still hit $150K minimum (bestimate) up to $200K (See BTC 1W Chart)
🧐 Historically (see BTC Halving to ATH Table), Bitcoin tends to hit its cycle peak between 12 to 18 months post-halving—roughly 365 to 550 days.
11k words away from reaching my bestimate* word goal for my first novella's draft! Also at a decent pace to meet my random deadline. 🤓
*best estimate
Whether it'll make sense is another (unedited) story... 😜
Slow progress is still progress.
#WritingCommunity #amwriting
*best estimate
Whether it'll make sense is another (unedited) story... 😜
Slow progress is still progress.
#WritingCommunity #amwriting
November 17, 2024 at 10:48 PM
11k words away from reaching my bestimate* word goal for my first novella's draft! Also at a decent pace to meet my random deadline. 🤓
*best estimate
Whether it'll make sense is another (unedited) story... 😜
Slow progress is still progress.
#WritingCommunity #amwriting
*best estimate
Whether it'll make sense is another (unedited) story... 😜
Slow progress is still progress.
#WritingCommunity #amwriting
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments https://www.biorxiv.org/content/10.1101/2025.05.19.654892v1
May 20, 2025 at 3:47 AM
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments https://www.biorxiv.org/content/10.1101/2025.05.19.654892v1
🧬 New in #Genome #Biology: BEstimate — a computational tool for #CRISPR base editor #gRNA design and functional interpretation. From Coelho & Garnett labs at Wellcome Sanger.
Open source + precomputed gRNA library for 50 cancer genes:
🔗 github.com/Garnett-Lab/BEstimate
🌐 bestimate.sanger.ac.uk
Open source + precomputed gRNA library for 50 cancer genes:
🔗 github.com/Garnett-Lab/BEstimate
🌐 bestimate.sanger.ac.uk
May 9, 2026 at 11:05 AM
🧬 New in #Genome #Biology: BEstimate — a computational tool for #CRISPR base editor #gRNA design and functional interpretation. From Coelho & Garnett labs at Wellcome Sanger.
Open source + precomputed gRNA library for 50 cancer genes:
🔗 github.com/Garnett-Lab/BEstimate
🌐 bestimate.sanger.ac.uk
Open source + precomputed gRNA library for 50 cancer genes:
🔗 github.com/Garnett-Lab/BEstimate
🌐 bestimate.sanger.ac.uk
Please check our website for pre-computed data bestimate.sanger.ac.uk and the command line tool to try it yourself github.com/Garnett-Lab/....
with thanks and congrats to @mgarnett.bsky.social , @cansudincer.bsky.social and Bo Fussing!
with thanks and congrats to @mgarnett.bsky.social , @cansudincer.bsky.social and Bo Fussing!
BEstimate Web
bestimate.sanger.ac.uk
May 6, 2026 at 7:15 PM
Please check our website for pre-computed data bestimate.sanger.ac.uk and the command line tool to try it yourself github.com/Garnett-Lab/....
with thanks and congrats to @mgarnett.bsky.social , @cansudincer.bsky.social and Bo Fussing!
with thanks and congrats to @mgarnett.bsky.social , @cansudincer.bsky.social and Bo Fussing!
Excited to see BEstimate out -
a computational tool for base editing guide RNA design for screening, disease modelling and correction of pathogenic variants.
It's SNP-aware, so you can parse non-reference genomes, and reports off-target sites.
paper:
link.springer.com/article/10.1...
a computational tool for base editing guide RNA design for screening, disease modelling and correction of pathogenic variants.
It's SNP-aware, so you can parse non-reference genomes, and reports off-target sites.
paper:
link.springer.com/article/10.1...
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments - Genome Biology
CRISPR base editors enable scalable targeted DNA mutagenesis and are a powerful tool for analysing the function of variants of uncertain significance and disease modelling. Existing guide RNA (gRNA) d...
link.springer.com
May 6, 2026 at 7:15 PM
Excited to see BEstimate out -
a computational tool for base editing guide RNA design for screening, disease modelling and correction of pathogenic variants.
It's SNP-aware, so you can parse non-reference genomes, and reports off-target sites.
paper:
link.springer.com/article/10.1...
a computational tool for base editing guide RNA design for screening, disease modelling and correction of pathogenic variants.
It's SNP-aware, so you can parse non-reference genomes, and reports off-target sites.
paper:
link.springer.com/article/10.1...
Basen in der #DNA mit Baseneditoren auszutauschen, kann ungeahnte Probleme machen. Das Tool BEstimate minimiert das Risiko, indem es geeignete guide-RNAs auswählt und die möglichen Auswirkungen auf der Protein-Ebene durchspielt. Andrea Pitzschke stellt es vor: www.laborjournal.de/editorials/3...
June 3, 2025 at 7:36 AM
Basen in der #DNA mit Baseneditoren auszutauschen, kann ungeahnte Probleme machen. Das Tool BEstimate minimiert das Risiko, indem es geeignete guide-RNAs auswählt und die möglichen Auswirkungen auf der Protein-Ebene durchspielt. Andrea Pitzschke stellt es vor: www.laborjournal.de/editorials/3...
not only estimated in fact its our very bestimate
October 7, 2025 at 9:13 AM
not only estimated in fact its our very bestimate
Discover BEstimate: a tool streamlining CRISPR base editing with precise gRNA design, targeting site analysis, and off-target predictions! 🧬✨ PMID:42045938, Genome Biol 2026 @OTSociety @NAR_Open https://doi.org/10.1186/s13059-026-04077-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments | Genome Biology | Springer Nature Link
CRISPR base editors enable scalable targeted DNA mutagenesis and are a powerful tool for analysing the function of variants of uncertain significance and d
doi.org
May 25, 2026 at 12:40 PM