Read the full paper: Formate from THF‐C1 metabolism induces the AOX1 promoter in formate dehydrogenase‐deficient Komagataella phaffii

While bacteria are common in the atmosphere, their activity in situ has remained unclear. Using stagnant radiation fogs as new study systems where sampling is optimal, the dynamics, composition, cellular characteristics, and metabolic rates of fog water microbiomes, dominated by Methylobacterium sp., show that they are a hub of active detoxification of atmospheric formaldehyde and likely growing in situ on the basis of heterotrophic or photoheterotrophic metabolism of volatile C1 compounds, with implications for atmospheric chemistry and fog harvesting as sources of freshwater.

The thermophilic acetogenic bacterium Moorella thermoacetica is a promising platform organism to convert C1 compounds to valuable products. Gaseous C1 substrates are technically difficult to use for ...

Abstract. Photorespiration is connected to other aspects of plant metabolism, including one-carbon (C1) metabolism. While a major contributor of C1 units i

Nature Metabolism - Editorial Expression of Concern: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

In developing biotechnological solutions for a circular economy, it is critical to valorize all parts of renewable resources, such as lignocellulose from vegetative components of agricultural crops an...

Nature Metabolism, Published online: 23 February 2026; doi:10.1038/s42255-026-01487-yEditorial Expression of Concern: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

This study reveals that Arabidopsis reassimilates formate produced during photorespiration via the cytosolic folate cycle to fuel DNA methylation, forming a metabolic–epigenetic bridge that links elev...

Nature Metabolism, Published online: 23 February 2026; doi:10.1038/s42255-026-01487-yEditorial Expression of Concern: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

The polyphenol procyanidin C1, a compound found in grape seeds, possesses senomorphic or senolytic activity and is shown to extend the healthspan and survival of old mice and in various models of sene...

This paper quantified carbon flux between two major plant metabolisms—photorespiration and C1 metabolism—using 13CO2 labelling and isotopically non-stationary metabolic flux analysis.

De novo metabolic pathways open possibilities for sustainable biotransformations in microbes. However, the in vivo-implementation of such new-to-nature pathways is highly challenging and heavily relies on adaptive laboratory evolution (ALE) of the host's native metabolic network. Here, we assess how much this need for host-centric ALE can be overcome and/or complemented through the informed design of the newly introduced pathway. Exemplifying for a synthetic CO2-fixation module via methylsuccinate, we established methylsuccinate-dependent growth of Escherichia coli over six months by ALE of E. coli's native metabolism. In parallel, we developed a machine-learning guided workflow (MEVIS) for the automated engineering of the synthetic pathway, resulting in methylsuccinate-dependent growth within three weeks. Critically, performing MEVIS in the background of the ALE-evolved strain is necessary to further approach wild-type like growth, demonstrating how ALE in combination with machine-learning-guided lab automation holds great potential to accelerate and improve design-build-test-learn cycles in contemporary metabolic engineering. ### Competing Interest Statement The authors have declared no competing interest. Max Planck Society, https://ror.org/01hhn8329 Bosch Research Foundation

The polyphenol procyanidin C1, a compound found in grape seeds, possesses senomorphic or senolytic activity and is shown to extend the healthspan and survival of old mice and in various models of sene...