1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
September 9, 2025 at 8:01 PM
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
#LaminarShearStress-KLF2 in #EndothelialCell ⏬BMP signaling ▶️⏬#VascularCalcification in hyperlipidemic🐭
BMP4 BMPER as direct targets of KLF2
LSS
⏫BMPER
⏬BMP4 MGP FST
OsteoSense 680 to image aortic calcification in vivo
#CircRes 2021 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
BMP4 BMPER as direct targets of KLF2
LSS
⏫BMPER
⏬BMP4 MGP FST
OsteoSense 680 to image aortic calcification in vivo
#CircRes 2021 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
November 23, 2024 at 8:24 PM
#LaminarShearStress-KLF2 in #EndothelialCell ⏬BMP signaling ▶️⏬#VascularCalcification in hyperlipidemic🐭
BMP4 BMPER as direct targets of KLF2
LSS
⏫BMPER
⏬BMP4 MGP FST
OsteoSense 680 to image aortic calcification in vivo
#CircRes 2021 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
BMP4 BMPER as direct targets of KLF2
LSS
⏫BMPER
⏬BMP4 MGP FST
OsteoSense 680 to image aortic calcification in vivo
#CircRes 2021 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
Hi paleontologist with a background in developmental biology here. Though we don’t have direct evidence of dinosaur penises, developmental evidence suggests they did.
Chickens don’t have penises because their developing genitals get a targeted cell death signal called bmp4.
Chickens don’t have penises because their developing genitals get a targeted cell death signal called bmp4.
May 22, 2025 at 3:05 PM
Hi paleontologist with a background in developmental biology here. Though we don’t have direct evidence of dinosaur penises, developmental evidence suggests they did.
Chickens don’t have penises because their developing genitals get a targeted cell death signal called bmp4.
Chickens don’t have penises because their developing genitals get a targeted cell death signal called bmp4.
So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this!
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
December 2, 2025 at 1:47 PM
So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this!
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
A lovely example of the interplay of morphogen dynamics, tissue mechanics, cell mechanics and signal transduction at the most crucial stage of embryogenesis. And a good example of why talk of development being "programmed" into the genome is simply the wrong language.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models
Brivanlou and colleagues used optogenetics to spatially control BMP4 expression in
human stem cell models across different mechanical regimes. By combining these experiments
with mathematical modeling...
www.cell.com
November 6, 2025 at 8:56 PM
A lovely example of the interplay of morphogen dynamics, tissue mechanics, cell mechanics and signal transduction at the most crucial stage of embryogenesis. And a good example of why talk of development being "programmed" into the genome is simply the wrong language.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
🚨 New Preprint from the Paluch & Chalut Labs 🚨
Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire
#mechanobiology #hESCs #substratemechanics
doi.org/10.64898/202...
Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire
#mechanobiology #hESCs #substratemechanics
doi.org/10.64898/202...
February 16, 2026 at 6:42 PM
🚨 New Preprint from the Paluch & Chalut Labs 🚨
Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire
#mechanobiology #hESCs #substratemechanics
doi.org/10.64898/202...
Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire
#mechanobiology #hESCs #substratemechanics
doi.org/10.64898/202...
new gunpla announcements and holy fucking shit this thing looks sick af. dont show the anti rogue orbits tho they might get an anneurism or something
HG 1/144 BMP4/6 “Bau Bahlam”
Rogue Orbit
HG 1/144 BMP4/6 “Bau Bahlam”
Rogue Orbit
October 2, 2026 at 3:05 AM
new gunpla announcements and holy fucking shit this thing looks sick af. dont show the anti rogue orbits tho they might get an anneurism or something
HG 1/144 BMP4/6 “Bau Bahlam”
Rogue Orbit
HG 1/144 BMP4/6 “Bau Bahlam”
Rogue Orbit
We used optogenetics to control the transcription of BMP4 in pluripotent stem cells. We create light-driven models of gastrulation with no colony edges or with streak-like geometries. Purely coincidental but good timing with the Nobel announcement this week...
October 7, 2026 at 5:12 PM
We used optogenetics to control the transcription of BMP4 in pluripotent stem cells. We create light-driven models of gastrulation with no colony edges or with streak-like geometries. Purely coincidental but good timing with the Nobel announcement this week...
Modern birds evolved *away* from the penis.
We know this not only because the ancient bird families still have penises but because bird embryos develop phalluses and then lose the phallus if the Bmp4 gene is active.
(Bird embryos also have dinosaur tails that form and then go away)
We know this not only because the ancient bird families still have penises but because bird embryos develop phalluses and then lose the phallus if the Bmp4 gene is active.
(Bird embryos also have dinosaur tails that form and then go away)
A lot of ppl are responding to this meme with the assumption that *all* Dinos copulate via a cloacal kiss
Counter to this logic is that Paleognaths (ostriches, emus, tinamous, etc …) & Galloanseriformes (ducks, geese, swans, etc … ) are some of the most *ancient* bird families & *they* have penises
Counter to this logic is that Paleognaths (ostriches, emus, tinamous, etc …) & Galloanseriformes (ducks, geese, swans, etc … ) are some of the most *ancient* bird families & *they* have penises
Claiming that Dinosaurs are "fake" because you can't image a way for them to copulate is such a weird way to announce to the world:
"I'm boring in bed"
"I'm boring in bed"
June 22, 2025 at 9:28 PM
Modern birds evolved *away* from the penis.
We know this not only because the ancient bird families still have penises but because bird embryos develop phalluses and then lose the phallus if the Bmp4 gene is active.
(Bird embryos also have dinosaur tails that form and then go away)
We know this not only because the ancient bird families still have penises but because bird embryos develop phalluses and then lose the phallus if the Bmp4 gene is active.
(Bird embryos also have dinosaur tails that form and then go away)
Reading because it looks fascinating & fundamental.
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation: Developmental Cell www.cell.com/developmenta... 🧪
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation: Developmental Cell www.cell.com/developmenta... 🧪
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
September 15, 2025 at 8:20 PM
Reading because it looks fascinating & fundamental.
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation: Developmental Cell www.cell.com/developmenta... 🧪
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation: Developmental Cell www.cell.com/developmenta... 🧪
Interesting work on #morphogen (BMP4, Wnt8) mobility and HSPGs in Xenopus🐸
Identification of N-acetyl-rich heparan sulfate binding motifs and their role in expanding BMP distribution and signaling by Cerberus https://www.biorxiv.org/content/10.1101/2025.04.16.649141v1
May 18, 2025 at 9:04 PM
Interesting work on #morphogen (BMP4, Wnt8) mobility and HSPGs in Xenopus🐸
#DBfeature 🐣
BMP and WNT signaling are involved in tracheal cartilage development in chicken embryos
COL2A1 co-localises with BMP2 but not with BMP4 in the tracheal cartilages
by Romman Muntzar, Tamara Anne Franz-Odendaal, et al
www.sciencedirect.com/science/arti...
BMP and WNT signaling are involved in tracheal cartilage development in chicken embryos
COL2A1 co-localises with BMP2 but not with BMP4 in the tracheal cartilages
by Romman Muntzar, Tamara Anne Franz-Odendaal, et al
www.sciencedirect.com/science/arti...
January 21, 2026 at 1:02 PM
#DBfeature 🐣
BMP and WNT signaling are involved in tracheal cartilage development in chicken embryos
COL2A1 co-localises with BMP2 but not with BMP4 in the tracheal cartilages
by Romman Muntzar, Tamara Anne Franz-Odendaal, et al
www.sciencedirect.com/science/arti...
BMP and WNT signaling are involved in tracheal cartilage development in chicken embryos
COL2A1 co-localises with BMP2 but not with BMP4 in the tracheal cartilages
by Romman Muntzar, Tamara Anne Franz-Odendaal, et al
www.sciencedirect.com/science/arti...
Our ✨ latest work ✨ is out today! Led by our incredibly talented PhD student @oliveringe.bsky.social and with @jamesbriscoe.bsky.social and many @crick.ac.uk friends and collaborators. Very grateful to all involved, and excited about this story.
check out Ollie’s post www.cell.com/developmenta...
check out Ollie’s post www.cell.com/developmenta...
September 9, 2025 at 8:14 PM
Our ✨ latest work ✨ is out today! Led by our incredibly talented PhD student @oliveringe.bsky.social and with @jamesbriscoe.bsky.social and many @crick.ac.uk friends and collaborators. Very grateful to all involved, and excited about this story.
check out Ollie’s post www.cell.com/developmenta...
check out Ollie’s post www.cell.com/developmenta...
Can the bmp4 file play on windows media player?
May 22, 2025 at 6:40 PM
Can the bmp4 file play on windows media player?
Periosteum #YAP/TAZ Bone fracture repair
Adult Osx+ osteoprogenitor YAP/TAZ KO🐭
👉Impeded initial periosteal expansion (4 d post fracture)
👉YAP/TEAD-dependent BMP4 paracrine➡️
⏫Osx- periosteal cell proliferation
1/5
@jboerckel.bsky.social bioRxiv 2024
www.biorxiv.org/content/10.1...
Adult Osx+ osteoprogenitor YAP/TAZ KO🐭
👉Impeded initial periosteal expansion (4 d post fracture)
👉YAP/TEAD-dependent BMP4 paracrine➡️
⏫Osx- periosteal cell proliferation
1/5
@jboerckel.bsky.social bioRxiv 2024
www.biorxiv.org/content/10.1...
December 31, 2024 at 8:32 PM
Periosteum #YAP/TAZ Bone fracture repair
Adult Osx+ osteoprogenitor YAP/TAZ KO🐭
👉Impeded initial periosteal expansion (4 d post fracture)
👉YAP/TEAD-dependent BMP4 paracrine➡️
⏫Osx- periosteal cell proliferation
1/5
@jboerckel.bsky.social bioRxiv 2024
www.biorxiv.org/content/10.1...
Adult Osx+ osteoprogenitor YAP/TAZ KO🐭
👉Impeded initial periosteal expansion (4 d post fracture)
👉YAP/TEAD-dependent BMP4 paracrine➡️
⏫Osx- periosteal cell proliferation
1/5
@jboerckel.bsky.social bioRxiv 2024
www.biorxiv.org/content/10.1...
Online Now! Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models #stemcells
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models
Brivanlou and colleagues used optogenetics to spatially control BMP4 expression in human stem cell models across different mechanical regimes. By combining these experiments with mathematical modeling, they dissected how biochemical signals and mechanical forces integrate to initiate symmetry breaking at the onset of gastrulation.
dlvr.it
October 13, 2025 at 7:09 PM
Online Now! Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models #stemcells
Oligodendrocyte precursor cells–microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oligodendrocyte precursor cells–microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer’s disease - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Oligodendrocyte precursor cells–microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer’s disease
www.nature.com
March 25, 2026 at 3:14 PM
Oligodendrocyte precursor cells–microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#DBfeature🫁
#InHoxWeTrust
HOXA5-driven transcriptional program in lung development
"HOXA5 directs Fgf10, Tbx4/5, Ptch1, Bmp4 and Wnt2 expression during lung formation"
by Béatrice Frenette, Lucie Jeannotte et al
www.sciencedirect.com/science/arti...
#InHoxWeTrust
HOXA5-driven transcriptional program in lung development
"HOXA5 directs Fgf10, Tbx4/5, Ptch1, Bmp4 and Wnt2 expression during lung formation"
by Béatrice Frenette, Lucie Jeannotte et al
www.sciencedirect.com/science/arti...
April 27, 2026 at 4:01 AM
#DBfeature🫁
#InHoxWeTrust
HOXA5-driven transcriptional program in lung development
"HOXA5 directs Fgf10, Tbx4/5, Ptch1, Bmp4 and Wnt2 expression during lung formation"
by Béatrice Frenette, Lucie Jeannotte et al
www.sciencedirect.com/science/arti...
#InHoxWeTrust
HOXA5-driven transcriptional program in lung development
"HOXA5 directs Fgf10, Tbx4/5, Ptch1, Bmp4 and Wnt2 expression during lung formation"
by Béatrice Frenette, Lucie Jeannotte et al
www.sciencedirect.com/science/arti...
A high-fidelity protocol for #hiPSC-derived Fibrosa vs Spongiosa #ValvularIntersistialCell
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
October 16, 2025 at 11:35 AM
A high-fidelity protocol for #hiPSC-derived Fibrosa vs Spongiosa #ValvularIntersistialCell
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
A preprint using: VAT (Vesicular Acety (RRID:AB_572269) from #Immunostar was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #RRID
BMP4 Restricts Axonal Ramification and Bouton Density in Cholinergic Projections from the Basal Forebrain
www.biorxiv.org
October 8, 2026 at 12:00 PM
A preprint using: VAT (Vesicular Acety (RRID:AB_572269) from #Immunostar was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #RRID
Congratulations to Katherina Tavernini on the completion of her PhD! Tavernini presented her dissertation titled “BMP4 induces a quiescent-like state in human radial glia neural stem cells” during her PhD defense.
December 16, 2025 at 12:45 PM
Congratulations to Katherina Tavernini on the completion of her PhD! Tavernini presented her dissertation titled “BMP4 induces a quiescent-like state in human radial glia neural stem cells” during her PhD defense.
Cell Signalling: Not all dimers are equal
Disease-causing mutations in the signalling protein BMP4 impair its secretion, but only when it is made as a homodimer. #DevBio
buff.ly/IOCuo3j
Disease-causing mutations in the signalling protein BMP4 impair its secretion, but only when it is made as a homodimer. #DevBio
buff.ly/IOCuo3j
May 14, 2025 at 3:15 PM
Cell Signalling: Not all dimers are equal
Disease-causing mutations in the signalling protein BMP4 impair its secretion, but only when it is made as a homodimer. #DevBio
buff.ly/IOCuo3j
Disease-causing mutations in the signalling protein BMP4 impair its secretion, but only when it is made as a homodimer. #DevBio
buff.ly/IOCuo3j
Does the Lada count as a Bmp4? How long before Russia starts confiscating them to use as infantry fighting vehicles.
November 25, 2024 at 7:07 AM
Does the Lada count as a Bmp4? How long before Russia starts confiscating them to use as infantry fighting vehicles.
TUSC3 serves as a rate-limiting gatekeeper of a glycan-mediated ER Triage Checkpoint for BMP4/Dpp
#Drosophila
#Drosophila
TUSC3 serves as a rate-limiting gatekeeper of a glycan-mediated ER Triage Checkpoint for BMP4/Dpp
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 19, 2025 at 12:23 PM
TUSC3 serves as a rate-limiting gatekeeper of a glycan-mediated ER Triage Checkpoint for BMP4/Dpp
#Drosophila
#Drosophila