#CACNA1B
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thevgccc.bsky.social
The Voltage-Gated #Calcium Channel Collective - a #CACNA1A, #CACNA1B, #CACNA1C, #CACNA1D, #CACNA1E, #CACNA1F, #CACNA1G, #CACNA1H, #CACNA1I & #CACNA1S collaboration alongside researchers and clinicians raising awareness, accelerating knowledge, signposting and empowering our communities.
#IonChannels
What is the VGCCC? Voltage-Gated Calcium Channels act like doors on cells, opening when there's an electrical signal. They let calcium ions* flow in, helping with muscle movement, neurotransmission, and other important body functions. The genes that represent the Voltage-Gated Calcium Channels are CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I and CACNA1S. In the same way the channels work together like a team to ensure proper cell communication and function, we are collaborating as patient gene groups with a network of researchers to raise awareness and accelerate knowledge for all our gene groups. We are the Voltage-Gated Calcium Channel Collective. * Calcium ions are positively charged particles of calcium, an essential mineral found in the body.
November 18, 2024 at 3:17 PM
biorxiv-neursci.bsky.social
Trpv1-dependent Cacna1b gene inactivation reveals cell-specific functions of CaV2.2 channels in vivo https://www.biorxiv.org/content/10.1101/2025.05.09.652131v1
May 11, 2025 at 1:15 AM
diabetologiajnl.bsky.social
DNA methylation at loci including CHMP6, CACNA1B and PKNOX1 was associated with 28 year neuropathy incidence in the Pittsburgh Epidemiology of Diabetes Complications study type 1 diabetes cohort #T1D #DiabetesResearch link.springer.com/article/10.1...
DNA methylation and 28 year incidence of two neuropathy phenotypes in type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications cohort study - Diabetologia
Aims/hypothesis Diabetic peripheral neuropathy (DPN) and neuropathic pain (NP) are common complications of type 1 diabetes that can greatly affect quality of life. Studying DNA methylation (DNAm) may ...
link.springer.com
April 30, 2025 at 6:24 AM
psychscene.bsky.social
Emerging gene therapy research targets the Cacna1b gene to reduce CaV2.2 expression or function in neuropathic states.

This approach offers long-term modulation without daily dosing.

But these approaches remain investigational and are not yet ready for clinical application.
June 22, 2025 at 9:55 AM
alleslab.bsky.social
Lovely preprint with some thought-provoking findings from Diane Lipscombe's group www.biorxiv.org/content/10.1...
Trpv1-dependent Cacna1b gene inactivation reveals cell-specific functions of CaV2.2 channels in vivo
Voltage-gated CaV2.2 channels underlie the N-type current, and they regulate calcium entry at many presynaptic nerve endings to control transmitter release. A role for CaV2.2 channels has been well-es...
www.biorxiv.org
May 12, 2025 at 12:21 PM
thevgccc.bsky.social
#CACNA1B
Raising awareness and promoting collaboration across the #calcium #channelopathies. Find us at thevgccc.org
A digital graphic with a purple background features white text and an illustrated unicorn with a pink mane and a glittery texture. Green stars are scattered around the unicorn. The bold heading reads, 'LOOKING FOR THE ONE IN A MILLION.' The text explains that the CACNA1B gene is important for brain communication and that changes in this gene are linked to neurological disorders such as seizures, epileptic encephalopathy, dystonia, autism spectrum disorder, and neuropathic pain. It invites families and individuals with confirmed CACNA1B gene changes to join the CACNA1B community and provides the website address 'thevgccc.org' for contact.
March 18, 2025 at 5:57 PM
sciencex.bsky.social
Back stroking was the only touch that clearly reduced infants’ spontaneous movement. In mouse pups, the same calming response appeared only after normal maternal care and partly depended on Cacna1b. doi.org/hb9k5n
Why the back? How stroking calms infants and mouse pups
Across cultures, the way we soothe an unsettled baby tends to look much the same: hold them close and gently rub their back.
medicalxpress.com
July 6, 2026 at 3:05 PM
biorxivpreprint.bsky.social
Cacna1b alternative splicing is linked to associative learning https://www.biorxiv.org/content/10.64898/2026.02.17.706441v1
February 18, 2026 at 8:15 AM
biorxivpreprint.bsky.social
Trpv1-dependent Cacna1b gene inactivation reveals cell-specific functions of CaV2.2 channels in vivo https://www.biorxiv.org/content/10.1101/2025.05.09.652131v1
May 11, 2025 at 1:15 AM
biorxivpreprint.bsky.social
ω-Phonetoxins inhibit voltage-gated calcium CaV2.2 ion channel splice isoforms of dorsal root ganglia https://www.biorxiv.org/content/10.1101/2023.08.29.555337v1
ω-Phonetoxins inhibit voltage-gated calcium CaV2.2 ion channel splice isoforms of dorsal root ganglia https://www.biorxiv.org/content/10.1101/2023.08.29.555337v1
Cell-specific alternative splicing of Cacna1b pre-mRNA generates functionally distinct voltage-gated
www.biorxiv.org
August 31, 2023 at 9:16 AM
biorxiv-neursci.bsky.social
Cacna1b alternative splicing is linked to associative learning https://www.biorxiv.org/content/10.64898/2026.02.17.706441v1
February 18, 2026 at 8:15 AM
biorxiv-neursci.bsky.social
ω-Phonetoxins inhibit voltage-gated calcium CaV2.2 ion channel splice isoforms of dorsal root ganglia https://www.biorxiv.org/content/10.1101/2023.08.29.555337v1
ω-Phonetoxins inhibit voltage-gated calcium CaV2.2 ion channel splice isoforms of dorsal root ganglia https://www.biorxiv.org/content/10.1101/2023.08.29.555337v1
Cell-specific alternative splicing of Cacna1b pre-mRNA generates functionally distinct voltage-gated
www.biorxiv.org
August 31, 2023 at 9:16 AM