#CACNA1D
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ajrcmb.bsky.social
Emerging Role of CircularRNA-Cacna1d in Sepsis-induced Lung Injury: A Potential Therapeutic Target and Biomarker
@atscommunity.bsky.social #medsky

🔓 Open Access

🔗 tinyurl.com/bdh38p52
Emerging Role of CircularRNA-Cacna1d in Sepsis-induced Lung Injury: A Potential Therapeutic Target and Biomarker | American Journal of Respiratory Cell and Molecular Biology
tinyurl.com
February 21, 2025 at 5:09 PM
ajrcmb.bsky.social
Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p
@atscommunity.bsky.social #medsky

🔗 tinyurl.com/5n7x8xmt
February 21, 2025 at 5:10 PM
ajrcmb.bsky.social
Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p
@atscommunity.bsky.social #medsky

🔗 tinyurl.com/5n7x8xmt
February 6, 2025 at 10:34 PM
thevgccc.bsky.social
The Voltage-Gated #Calcium Channel Collective - a #CACNA1A, #CACNA1B, #CACNA1C, #CACNA1D, #CACNA1E, #CACNA1F, #CACNA1G, #CACNA1H, #CACNA1I & #CACNA1S collaboration alongside researchers and clinicians raising awareness, accelerating knowledge, signposting and empowering our communities.
#IonChannels
What is the VGCCC? Voltage-Gated Calcium Channels act like doors on cells, opening when there's an electrical signal. They let calcium ions* flow in, helping with muscle movement, neurotransmission, and other important body functions. The genes that represent the Voltage-Gated Calcium Channels are CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I and CACNA1S. In the same way the channels work together like a team to ensure proper cell communication and function, we are collaborating as patient gene groups with a network of researchers to raise awareness and accelerate knowledge for all our gene groups. We are the Voltage-Gated Calcium Channel Collective. * Calcium ions are positively charged particles of calcium, an essential mineral found in the body.
November 18, 2024 at 3:17 PM
rnadoctor.bsky.social
2/4 Grad student Md Mostafizur Rahman presented a poster on RNA splicing of voltage-gated calcium channel CaV1.3 #CACNA1D

#RNAsplicing
#calcium
#ionchannel
April 14, 2026 at 7:23 PM
vetcancerhealth.bsky.social
Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat #Aldosterone-Secreting Tumors.
#veterinary #oncology
www.ahajournals.org/doi/10.1161/...
Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors | Hypertension
BACKGROUND: Primary aldosteronism (PA) is a common cause of human hypertension. Somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 are found in at least 80% of aldosterone-producing adenomas, whi...
www.ahajournals.org
November 24, 2024 at 8:38 PM
ajrcmb.bsky.social
Emerging Role of CircularRNA-Cacna1d in Sepsis-induced Lung Injury: A Potential Therapeutic Target and Biomarker
@atscommunity.bsky.social #medsky

🔓 Open Access

🔗 tinyurl.com/bdh38p52
Emerging Role of CircularRNA-Cacna1d in Sepsis-induced Lung Injury: A Potential Therapeutic Target and Biomarker | American Journal of Respiratory Cell and Molecular Biology
tinyurl.com
February 6, 2025 at 10:25 PM
biorxivpreprint.bsky.social
Electrophysiological abnormalities associated with a CACNA1D variant are rescued by AAV6-Cav1.3-C-terminus gene therapy in patient-iPSC-CMs https://www.biorxiv.org/content/10.64898/2025.12.15.694396v1
December 18, 2025 at 4:01 AM
rnadoctor.bsky.social
Mostafiz presented a poster entitled: "Splicing-Dependent Modulation of CaV1.3 Calcium Channels: Implications for Neurological Disease and Therapeutic Targeting".

#ionchannel
#calciumchannel
#CACNA1D
#AlternativeSplicing
#RNAsplicing
#RNA
#splicing
April 24, 2026 at 6:26 PM
rridrobot.bsky.social
RRID:AB_11180613 from @thermofishersci.bsky.social was used by authors in their paper. Thanks for making your methods matter! #methodsmatter #ReproducibleResearch #methodsmatter
Aberrant calcium signaling and neuronal activity in the L271H CACNA1D (Cav1.3) iPSC model of neurodevelopmental disease
doi.org
January 28, 2026 at 11:02 PM
rnadoctor.bsky.social
Congratulations to my PhD student Md Mostafizur Rahman for winning an award at St. John's University Student Research Conference 2026 with his poster entitled: "Alternative Splicing as a Driver of CaV1.3 Functional Diversity"🏆

#ionchannel
#calciumchannel
#CACNA1D
#AlternativeSplicing
#RNAsplicing
April 23, 2026 at 2:41 PM
thevgccc.bsky.social
#CACNA1D
Raising awareness and promoting collaboration across the calcium channelopathies. Find us at thevgccc.org
A digital graphic with a purple background features white text and an illustrated unicorn with a light purple mane. The heading, "LOOKING FOR THE ONE IN A MILLION," is in bold uppercase letters. The text below explains that the CACNA1D gene regulates calcium entry in tissues like the heart and brain. It describes how changes in this gene can lead to conditions such as hypoglycemia, hyperinsulinism, bradycardia, epilepsy, autism spectrum disorder, neurological delays, and difficulties with speech and walking. The message invites families and individuals with confirmed CACNA1D gene changes to join the CACNA1D community and provides a contact call-to-action. The VGCCC website, "thevgccc.org," is listed at the bottom. Small green stars are scattered around the unicorn.
March 7, 2025 at 3:29 PM
research.migraine.kr
Genetic variants in pharmacokinetic and pharmacodynamic pathways impact the metabolism, efficacy, and adverse drug reactions of drugs used in migraine. Variants in genes such as PLCE1, SRP72, CACNA1D, and CACNA1C affect calcium channel blockers' efficacy, while polymorphisms in (🧵 3/7)
March 16, 2026 at 3:21 AM
idw-online.de
Forschungsgruppe untersucht für seltene Erkrankungen verantwortliche Genmutationen
Spannungsabhängige Kalziumkanäle stehen mit zahlreichen Erkrankungen in Verbindung. Eine neue Forschungsgruppe unter der Leitung von Nadine Ortner vom Institut...
weiterlesen
V.l.: Frank Edenhofer, Stefanie Geisler, Nadine Ortner, Petronel Tuluc und Christopher Esk, Petronel Tuluc bilden die neue Forschungsgruppe "Multisystemische Studie von pathogenen CACNA1D-Varianten". - Copyright Universität Innsbruck
May 12, 2025 at 6:44 AM
paper.migraine.kr
약동학 및 약력학 경로의 유전적 변이는 편두통 치료에 사용되는 약물의 대사, 효능 및 부작용에 영향을 미칩니다. PLCE1, SRP72, CACNA1D, CACNA1C와 같은 유전자의 변이는 칼슘 채널 차단제의 효능에 영향을 미치는 반면, GNB3 및 DRD2의 다형성은 트립탄 계열 약물에 대한 반응에 영향을 미칩니다. (🧵 2/4)
March 16, 2026 at 12:27 AM
longtail-news.bsky.social
Feed: "Molecular Psychiatry"
By: Frank Edenhofer
Aberrant calcium signaling and neuronal activity in the L271H CACNA1D (Cav1.3) iPSC model of neurodevelopmental disease
Molecular Psychiatry - Aberrant calcium signaling and neuronal activity in the L271H CACNA1D (Cav1.3) iPSC model of neurodevelopmental disease
www.nature.com
January 11, 2026 at 4:32 PM
single-molecule.bsky.social
#AGBTGM26 HF: CBL encodes E3 ubiq ligase. Acts as dominant negative. Q367P does not affect binding but prevents ubiquitination by wild type. CACNA1D not previously implicated in autism but 2 mutations in active site neighborhood
February 25, 2026 at 2:52 PM
biorxiv-physio.bsky.social
Electrophysiological abnormalities associated with a CACNA1D variant are rescued by AAV6-Cav1.3-C-terminus gene therapy in patient-iPSC-CMs https://www.biorxiv.org/content/10.64898/2025.12.15.694396v1
December 18, 2025 at 4:01 AM
biorxivpreprint.bsky.social
Autism associated mutation in Cacna1d causes perseverative behavioral phenotype in mice https://www.biorxiv.org/content/10.64898/2026.01.13.699343v1
January 14, 2026 at 10:16 AM
rnadoctor.bsky.social
We uncover an unexpected synergy between RNA editing & alternative splicing in the CaV1.3 calcium channel. This mechanism fine-tunes neuronal Ca²⁺ entry & may protect against excitotoxicity.

#IonChannels #CalciumChannel #CACNA1D #ExcitoToxicity
October 14, 2025 at 2:39 PM
biorxiv-neursci.bsky.social
Autism associated mutation in Cacna1d causes perseverative behavioral phenotype in mice https://www.biorxiv.org/content/10.64898/2026.01.13.699343v1
January 14, 2026 at 10:16 AM