Bemisia tabaci is a highly destructive pest that affects many crops worldwide. Its feeding behavior on phloem sap and secretion of honeydew on leaves leads to the accumulation of mold, which impairs p...

<span><i>Bemisia tabaci</i> cryptic species Middle East-Asia Minor I (MEAM1) is a serious agricultural polyphagous insect pest and vector of numerous plant viruses, causing major worldwide economic losses. <i>B. tabaci</i> control is limited by lack of robust gene editing tools. Gene editing is difficult</span> …

Based on the systematic functional analysis of trehalose metabolism genes in Bemisia tabaci, this study reveals that RNAi-mediated silencing of BtTre1 induces significant mortality and disrupts energ...

Cal Mosaic disease, caused by Cassava mosaic virus and transmitted by the whitefly Bemisia tabaci, threatens cassava production. This study examined whitefly–virus interactions across resistant and…

Bemisia tabaci cryptic species Middle East-Asia Minor I (MEAM1) is a serious agricultural polyphagous insect pest and vector of numerous plant viruses, causing major worldwide economic losses. B. taba...

Bemisia tabaci is a highly destructive pest that affects many crops worldwide. Its feeding behavior on phloem sap and secretion of honeydew on leaves leads to the accumulation of mold, which impairs photosynthesis and fruit quality. Additionally, it transmits more than 100 plant viruses, which interfere with plant growth and reduce crop productivity. In this work, we targeted the ecdysone receptor (EcR) of B. tabaci, as it is involved in metamorphosis, cell differentiation, and reproduction processes. The EcR sequence was retrieved from the UniProt database (A0A142K0N3), and multiple sequence alignment (MSA) revealed that the ligand-binding domain is conserved among other plant-destroying pests and insects. The EcR structure of B. tabaci (PDB ID: 1Z5X) was used for high-throughput virtual screening with 32,552 secondary metabolites, retrieved from the NPAtlas 2.0 database using iDock 2.2.3. The top 40 metabolites were selected based on their predicted binding energy by iDock 2.2.3 and redocked using AutoDock Vina 1.1.2. The complexes of the top four compounds with EcR were selected for molecular dynamics simulation (total simulation time: 0.5 μs) and compared with the apo-EcR structure. Additionally, umbrella sampling simulations were performed for 1.64 μs. The insecticide-like properties and toxicity of the four metabolites were compared with conventional pesticides such as ponasterone A. Our computational predictions suggest that NPA008492, NPA006374, NPA012964, and NPA012752 are potential lead molecules and promising candidates for experimental validation.

The whitefly, Bemisia tabaci, is a hemipteran with a haplodiploid sex determination system, which pr

Cassava mosaic disease (CMD), caused by the cassava mosaic virus (CMV) and transmitted primarily by the whitefly Bemisia tabaci, reflects the most severe and widespread viral threat to cassava cultiva...