BREAKING: Development of a spike protein-specific radiolabeled antibody used with PET imaging shows presence of spike in brain & lungs of macaque monkeys 3 months post-COVID; provides new viral reservoir detection opportunity for long COVID: www.nature.com/articles/s41...
Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates - Nature Communications
There are limited approaches to monitor virus spread in vivo. Here, the authors report PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a ra...
www.nature.com
March 28, 2025 at 6:13 PM
BREAKING: Development of a spike protein-specific radiolabeled antibody used with PET imaging shows presence of spike in brain & lungs of macaque monkeys 3 months post-COVID; provides new viral reservoir detection opportunity for long COVID: www.nature.com/articles/s41...
Biology was never meant to be studied in 2D.
One of the coolest things about my new work is being able to visualize:
🧠 Neural circuits
🩸 Vascular networks
🎯 Drug biodistribution
🎗️ Disease progression
Here's a small glimpse of what we're building at @deeppiction.bsky.social 🤩🔬
#3DImaging
One of the coolest things about my new work is being able to visualize:
🧠 Neural circuits
🩸 Vascular networks
🎯 Drug biodistribution
🎗️ Disease progression
Here's a small glimpse of what we're building at @deeppiction.bsky.social 🤩🔬
#3DImaging
June 22, 2026 at 4:10 PM
Biology was never meant to be studied in 2D.
One of the coolest things about my new work is being able to visualize:
🧠 Neural circuits
🩸 Vascular networks
🎯 Drug biodistribution
🎗️ Disease progression
Here's a small glimpse of what we're building at @deeppiction.bsky.social 🤩🔬
#3DImaging
One of the coolest things about my new work is being able to visualize:
🧠 Neural circuits
🩸 Vascular networks
🎯 Drug biodistribution
🎗️ Disease progression
Here's a small glimpse of what we're building at @deeppiction.bsky.social 🤩🔬
#3DImaging
I can't categorize or summarize the next question. Bizarre mix of word salad. Worried about "biodistribution" of vaccines that "they don't stay in the arm". Yes, the immune system is not confined to the arm...🤦
September 19, 2025 at 3:47 PM
I can't categorize or summarize the next question. Bizarre mix of word salad. Worried about "biodistribution" of vaccines that "they don't stay in the arm". Yes, the immune system is not confined to the arm...🤦
(ES&T) Correction
to “Quantitative Assessment of Particulate
Matter Biodistribution Using 14 C-Nanotracing and
Accelerator Mass Spectrometry”: Korea Institute of Science and Technology10.13039/5011000036932E32411 #MassSpecRSS
to “Quantitative Assessment of Particulate
Matter Biodistribution Using 14 C-Nanotracing and
Accelerator Mass Spectrometry”: Korea Institute of Science and Technology10.13039/5011000036932E32411 #MassSpecRSS
Correction
to “Quantitative Assessment of Particulate
Matter Biodistribution Using 14 C-Nanotracing and
Accelerator Mass Spectrometry”
Korea Institute of Science and Technology10.13039/5011000036932E32411
dlvr.it
September 30, 2026 at 4:02 AM
(ES&T) Correction
to “Quantitative Assessment of Particulate
Matter Biodistribution Using 14 C-Nanotracing and
Accelerator Mass Spectrometry”: Korea Institute of Science and Technology10.13039/5011000036932E32411 #MassSpecRSS
to “Quantitative Assessment of Particulate
Matter Biodistribution Using 14 C-Nanotracing and
Accelerator Mass Spectrometry”: Korea Institute of Science and Technology10.13039/5011000036932E32411 #MassSpecRSS
A paper in Nature Communications reports PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a radiolabeled human antibody revealing persistent detection in the lung and brain three months after infection. #medsky 🧪
Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates - Nature Communications
There are limited approaches to monitor virus spread in vivo. Here, the authors report PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a radiolabeled human antibody revealing persistent detection in the lung and brain 3 months after infection.
go.nature.com
March 26, 2025 at 10:37 PM
A paper in Nature Communications reports PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a radiolabeled human antibody revealing persistent detection in the lung and brain three months after infection. #medsky 🧪
This is cool stuff - imaging covalent drug biodistribution using tissue clearing methods
December 22, 2025 at 4:48 PM
This is cool stuff - imaging covalent drug biodistribution using tissue clearing methods
Dieser Ansatz bietet eine neue Möglichkeit zur Erkennung viraler SARS-CoV-2-Reservoirs bei Long COVID.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates - Nature Communications
There are limited approaches to monitor virus spread in vivo. Here, the authors report PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a radiolabeled human antibody revealing persistent detection in the lung and brain 3 months after infection.
www.nature.com
March 28, 2025 at 9:10 PM
Dieser Ansatz bietet eine neue Möglichkeit zur Erkennung viraler SARS-CoV-2-Reservoirs bei Long COVID.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The thing that drives me absolutely bizonkers about this is that I worked on preclinical toxicology studies of biodistribution/bioavailability of mRNA therapeutics back in 2012, and the main problem with them was they didn't stick in the body long enough to be good cancer drugs
In what proportions is our new NIH Director a flaming ignoramus vs. a brazen liar?
![Jonny Paradise 🌱
@plantparadise7
·
NIH Director Jay Bhattacharya on mRNA tech:
"The next step is [to halt] the mRNA platform itself... the manufacturer has no idea what dose they're giving, no idea where it goes in the body, and whether they are producing off-target antigens"](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:q25tg5qy6kzwtuecpe6b4shw/bafkreie7wm23po34vcypd5357s2a2dgav7bhdzypwmkdjgb7jxsfijjf2y)
April 23, 2025 at 10:55 PM
The thing that drives me absolutely bizonkers about this is that I worked on preclinical toxicology studies of biodistribution/bioavailability of mRNA therapeutics back in 2012, and the main problem with them was they didn't stick in the body long enough to be good cancer drugs
Cool application of in vivo bioorthogonal chemistry from Biogen, imaging biodistribution of ASOs in the brain 🤯
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry
Intrathecally dosed antisense oligonucleotide distribution can be imaged in rat and nonhuman primate brains using a PET tracer and click chemistry.
www.science.org
May 8, 2025 at 10:12 PM
Cool application of in vivo bioorthogonal chemistry from Biogen, imaging biodistribution of ASOs in the brain 🤯
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Currently approved mRNA vaccines are safe and effective at preventing infectious diseases, with promise for future disease prevention and treatment, new review confirms.
Read more: spkl.io/633287145E
Read more: spkl.io/633287145E
June 30, 2026 at 10:34 PM
Currently approved mRNA vaccines are safe and effective at preventing infectious diseases, with promise for future disease prevention and treatment, new review confirms.
Read more: spkl.io/633287145E
Read more: spkl.io/633287145E
mRNA is transient. No DNA integration. Limited biodistribution. Massive safety data. If these fears were real, viral infections would be far worse. This isn’t dissent; it’s misinformation dressed as science. Credentials don’t replace evidence. Read the facts.
2/2
2/2
December 19, 2025 at 2:49 PM
mRNA is transient. No DNA integration. Limited biodistribution. Massive safety data. If these fears were real, viral infections would be far worse. This isn’t dissent; it’s misinformation dressed as science. Credentials don’t replace evidence. Read the facts.
2/2
2/2
Where do therapeutics go in the body?
SCP-Nano combines whole-body imaging and AI to map nanocarrier biodistribution at single-cell resolution, revealing both intended targets and unexpected off-target destinations.
Our recent work at @nature.com Biotechnology:
www.nature.com/articles/s41...
SCP-Nano combines whole-body imaging and AI to map nanocarrier biodistribution at single-cell resolution, revealing both intended targets and unexpected off-target destinations.
Our recent work at @nature.com Biotechnology:
www.nature.com/articles/s41...
June 13, 2026 at 3:04 PM
Where do therapeutics go in the body?
SCP-Nano combines whole-body imaging and AI to map nanocarrier biodistribution at single-cell resolution, revealing both intended targets and unexpected off-target destinations.
Our recent work at @nature.com Biotechnology:
www.nature.com/articles/s41...
SCP-Nano combines whole-body imaging and AI to map nanocarrier biodistribution at single-cell resolution, revealing both intended targets and unexpected off-target destinations.
Our recent work at @nature.com Biotechnology:
www.nature.com/articles/s41...
and ACOG used them as a basis to recommend COVID-19 vaccination to pregnant individuals even though they were not specifically studied in a pregnant population). We also do have biodistribution studies- these have gone viral. They contain important data, but, importantly, give doses much higher...
June 25, 2025 at 5:57 PM
and ACOG used them as a basis to recommend COVID-19 vaccination to pregnant individuals even though they were not specifically studied in a pregnant population). We also do have biodistribution studies- these have gone viral. They contain important data, but, importantly, give doses much higher...
Not at all clear from your question to AI. You also don’t need AI to make that statement. The statement is also moot since regulators test pharmacokinetics of mRNA vaccines and both their persistence and biodistribution is comparable to other non-live vaccines. Do you think those tests aren’t done?
April 1, 2026 at 12:57 PM
Not at all clear from your question to AI. You also don’t need AI to make that statement. The statement is also moot since regulators test pharmacokinetics of mRNA vaccines and both their persistence and biodistribution is comparable to other non-live vaccines. Do you think those tests aren’t done?
Currently approved mRNA vaccines are safe and effective at preventing infectious diseases, with promise for future disease prevention and treatment, review confirms.
Read more: spkl.io/633207y0ZI
Read more: spkl.io/633207y0ZI
July 18, 2026 at 10:09 AM
Currently approved mRNA vaccines are safe and effective at preventing infectious diseases, with promise for future disease prevention and treatment, review confirms.
Read more: spkl.io/633207y0ZI
Read more: spkl.io/633207y0ZI
and extensively evaluated in preclinical neurotoxicity and biodistribution studies.We already have decades of experience with intranasal vaccines (e.g., flu), and no signal of increased neurologic or psychiatric harm has emerged.
January 13, 2026 at 8:34 PM
and extensively evaluated in preclinical neurotoxicity and biodistribution studies.We already have decades of experience with intranasal vaccines (e.g., flu), and no signal of increased neurologic or psychiatric harm has emerged.
There must be a reason why a neuroscientist and a respiratory physician get together to say some things are not quite right in #LongCovid. Persistence of spike protein in the lungs and brain?
-with @davidjoffe64.bsky.social
-with @davidjoffe64.bsky.social
![Manuscript published at Nature Communications on 21 March 2025. Title reads: Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates?. Part of the abstract reads: Convalescent animals exhibit a persistent [89Zr]COVA1-27-DFO PET signal in the lungs, as well as in the brain, three months following infection.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:wsvuncumgqbgywier5z67lvp/bafkreiaiw7rrdkb2vjgosvlrcbhhnhyr4ddkie7mlu2oe5cjrgho3277iy)
March 29, 2025 at 8:05 AM
There must be a reason why a neuroscientist and a respiratory physician get together to say some things are not quite right in #LongCovid. Persistence of spike protein in the lungs and brain?
-with @davidjoffe64.bsky.social
-with @davidjoffe64.bsky.social
were tested. Can it be improved, sure. But WHAT?? You have control over how much antigen and the biodistribution? You are really unaware of all the literature? There is very little antigen around, you need very specialised methods to even detect it!
See evidence of harms in different systems??
5/8
See evidence of harms in different systems??
5/8
April 24, 2025 at 8:37 AM
were tested. Can it be improved, sure. But WHAT?? You have control over how much antigen and the biodistribution? You are really unaware of all the literature? There is very little antigen around, you need very specialised methods to even detect it!
See evidence of harms in different systems??
5/8
See evidence of harms in different systems??
5/8
Redwood chimes in to talk about the biodistribution of thimerosal, noting that clearance from the brain has the potential to accumulate.
Except this is not associated with neurotoxic effects, so this point is meaningless. Redwood also incorrectly states that ethylmercury has greater potential...
Except this is not associated with neurotoxic effects, so this point is meaningless. Redwood also incorrectly states that ethylmercury has greater potential...
June 26, 2025 at 3:33 PM
Redwood chimes in to talk about the biodistribution of thimerosal, noting that clearance from the brain has the potential to accumulate.
Except this is not associated with neurotoxic effects, so this point is meaningless. Redwood also incorrectly states that ethylmercury has greater potential...
Except this is not associated with neurotoxic effects, so this point is meaningless. Redwood also incorrectly states that ethylmercury has greater potential...
In her Featured Abstract talk, Kerstin Menck shows syntenin drastically controls the protein composition of tumor EVs, with effects on tumor cell migration and biodistribution
#ISEV2025
#ISEV2025
April 26, 2025 at 9:51 AM
In her Featured Abstract talk, Kerstin Menck shows syntenin drastically controls the protein composition of tumor EVs, with effects on tumor cell migration and biodistribution
#ISEV2025
#ISEV2025
🧵
Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates
assets-eu.researchsquare.com/files/rs-523...
#Covid #Covid19 #LongCovid #PASC
1/
Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates
assets-eu.researchsquare.com/files/rs-523...
#Covid #Covid19 #LongCovid #PASC
1/
assets-eu.researchsquare.com
November 4, 2024 at 2:02 PM
🧵
Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates
assets-eu.researchsquare.com/files/rs-523...
#Covid #Covid19 #LongCovid #PASC
1/
Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates
assets-eu.researchsquare.com/files/rs-523...
#Covid #Covid19 #LongCovid #PASC
1/
New paper from our lab (@erturklab.bsky.social)
We show how tissue clearing, light sheet microscopy, and AI-based image analysis can be combined to determine the biodistribution and drug delivery efficiency of nanocarriers throughout entire mouse bodies with single-cell resolution.
We show how tissue clearing, light sheet microscopy, and AI-based image analysis can be combined to determine the biodistribution and drug delivery efficiency of nanocarriers throughout entire mouse bodies with single-cell resolution.
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature Biotechnology
An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies.
www.nature.com
January 14, 2025 at 11:15 AM
New paper from our lab (@erturklab.bsky.social)
We show how tissue clearing, light sheet microscopy, and AI-based image analysis can be combined to determine the biodistribution and drug delivery efficiency of nanocarriers throughout entire mouse bodies with single-cell resolution.
We show how tissue clearing, light sheet microscopy, and AI-based image analysis can be combined to determine the biodistribution and drug delivery efficiency of nanocarriers throughout entire mouse bodies with single-cell resolution.
Preclinical evaluation of the biodistribution, safety, and hemocompatibility of PEG-coated iron oxide magnetic nanoparticles in a viral oncogenesis mouse model https://www.biorxiv.org/content/10.64898/2026.09.29.755312v1
October 2, 2026 at 5:00 AM
Preclinical evaluation of the biodistribution, safety, and hemocompatibility of PEG-coated iron oxide magnetic nanoparticles in a viral oncogenesis mouse model https://www.biorxiv.org/content/10.64898/2026.09.29.755312v1