Congratulations!
Our group leader Tristan Wagner wins an
@ERC_Research #ConsolidatorGrant!
His project #EnLightEn targets the #C1-metabolism and will shed light on the #metabolism of #microbes in #anaerobic environments.
mpi-bremen.de/en/ERC-Conso...
Our group leader Tristan Wagner wins an
@ERC_Research #ConsolidatorGrant!
His project #EnLightEn targets the #C1-metabolism and will shed light on the #metabolism of #microbes in #anaerobic environments.
mpi-bremen.de/en/ERC-Conso...
November 24, 2023 at 7:40 AM
Congratulations!
Our group leader Tristan Wagner wins an
@ERC_Research #ConsolidatorGrant!
His project #EnLightEn targets the #C1-metabolism and will shed light on the #metabolism of #microbes in #anaerobic environments.
mpi-bremen.de/en/ERC-Conso...
Our group leader Tristan Wagner wins an
@ERC_Research #ConsolidatorGrant!
His project #EnLightEn targets the #C1-metabolism and will shed light on the #metabolism of #microbes in #anaerobic environments.
mpi-bremen.de/en/ERC-Conso...
Using high-throughput 13CO2 labeling to determine if photorespiration can be engineered to increase flux to one-carbon metabolism academic.oup.com/jxb/article/... @jxbotany.bsky.social
Using high-throughput 13CO2 labeling to determine if photorespiration can be engineered to increase flux to one-carbon metabolism
Abstract. Photorespiration is connected to other aspects of plant metabolism, including one-carbon (C1) metabolism. While a major contributor of C1 units i
academic.oup.com
July 22, 2026 at 1:29 PM
Using high-throughput 13CO2 labeling to determine if photorespiration can be engineered to increase flux to one-carbon metabolism academic.oup.com/jxb/article/... @jxbotany.bsky.social
#Synthetic C1 #metabolism in #Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway—led by J. Turlin, M. G. Alván, @oscarpuiggene.bsky.social w/@stefanodonati.bsky.social & @sebwenk.bsky.social @mbio.bsky.social #SynBio
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Synthetic C1 metabolism in Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway | mBio
Soluble C1 feedstocks, such as formate and methanol, have gained attention as sustainable substrates for biotechnology, with the potential to reduce greenhouse gas emissions and reliance on sugar-based resources. Despite their promise, the metabolic ...
journals.asm.org
August 21, 2025 at 3:45 PM
#Synthetic C1 #metabolism in #Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway—led by J. Turlin, M. G. Alván, @oscarpuiggene.bsky.social w/@stefanodonati.bsky.social & @sebwenk.bsky.social @mbio.bsky.social #SynBio
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Before giving a lecture on C1 metabolism at Microbial Diversity, Leslie Day (a postdoc in my lab and a member of the course faculty, shared her road in science. @mblscience.bsky.social
July 15, 2026 at 1:13 PM
Before giving a lecture on C1 metabolism at Microbial Diversity, Leslie Day (a postdoc in my lab and a member of the course faculty, shared her road in science. @mblscience.bsky.social
2021年に発表されたブドウ種子エキスのプロシアニジンC1にセノリシス効果があるという論文に注意喚起が出ています。共同研究者にJudith Campisi, James Kirklandもいて、自分の周りでも結構話題だった気がします。自分のグループでも雑誌会で紹介してた
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Editorial Expression of Concern: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice - Nature Metabolism
Nature Metabolism - Editorial Expression of Concern: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
www.nature.com
March 9, 2026 at 12:50 PM
2021年に発表されたブドウ種子エキスのプロシアニジンC1にセノリシス効果があるという論文に注意喚起が出ています。共同研究者にJudith Campisi, James Kirklandもいて、自分の周りでも結構話題だった気がします。自分のグループでも雑誌会で紹介してた
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Methanol and Carbon Monoxide Metabolism of the Thermophile Moorella caeni enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... #jcampubs
Methanol and Carbon Monoxide Metabolism of the Thermophile Moorella caeni
An omics approach was used to elucidate the C1 metabolism of Moorella caeni DSM 21394 T, which exhibits acetogenic metabolism on methanol and hydrogenogenic metabolism on CO. Our results suggest that...
enviromicro-journals.onlinelibrary.wiley.com
April 15, 2025 at 2:42 PM
Methanol and Carbon Monoxide Metabolism of the Thermophile Moorella caeni enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... #jcampubs
Proudly presenting a new minireview on single carbon assimilation by yeasts for a circular carbon economy
doi.org/10.1093/fems...
Wonderful collaboration with Miriam Kuzman and Özge Ata
@bokuvienna.bsky.social
acib
@femsjournals.bsky.social
doi.org/10.1093/fems...
Wonderful collaboration with Miriam Kuzman and Özge Ata
@bokuvienna.bsky.social
acib
@femsjournals.bsky.social
Advancing yeast metabolism for a sustainable single carbon bioeconomy
The recent advancements in engineering of single carbon (C1) utilization pathways in yeast biotechnology for future C1-based processes are discussed.
doi.org
April 25, 2025 at 8:23 PM
Proudly presenting a new minireview on single carbon assimilation by yeasts for a circular carbon economy
doi.org/10.1093/fems...
Wonderful collaboration with Miriam Kuzman and Özge Ata
@bokuvienna.bsky.social
acib
@femsjournals.bsky.social
doi.org/10.1093/fems...
Wonderful collaboration with Miriam Kuzman and Özge Ata
@bokuvienna.bsky.social
acib
@femsjournals.bsky.social
Very happy and proud of this work led by @beaubd.bsky.social with many others involved, in which we show that synthetic C1 metabolism can do better than nature for biotech!
Super excited to see my main PhD project finally out in @naturemicrobiol.bsky.social www.nature.com/articles/s41.... We show for the first time that a synthetic and engineered pathway can indeed exceed nature at one-carbon fixation.
One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle - Nature Microbiology
An engineered one-carbon-fixation pathway increases biomass yields of Cupriavidus necator compared with the Calvin cycle and can support future, sustainable bio-based production.
www.nature.com
February 27, 2025 at 3:46 PM
Very happy and proud of this work led by @beaubd.bsky.social with many others involved, in which we show that synthetic C1 metabolism can do better than nature for biotech!
✨ Paper spotlight ✨
(🧵 1/7) Evolutionary and functional relationships of plant and microbial C1 metabolism in terrestrial ecosystems
nph.onlinelibrary.wiley.com/doi/10.1111/...
(🧵 1/7) Evolutionary and functional relationships of plant and microbial C1 metabolism in terrestrial ecosystems
nph.onlinelibrary.wiley.com/doi/10.1111/...
August 12, 2025 at 10:00 AM
✨ Paper spotlight ✨
(🧵 1/7) Evolutionary and functional relationships of plant and microbial C1 metabolism in terrestrial ecosystems
nph.onlinelibrary.wiley.com/doi/10.1111/...
(🧵 1/7) Evolutionary and functional relationships of plant and microbial C1 metabolism in terrestrial ecosystems
nph.onlinelibrary.wiley.com/doi/10.1111/...
Formate dehydrogenase is targeted to mitochondria (not chloroplasts) and constitutes a C1 shunt between mitochondria and cytoplasm
Mitochondrial formate dehydrogenase links mitochondrial and cytosolic one carbon metabolism via a one-carbon shunt url: academic.oup.com/plphys/artic...
Mitochondrial formate dehydrogenase links mitochondrial and cytosolic one carbon metabolism via a one-carbon shunt url: academic.oup.com/plphys/artic...
December 6, 2025 at 2:19 PM
Formate dehydrogenase is targeted to mitochondria (not chloroplasts) and constitutes a C1 shunt between mitochondria and cytoplasm
Mitochondrial formate dehydrogenase links mitochondrial and cytosolic one carbon metabolism via a one-carbon shunt url: academic.oup.com/plphys/artic...
Mitochondrial formate dehydrogenase links mitochondrial and cytosolic one carbon metabolism via a one-carbon shunt url: academic.oup.com/plphys/artic...
Just 2 days to go until we can welcome the participants of the EuroC1 Meeting 2025 here in #Bremen.
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
mpi-bremen.de/EuroC1-Sympo...
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
mpi-bremen.de/EuroC1-Sympo...
May 5, 2025 at 6:59 AM
Just 2 days to go until we can welcome the participants of the EuroC1 Meeting 2025 here in #Bremen.
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
mpi-bremen.de/EuroC1-Sympo...
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
mpi-bremen.de/EuroC1-Sympo...
Please repost!
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
efzu.fa.em2.oraclecloud.com
September 12, 2025 at 11:43 AM
Please repost!
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Register now for the EuroC1 Meeting 2025, taking place on from May 7 to 8 in #Bremen.
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
Register by March 31
mpi-bremen.de/EuroC1-Sympo...
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
Register by March 31
mpi-bremen.de/EuroC1-Sympo...
January 22, 2025 at 1:29 PM
Register now for the EuroC1 Meeting 2025, taking place on from May 7 to 8 in #Bremen.
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
Register by March 31
mpi-bremen.de/EuroC1-Sympo...
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
Register by March 31
mpi-bremen.de/EuroC1-Sympo...
#TansleyReview: Evolutionary and functional #relationships between plant and microbial C1 metabolism in terrestrial #ecosystems
Jardine et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
Jardine et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
October 4, 2025 at 11:22 AM
#TansleyReview: Evolutionary and functional #relationships between plant and microbial C1 metabolism in terrestrial #ecosystems
Jardine et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
Jardine et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
🚨 New paper in mBio!
We established strict formatotrophic & methylotrophic growth in engineered Pseudomonas putida via the reductive glycine pathway (rGlyP). journals.asm.org/doi/full/10....
Here’s a teaser of how we did it 🧵👇1/5
We established strict formatotrophic & methylotrophic growth in engineered Pseudomonas putida via the reductive glycine pathway (rGlyP). journals.asm.org/doi/full/10....
Here’s a teaser of how we did it 🧵👇1/5
Synthetic C1 metabolism in Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway | mBio
Soluble C1 feedstocks, such as formate and methanol, have gained attention as sustainable substrates for biotechnology, with the potential to reduce greenhouse gas emissions and reliance on sugar-based resources. Despite their promise, the metabolic ...
journals.asm.org
August 22, 2025 at 10:19 AM
🚨 New paper in mBio!
We established strict formatotrophic & methylotrophic growth in engineered Pseudomonas putida via the reductive glycine pathway (rGlyP). journals.asm.org/doi/full/10....
Here’s a teaser of how we did it 🧵👇1/5
We established strict formatotrophic & methylotrophic growth in engineered Pseudomonas putida via the reductive glycine pathway (rGlyP). journals.asm.org/doi/full/10....
Here’s a teaser of how we did it 🧵👇1/5
@nicoc-micsynmet.bsky.social ramps up synthetic C1 metabolism, pushing C1 biotech from the lab close to the launchpad at #MPA2025 @univie.ac.at
July 29, 2025 at 9:57 AM
@nicoc-micsynmet.bsky.social ramps up synthetic C1 metabolism, pushing C1 biotech from the lab close to the launchpad at #MPA2025 @univie.ac.at
🧪Researching microbial C1 metabolism? #FEMSMicrobiolEcol invites submissions for our thematic issue exploring the latest advances in C1 compound transformations and its role in global biogeochemical cycles. One month left to submit: buff.ly/aVfZJoR
#CallForPapers #MicrobiologyResearch #Ecology
#CallForPapers #MicrobiologyResearch #Ecology
August 30, 2025 at 10:01 AM
🧪Researching microbial C1 metabolism? #FEMSMicrobiolEcol invites submissions for our thematic issue exploring the latest advances in C1 compound transformations and its role in global biogeochemical cycles. One month left to submit: buff.ly/aVfZJoR
#CallForPapers #MicrobiologyResearch #Ecology
#CallForPapers #MicrobiologyResearch #Ecology
New Article: "Metabolic flux analysis in leaf metabolism quantifies the link between photorespiration and one carbon metabolism" rdcu.be/eDWLH
C flux quantification between two major plant metabolisms—photorespiration and C1 metabolism—using 13CO2 labelling and...
C flux quantification between two major plant metabolisms—photorespiration and C1 metabolism—using 13CO2 labelling and...
September 3, 2025 at 3:54 PM
New Article: "Metabolic flux analysis in leaf metabolism quantifies the link between photorespiration and one carbon metabolism" rdcu.be/eDWLH
C flux quantification between two major plant metabolisms—photorespiration and C1 metabolism—using 13CO2 labelling and...
C flux quantification between two major plant metabolisms—photorespiration and C1 metabolism—using 13CO2 labelling and...
We were thrilled to welcome @cuwelte.bsky.social as our second keynote speaker at the Euro C1 Conference. Her talk “Challenging Methanotrophy: Carbon Monoxide Metabolism in Anaerobic Methanotrophic Archaea” shed light on surprising new aspects of archaeal carbon cycling.
#EuroC1 #MPI #Keynote
#EuroC1 #MPI #Keynote
May 12, 2025 at 12:18 PM
We were thrilled to welcome @cuwelte.bsky.social as our second keynote speaker at the Euro C1 Conference. Her talk “Challenging Methanotrophy: Carbon Monoxide Metabolism in Anaerobic Methanotrophic Archaea” shed light on surprising new aspects of archaeal carbon cycling.
#EuroC1 #MPI #Keynote
#EuroC1 #MPI #Keynote
The utilization of #C1-feedstocks, such as methanol, by non-model bacteria demands an in-depth analysis of design alternatives, a modular strategy to identify bottlenecks and efficient solutions within the host #metabolism of the chosen host...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation
The urgent need for a circular carbon economy has driven research into sustainable substrates, including one-carbon (C1) compounds. The non-pathogenic soil bacterium Pseudomonas putida is a promising ...
www.biorxiv.org
March 9, 2025 at 10:51 AM
The utilization of #C1-feedstocks, such as methanol, by non-model bacteria demands an in-depth analysis of design alternatives, a modular strategy to identify bottlenecks and efficient solutions within the host #metabolism of the chosen host...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
About me, I work at DTU Biosustain applying systems and synthetic biology approaches to microbial metabolism, focusing on assimilation of C1 compounds
www.biosustain.dtu.dk/research/res...
www.biosustain.dtu.dk/research/res...
C1 Systems Biology
In this group we study the metabolism of microbes capable of growth on CO2 and derivative molecules (C1 substrates). Our objective is to understand and engineer microorganisms suitable for sustainable...
www.biosustain.dtu.dk
November 19, 2024 at 10:36 AM
About me, I work at DTU Biosustain applying systems and synthetic biology approaches to microbial metabolism, focusing on assimilation of C1 compounds
www.biosustain.dtu.dk/research/res...
www.biosustain.dtu.dk/research/res...
New in JB: Bauer, Rudel & Beier explore the mechanisms of riboregulation via 4 sRNAs in Neisseria gonorrhoeae C1 metabolism.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriol
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriol
May 4, 2026 at 12:01 PM
New in JB: Bauer, Rudel & Beier explore the mechanisms of riboregulation via 4 sRNAs in Neisseria gonorrhoeae C1 metabolism.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriol
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriol
Here we further characterize methylolanthanin (MLL), a chelator that is involved in Ln metabolism in bacteria (see www.pnas.org/doi/10.1073/...) Yes, methylotrophic bacteria use La, Nd... in their C1 metabolism! #fblockrocks They use them in the active site of methanol dehydrogenase enzymes. Anyway…
December 3, 2024 at 3:54 PM
Here we further characterize methylolanthanin (MLL), a chelator that is involved in Ln metabolism in bacteria (see www.pnas.org/doi/10.1073/...) Yes, methylotrophic bacteria use La, Nd... in their C1 metabolism! #fblockrocks They use them in the active site of methanol dehydrogenase enzymes. Anyway…
New print from our lab! Insights into vanillic acid metabolism in Methylobacterium!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Aromatic acid metabolism in Methylobacterium extorquens reveals interplay between methylotrophic and heterotrophic pathways
Efforts towards microbial conversion of lignin to value-added products face many challenges because lignin's methoxylated aromatic monomers release toxic C1 byproducts such as formaldehyde. The abilit...
www.biorxiv.org
March 24, 2025 at 4:03 PM
New print from our lab! Insights into vanillic acid metabolism in Methylobacterium!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The enzyme PLA2G15 breaks down BMP, and inhibiting PLA2G15 extends lifespan in a mouse model of Niemann–Pick type C1, a neurodegenerative disorder marked by impaired lysosomal lipid metabolism
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
May 8, 2025 at 7:18 PM
The enzyme PLA2G15 breaks down BMP, and inhibiting PLA2G15 extends lifespan in a mouse model of Niemann–Pick type C1, a neurodegenerative disorder marked by impaired lysosomal lipid metabolism
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com